I-Biologics ne-PsA: Yini Izinketho Zakho?

-Delile

• Yini i-biologics?
• Isetshenziswa kanjani i-biologics ukwelapha iPSA?
• Yiziphi izinketho zami zokwelapha iPSA nge-biologic?
• I-TNF-alpha inhibitors
• IL-12, IL-23, kanye ne-IL-17 inhibitors
• Ama-T-cell inhibitors
• I-JAK kinase inhibitor
• Ngabe i-biologics iphephile kuwo wonke umuntu one-PsA?
• Iyini imiphumela emibi yokuthatha i-biologic?
• Ukuthatha

Ukubuka konke

I-Psoriatic arthritis, noma i-PsA, ibangela ukuvuvukala, ukuqina, nobuhlungu obuhlangene. Alikho ikhambi le-PsA, kepha ushintsho lwendlela yokuphila nemithi kungasiza ukuphatha izimpawu.

Imithi ejwayele ukusetshenziswa yizidakamizwa ezingezona ukuvuvukala (ama-NSAID), izidakamizwa eziguqula izifo zokulwa nezifo (ama-DMARD), kanye ne-biologics.

Ama-biologics awamasha, kepha anikeza ukwelashwa okuthuthuke kakhulu manje kunanini ngaphambili. Imihlahlandlela emisha incoma le mithi njengenye yezindlela zokwelashwa komugqa wokuqala ze-PsA.

Yini i-biologics?

Imithi yendabuko iqukethe izinto zokwenziwa. Zenziwe ngamakhemikhali angatholakali emvelweni.

Izidakamizwa ezijwayelekile abantu abazaziyo nabazethembayo zenziwa kusethingi laselebhu kusuka ezintweni ezingezona ezemvelo. I-Aspirin, isibonelo, yayimodeliswa ngemuva kwento ethile egxolweni lomnyezane, kodwa manje yenziwa ngezinto zokwenziwa.

Ngakolunye uhlangothi, i-biologics yakhiwe ngezinto eziphilayo. Ososayensi basebenzisa amaseli aphelele, ama-enzyme, amasosha omzimba, nezinye izinto ukudala umuthi onomsebenzi othile.

Kungenzeka ukuthi usuvele uvezwe kubuchwepheshe bezokwelapha obenziwe ngezinto ezitholakala kwimvelo. Uma ngabe uke waba nomuthi wokugoma noma wampontshelwa igazi, uthole ukwelashwa okwenziwe ngokususelwa ezintweni eziphilayo.

Ngoba i-biologics inemba ngqo lapho ikhomba amaseli, futhi ilingisa ama-molecule atholakala ngokwemvelo emzimbeni, ngokuvamile asebenza kangcono. Futhi banemiphumela emibi embalwa kunezidakamizwa ezenziwe ngamakhemikhali.

Isetshenziswa kanjani i-biologics ukwelapha iPSA?

Ukuvuvukala kuvame ukudala ukuvuvukala, ukuqina, nobuhlungu obuhlangene obuchaza i-PsA. I-Biologics esetshenziselwa ukwelapha i-PsA ikhomba ngqo izindlela ezahlukahlukene emzimbeni ezakha ukuvuvukala. Lokhu kwehlukile emithini yendabuko, ekhomba izinyathelo eziningi emasosheni omzimba.

Ngokuya ngezimpawu zakho ze-psoriatic arthritis kanye nomlando wezokwelapha, udokotela wakho angancoma enye ye-biologics eziningana ukuze kutholakale usizo.

Yiziphi izinketho zami zokwelapha iPSA nge-biologic?

Kunezinketho eziningi zokwelapha i-PsA yakho nge-biologic. Le mithi ingaqoqwa ngudokotela wakho ngokuya ngokuthi isebenza kanjani maqondana namasosha omzimba.

I-TNF-alpha inhibitors

I-Tumor necrosis factor-alpha (TNF-alpha) yiprotheni eholela ekuvukeleni. Abantu abane-PsA banezilinganiso ezeqile ze-TNF-alpha esikhunjeni sabo noma emajoyintini abo.

Le mithi emihlanu yenzelwe ukuvimba le protein:

• I-Cimzia (certolizumab pegol)
• I-Enbrel (etanercept)
• I-Humira (adalimumab)
• I-Remicade (infliximab)
• I-Simponi (golimumab)

Basebenza ngokumisa ukukhula ngokweqile kwamaseli esikhumba nokuvuvukala okungaholela ekulimaleni kwezicubu ezihlangene.

