I-Hepatitis C Genotype 2: Ongakulindela

-Delile

• Kungani kubalulekile ukuthi ngine-genotype 2?
• Yelashwa kanjani i-hepatitis C genotype 2?
• I-Glecaprevir ne-pibrentasvir (Mavyret)
• ISofosbuvir ne-velpatasvir (i-Epclusa)
• IDaclatasvir (Daklinza) nesofosbuvir (Sovaldi)
• Aphathwa kanjani amanye ama-genotypes
• Yiziphi izinkinga ezingaba khona?
• Umbono

Ukubuka konke

Uma usuthole ukuxilongwa kwesifo sokusha kwesibindi kohlobo C, nangaphambi kokuba uqale ukwelashwa, uzodinga okunye ukuhlolwa kwegazi ukuthola uhlobo lwegciwane. Kunezinhlobo eziyisithupha ezakhiwe kahle ze-genotypes (izinhlobo) ze-hepatitis C, kanye nama-subtypes angaphezu kwama-75.

Ukuhlolwa kwegazi kunikeza imininingwane ethile mayelana nokuthi lingakanani igciwane okwamanje elisegazini lakho.

Lokhu kuhlolwa ngeke kudingeke ukuthi kuphindwe ngoba i-genotype ayishintshi. Yize kungavamile, kungenzeka ukuthi utheleleke nge-genotype engaphezu kweyodwa. Lokhu kubizwa ngokuthi yi-superinfection.

E-United States, cishe amaphesenti ayi-13 kuye kwayi-15 abantu abane-hepatitis C bane-genotype 2. IGenotype 1 inguye futhi ithinta abantu abangamaphesenti angama-75 abane-hepatitis C.

Ukwazi i-genotype yakho kuthinta izincomo zakho zokwelashwa.

Kungani kubalulekile ukuthi ngine-genotype 2?

Ukwazi ukuthi une-genotype 2 inikeza ulwazi olubalulekile mayelana nezinketho zakho zokwelashwa nokuthi zingasebenza kangakanani.

Ngokuya ngohlobo lwe-genotype, odokotela banganciphisa ukuthi iziphi izindlela zokwelashwa ezingasebenza ngempumelelo nokuthi kufanele uzithathe isikhathi esingakanani. Lokhu kungakuvimbela ekuchitheni isikhathi ekwelashweni okungalungile noma ekuphuzeni imishanguzo isikhathi eside kunalokho okudingeka ukwenze.

Amanye ama-genotype aphendula ngokuhlukile ekwelashweni kunamanye. Futhi udinga isikhathi esingakanani ukuthatha umuthi kungahluka ngokuya ngohlobo lwakho lofuzo.

Kodwa-ke, i-genotype ayikwazi ukutshela odokotela ukuthi isimo sizothuthuka ngokushesha kangakanani, ukuthi izimpawu zakho zingaba zimbi kangakanani, noma uma ukutheleleka okunamandla kuzoba okungapheli.

Yelashwa kanjani i-hepatitis C genotype 2?

Akucaci ukuthi kungani, kodwa kubantu kusula ukutheleleka kwe-hepatitis C ngaphandle kokwelapha. Njengoba ingekho indlela yokwazi ukuthi ngubani owela kulesi sigaba, ekuthelelekeni okunamandla, udokotela wakho uzoncoma ukulinda izinyanga eziyi-6 ukwelapha igciwane, ngoba lingasula ngokuzenzekelayo.

I-Hepatitis C ilashwa ngemithi elwa namagciwane esula umzimba wakho igciwane futhi ivimbele noma inciphise ukulimala esibindini sakho. Imvamisa, uzothatha inhlanganisela yemithi emibili elwa namagciwane amasonto ayi-8 noma ngaphezulu.

Kukhona ithuba elihle lokuthi uzoba nempendulo eqhubekayo ye-virologic (SVR) ekwelashweni kwezidakamizwa zomlomo. Ngamanye amagama, iyelapheka kakhulu. Izinga le-SVR yezinhlanganisela eziningi zemishanguzo yesifo sokusha kwesibindi kohlobo C liphakeme ngamaphesenti angama-99.

Lapho ukhetha izidakamizwa futhi unquma ukuthi kufanele uzithathe isikhathi esingakanani, udokotela wakho uvame ukubheka lezi zinto ezilandelayo:

• impilo yakho yonke
• lingakanani igciwane elikhona ohlelweni lwakho (inani legciwane egazini)
• noma ngabe usuvele une-cirrhosis noma omunye umonakalo esibindini sakho
• ukuthi ngabe usuvele welashelwa i-hepatitis C, nokuthi unayiphi imishanguzo

I-Glecaprevir ne-pibrentasvir (Mavyret)

Ungahle unikezwe le nhlanganisela uma umusha ekwelashweni noma welashwe nge-peginterferon kanye ne-ribavirin noma i-sofosbuvir kanye ne-ribavirin (i-RibaPack) futhi ayikulaphile. Umthamo amaphilisi amathathu, kanye ngosuku.

Uzoyiphuza isikhathi esingakanani umuthi:

• uma ungenayo i-cirrhosis: amasonto ayi-8
• uma une-cirrhosis: amasonto ayi-12

ISofosbuvir ne-velpatasvir (i-Epclusa)

Le nhlanganisela ingenye indlela yabantu abasha ekwelashweni, noma labo abake baphathwa ngaphambilini. Uzothatha ithebhulethi eyodwa ngosuku amasonto ayi-12. Umthamo uyefana, noma ngabe une-cirrhosis.

IDaclatasvir (Daklinza) nesofosbuvir (Sovaldi)

Le rejimeni ivunyelwe i-hepatitis C genotype 3. Akuvunyelwe ukwelapha i-genotype 2, kodwa odokotela bangayisebenzisa ngaphandle kwelebula kubantu abathile abanale genotype.

