Ukuhlolwa kwe-anti-insulin antibody

Ukuhlolwa kwe-anti-insulin antibody kuyahlola ukubona ukuthi umzimba wakho ukhiqize yini amasosha omzimba alwa ne-insulin.

Ama-antibody amaprotheni akhiqizwa ngumzimba ukuzivikela lapho ethola noma yini "engaphandle," njengegciwane noma isitho esitshalwe kabusha.

Kudingeka isampula yegazi.

Akukho ukulungiselela okukhethekile okudingekayo.

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bazizwa beshaywa noma betinyelwa kuphela. Ngemuva kwalokho, kungahle kube nokushaywa okuthile noma ukulimazeka okuncane. Lokhu maduzane kuyaphela.

Lokhu kuhlolwa kungenziwa uma:

• Unobungozi noma usengozini yesifo sikashukela sohlobo 1.
• Kubonakala sengathi unempendulo yokungezwani ne-insulin.
• I-insulini ayisabonakali ilawula isifo sakho sikashukela.
• Uthatha i-insulin ukulawula isifo sakho sikashukela futhi izinga likashukela egazini lakho liyahlukahluka kakhulu, ngazo zombili izinombolo eziphakeme neziphansi ezingenachazwa ngokudla okudlayo maqondana nesikhathi somjovo wakho we-insulin.

Ngokuvamile, awekho amasosha omzimba alwa ne-insulin egazini lakho. Ama-antibody angatholakala egazini labantu abaningi abathatha i-insulin ukulawula isifo sikashukela.

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma avivinye amasampula ahlukile. Khuluma nomhlinzeki wakho wezokunakekelwa kwempilo mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Uma unamasosha omzimba we-IgG ne-IgM alwa ne-insulin, umzimba wakho uphendula sengathi i-insulin esemzimbeni wakho iyiprotheni yangaphandle edinga ukususwa. Lo mphumela ungaba yingxenye yokuhlolwa okukuxilonga nge-autoimmune noma uthayiphe isifo sikashukela esingu-1.

Uma unesifo sikashukela futhi uthuthukisa ama-anti-insulin antibodies, lokhu kungenza i-insulin ingasebenzi kahle, noma ingasebenzi nhlobo.

Lokhu kungenxa yokuthi i-antibody ivimbela i-insulin ukuthi isebenze ngendlela efanele kumaseli akho. Ngenxa yalokho, ushukela wegazi lakho ungaphakama ngokungavamile. Abantu abaningi abathatha i-insulin ukwelapha isifo sikashukela banamasosha omzimba abonakalayo. Kodwa-ke, la ma-antibody awazibangeli izimpawu noma ashintshe ukusebenza kwe-insulin.

Ama-antibodies futhi angandisa umphumela we-insulin ngokukhipha i-insulin ethile ngemuva kokudla kwakho. Lokhu kungakubeka engcupheni yokuba noshukela ophansi wegazi.

Uma isivivinyo sikhombisa izinga eliphakeme le-antibody ye-IgE elwa ne-insulin, umzimba wakho usungule impendulo yokungezwani ne-insulin. Lokhu kungakubeka engcupheni yokuphendula kwesikhumba lapho ujova khona i-insulin. Ungakha futhi ukusabela okunzima kakhulu okuthinta umfutho wegazi noma ukuphefumula kwakho.

Eminye imithi, efana nama-antihistamine noma ama-steroid anomjovo ophansi, ingasiza ukunciphisa ukusabela. Uma ukusabela kube nzima, ungadinga inqubo yokwelashwa ebizwa ngokuthi ukungafuneki kwemvelo noma olunye ukwelashwa ukususa amasosha omzimba egazini lakho.

Kunengozi encane ethintekayo ekuthatheni igazi lakho. Imithambo nemithambo yegazi kuyahluka ngosayizi komunye umuntu kuya kolunye uhlangothi lomzimba kuya kolunye. Ukuthola isampula yegazi kwabanye abantu kungaba nzima kakhulu ukwedlula kwabanye.

Ezinye izingozi zokudonswa igazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• Ukubhoboza okuningi ukuthola imithambo
• I-Hematoma (ukwakha igazi ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

Amasosha omzimba we-insulin - i-serum; Ukuhlolwa kwe-Insulin Ab; Ukumelana ne-insulin - amasosha omzimba e-insulin; Isifo sikashukela - amasosha omzimba e-insulin

• Ukuhlolwa kwegazi

I-Atkinson MA, Mcgill DE, Dassau E, Laffel L. Thayipha i-1 yesifo sikashukela. Ku: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, abahleli. Incwadi kaWilliams ye-Endocrinology. Umhlaka 14. IPhiladelphia, PA: Elsevier; 2020: isahluko 36.

IChernecky CC, iBerger BJ. Ama-antibodies e-insulin kanye ne-insulin - igazi. Ku: IChernecky CC, iBerger BJ, ama-eds. Ukuhlolwa Kwelabhoratri Nezinqubo Zokuxilonga. Umhlaka 6. IPhiladelphia, PA: Elsevier Saunders; 2013: 682-684.