ULevodopa noCarbidopa

-Delile

• Ngaphambi kokuthatha i-levodopa ne-carbidopa,
• I-Levodopa ne-carbidopa kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezibalwe esigabeni SOKUQAPHA OKUKHETHEKILE, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Inhlanganisela ye-levodopa ne-carbidopa isetshenziselwa ukwelapha izimpawu zesifo sika-Parkinson kanye nezimpawu ezifana ne-Parkinson ezingakhula ngemuva kwe-encephalitis (ukuvuvukala kobuchopho) noma ukulimala ohlelweni lwezinzwa olubangelwa ubuthi be-carbon monoxide noma ubuthi be-manganese. Izimpawu zikaParkinson, kufaka phakathi ukuthuthumela (ukuqhaqhazela), ukuqina, nokuhamba kancane, kubangelwa ukungabi ne-dopamine, into yemvelo evame ukutholakala ebuchosheni. I-Levodopa isekilasini lemithi ebizwa ngama-central system system agents. Isebenza ngokuguqulwa ibe yi-dopamine ebuchosheni. UCarbidopa usesigabeni semithi ebizwa nge-decarboxylase inhibitors. Isebenza ngokuvimbela i-levodopa ukuthi ingahlehli ngaphambi kokuba ifinyelele ebuchosheni. Lokhu kuvumela umthamo ophansi we-levodopa, obangela isicanucanu nokuhlanza okuncane.

Inhlanganisela ye-levodopa ne-carbidopa iza njengethebhulethi ejwayelekile, ithebhulethi ehlukaniswa ngomlomo, ithebhulethi ekhishwa isikhathi eside (esebenza isikhathi eside), kanye ne-capsule ekhishwe isikhathi eside (esebenza isikhathi eside) ukuthatha ngomlomo. Inhlanganisela ye-levodopa ne-carbidopa nayo iza njengokumiswa (uketshezi) okuzonikezwa esiswini sakho ngepayipi le-PEG-J (ithubhu elifakwa ngokuhlinzwa ngesikhumba nangodonga lwesisu) noma kwesinye isikhathi ngokusebenzisa ithubhu ye-naso-jejunal (NJ; a ithubhu efakwe emakhaleni akho bese yehla isisu sakho) usebenzisa ipompo ekhethekile yokumnika. Amaphilisi ahlukaniseka njalo nangomlomo ngokuvamile athathwa kathathu noma kane ngosuku. Ithebhulethi ekhishwa isikhathi eside ithathwa kabili noma kane ngosuku. I-capsule ekhishwe isikhathi eside ivame ukuthathwa kathathu noma kahlanu ngosuku. Ukumiswa kuvame ukunikezwa njengomthamo wasekuseni (okunikezwa ukumnika ngaphezulu kwemizuzu eyi-10 kuye kwengu-30) bese kuthi njengomthamo oqhubekayo (onikezwe ukumnika ngaphezu kwamahora ayi-16), ngemithamo eyengeziwe enganikezwa ngaphezu kwesisodwa njalo emahoreni ama-2 njengoba kudingeka ukulawula izimpawu. Thatha i-levodopa ne-carbidopa ngezikhathi ezifanayo nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-levodopa ne-carbidopa njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi akhululiwe; ungawahlafune noma uwachoboze.

Gwinya wonke amaphilisi akhishwe isikhathi eside; ungawahlafune, ungawahlukanisi noma uwagxoze. Thatha umthamo wokuqala wansuku zonke we-capsule ekhishwe isikhathi eside 1 kuya 2 amahora ngaphambi kokudla. Uma unenkinga yokugwinya, ungavula ngokucophelela i-capsule ekhishwe isikhathi eside, ufafaze konke okuqukethwe ku-1 kuya ku-2 wezipuni (15 kuya ku-30 ​​mL) we-apple sauce, bese uyisebenzisa ngokushesha. Ungayigcini le ngxube ukuze uyisebenzise esikhathini esizayo.

Ukuthatha ithebhulethi ehlakazeka ngomlomo, susa ithebhulethi ebhodleleni usebenzisa izandla ezomile bese uyibeka emlonyeni wakho ngokushesha.Ithebhulethi izoncibilika ngokushesha futhi ingagwinywa ngamathe. Awekho amanzi adingekayo ukugwinya amaphilisi ahlukanisayo.

Uma ushintsha usuka ku-levodopa (iDopar noma iLarodopa; ayisatholakali e-US) uye ekuhlanganisweni kwe-levodopa ne-carbidopa, landela imiyalo kadokotela wakho. Mhlawumbe uzotshelwa ukuthi ulinde okungenani amahora ayi-12 ngemuva kwesilinganiso sakho sokugcina se-levodopa ukuze uthathe umthamo wakho wokuqala we-levodopa kanye ne-carbidopa.

