Simeprevir

-Delile

• Ngaphambi kokuthatha i-simeprevir,
• ISimeprevir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezibalwe ezigabeni EZIBALULEKILE ZESEXWAYISO NOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

ISimeprevir ayisatholakali e-United States. Uma njengamanje uthatha i-simeprevir, kufanele ushayele udokotela wakho ukuze axoxe ngokushintshela kolunye ukwelashwa.

Kungenzeka ukuthi usungenwe yi-hepatitis B (igciwane elithelela isibindi futhi lingadala ukulimala kwesibindi) kepha ungabi nazimpawu zesifo. Kulokhu, ukuthatha i-simeprevir kungandisa ubungozi bokuthi ukutheleleka kwakho kuzoba kubi kakhulu noma kusongele impilo futhi uzoba nezimpawu. Tshela udokotela wakho uma ngabe uke waba nokutheleleka ngegciwane lesifo sokusha kwesibindi kohlobo B. Udokotela wakho uzokuyalela ukuhlolwa kwegazi ukuze abone ukuthi uke waba nokutheleleka kwesifo sikashukela B. Udokotela wakho uzokuhlola futhi nangezimpawu zokutheleleka kwesifo sokusha kwesibindi kohlobo B ngesikhathi nangezinyanga ezimbalwa ngemuva kokwelashwa kwakho. Uma kunesidingo, udokotela wakho angakunika imithi yokwelapha lesi sifo ngaphambi nangesikhathi sokwelashwa kwakho nge-simeprevir. Uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva kokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhathala ngokweqile, ukuphuzi kwesikhumba noma kwamehlo, ukulahlekelwa isifiso sokudla, isicanucanu noma ukuhlanza, indle ephaphathekile, ubuhlungu besisu, noma umchamo omnyama.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile ngaphambi, ngesikhathi, nangemva kokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-simeprevir.

Khuluma nodokotela wakho ngobungozi (s) bokuthatha i-simeprevir.

ISimeprevir isetshenziswa kanye ne-ribavirin (Copegus, Rebetol) ne-peginterferon alfa (Pegasys) ukwelapha isifo sokusha kwesibindi kohlobo C (okutheleleka okuqhubekayo kwegciwane okulimaza isibindi). ISimeprevir isekilasini lemithi ebizwa nge-protease inhibitors. Isebenza ngokunciphisa inani le-virus ye-hepatitis C (HCV) emzimbeni. ISimeprevir kungenzeka ingavimbeli ukusakazeka kwesifo sokusha kwesibindi kohlobo C kwabanye abantu.

