Simvastatin

-Delile

• Ngaphambi kokuthatha i-simvastatin,
• ISimvastatin ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha noma uthole usizo oluphuthumayo lwezokwelapha.

ISimvastatin isetshenziswa kanye nokudla, ukwehlisa isisindo somzimba, nokuzivocavoca umzimba ukunciphisa ingozi yokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi nokunciphisa amathuba okuthi kudingeke ukuhlinzwa kwenhliziyo kubantu abanesifo senhliziyo noma abasengozini yokuhlaselwa yisifo senhliziyo. ISimvastatin nayo isetshenziselwa ukwehlisa inani lezinto ezinamafutha ezinjenge-low-density lipoprotein (LDL) cholesterol ('' cholesterol embi '') kanye ne-triglycerides egazini nokukhulisa inani le-cholesterol ephakeme kakhulu (i-HDL) cholesterol ' 'cholesterol enhle' ') egazini. ISimvastatin nayo ingasetshenziselwa ukwehlisa inani le-cholesterol nezinye izinto ezinamafutha egazini ezinganeni nasebusheni abaneminyaka engu-10 kuya kwengu-17 ubudala abane-heterozygous hypercholesterolemia (isimo esizuzwe njengefa lapho i-cholesterol ingasuswa emzimbeni ngokujwayelekile).ISimvastatin isekilasini lemithi ebizwa nge-HMG-CoA reductase inhibitors (ama-statins). Isebenza ngokunciphisa ukukhiqizwa kwe-cholesterol emzimbeni ukwehlisa inani le-cholesterol engakha ezindongeni zemithambo futhi ivimbele ukugeleza kwegazi liye enhliziyweni, ebuchosheni nakwezinye izingxenye zomzimba.

Ukuqoqeka kwe-cholesterol namafutha eceleni kwezindonga zemithambo (inqubo eyaziwa ngokuthi i-atherosclerosis) kunciphisa ukugeleza kwegazi, ngakho-ke, ukunikezwa komoya-mpilo enhliziyweni yakho, ebuchosheni nakwezinye izingxenye zomzimba wakho. Ukwehlisa izinga lakho legazi le-cholesterol namafutha nge-simvastatin kukhonjisiwe ukuvimbela isifo senhliziyo, i-angina (ubuhlungu besifuba), imivimbo nokuhlaselwa yinhliziyo.

ISimvastatin iza njengethebhulethi nanjengokumiswa okuzothathwa ngomlomo. Amaphilisi ngokuvamile athathwa kanye ngosuku kusihlwa. Ukumiswa kuvame ukuthathwa kanye ngosuku kusihlwa esiswini esingenalutho. Thatha i-simvastatin ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-simvastatin njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Shake ukumiswa kahle okungenani imizuzwana engama-20 ngaphambi kokusetshenziswa ngakunye.

Uma uzothatha ukumiswa kwe-simvastatin, ungasebenzisi isipuni sasekhaya ukukala umthamo wakho. Amathisipuni asekhaya awawona amadivayisi wokulinganisa anembile, futhi ungathola imithi eningi kakhulu noma imithi eyanele uma ulinganisa umthamo wakho ngethisipuni lasekhaya. Esikhundleni salokho, sebenzisa okokulinganisa okumakwe kahle njengesipuni somuthi noma isirinji yomlomo. Buza udokotela noma usokhemisi wakho uma udinga usizo ukuthola noma ukusebenzisa ithuluzi lokulinganisa.

Udokotela wakho angakuqala ngomthamo ophansi we-simvastatin futhi akhuphule kancane umthamo wakho, hhayi ngaphezu kwesisodwa njalo emavikini amane.