Udokotela wakho angakuqala ngomthamo ophansi we-levodopa ne-carbidopa futhi kancane kancane wandise umthamo wakho wethebhulethi ejwayelekile noma yomlomo ehlukanisayo ngomlomo nsuku zonke noma ngalo lonke usuku njengoba kudingeka. Udokotela wakho angakhuphula kancane kancane umthamo wakho wethebhulethi ekhishwe isikhathi eside noma i-capsule ngemuva kwezinsuku ezintathu njengoba kudingeka.

Ukuthatha ukumiswa, udokotela wakho noma usokhemisi uzokukhombisa ukuthi ungayisebenzisa kanjani iphampu ukunikeza imithi yakho. Funda imiyalelo ebhaliwe eza nepompo nemithi. Bheka imidwebo ngokucophelela futhi uqiniseke ukuthi uyazibona zonke izingxenye zepompo kanye nokuchazwa kokhiye. Buza udokotela wakho noma usokhemisi ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi.

Ukumiswa kwe-Levodopa ne-carbidopa kuza ngekhasethi elisebenzisa kanye ukuxhuma kupompo elizolawula inani lemithi oyothola ngesikhathi sokumnika. Ngaphambi kokuyisebenzisa, susa ikhasethi eliqukethe umuthi esiqandisini ulivumele ukuthi lihlale ekamelweni lokushisa imizuzu engu-20. Ungayisebenzisi kabusha ikhasethi noma uyisebenzise isikhathi esingaphezu kwamahora ayi-16. Lahla ikhasethi ekugcineni kokumnika noma ngabe lisenemithi.

Lapho uqala ukuthatha ukumiswa kwe-levodopa ne-carbidopa, udokotela wakho uzolungisa imithamo yakho yokumnika ekuseni nokuqhubeka futhi mhlawumbe amanani eminye imithi yakho yesifo sikaParkinson ukulawula izimpawu zakho. Imvamisa kuthatha izinsuku ezi-5 ukufinyelela kumthamo ozinzile wokumiswa, kepha imithamo yakho ingadinga ukuguqulwa futhi ngokuhamba kwesikhathi ngokuya ngempendulo yakho eqhubekayo emithini. Umthamo wakho obekiwe wokumiswa uzofakwa kupompo yakho ngudokotela wakho. Ungaguquli umthamo noma izilungiselelo kupompo yakho ngaphandle uma utshelwa ngudokotela wakho ukuthi wenze njalo. Qikelela ukuthi uqinisekise ukuthi ithubhu yakho ye-PEG-J ayikhonki, ingabi namafindo noma ivinjwe ngoba lokhu kuzothinta inani lemithi oyitholayo.

I-Levodopa ne-carbidopa ilawula isifo sika-Parkinson kodwa ayiselaphi. Kungathatha izinyanga ezimbalwa ngaphambi kokuba uzwe inzuzo ephelele ye-levodopa ne-carbidopa. Qhubeka uthathe i-levodopa ne-carbidopa noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-levodopa ne-carbidopa ngaphandle kokukhuluma nodokotela wakho. Uma ngokungazelelwe uyeka ukuthatha i-levodopa ne-carbidopa, ungaba nesifo esibi esibangela umkhuhlane, imisipha eqinile, ukunyakaza komzimba okungajwayelekile nokudideka. Udokotela wakho mhlawumbe uzokwehlisa umthamo wakho kancane kancane. Uma udokotela wakho ekutshela ukuthi uyeke ukuthatha ukumiswa kwe-levodopa ne-carbidopa, uchwepheshe wezokunakekelwa kwezempilo uzosusa ithubhu yakho ye-PEG-J; ungazisusi ishubhu ngokwakho.

Cela usokhemisi noma udokotela wakho ikhophi leshidi lemininingwane yesiguli lomkhiqizi le-levodopa ne-carbidopa kanye ne-Medication Guide yokumiswa kwe-levodopa ne-carbidopa.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-levodopa ne-carbidopa,

