I-Crohn's Disease Rash: Kubukeka Kanjani?

-Delile

• Izimpawu zesikhumba
• Izilonda zePerianal
• Izilonda zomlomo
• Isifo seMetastatic Crohn
• U-Erythema nodosum
• I-Pyoderma gangrenosum
• I-Sweet’s syndrome
• Izimo ezihlanganisiwe
• Ukusabela ezidakamizweni
• Ukushoda kwamavithamini
• Izithombe
• Kungani lokhu kwenzeka
• Ukwelashwa
• Ukubonana nodokotela nini
• Okubalulekile

Isifo sikaCrohn uhlobo lwesifo samathumbu esivuthayo (IBD). Abantu abanesifo sikaCrohn bahlangabezana nokuvuvukala emkhakheni wabo wokugaya ukudla, okungaholela ezimpawu ezifana nalezi:

• ubuhlungu besisu
• isifo sohudo
• ukuncipha komzimba

Kulinganiselwa ukuthi abantu abangamaphesenti angama-40 abanesifo sikaCrohn bahlangabezana nezimpawu ezingabandakanyi umgudu wokugaya ukudla.

Indawo lapho izimpawu zivela khona ngaphandle kwendlela yokugaya ukudla yisikhumba.

Kungani isifo sikaCrohn ngqo singathinta isikhumba kusazwisiswa kahle. Kungahle kube ngenxa:

• imiphumela eqondile yalesi sifo
• izici zomzimba
• ukusabela emithini

Qhubeka ufunde ukuze ufunde kabanzi ngesifo sikaCrohn nesikhumba.

Izimpawu zesikhumba

Abantu abanesifo sikaCrohn bangaba nezinhlobonhlobo zezilonda zesikhumba. Ake sihlole ezinye zazo ngokuningiliziwe ngezansi.

Izilonda zePerianal

Izilonda zePerianal zitholakala eduze kwendunu. Bangaba:

• okubomvu
• kuvuvukele
• kubuhlungu kwesinye isikhathi

Izilonda zePerianal zingathatha ukubonakala okuhlukahlukene, kufaka phakathi:

• izilonda
• amathumba
• imifantu, noma uqhekeko esikhunjeni
• i-fistula, noma ukuxhumana okungajwayelekile phakathi kwezingxenye ezimbili zomzimba
• amathegi esikhumba

Izilonda zomlomo

Izilonda nazo zingavela emlonyeni. Lapho kuvela izilonda zomlomo, ungabona izilonda ezibuhlungu ngaphakathi komlomo wakho, ikakhulukazi ngaphakathi kwezihlathi noma izindebe.

Kwesinye isikhathi ezinye izimpawu zingaba khona, kufaka phakathi:

• udebe oluhlukanisiwe
• amabala abomvu noma aqhephukile emakhoneni omlomo, okubizwa nge-angular cheilitis
• izindebe ezivuvukele noma izinsini

Isifo seMetastatic Crohn

Isifo seMetastatic Crohn's asivamile.

Izindawo ezivame kakhulu ukuthinteka yilezi:

• ubuso
• izitho zangasese
• emaphethelweni

Ingatholakala futhi ezindaweni lapho iziqeshana ezimbili zesikhumba zihlangana khona.

Lezi zilonda zivame ukubukeka njenge-plaque, yize kwezinye izimo zingabukeka zifana nezilonda. Anombala obomvu noma onsomi ngombala. Izilonda zemetastatic zingavela zodwa noma ngamaqembu.

U-Erythema nodosum

I-Erythema nodosum ibonakala ngamabhampu abomvu noma amaqhubu athambile avela ngaphansi kwesikhumba.

Zivame ukutholakala emaphethelweni akho aphansi, ikakhulukazi ngaphambili kwe-shin yakho. Imfiva, ukubanda, ubuhlungu, nezinhlungu nakho kungenzeka.

I-Erythema nodosum ukubonakaliswa kwesikhumba okuvame kakhulu kwesifo sikaCrohn. Kaningi, kepha hhayi ngaso sonke isikhathi, iqondana ne-flare-up.

