Ukuhlolwa kwegazi lePyruvate kinase

Ukuhlolwa kwe-pyruvate kinase kukala izinga le-enzyme pyruvate kinase egazini.

I-Pyruvate kinase iyi-enzyme etholakala kumaseli abomvu egazi. Kuyasiza ukushintsha ushukela osegazini (i-glucose) uye emandleni lapho amazinga e-oxygen ephansi.

Kudingeka isampula yegazi. Elebhu, amaseli amhlophe egazi ayasuswa esampuleni yegazi ngoba angashintsha imiphumela yokuhlolwa. Izinga le-pyruvate kinase liyalinganiswa.

Akukho ukulungiselela okukhethekile okudingekayo.

Uma ingane yakho yenza lokhu kuhlolwa, kungasiza ukuchaza ukuthi isivivinyo sizozizwa kanjani futhi sibonise nakudoli. Chaza isizathu sokuhlolwa. Ukwazi ukuthi "kanjani futhi kungani" kunganciphisa ukukhathazeka kwengane yakho.

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bazizwa beshaywa noma betinyelwa kuphela. Ngemuva kwalokho, kungahle kube nokushaywa okuthile noma ukulimazeka okuncane. Lokhu maduzane kuyaphela.

Lokhu kuhlolwa kwenziwa ukuthola izinga eliphansi ngokungajwayelekile le-pyruvate kinase. Ngaphandle kwale enzyme eyanele, amangqamuzana abomvu egazi ancipha ngokushesha kunokujwayelekile. Lokhu kubizwa ngokuthi yi-hemolytic anemia.

Lokhu kuhlolwa kusiza ukuxilonga ukushoda kwe-pyruvate kinase (PKD).

Imiphumela iyahluka ngokuya ngendlela yokuhlola esetshenzisiwe. Ngokuvamile, inani elijwayelekile ngamayunithi ayi-179 ± 16 nge-100 ml yamaseli abomvu egazi.

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma avivinye amasampula ahlukile. Khuluma nomhlinzeki wakho wezokunakekelwa kwempilo mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Izinga eliphansi le-pyruvate kinase liqinisekisa i-PKD.

Kunengozi encane ethintekayo ekuthatheni igazi lakho. Imithambo nemithambo yegazi kuyahluka ngosayizi komunye umuntu kuya kolunye uhlangothi lomzimba kuya kolunye. Ukuthatha igazi kwabanye abantu kungaba nzima kakhulu ukwedlula kwabanye.

Ezinye izingozi ezihambisana nokudonswa igazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• Ukubhoboza okuningi ukuthola imithambo
• I-hematoma (i-blood buildup ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

I-Elghetany MT, iSchexneider KI, ukuphazamiseka kwe-Banki K. Erythrocytic. Ku: McPherson RA, Pincus MR, abahleli. UHenry’s Clinical Diagnosis and Management by Laboratory Methods. Umhla ka-23. ISt Louis, MO: Elsevier; I-2017: isahluko 32.

IGallagher PG. I-hemolytic anemias: i-red cell ulwelwesi namaphutha we-metabolic. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 152.

Papachristodoulou D. Amandla emethabolism. Ku: Naish J, Inkantolo yaseSyndercombe D, ama-eds. Isayensi Yezokwelapha. 3rd ed. IPhiladelphia, PA: Elsevier; 2019: isahluko 3.

van Solinge WW, van Wijk R. Ama-enzyme weseli elibomvu legazi. Ku: Rifai N, ed. I-Tietz Textbook ye-Clinical Chemistry kanye ne-Molecular Diagnostics. Umhlaka 6. IPhiladelphia, PA: Elsevier; 2018: isahluko 30.