ISimeprevir iza njengephilisi elizothathwa ngomlomo. Kuvame ukuthathwa nokudla kanye ngosuku. Thatha i-simeprevir ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-simeprevir njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Uzothatha i-simeprevir ne-peginterferon alfa ne-ribavirin amasonto ayi-12. Ngemuva kwalokho uzoyeka ukuthatha i-simeprevir futhi uzothatha i-peginterferon ne-ribavirin amanye amasonto ayi-12 noma angama-36. Ubude bokwelashwa kwakho buxhomeke ekutheni ngabe uthole ukwelashwa kwangaphambili yini kwesifo sokusha kwesibindi kohlobo C, ukuthi uphendule kanjani ekwelashweni kwangaphambili, ukuthi uphendula kanjani emithini, nokuthi ngabe unemiphumela emibi kakhulu yini. Qhubeka nokusebenzisa i-simeprevir, i-peginterferon alfa, ne-ribavirin inqobo nje uma kunqunywe udokotela wakho. Ungayeki ukuthatha noma iyiphi yale mithi ngaphandle kokukhuluma nodokotela wakho noma ngabe uzizwa uphilile.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-simeprevir,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-simeprevir, izidakamizwa ze-sulfa, noma imuphi omunye umuthi, noma iziphi izithako ezikuma-simeprevir capsules. Buza usokhemisi wakho noma hlola imininingwane yesiguli somkhiqizi ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: imishanguzo ethize yokubulala izinhlungu efana ne-fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), noma i-voriconazole (Vfend); ama-calcium channel blocker anjenge-amlodipine (Norvasc), diltiazem (Cardizem, Dilacor XR, Tiazac), felodipine, nicardipine (Cardene), nifedipine (Adalat, Procardia), nisoldipine (Sular), noma i-verapamil (Calan, Verelan, abanye); imithi ethile ye-cholesterol ephezulu njenge-atorvastatin (Lipitor, eCaduet), lovastatin (Altoprev), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor), noma i-simvastatin (Flolipid, Zocor, eVytorin); i-cisapride (Propulsid) (ayitholakali e-U.S.); i-clarithromycin (i-Biaxin, ku-Prevpac); imithi equkethe i-cobicistat (Stribild); erythromycin (EES, Eryc, Ery-tab, others), imishanguzo ethile ye-HIV efana ne-atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (Kaletra), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), saquinavir (Invirase), noma tipranavir (Aptivus); imithi ethile yokushaya kwenhliziyo okungajwayelekile njenge-amiodarone (Nexterone, Pacerone), i-disopyramide (i-Norpace), i-flecainide (i-Tambocor), i-mexiletine, i-propafenone (i-Rythmol SR), noma i-quinidine (e-Nuedexta); i-cyclosporine (Gengraf, Neoral, Sandimmune); i-dexamethasone; i-digoxin (i-Lanoxin); i-ledipasvir (Harvoni); i-midazolam ethathwe ngomlomo; i-rifabutin (i-Mycobutin); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); i-rifapentine (Priftin); imishanguzo ethile yokuquleka efana ne-carbamazepine (Epitol, Equetro, Tegretol), oxcarbazepine (Trileptal), phenobarbital, noma phenytoin (Dilantin, Phenytek); i-sildenafil (uphawu lwe-Revatio kuphela olusetshenziselwa isifo samaphaphu); i-sirolimus (i-Rapamune); itacrolimus (Prograf); i-tadalafil (kuphela i-Adcirca brand esetshenziselwa isifo samaphaphu); i-telithromycin (Ketek); i-triazolam (Halcion) ethathwe ngomlomo; vardenafil (Levitra, Staxyn), noma warfarin (Coumadin, Jantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-simeprevir, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo engamakhambi oyithathayo, ikakhulukazi ubumbane noma ubisi lweSt. Akufanele uthathe i-thistle yobisi noma iSt John's wort ngesikhathi sokwelashwa kwakho nge-simeprevir.
• Tshela udokotela wakho ukuthi uke wafakelwa isibindi yini, uma uthola i-phototherapy, uma ungowokuzalwa eMpumalanga Asia, futhi uma ngabe uke waba nanoma yiluphi uhlobo lwesifo sesibindi ngaphandle kwe-hepatitis C.
• Tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma kungenzeka ukhulelwe. Uma ungowesilisa, tshela udokotela wakho uma umlingani wakho ekhulelwe, ehlela ukukhulelwa, noma angakhulelwa. ISimeprevir kumele ithathwe nge-ribavirin engalimaza umbungu kakhulu. Kufanele usebenzise izindlela ezimbili zokuvimbela inzalo ukuvimbela ukukhulelwa kuwe noma kumlingani wakho ngenkathi welashwa ngale mithi nangezinyanga eziyisithupha ngemuva kokwelashwa kwakho. Khuluma nodokotela wakho mayelana nokuthi yiziphi izindlela okufanele uzisebenzise; Izindlela zokuvimbela inzalo zamahomoni (amaphilisi okulawula ukubeletha, iziqeshana, izimila, izindandatho, noma imijovo) kungenzeka zingasebenzi kahle kwabesifazane abathatha le mithi. Wena noma umlingani wakho kufanele nihlolelwe ukukhulelwa ngaphambi kokwelashwa, njalo ngenyanga ngesikhathi sokwelashwa, futhi izinyanga eziyisithupha emva kokwelashwa kwakho. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha le mithi, shayela udokotela wakho ngokushesha.
• tshela udokotela wakho uma uncelisa.
• hlela ukugwema ukuvezwa yilanga ngokungadingekile noma isikhathi eside futhi ugqoke izingubo zokuzivikela, izibuko zelanga, isigqoko, kanye nelanga lapho ulashwa nge-simeprevir. Futhi gwema ukusebenzisa imibhede yokushuka, izibani zelanga, noma ezinye izinhlobo zokwelashwa okulula ngesikhathi sokwelashwa kwakho. ISimeprevir ingenza isikhumba sakho sizwele ekukhanyeni kwelanga. Shayela udokotela wakho ngokushesha uma uhlangabezana nokushiswa yilanga okunzima noma ukushiswa, ubomvu, ukuvuvukala, amabhamuza esikhunjeni sakho, noma amehlo abomvu noma avuvukile.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ophuthelwe ngokudla ngokushesha nje lapho usakukhumbula. Kodwa-ke, uma kungaphansi kwamahora angu-12 ngaphambi kwesikhathi esihleliwe sethamo lakho elilandelayo, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

ISimeprevir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukulunywa
• isicanucanu
• ubuhlungu bemisipha

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezibalwe ezigabeni EZIBALULEKILE ZESEXWAYISO NOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuphefumula kanzima
• ukuqubuka
• izilonda zomlomo noma izilonda
• amehlo abomvu noma avuvukile ("iso elibomvana")

ISimeprevir ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Ukugcine ekamelweni lokushisa kude nokukhanya, ukushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• U-Olysio^®