IL-12, IL-23, kanye ne-IL-17 inhibitors

I-Interleukin-12, i-interleukin-17, ne-interleukin-23 zingamaprotheni ahlukile ahambisana nokuvuvukala. Ama-biologics amahlanu akhona njengamanje azophazamisa umsebenzi noma ne-receptor ehambisanayo yalawa maprotheni.

Le mithi yenzelwe ukuvimbela ukuvuvukala:

• UStelara (ustekinumab): IL-12/23
• ICosentyx (secukinumab): IL-17
• I-Taltz (ixekizumab): IL-17
• I-Siliq (brodalumab): IL-17
• I-Tremfya (guselkumab): IL-23

Ama-T-cell inhibitors

Kubantu abane-arthritis, amaseli e-T-lymphocyte, noma ama-T-cell, ayasebenza, okungaholela ekwandeni kwalawa maseli. Abanye abantu abane-arthritis empeleni bazokwakha okweqile kwama-T-cell.

Lawa ngamaseli omzimba, okuyinto sonke esiyidingayo. Kodwa ngobuningi, akhiqiza amakhemikhali aholela ekulimaleni ngokuhlanganyela, ebuhlungwini nasekuvuvukeni.

I-Orencia (abatacept) umuthi othinta ama-T-cell. I-Orencia ayinciphisi isibalo sama-T-cell, kepha iyamisa ukuphuma kwamakhemikhali adala izimpawu ngokuvimba ukusebenza kwe-T-cell.

I-JAK kinase inhibitor

I-Xeljanz (tofacitinib) ngomunye umuthi ovunyelwe i-PsA. Yi-JAK kinase inhibitor, ebhekisa kwimolekyuli encane evimba indlela ebandakanyeka ekuphenduleni kokuvuvukala kwamasosha omzimba.

Le mithi akuyona i-biologic, kodwa udokotela wakho angakhuluma nawe ngakho. Kuvame ukuqoqwa ndawonye ne-biologics ezingxoxweni mayelana nama-ejenti aqondiswe kakhulu wokuzimela.

Ngabe i-biologics iphephile kuwo wonke umuntu one-PsA?

Kunconywa ama-biologics kulabo abaphila ne-PsA emaphakathi kuya enzima. Kodwa abanye abantu abalona ukhetho lwe-biologics.

Lokho kungenxa yokuthi imiphumela emibi yomuthi ingenza okubi kunokuhle. Abantu abanamasosha omzimba abekiwe noma ukutheleleka okusebenzayo akumele bathathe i-biologics ye-PsA yabo. Le mithi icindezela amasosha omzimba futhi ingaphepha uma ngabe eyakho isivele yonakaliswe ngandlela thile.

Izindleko nezindleko eziphuma ephaketheni ze-biologics nazo zingaba yisithiyo kwabanye abantu.

Iyini imiphumela emibi yokuthatha i-biologic?

I-biologic ngayinye ye-PsA yehlukile. Ngayinye inemiphumela yayo emibi engaba khona. Kodwa-ke, kukhona nokufana kulesi sigaba semithi. Umphumela ovame kakhulu we-biologics yingozi eyengeziwe yokutheleleka okungajwayelekile, noma okungosomathuba.

Uma wena nodokotela wakho ninquma ukuzama le ndlela yokwelashwa nge-biologic, ungahlangabezana nezimpawu ezinjengomkhuhlane noma izifo zokuphefumula. Njengoba i-biologics inikezwa ngomjovo noma i-IV, ungahle uzwe ukungakhululeki lapho inaliti ihlaba khona isikhumba sakho.

I-biologics ingaholela emiphumeleni emibi kakhulu, njengokuphazamiseka kwegazi noma umdlavuza. Ngalezi zizathu, kuwumqondo omuhle ukwakha ubuhlobo obuqinile nodokotela wakho. Ngokubambisana, ninganquma ukuthi ngabe i-biologic iyindlela efanele yini yokwelapha i-psoriatic arthritis yakho.

Ukuthatha

I-Biologics yethule izinketho zokwelashwa ezihlosiwe kulabo abaphila ne-PsA emaphakathi kuya enzima. Akubona bonke abasha, kepha manje sebethathwa njengokwelashwa komugqa wokuqala wokwelapha iPSA.