• Tshela udokotela wakho kanye nosokhemisi uma une-alevopa kanye ne-carbidopa noma yimiphi eminye imithi, noma iziphi izithako ezikumaphilisi e-levodopa kanye ne-carbidopa, amaphilisi, noma ukumiswa. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha i-phenelzine (Nardil) noma i-tranylcypromine (i-Parnate) noma uma uyekile ukuwaphuza emasontweni amabili edlule. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-levodopa ne-carbidopa.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: imishanguzo yokulwa nokudangala ('imishini yokunyusa imizwa') efana ne-amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), i-nortriptyline (i-Aventyl, i-Pamelor), i-protriptyline (i-Vivactil), ne-trimipramine (i-Surmontil); ama-antihistamine; i-haloperidol (iHaldol); ipratropium (Atrovent); amaphilisi okusansimbi namavithamini aqukethe i-iron; isocarboxazid (Marplan); i-isoniazid (INH, Nydrazid); imishanguzo yomfutho wegazi ophakeme, isifo samathumbu esicasulayo, ukugula kwengqondo, ukugula okunyakazayo, isicanucanu, izilonda, noma izinkinga zomchamo; i-metoclopramide (Reglan); eminye imithi yesifo sikaParkinson; i-papaverine (i-Pavabid); i-phenytoin (iDilantin); i-rasagiline (Azilect); i-risperidone (i-Risperdal); isidambisi; u-selegiline (u-Emsam, u-Eldepryl, uZelapar); amaphilisi okulala; i-tetrabenazine (i-Xenazine); kanye nezithambisi. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• tshela udokotela wakho uma uke waba ne-glaucoma, i-melanoma (umdlavuza wesikhumba), noma ukukhula kwesikhumba okungakatholakali. Udokotela wakho angakutshela ukuthi ungathathi i-levodopa ne-carbidopa.
• utshele udokotela wakho uma uke waba nezinkinga ze-hormone noma wake waba nazo; isifuba somoya; emphysema; ukugula ngengqondo; isifo sikashukela; izilonda zesisu; isifo senhliziyo; ukushaya kwenhliziyo okungajwayelekile; noma umthambo wegazi, inhliziyo, izinso, isibindi noma isifo samaphaphu. Uma usebenzisa ukumiswa kwe-levodopa ne-carbidopa, phinda utshele udokotela wakho uma uke wahlinzwa isisu, waba nezinkinga zemizwa, umfutho wegazi ophansi, noma waquleka.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-levodopa ne-carbidopa, shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-levodopa ne-carbidopa.
• kufanele wazi ukuthi i-levodopa ne-carbidopa kungakwenza ukozele noma kungakubangela ukuthi ulale ngokuzumayo phakathi nemisebenzi yakho ejwayelekile yansuku zonke. Ungahle ungazeli ukozela noma ube nezinye izimpawu zokuxwayisa ngaphambi kokuba ulale ngokuzumayo. Ungashayeli imoto, sebenzisa imishini, usebenze ezindaweni eziphakeme, noma uhlanganyele emisebenzini engaba yingozi ekuqaleni kokwelashwa kwakho uze wazi ukuthi umuthi ukuthinta kanjani. Uma ulala ngokungazelelwe ngenkathi wenza okuthile njengokubuka ithelevishini, ukukhuluma, ukudla, noma ukugibela emotweni, noma uma wozela kakhulu, ikakhulukazi ngesikhathi sasemini, shayela udokotela wakho ucingo. Ungashayeli, usebenze ezindaweni eziphakeme, noma usebenzise imishini uze ukhulume nodokotela wakho.
• buza udokotela wakho ngokusetshenziswa okuphephile kweziphuzo ezidakayo ngenkathi uthatha i-levodopa ne-carbidopa. Utshwala bungenza imiphumela emibi ye-levodopa ne-carbidopa ibe yimbi kakhulu.
• kufanele wazi ukuthi abanye abantu abathathe imishanguzo efana ne-levodopa ne-carbidopa baba nezinkinga zokugembula noma ezinye izifiso ezinamandla noma izindlela zokuziphatha ezazicindezela noma ezingavamile kubo, njengokukhuphuka kwezifiso zocansi noma isimilo. Akukho mininingwane eyanele yokutshela ukuthi ngabe abantu baba nezinkinga yini ngenxa yokuthi bathathe umuthi noma ngenxa yezinye izizathu. Shayela udokotela wakho uma unesifiso sokugembula okunzima ukusilawula, unezikhalazo ezinkulu, noma awukwazi ukulawula ukuziphatha kwakho. Tshela amalungu omndeni wakho ngale ngozi ukuze bakwazi ukubiza udokotela noma ngabe awuboni ukuthi ukugembula kwakho noma yiziphi ezinye izifiso ezinamandla noma ukuziphatha okungajwayelekile kube yinkinga.
• kufanele wazi ukuthi ngenkathi uthatha i-levodopa ne-carbidopa, amathe, umchamo, noma umjuluko wakho ungaba umbala omnyama (obomvu, onsundu, noma omnyama). Lokhu akulimazi, kepha izingubo zakho zingangcoliswa.
• kufanele wazi ukuthi i-levodopa ne-carbidopa kungadala isizungu, ikhanda elikhanyayo, nokuquleka lapho uvuka ngokushesha okukhulu endaweni yokulala. Lokhu kuvame kakhulu lapho uqala ukuthatha i-levodopa ne-carbidopa. Ukugwema le nkinga, phuma embhedeni kancane, uphumule izinyawo zakho phansi imizuzu embalwa ngaphambi kokuma.
• uma une-phenylketonuria (i-PKU, isimo esizuzwe njengefa lapho kufanele kulandelwe ukudla okukhethekile ukuvimbela ukubola kwengqondo), kufanele wazi ukuthi amaphilisi ahlukaniswa ngomlomo aqukethe i-aspartame eyakha i-phenylalanine.

