I-fasciitis ye-Eosinophilic

I-Eosinophilic fasciitis (EF) yisifo lapho izicubu ezingaphansi kwesikhumba nangaphezulu kwemisipha, ezibizwa ngokuthi i-fascia, ziyavuvukala, zivuthe futhi ziqine. Isikhumba esisezingalweni, emilenzeni, entanyeni, esiswini noma ezinyaweni singakhukhumala ngokushesha. Isimo asivamile kakhulu.

I-EF ingabukeka ifana ne-scleroderma, kepha ayihlobene. Ngokungafani ne-scleroderma, ku-EF, iminwe ayibandakanyeki.

Imbangela ye-EF ayaziwa. Amacala angavamile enzekile ngemuva kokuthatha izengezo ze-L-tryptophan. Kubantu abanalesi simo, amangqamuzana amhlophe egazi, abizwa ngama-eosinophil, ayakheka emisipheni nasezicutshini. Ama-eosinophil axhumene nokusabela okweqile. I-syndrome ivame kakhulu kubantu abaneminyaka engama-30 kuya kwengu-60.

Izimpawu zingafaka:

• Ukuthamba nokuvuvukala kwesikhumba ezingalweni, emilenzeni, noma kwesinye isikhathi amalunga (imvamisa ezinhlangothini zombili zomzimba)
• Isifo samathambo
• I-Carpal tunnel syndrome
• Ubuhlungu bemisipha
• Isikhumba esijiyile esibukeka sigaxekile

Ukuhlolwa okungenziwa kufaka phakathi:

• I-CBC enomehluko
• I-Gamma globulins (uhlobo lwama-protein system)
• Izinga le-sedimentation ye-Erythrocyte (ESR)
• I-MRI
• Imisipha biopsy
• I-biopsy yesikhumba (i-biopsy idinga ukufaka izicubu ezijulile ze-fascia)

Ama-Corticosteroids kanye neminye imithi ecindezela amasosha omzimba isetshenziselwa ukuqeda izimpawu. Le mithi isebenza kangcono lapho iqalwa ekuqaleni kwesifo. Izidakamizwa ezingezona ukuvuvukala (ama-NSAID) nazo zingasiza ukunciphisa izimpawu.

Ezimweni eziningi, lesi simo siyaphela kungakapheli unyaka owodwa kuya kwemithathu. Kodwa-ke, izimpawu zingahlala isikhathi eside noma zibuye.

I-arthritis inkinga eyingqayizivele ye-EF. Abanye abantu bangaba nezinkinga ezinkulu zegazi noma umdlavuza ohlobene negazi, njenge-aplastic anemia noma i-leukemia. Isimo sibi kakhulu uma kwenzeka izifo zegazi.

Shayela umhlinzeki wakho wezokunakekelwa kwezempilo uma unezimpawu zalesi sifo.

Akukho ukuvimbela okwaziwayo.

Isifo Shulman

• Imisipha yangaphandle engaphezulu

U-Aronson JK. I-Tryptophan. Ku: Aronson JK, ed. Imiphumela emibi kaMeyler yezidakamizwa. Umhla ka-16. I-Waltham, MA: I-Elsevier BV ;; 2016: 220-221.

UJames WD, u-Elston DM, Phatha i-JR, i-Rosenbach MA, i-IM ye-Neuhaus. Izifo zezicubu ezixhuma. Ku: James WD, Elston DM, Treat JR, Rosenbach MA, Neuhaus IM, eds. Izifo zika-Andrews 'Zesikhumba: I-Clinical Dermatology. Umhlaka 13. IPhiladelphia, PA: Elsevier; 2020: isahluko 8.

U-Lee LA, Werth VP. Isikhumba nezifo zamathambo. Ku: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, abahleli. Incwadi kaKelley noFirestein yeRheumatology. Umhlaka 10. IPhiladelphia, PA: Elsevier; I-2017: isahluko 43.

UPinal-Fernandez I, uSelva-O ’uCallaghan A, uGrau JM. Ukuxilongwa nokuhlukaniswa kwe-eosinophilic fasciitis. Gwema ngokuzenzakalela uMfu. 2014; 13 (4-5): 379-382. I-PMID: 24424187 www.ncbi.nlm.nih.gov/pubmed/24424187.

Inhlangano Kazwelonke Yezinkinga Ezingajwayelekile. I-fasciitis ye-Eosinophilic. rarediseases.org/rare-diseases/eosinophilic-fasciitis/. Kubuyekezwe i-2016. Kufinyelelwe ngoMashi 6, 2017.