Qhubeka uthathe i-simvastatin noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-simvastatin ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-simvastatin,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-simvastatin, noma imuphi omunye umuthi, noma iziphi izithako kumathebulethi e-simvastatin noma ukumiswa ngomlomo. Buza udokotela wakho noma usokhemisi uhlu lwezithako.
• Tshela udokotela wakho uma uthatha imishanguzo efana ne-itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil) ne-voriconazole (Vfend); i-clarithromycin (i-Biaxin, ku-Prevpac); imithi equkethe i-cobicistat (Stribild); i-cyclosporine (Gengraf, Neoral, Sandimmune); i-danazol; i-erythromycin (E.E.S., E-Mycin, Erythrocin); gemfibrozil (Lopid); I-HIV protease inhibitors efana ne-atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (eKaletra), nelfinavir (Viracept), ritonavir (Norvir, e Kaletra), saquinavir (Invirase) i-tipranavir (i-Aptivus); nefazodone; iTelaprevir (Incivek); kanye ne-telithromycin (Ketek). Udokotela wakho mhlawumbe uzokutshela ukuthi ungayithathi i-simvastatin uma uphuza le mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: amiodarone (Cordarone, Pacerone); i-amlodipine (iNorvasc, eCaduet, eLotrel); ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven); i-colchicine (ama-Colcrys); i-digoxin (i-Digitek, i-Lanoxicaps, i-Lanoxin); i-diltiazem (iCardizem, iDilacor, iTiazac); i-dronedarone (iMultaq); eminye imithi yokwehlisa i-cholesterol efana ne-fenofibrate (Tricor), lomitapide (Juxtapid), ne-niacin (i-nicotinic acid, i-Niacor, i-Niaspan); i-ranolazine (Ranexa); kanye ne-verapamil (Calan, Covera, Isoptin, Verelan). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo nayo ingaxhumana ne-simvastatin, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• tshela udokotela wakho uma unesifo sesibindi. Udokotela wakho uzo-oda ukuhlolwa kwegazi ukuze abone ukuthi isibindi sakho sisebenza kahle kanjani noma ungacabangi ukuthi unesifo sesibindi. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-simvastatin uma unesifo sesibindi noma uma izivivinyo zikhombisa ukuthi ungahle ube nesifo sesibindi.
• tshela udokotela wakho uma uphuza iziphuzo ezidakayo ezingaphezu kwezimbili ngosuku, uma uneminyaka engama-65 noma ngaphezulu, noma uma ungowase-Asia, ikakhulukazi uma ungumShayina. Phinda utshele udokotela wakho uma uke waba nengwadla yegilo engasebenzi kahle, isifo sikashukela, ukuquleka, ubuhlungu bemisipha noma ubuthakathaka, umfutho wegazi ophansi, noma isifo sezinso.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Akufanele ukhulelwe ngesikhathi sokwelashwa kwakho nge-simvastatin. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi uthatha i-simvastatin, yeka ukuthatha i-simvastatin bese ushayela udokotela wakho ngokushesha. ISimvastatin ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthatha i-simvastatin.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-simvastatin. Uma ungeniswe esibhedlela ngenxa yokulimala kanzima noma ukutheleleka, tshela udokotela okuphatha ukuthi uthatha i-simvastatin.
• buza udokotela wakho mayelana nokusetshenziswa okuphephile kweziphuzo ezidakayo ngenkathi uthatha i-simvastatin. Utshwala bungakhuphula ubungozi bemiphumela emibi kakhulu.

Yidla ukudla okunamafutha aphansi, okunamafutha amancane. Qiniseka ukuthi ulandela zonke izincomo zokuzivocavoca nezokudla ezenziwa ngudokotela wakho noma udokotela odlayo. Ungavakashela futhi iwebhusayithi ye-National Cholesterol Education Program (NCEP) ukuthola eminye imininingwane yokudla ku-http: //www.nhlbi.nih.gov/health/public/heart/chol/chol_tlc.pdf.

Gwema ukuphuza ijusi lamagilebhisi ngenkathi uthatha i-simvastatin.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekusondele isikhathi somthamo olandelayo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yokulinganisa ejwayelekile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

ISimvastatin ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuqunjelwa
• ubuhlungu besisu
• isicanucanu
• ikhanda
• inkumbulo noma ukukhohlwa
• ukudideka
• uluma noma ubomvu isikhumba

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha noma uthole usizo oluphuthumayo lwezokwelapha.

• ubuhlungu bemisipha, ubumnene, noma ubuthakathaka obunomkhuhlane noma ongenawo amandla noma ukungabi namandla
• umchamo obomvu omnyama
• ukuncipha kokuchama
• ukungabi namandla, ukukhathala, noma ubuthakathaka
• ukulahlekelwa isifiso sokudla
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• ukuphuzi kwesikhumba noma kwamehlo
• umchamo onombala omnyama
• umkhuhlane noma amakhaza
• ukuqhuma
• amabhamuza
• ukuqubuka
• isifuba
• ukulunywa
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukuphefumula kanzima noma ukugwinya
• ukushaqeka
• ubuhlungu obuhlangene
• ukuzwela ekukhanyeni

Lo muthi ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina amaphilisi ekamelweni lokushisa kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Gcina ukumiswa ekamelweni lokushisa. Ungafaki iqhwa noma ukufake esiqandisini. Qinisekisa ukusebenzisa ukumiswa kungakapheli izinsuku ezingama-30 uvule ibhodlela bese ulahla noma imuphi umuthi osele ngemuva kwezinsuku ezingama-30.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile zebhu ngesikhathi sokwelashwa kwakho, ikakhulukazi uma uba nezimpawu zokulimala kwesibindi.

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho kanye nabasebenzi be-laboratory ukuthi uthatha i-simvastatin.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Flolipid^®
• Zocor^®

• Mandla^® (equkethe iSimvastatin, iSitagliptin)^¶
• I-Simcor^® (equkethe i-Niacin, Simvastatin)
• UVytorin^® (equkethe i-Ezetimibe, Simvastatin)

^¶ Lo mkhiqizo onophawu alusekho emakethe. Ezinye izindlela ezijwayelekile zingatholakala.