Umthamo uyithebhulethi eyodwa yedaclatasvir nethebhulethi eyodwa ye-sofosbuvir kanye ngosuku.

Uzoyiphuza isikhathi esingakanani umuthi:

• uma ungenayo i-cirrhosis: amasonto ayi-12
• uma unesifo sokuqina kwesibindi: amasonto ayi-16 kuya kwangama-24

Ukuhlolwa kwegazi okulandelwayo kuzoveza ukuthi usabela kahle kangakanani ekwelashweni.

Qaphela: Ukusetshenziswa kwezidakamizwa ezingekho kwelebula kusho ukuthi umuthi ovunyelwe yi-FDA ngenhloso eyodwa usetshenziselwa injongo ehlukile engavunyelwe. Kodwa-ke, udokotela usengasisebenzisa lesi sidakamizwa ngaleyo njongo. Lokhu kungenxa yokuthi i-FDA ilawula ukuhlolwa nokuvunywa kwezidakamizwa, kodwa hhayi ukuthi odokotela bazisebenzisa kanjani izidakamizwa ukwelapha iziguli zabo. Ngakho-ke, udokotela wakho angakunikeza umuthi kodwa bacabanga ukuthi kungcono kakhulu ukunakekelwa kwakho. Funda kabanzi ngokusetshenziswa kwezidakamizwa ezingekho kwelebula.

Aphathwa kanjani amanye ama-genotypes

Ukwelashwa kwama-genotypes 1, 3, 4, 5, no-6 nakho kuncike ezintweni ezahlukahlukene ezifana nomthamo wegciwane kanye nobukhulu bokulimala kwesibindi. AmaGenotypes 4 no-6 awavamile kakhulu, kanti ama-genotypes 5 no-6 awavamile e-United States.

Imithi elwa namagciwane ingafaka le mithi noma inhlanganisela yayo:

• daclatasvir (Daklinza)
• i-elbasvir / grazoprevir (iZepatier)
• glecaprevir / pibrentasvir (Mavyret)
• ledipasvir / sofosbuvir (Harvoni)
• ombitasvir / paritaprevir / ritonavir (Technivie)
• i-ombitasvir / paritaprevir / ritonavir ne-dasabuvir (i-Viekira Pak)
• simeprevir (Olysio)
• i-sofosbuvir (Sovaldi)
• i-sofosbuvir / velpatasvir (i-Epclusa)
• i-sofosbuvir / velpatasvir / voxilaprevir (Yonkevi)
• ribavirin

Ubude bezokwelapha bungahluka ngohlobo lwe-genotype.

Uma ukulimala kwesibindi kukhulu ngokwanele, kunganconywa ukufakelwa kwesibindi.

Yiziphi izinkinga ezingaba khona?

IHepatitis C genotype 2 ivame ukwelashwa. Kodwa ukutheleleka okungapheli kungaholela ezinkingeni ezinkulu.

Iningi labantu abane-hepatitis C abanazo izimpawu noma izimpawu ezimnene kuphela, noma ngabe isibindi sonakala.

Izinyanga eziyisithupha zokuqala ngemuva kokutheleleka zichazwa njengokutheleleka okunamandla kwe-hepatitis C. Lokhu kuyiqiniso noma ngabe unezimpawu noma cha. Ngokwelashwa, futhi kwesinye isikhathi ngaphandle kokwelashwa, abantu abaningi basusa ukutheleleka ngalesi sikhathi.

Akunakwenzeka ukuthi ube nokulimala okukhulu kwesibindi phakathi nesigaba esibucayi, noma ezimweni ezingavamile kungenzeka ukuthi uzwe ukwehluleka kwesibindi okugcwele.

Uma usenalo igciwane kusistimu yakho ngemuva kwezinyanga eziyisithupha, unesifo esingalapheki se-hepatitis C. Noma kunjalo, lesi sifo ngokuvamile sithatha iminyaka eminingi ukuthuthuka. Izinkinga ezinkulu zingabandakanya ukuqina kwesibindi, umdlavuza wesibindi, nokwehluleka kwesibindi.

Izibalo zezinkinga ze-genotype 2 zizodwa ziyashoda.

Kuzo zonke izinhlobo zesifo sokusha kwesibindi kohlobo C e-United States, kulinganiselwa ukuthi:

• Abantu abangama-75 kuya kwabangu-85 kwabali-100 abathelelekile bazoqhubeka nokuthola ukutheleleka okungapheli
• I-10 kuye ku-20 izokwakha ukuqina kwesibindi kungakapheli iminyaka engama-20 kuye kwengu-30

Lapho nje abantu beba nesifo sokuqina kwesibindi, baqala ukuthola umdlavuza wesibindi unyaka nonyaka.

Umbono

Ngokushesha uthola ukwelashwa, ngcono amathuba akho okuvimbela ukulimala kwesibindi okukhulu. Ngokungeziwe ekwelashweni kwezidakamizwa, uzodinga ukuhlolwa kwegazi okulandelwayo ukuze ubone ukuthi isebenza kahle kangakanani.

Umbono we-hepatitis C genotype 2 muhle kakhulu. Lokho kuyiqiniso ikakhulukazi uma uqala ukwelashwa kusenesikhathi, ngaphambi kokuba igciwane lithole ithuba lokulimaza isibindi sakho.

Uma uphumelela ukususa i-hepatitis C genotype 2 kusuka kusistimu yakho, uzoba nama-antibody okusiza ukukuvikela ekuhlaselweni okuzayo. Kepha usengatheleleka ngohlobo oluhlukile lwe-hepatitis noma uhlobo oluhlukile lwe-hepatitis C.