Yini Ebangela Ukudlathubala?

-Delile

• Ingabe i-narcolepsy iyithinta kanjani imijikelezo yokulala?
• Izifo ezizimele
• Ukungalingani kwamakhemikhali
• Izakhi zofuzo nomlando womndeni
• Ukulimala kobuchopho
• Izifo ezithile
• Ukuthatha

I-narcolepsy uhlobo lwesifo sobuchopho esingapheli esithinta imijikelezo yakho yokulala.

Imbangela ngqo yokuhlaselwa yisiyezi ayaziwa, kepha ochwepheshe bakholelwa ukuthi kunezici ezithile ezingadlala indima.

Lezi zinto zibandakanya izifo ezizimele, ukungalingani kwamakhemikhali ebuchosheni, izakhi zofuzo, kokunye ukulimala kobuchopho.

Funda ukuze ufunde kabanzi ngezimbangela ezingaba khona nezici zobungozi be-narcolepsy.

Ingabe i-narcolepsy iyithinta kanjani imijikelezo yokulala?

Ubusuku obujwayelekile bokulala buqukethe iphethini yokuhamba kwamehlo okusheshayo (REM) kanye nemijikelezo engeyona eye-REM. Ngesikhathi somjikelezo we-REM, umzimba wakho ungena esimweni sokukhubazeka nokuphumula okujulile.

Imvamisa kuthatha imizuzu engama-90 yokulala okungeyona eye-REM ukufaka umjikelezo we-REM - kepha uma une-narcolepsy, ukulala okungeyona i-REM ne-REM akuhambi njengoba kufanele. Ungafaka umjikelezo we-REM ngemizuzu eyi-15, noma ngesikhathi sasemini lapho ungazami ukulala.

Ukuphazanyiswa okunjalo kwenza ukulala kwakho kungabuyisi kakhulu kunokufanele futhi kungenzeka kukuvuse njalo ubusuku bonke. Kungase futhi kuholele ezinkingeni phakathi nosuku, kufaka phakathi ukulala ngokweqile emini nezinye izimpawu ze-narcolepsy.

Yize kungaziwa imbangela ngqo yalokhu kuphazamiseka, abacwaningi bathole izinto eziningana ezingaba nomthelela.

Izifo ezizimele

Obunye ubufakazi busikisela ukuthi izifo ezizimele zingadlala indima ekuthuthukiseni i-narcolepsy.

Emasosheni omzimba aphilile, amaseli omzimba ahlasela abahlaseli njengamagciwane abangela izifo namagciwane. Lapho amasosha omzimba ehlasela ngephutha amaseli nezicubu zomzimba ezinempilo, lokhu kuchazwa njengesifo sokuzivikela komzimba.

Kuhlobo lokuxinwa kohlobo 1, amaseli kumasosha omzimba angahlasela amaseli athile obuchopho akhiqiza i-hormone eyaziwa njenge-hypocretin. Idlala indima ekulawuleni imijikelezo yokulala.

Kungenzeka ukuthi isifo se-autoimmune naso singadlala indima kuhlobo lwesi-2 se-narcolepsy. Ucwaningo olulodwa olushicilelwe ephephabhukwini iNeurology luthole ukuthi abantu abane-narcolepsy yohlobo lwe-2 babenamathuba amaningi kunabantu abangenayo i-narcolepsy yokuba nezinye izinhlobo zezifo ezizimele.

Ukungalingani kwamakhemikhali

I-Hypocretin yi-hormone ekhiqizwa ubuchopho bakho. Kuyaziwa nangokuthi i-orexin. Kuyasiza ukukhuthaza ukuphaphama ngenkathi kucindezela ukulala kwe-REM.

Amazinga we-hypocretin angaphansi kokujwayelekile angahle abangele uphawu olubizwa ngokuthi yi-cataplexy kubantu abane-narcolepsy yohlobo 1. ICataplexy ukulahleka okungazelelwe, kwesikhashana kwethoni yemisipha ngenkathi uphapheme.

Abanye abantu abane-narcolepsy yohlobo 2 banamazinga aphansi e-hypocretin. Kodwa-ke, abantu abaningi abane-narcolepsy yohlobo 2 banamazinga ajwayelekile ale hormone.

Phakathi kwabantu abane-narcolepsy yohlobo lwe-2 abanamazinga aphansi e-hypocretin, abanye bangagcina behlakule i-cataplexy bese bethayipha i-narcolepsy yokuqala.

Izakhi zofuzo nomlando womndeni

Ngokusho kweNational Organisation for Rare Disorders, ucwaningo luthole ukuthi abantu abane-narcolepsy banezinguquko ku-T cell receptor gene. I-narcolepsy iphinde yaxhunyaniswa nokuhlukahluka okuthile kofuzo eqenjini lezakhi zofuzo elibizwa ngokuthi yi-human leukocyte antigen complex.

Lezi zofuzo zithinta ukusebenza kwamasosha akho omzimba. Kudingeka izifundo eziningi ukuze zifunde ukuthi zingaba kanjani nesandla ekuqothulweni kwezidakamizwa.

Ukuba nalezi zici zofuzo akusho ukuthi nakanjani uzokuthuthukisa i-narcolepsy, kepha kukubeka engcupheni ephezulu yokuphazamiseka.

Uma unomlando womndeni we-narcolepsy, kuphakamisa amathuba akho okuba nesimo. Kodwa-ke, abazali abane-narcolepsy badlulisela lesi simo enganeni yabo kumaphesenti angaba ngu-1 kuphela.

Ukulimala kobuchopho

I-narcolepsy yesibili iyindlela engavamile kakhulu ye-narcolepsy, okuyinto engaphansi kakhulu kunehlobo 1 noma uhlobo lwe-2 narcolepsy.

Esikhundleni sokubangelwa yisifo esizimele noma i-genetics, i-narcolepsy yesibili ibangelwa ukulimala kwengqondo.

Uma uhlangabezana nokulimala ekhanda okulimaza ingxenye ethile yobuchopho bakho obaziwa ngokuthi yi-hypothalamus, ungahle uthuthukise izimpawu zesifo sokuluthwa kwesibili. Izicubu zobuchopho nazo zingadala lesi simo.

Abantu abane-narcolepsy yesibili bavame ukuhlangabezana nezinye izingqinamba zezinzwa. Lokhu kungafaka ukudangala noma okunye ukuphazamiseka kwemizwelo, ukulahleka kwememori, kanye ne-hypotonia (ukwehla kwethoni yemisipha).

Izifo ezithile

Imibiko embalwa yamacala iphakamise ukuvezwa kwezifo ezithile kungadala ukuqala kokudlondlobalisa kwabanye abantu. Kodwa abukho ubufakazi obuqinile besayensi bokuthi noma yikuphi ukutheleleka noma ukwelashwa kubangela isimo.

Ukuthatha

Izici eziningana zingaba nomthelela ekukhuleni kwe-narcolepsy, njengesifo se-autoimmune, ukungalingani kwamakhemikhali, kanye nofuzo.

Ososayensi bayaqhubeka nokuphenya izimbangela ezingaba khona nezici zobungozi be-narcolepsy, kufaka phakathi izingxenye ezizimele nezakhi zofuzo.

Ukufunda kabanzi ngezimbangela zalesi simo kungasiza ukuvula indlela eya kumasu okwelashwa asebenza kangcono.