I-Pyoderma gangrenosum

Lesi simo siqala ngesigaxa esikhunjeni esigcina sikhule sibe yisilonda noma isilonda esinesisekelo esiphuzi. Ungaba nesilonda esisodwa se-pyoderma gangrenosum noma izilonda eziningi. Indawo evame kakhulu imilenze.

Njenge-erythema nodosum, i-pyoderma gangrenosum ingahle yenzeke ngesikhathi sokuqhuma. Lapho izilonda ziyelapheka, kungaba khona izibazi ezinkulu. Cishe amaphesenti angama-35 abantu angabuyela ekuphindeni.

I-Sweet’s syndrome

I-Sweet’s syndrome ifaka phakathi ama-papules abomvu athambile amboza ikhanda lakho, isibilini nezingalo. Zingavela ngokwehlukana noma zikhule ndawonye zenze uqweqwe.

Ezinye izimpawu ze-sweet's syndrome zifaka:

• imfiva
• ukukhathala
• izinhlungu
• izinhlungu

Izimo ezihlanganisiwe

Ezinye ezinye izimo zihlotshaniswa nesifo sikaCrohn futhi zingadala nezimpawu zesikhumba. Ezinye izibonelo zifaka:

• ukhwekhwe
• i-vitiligo
• i-systemic lupus erythematosus (SLE)
• i-amyloidosis ezenzakalelayo

Ukusabela ezidakamizweni

Kwezinye izimo, izilonda zesikhumba zitholakala kubantu abathatha uhlobo lwemithi ye-biologic ebizwa ngomuthi olwa ne-TNF. Lezi zilonda zibukeka njenge-eczema noma i-psoriasis.

Ukushoda kwamavithamini

Isifo sikaCrohn singaholela ekungondlekeni, kufaka phakathi ukushoda kwamavithamini. Izinhlobonhlobo zalezi zingadala izimpawu zesikhumba. Izibonelo zifaka:

• Ukushoda kweZinc. Ukushoda kwe-Zinc kubanga amabala abomvu noma ama-plaque angahle abe nama-pustules.
• Ukushoda kwe-Iron. Ukushoda kwe-iron kubanga amabala abomvu, aqhekekile emakhoneni omlomo.
• Ukushoda kuka-Vitamin C. Ukushoda kuka-Vitamin C kubangela ukopha ngaphansi kwesikhumba, okwenza amabala afana nokulimala avele.

Izithombe

Izimpawu zesikhumba ezihambisana nesifo sikaCrohn zingavela ngokuhlukahluka kakhulu, kuya ngohlobo lwazo nendawo.

Skrolela kulezi zithombe ezilandelayo ngezibonelo ezithile.

Kungani lokhu kwenzeka

Akuqondakali kahle ukuthi isifo sikaCrohn sibangela kanjani izimpawu zesikhumba. Abaphenyi bayaqhubeka nokuphenya lo mbuzo.

Nakhu esikwaziyo:

• Ezinye izilonda, ezinjengezilonda ze-perianal kanye ne-metastatic, kubonakala sengathi zibangelwa ngqo yisifo sikaCrohn. Lapho i-biopsied futhi ihlolwa ngemicroscope, izilonda zinezici ezifanayo nesifo sokugaya esingaphansi.
• Ezinye izilonda, njenge-erythema nodosum ne-pyoderma gangrenosum, kukholelwa ukuthi zabelana ngezindlela zezifo nesifo sikaCrohn's.
• Ezinye izimo ezizimele ezenza izimpawu zesikhumba, njenge-psoriasis ne-SLE, zihlotshaniswa nesifo sikaCrohn.
• Izici zesibili ezihlobene nesifo sikaCrohn, njengokungondleki kanye nemithi esetshenziswa ekwelashweni, nakho kungadala izimpawu zesikhumba.

Ngakho-ke konke lokhu kungahlangana kanjani ndawonye? Njengezinye izimo ezizimele, isifo sikaCrohn sibandakanya amasosha omzimba ahlasela amaseli aphilile. Yilokhu okuholela ekuvukeleni okuhambisana nesimo.