Khuluma nodokotela wakho uma uhlela ukushintsha indlela odla ngayo iye ekudleni okunamaprotheni amaningi, njengenyama, izinkukhu nemikhiqizo yobisi.

Thatha umthamo ongabanjwanga wethebhulethi ejwayelekile, ithebhulethi ehlukaniswa ngomlomo, ithebhulethi ekhishwa isikhathi eside (esebenza isikhathi eside), noma i-capsule enwetshiwe (esebenza isikhathi eside) ngokushesha nje lapho uyikhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Uma usebenzisa ukumnika kwe-levodopa ne-carbidopa futhi uzobe unqamula ipompo lokumnika isikhashana (ngaphansi kwamahora amabili), ngaphandle kokunqanyulwa okuvamile ebusuku, buza udokotela wakho ukuthi kufanele usebenzise umthamo owengeziwe ngaphambi kokuthi unqamule ipompo. Uma ipompo lokumnika lizonqanyulwa isikhathi esingaphezu kwamahora ama-2, shayela udokotela wakho; mhlawumbe uzokwaziswa ukuthi uthathe i-levodopa ne-carbidopa ngomlomo ngenkathi ungasebenzisi ukumiswa.

I-Levodopa ne-carbidopa kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isiyezi
• ukulahlekelwa isifiso sokudla
• isifo sohudo
• umlomo owomile
• ubuhlungu bomlomo nomphimbo
• ukuqunjelwa
• shintsha ngomqondo wokunambitha
• ukukhohlwa noma ukudideka
• uvalo
• amaphupho amabi
• ubunzima bokulala noma ukulala
• ikhanda
• ubuthakathaka

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezibalwe esigabeni SOKUQAPHA OKUKHETHEKILE, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukunyakaza okungajwayelekile noma okungalawulwa komlomo, ulimi, ubuso, ikhanda, intamo, izingalo nemilenze
• ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla
• ukujuluka okwandayo
• ubuhlungu besifuba
• ukudana
• imicabango yokufa noma ukuzibulala
• ukubona izinto ezingekho (ukubona izinto noma ukuzwa amazwi angekho)
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukushaqeka
• ubunzima bokugwinya noma ukuphefumula
• isifuba
• ubuthakathaka, ukuba ndikindiki, noma ukulahlekelwa umuzwa eminweni noma ezinyaweni
• amanzi, ubomvu, ukuvuvukala, ubuhlungu, noma ukufudumala endaweni ezungeze ithubhu yakho ye-PEG-J (uma uthatha ukumiswa kwe-levodopa ne-carbidopa)
• indle emnyama neyokulinda
• igazi elibomvu endle
• imfiva
• ubuhlungu besisu
• isicanucanu
• ukuhlanza
• ukuhlanza okunegazi
• hlanza okubukeka njengezizathu zekhofi

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Gcina amakhasethi aqukethe ukumiswa kwe-levodopa ne-carbidopa esiqandisini kwikhathoni lawo langempela, avikelwe ekukhanyeni. Ungafaki ukumiswa okwesikhashana.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zebhu ukuze ahlole impendulo yakho ku-levodopa ne-carbidopa.

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho kanye nabasebenzi be-laboratory ukuthi uthatha i-levodopa ne-carbidopa.

I-Levodopa ne-carbidopa zingalahlekelwa umphumela wazo ngokuphelele ngokuhamba kwesikhathi noma ngezikhathi ezithile kuphela phakathi nosuku. Shayela udokotela wakho uma izimpawu zesifo sakho se-Parkinson (ukuthuthumela, ukuqina, nokuhamba kancane kokuhamba) ziba zimbi noma zihluke ngobukhulu.

Njengoba isimo sakho sithuthuka futhi kuba lula ukuthi unyakaze, qaphela ukuthi ungeqisi imisebenzi yomzimba. Khulisa umsebenzi wakho kancane kancane ukugwema ukuwa nokulimala.

I-Levodopa ne-carbidopa kungadala imiphumela engeyona ekuhlolweni komchamo (i-Clinistix, i-Clinitest, ne-Tes-Tape) kanye ne-ketone (i-Acetest, i-Ketostix ne-Labstix).

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UDuopa^®
• IParcopa^®¶
• I-Rytary^®
• I-Sinemet^®

• UStalevo^® (equkethe iCarbidopa, Entacapone, Levodopa)

^¶ Lo mkhiqizo onophawu alusekho emakethe. Ezinye izindlela ezijwayelekile zingatholakala.