Vemurafenib

-Delile

• Ngaphambi kokuthatha vemurafenib,
• IVemurafenib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:
• Uma uhlangabezana nalezi zimpawu ezilandelayo zokungezwani komzimba noma ukusabela okunzima kwesikhumba, yeka ukuthatha i-vemurafenib bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Vemurafenib isetshenziselwa ukwelapha izinhlobo ezithile ze-melanoma (uhlobo lomdlavuza wesikhumba) ongeke welashwe ngokuhlinzwa noma osabalele kwezinye izingxenye zomzimba. Iphinde isetshenziselwe ukwelapha uhlobo oluthile lwesifo i-Erdheim-Chester (ECD; isifo esibanga ukukhiqizwa ngokweqile kohlobo lwamaseli amhlophe egazi). UVemurafenib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunciphisa noma ukumisa ukusabalala kwamangqamuzana omdlavuza.

IVemurafenib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa noma ngaphandle kokudla kabili ngosuku, ekuseni nakusihlwa, cishe ngamahora ayi-12 ngokuhlukana. Thatha vemurafenib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha vemurafenib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho. Ungayeki ukuthatha vemurafenib ngaphandle kokukhuluma nodokotela wakho.

Gwinya wonke amaphilisi ngengilazi yamanzi; ungawahlafune noma uwachoboze.

Uma uhlanza ngemuva kokuthatha i-vemurafenib, ungathathi omunye umthamo ngokushesha. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho kungadingeka ukuthi ayeke ukwelashwa kwakho okwesikhashana noma unomphela noma anciphise umthamo wakho we-vemurafenib ngesikhathi sokwelashwa kwakho. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe kanye nemiphumela emibi oyitholayo. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngenkathi welashwa nge-vemurafenib.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-vemurafenib futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha vemurafenib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-vemurafenib, noma imuphi omunye umuthi, noma iziphi izithako ezikumaphilisi e-vemurafenib. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi kokulandelayo: ama-antifungal athile afana ne-itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), ne-voriconazole (Vfend); i-clarithromycin (i-Biaxin, ku-PrevPac); imishanguzo ethile yegciwane lesandulela ngculaza (i-HIV) noma i-immunodeficiency syndrome (i-AIDS) efana ne-indinavir (Crixivan), i-nelfinavir (i-Viracept), i-ritonavir (i-Norvir, e-Kaletra), ne-saquinavir (i-Invirase); imithi ethile yokuquleka efana ne-carbamazepine (Carbatrol, Epitol, Tegretol, abanye), phenobarbital, ne-phenytoin (Dilantin, Phenytek); nefazodone; i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); tizanidine; kanye ne-warfarin (Coumadin, Jantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-vemurafenib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• tshela udokotela wakho uma ngabe uke waba nanoma yiluphi uhlobo lomdlavuza wesikhumba noma wake waba nalo; isikhathi se-QT eside (inkinga yenhliziyo engajwayelekile engadala ukushaya kwenhliziyo okungajwayelekile, ukuquleka, noma ukufa ngokuzuma); ukwehluleka kwenhliziyo; izinga eliphansi le-calcium, i-magnesium, noma i-potassium egazini lakho; inhliziyo, izinso, noma isifo sesibindi. Futhi, tshela udokotela wakho uma uke wathola noma uhlela ukuthola ukwelashwa ngemisebe.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Akufanele ukhulelwe ngenkathi uthatha i-vemurafenib. Kufanele usebenzise ukulawulwa kokuzalwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho ne-vemurafenib kanye namasonto ama-2 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi uthatha i- vemurafenib, shayela udokotela wakho. IVemurafenib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthatha i-vemurafenib kanye namasonto ama-2 ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-vemurafenib.
• hlela ukugwema ukuvezwa yilanga ngokungadingekile noma isikhathi eside futhi ugqoke izingubo zokuzivikela, izibuko zelanga, i-lip balm kanye ne-sunscreen (i-SPF 30 noma ngaphezulu). IVemurafenib ingenza isikhumba sakho sizwele ekukhanyeni kwelanga.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphakathi kwamahora ama-4 wedosi yakho elandelayo ehleliwe, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

IVemurafenib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhathala
• ukujoyina, imisipha, ingalo, umlenze, noma izinhlungu emuva
• ububomvu noma ukuvuvukala ezandleni, ezinyaweni, emaqakaleni, noma emilenzeni engezansi
• shintsha ngomqondo wokunambitha
• ikhanda
• ukulahleka kwezinwele
• isikhumba esomile noma esilumayo
• isifo sohudo
• ukuqunjelwa
• ukukhwehlela

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• izinguquko ekubukeni kwesikhumba
• insumpa entsha
• isikhumba esibuhlungu noma isibomvu esibomvu esopha noma esingapholi
• shintsha ngosayizi noma umbala wemvukuzane
• ukukhathala ngokweqile
• ukulimaza noma ukopha okungavamile
• isicanucanu
• ukuhlanza
• ukulahlekelwa isifiso sokudla
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• ukuphuzi kwesikhumba noma kwamehlo
• ukuzwela kweso ekukhanyeni
• ukubomvu kweso noma ubuhlungu
• umbono uyashintsha
• ukuqina okungajwayelekile kwezintende zezandla
• ukuqiniswa kweminwe ngaphakathi kuya entendeni yesandla
• ukuqina okungajwayelekile kwamathe ezinyawo, okungaba buhlungu

Uma uhlangabezana nalezi zimpawu ezilandelayo zokungezwani komzimba noma ukusabela okunzima kwesikhumba, yeka ukuthatha i-vemurafenib bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuphefumula kanzima noma ukugwinya
• ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla
• ukuquleka
• ukuqubuka noma ububomvu emzimbeni wonke
• isifuba
• isikhumba esihlabayo noma esishayayo
• imfiva

IVemurafenib ingakhuphula ubungozi bokuthi uzoba neminye imidlavuza. Khuluma nodokotela wakho ngale ngozi.

IVemurafenib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kuma-vemurafenib. Udokotela wakho uzohlola isikhumba sakho ngaphambi kokuqala ukwelashwa, njalo ezinyangeni ezimbili ngesikhathi sokwelashwa kwakho, futhi kuze kube izinyanga eziyisithupha emva kokwelashwa.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Zelboraf^®