Ucwaningo lwezilwane lukhombisile ukuthi iseli lomzimba elibizwa nge-Th17 cell libalulekile kwisifo sikaCrohn. Amaseli we-Th17 nawo ahambisana nezinye izimo ezizimele, kufaka phakathi lezo ezingathinta isikhumba.

Njengalokhu, lawa maseli kungenzeka abe ukuxhumana phakathi kwesifo sikaCrohn nezinye izimpawu zesikhumba ezihambisana naso.

Olunye ucwaningo lukhombisa ukuthi kunezici eziningi zomzimba ezihambisana nalesi sifo.

Kodwa-ke, ucwaningo olwengeziwe luyadingeka ukubhekana nokuxhumana phakathi kwesifo sikaCrohn nesikhumba.

Ukwelashwa

Kunezinhlobo zokwelashwa ezingaba khona zezilonda zesikhumba ezihlobene nesifo sikaCrohn. Ukwelashwa okuqondile okutholayo kuzoya ngohlobo lwezilonda zesikhumba onazo.

Kwesinye isikhathi imithi ingasiza ekunciphiseni izimpawu zesikhumba. Ezinye izibonelo zemithi umhlinzeki wakho wezokunakekelwa kwempilo angayinikeza zifaka:

• corticosteroids, okungaba ngomlomo, ukujova, noma isihloko.
• izidakamizwa zokuzivikela emzimbeni, njenge-methotrexate noma i-azathioprine
• imithi elwa nokuvuvukala, njenge-sulfasalazine
• anti-TNF biologics, njenge-infliximab noma i-adalimumab
• ama-antibiotic, angasiza ngama-fistula noma amathumba

Ezinye izindlela zokwelashwa ezingaba khona zifaka:

• ukuyeka i-anti-TNF biologic uma kubangela izimpawu zesikhumba
• okuphakamisa izithasiselo zamavithamini lapho ukungondleki kubangele ukuntuleka kwamavithamini
• ukwenza ukuhlinzwa ukuze kususwe i-fistula enamandla, noma i-fistulotomy

Kwezinye izimo, izimpawu zesikhumba zingenzeka njengengxenye yesifo seCrohn's flare-up. Uma lokhu kwenzeka, ukuphatha ukuvuleka kungasiza ekunciphiseni izimpawu zesikhumba.

Ukubonana nodokotela nini

Uma unesifo sikaCrohn futhi uthuthukisa izimpawu zesikhumba okholelwa ukuthi zihlobene nesimo sakho, yenza i-aphoyintimenti nomhlinzeki wakho wezokunakekelwa kwempilo.

Kungadingeka ukuthi bathathe i-biopsy ukuthola ukuthi yini ebangela izimpawu zakho.

Ngokuvamile, kuhlale kungumthetho omuhle ukubona umhlinzeki wakho wezokunakekelwa kwezempilo uma ubona izimpawu zesikhumba ukuthi:

• ukumboza indawo enkulu
• ukusabalala ngokushesha
• kubuhlungu
• babe namabhamuza noma amanzi oketshezi
• kwenzeka ngomkhuhlane

Okubalulekile

Abantu abaningi abanesifo sikaCrohn bazohlangabezana nezimpawu ezithinta izindawo ezingezona ezokugaya ukudla.

Enye yalezi zindawo yisikhumba.

Kunezinhlobo eziningi zezilonda zesikhumba ezihambisana nesifo sikaCrohn. Lokhu kungenzeka ngenxa ye:

• imiphumela eqondile yalesi sifo
• izici ezithile zomzimba ezihambisana nalesi sifo
• izinkinga ezihambisana nalesi sifo, njengokungondleki

Ukwelashwa kungancika ohlotsheni lwesilonda. Kungavame ukubandakanya ukuthatha umuthi ukusiza ukukhulula izimpawu zakho.

Uma unesifo sikaCrohn futhi ubona izimpawu zesikhumba ocabanga ukuthi kungenzeka zihlobene, bheka umhlinzeki wakho wezokunakekelwa kwempilo.