Umlobi: Gregory Harris
Usuku Lokudalwa: 15 Epreli 2021
Ukuvuselela Usuku: 17 Unovemba 2024
Anonim
Tafenoquine: Malaria Drug Development
Ividiyo: Tafenoquine: Malaria Drug Development

-Delile

I-Tafenoquine (Krintafel) isetshenziselwa ukuvimbela ukubuya kukamalaleveva (isifo esibi esasatshalaliswa omiyane ezingxenyeni ezithile zomhlaba futhi singadala ukufa) kubantu abaneminyaka engu-16 nangaphezulu abathelelekile futhi njengamanje bathola i-chloroquine noma i-hydroxychloroquine ukwelapha umalaleveva. I-Tafenoquine (i-Arakoda) isetshenziswa yodwa ukuvimbela umalaleveva kubahambi abavakashela izindawo lapho umalaleveva ujwayelekile khona. I-Tafenoquine isekilasini lemithi ebizwa ngama-antimalarials. Isebenza ngokubulala izinto ezibanga umalaleveva.

I-Tafenoquine iza njengamaphilisi okuphuza ngomlomo ngokudla. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-tafenoquine njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma uthatha i-tafenoquine (Krintafel) ukuvikela umalaleveva ukuthi ungabuyi, uvame ukuthathwa njengomthamo owodwa (amaphilisi ama-2) ngosuku lokuqala noma lwesibili lokwelashwa kwakho nge-chloroquine noma i-hydroxychloroquine.


Uma uthatha i-tafenoquine (Arakoda) ukuvikela umalaleveva, umthamo owodwa (amaphilisi ama-2) uvame ukuphuzwa kanye ngosuku izinsuku ezintathu, ukuqala izinsuku ezintathu ngaphambi kokuya endaweni lapho kukhona i-malaria. Ngenkathi ukule ndawo, umthamo owodwa (amaphilisi ama-2) uvame ukuthathwa kanye ngesonto ngosuku olufanayo lwesonto. Ngemuva kokubuya endaweni, umthamo owodwa (amaphilisi ama-2) uvame ukuthathwa ezinsukwini eziyi-7 ngemuva komthamo wokugcina owathathwa ngaphambi kokubuya kwakho. Akufanele uthathe i-tafenoquine (Arakoda) yokuvikela umalaleveva izinyanga ezingaphezu kwezingu-6.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Uma uhlanza kungakapheli ihora ngemuva kokuthatha i-tafenoquine (Krintafel), shayela udokotela wakho. Ungadinga ukuthatha omunye umthamo walo muthi.

Thatha i-tafenoquine uze uqede incwadi kadokotela, noma ngabe uzizwa ungcono. Uma uyeka ukuthatha i-tafenoquine maduzane noma weqe imithamo, ukutheleleka kwakho kungenzeka kungalashwa ngokuphelele noma ungahle uvikeleke ezifweni ezizayo.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi wesiguli uma uthatha iTafenoquine (Krintafel). Uma uthatha i-tafenoquine (Arakoda), udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wokwelashwa) lapho uqala ukwelashwa futhi isikhathi ngasinye ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukuthola uMhlahlandlela Wezokwelapha.


Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-tafenoquine,

  • Tshela udokotela kanye nosokhemisi wakho uma une-aleji ku-tafenoquine, primaquine, noma imuphi omunye umuthi, noma iziphi izithako kumathebulethi e-tafenoquine.
  • Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-dofetilide (Tikosyn) ne-metformin (i-Fortamet, i-Glucophage, i-Riomet, e-Actoplus Met, ezinye). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
  • Tshela udokotela wakho uma une-glucose-6-phosphate dehydrogenase (G-6-PD) yokushoda (isifo segazi esizuzwe njengefa). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-tafenoquine. Tshela nodokotela wakho uma uke waba nezinkinga zempilo yengqondo noma wake waba nazo. Udokotela wakho angakutshela ukuthi ungathathi i-tafenoquine.
  • Tshela udokotela wakho uma ngabe uke waba ne-hemolytic anemia (isimo esinenani eliphansi ngokungajwayelekile lamaseli abomvu egazi), i-methemoglobinemia (isimo esinamaseli abomvu egazi angasebenziyo angakwazi ukuthwala umoya-mpilo aye ezicutshini emzimbeni), i-nicotinamide i-adenine dinucleotide (NADH) ukushoda (isimo sofuzo), noma isifo sezinso noma sesibindi.
  • utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma ungowesifazane oseminyakeni yobudala bokubeletha, kuzofanele wenze ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa. Kufanele usebenzise ukulawulwa kokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nge-tafenoquine nangezinyanga ezintathu ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi uthatha i-tafenoquine, shayela udokotela wakho ngokushesha. I-Tafenoquine ingalimaza umbungu.
  • tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.


Shayela udokotela noma usokhemisi wakho akubuze ukuthi wenzeni uma uphuthelwa umthamo we-tafenoquine (Arakoda).

I-Tafenoquine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

  • isicanucanu
  • ukuhlanza
  • isifo sohudo
  • ubunzima bokulala noma ukulala
  • ukukhathazeka
  • ukushintsha kwemizwa
  • amaphupho angajwayelekile
  • ikhanda
  • izinkinga zombono, kufaka phakathi ukungaboni kahle noma ukuzwela ekukhanyeni

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

  • ukuqubuka
  • isifuba
  • ukuvuvukala kwamehlo, ubuso, izindebe, ulimi, umlomo, noma umphimbo
  • ukuphefumula kanzima noma ukugwinya
  • ukuphelelwa umoya
  • ukushuba noma ukuqina komphimbo
  • umchamo onombala omnyama
  • umbala ompunga nohlaza okwesibhakabhaka wezindebe kanye / noma isikhumba
  • isiyezi
  • ukudideka
  • ukusangana (ukubona izinto noma ukuzwa amazwi angekho)
  • ukukhohlisa (ukuba nemicabango noma izinkolelo eziyinqaba ezingenasisekelo eqinisweni) njengemicabango abantu abazama ukukulimaza noma bengenayo
  • ubumhlophe
  • ukuphuzi kwesikhumba noma kwamehlo

I-Tafenoquine ingadala eminye imiphumela emibi.Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho anga-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-tafenoquine.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

  • Arakoda®
  • I-Krintafel®
Kugcine ukubuyekezwa - 02/15/2021

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