Isifo semvubu

Isifo se-Whipple yisimo esingajwayelekile esithinta kakhulu amathumbu amancane. Lokhu kuvimbela amathumbu amancane ekuvumeleni izakhamzimba zidlule kuwo wonke umzimba. Lokhu kubizwa ngokuthi yi-malabsorption.

Isifo se-Whipple sibangelwa ukutheleleka ngohlobo lwebhaktheriya olubizwa ngokuthi I-Tropheryma whipplei. Lesi sifo sithinta kakhulu amadoda amhlophe aphakathi nendawo.

Isifo se-Whipple asivamile kakhulu. Izici zobungozi azaziwa.

Izimpawu zivame ukuqala kancane. Ubuhlungu obuhlangene kuyisifo sokuqala esivame kakhulu. Izimpawu zokutheleleka kwamathumbu (GI) zivame ukuvela eminyakeni eminingana kamuva. Ezinye izimpawu zingafaka:

• Ubuhlungu besisu
• Uhudo
• Imfiva
• Ukwenza mnyama kwesikhumba ezindaweni ezikhanyayo zomzimba
  
• Ubuhlungu obuhlangene emaqakaleni, emadolweni, endololwaneni, eminweni, noma kwezinye izindawo
• Ukulahleka kwememori
• Izinguquko zengqondo
• Ukwehla kwesisindo

Umhlinzeki wezokunakekelwa kwempilo uzokwenza ukuhlolwa komzimba. Lokhu kungakhombisa:

• Izindlala ze-lymph ezandisiwe
• Inhliziyo ibubula
• Ukuvuvukala kwezicubu zomzimba (i-edema)

Ukuhlolwa kokuthola isifo se-Whipple kungafaka:

• Qedela ukubalwa kwegazi (CBC)
• Ukuhlolwa kwe-Polymerase chain reaction (PCR) ukuhlola amagciwane abanga lesi sifo
• I-biopsy encane yamathumbu
• I-endoscopy ephezulu ye-GI (ukubuka amathumbu ngebhubhu eguquguqukayo, ekhanyisiwe ngenqubo ebizwa nge-enteroscopy)

Lesi sifo singashintsha nemiphumela yokuhlolwa okulandelayo:

• Izinga le-albhamu egazini
• Amafutha angafakwanga esitokisini (amafutha endle)
• Ukufakwa ngaphakathi kwamathumbu kohlobo lukashukela (ukumuncwa kwe-d-xylose)

Abantu abanesifo se-Whipple badinga ukuthatha ama-antibiotic wesikhathi eside ukwelapha noma yikuphi ukutheleleka kobuchopho kanye nesistimu yezinzwa emaphakathi. I-antibiotic ebizwa nge-ceftriaxone inikezwa ngomthambo (IV). Ilandelwa elinye i-antibiotic (njenge-trimethoprim-sulfamethoxazole) ethathwe ngomlomo kuze kube unyaka owodwa.

Uma izimpawu zibuya ngesikhathi sokusetshenziswa kwama-antibiotic, imithi ingashintshwa.

Umhlinzeki wakho kufanele alandele eduze inqubekelaphambili yakho. Izimpawu zalesi sifo zingabuya ngemuva kokuqeda ukwelashwa. Abantu abahlala bengondlekile futhi kuzodingeka bathathe izithako zokudla.

Uma singelashwa, lesi sifo sivame ukubulala. Ukwelashwa kudambisa izimpawu futhi kungaselapha lesi sifo.

Izinkinga zingafaka:

• Ukulimala kobuchopho
• Ukulimala kwe-valve yenhliziyo (kusuka ku-endocarditis)
• Ukushoda kokudla okunempilo
• Izimpawu ziyabuya (okungaba ngenxa yokumelana nemithi)
• Ukwehla kwesisindo

Shayela umhlinzeki wakho uma une:

• Ubuhlungu obuhlangene obungapheli
• Ubuhlungu besisu
• Uhudo

Uma welashelwa isifo se-Whipple, shayela umhlinzeki wakho uma:

• Izimpawu ziba zimbi kakhulu noma azithuthuki
• Izimpawu ziyavela futhi
• Izimpawu ezintsha ziyakhula

I-lipodystrophy yamathumbu

UMaiwald M, von Herbay A, i-Relman DA. Isifo semvubu. Ku: Feldman M, Friedman LS, Brandt LJ, ama-eds. Sleisenger kanye neFordtran's Gastrointestinal and Liver Disease. Umhla ka-11. IPhiladelphia, PA: Elsevier; 2021: isahluko 109.

UMarth T, isifo seSchneider T. Whipple. Ku: Bennett JE, Dolin R, Blaser MJ, ama-eds. Mandell, Douglas, kanye neBennett's Principles and Practice of Infectious Diseases. Umhlaka 9. IPhiladelphia, PA: Elsevier; 2020: isahluko 210.

ENtshonalanga SG. Izifo zesistimu lapho i-arthritis iyisici. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 259.