I-Duloxetine

-Delile

• Ngaphambi kokuthatha i-duloxetine,
• I-Duloxetine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yimiphi imiphumela emibi elandelayo, noma leyo eshiwo esigabeni ESIBALULEKILE SEXWAYISO noma SOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Inani elincane lezingane, intsha, nabantu abadala abasebasha (abangafika eminyakeni engama-24 ubudala) abathathe imishanguzo yokudambisa ingcindezi ('' imishini yokunyusa imizwa '') efana ne-duloxetine phakathi nezifundo zomtholampilo baba nokuzibulala (becabanga ngokuzilimaza noma ukuzibulala noma ukuhlela noma ukuzama yenza kanjalo). Izingane, intsha, kanye nabantu abadala abasebancane abathatha imishanguzo yokulwisana nokucindezelwa ukwelapha ukudangala noma ezinye izifo zengqondo bangase babe sethubeni lokuzibulala kunezingane, intsha kanye nabantu abadala abangawasebenzisi ama-anti-depressants ukwelapha lezi zimo. Kodwa-ke, ochwepheshe abaqiniseki ngokuthi le ngozi ingakanani nokuthi kufanele icatshangelwe kangakanani ekunqumeni ukuthi ingane noma osemusha kufanele yini athathe i-anti-depressant. Izingane ezingaphansi kweminyaka engu-18 ubudala akufanele zivame ukuthatha i-duloxetine, kodwa kwezinye izimo, udokotela anganquma ukuthi i-duloxetine iyimithi engcono kakhulu yokwelapha isimo sengane.

Kufanele wazi ukuthi impilo yakho yengqondo ingashintsha ngezindlela ezingalindelekile lapho uthatha i-duloxetine noma amanye ama-anti-depressants noma ngabe ungumuntu omdala ongaphezu kweminyaka engama-24 ubudala. Lezi zinguquko kungenzeka noma ngabe awunakho ukugula ngengqondo futhi uthatha i-duloxetine ukwelapha uhlobo oluthile lwesimo. Ungase uzibulale, ikakhulukazi ekuqaleni kokwelashwa kwakho futhi nganoma yisiphi isikhathi lapho umthamo wakho wanda noma wehla. Wena, umndeni wakho, noma umnakekeli kufanele ushayele udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: ukucindezeleka okusha noma okuya kuba kubi; ukucabanga ngokuzilimaza noma ukuzibulala, noma ukuhlela noma ukuzama ukwenza kanjalo; ukukhathazeka ngokweqile; ukuyaluza; ukwethuka; ubunzima bokulala noma ukulala; isimilo esinolaka noma esinobutha; ukucasuka; ukwenza ngaphandle kokucabanga; ukungahlaliseki okukhulu; injabulo evuthayo engavamile; noma olunye uguquko olungavamile ekuziphatheni. Qiniseka ukuthi umndeni wakho noma umnakekeli uhlola wena nsuku zonke futhi uyazi ukuthi yiziphi izimpawu ezingaba zimbi kakhulu ukuze bakwazi ukushayela udokotela uma ungakwazi ukufuna ukwelashwa wedwa.

Umhlinzeki wakho wezokunakekelwa kwempilo uzofuna ukukubona kaningi ngenkathi uthatha i-duloxetine, ikakhulukazi ekuqaleni kokwelashwa kwakho. Qiniseka ukuthi ugcina wonke ama-aphoyintimenti wokuvakashelwa ehhovisi nodokotela wakho.

Udokotela noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-duloxetine. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungathola futhi i-Medication Guide kuwebhusayithi ye-FDA: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.

Akunandaba ukuthi uneminyaka emingaki, ngaphambi kokuba uthathe i-anti-depressant, wena, umzali wakho, noma umnakekeli wakho kufanele ukhulume nodokotela wakho ngezingozi nezinzuzo zokwelapha isimo sakho nge-anti-depressant noma ngezinye izindlela zokwelapha. Kufanele futhi ukhulume ngobungozi nezinzuzo zokungaselaphi isimo sakho. Kufanele wazi ukuthi ukuba nokudangala noma esinye isifo sengqondo kusandisa kakhulu ingozi yokuthi uzozibulala. Le ngozi iba phezulu uma wena noma omunye emndenini wakho unenkinga yokuphazamiseka kwengqondo okuguquguqukayo (imizwa eguquka isuke ekucindezelekeni iye ekuthokozeni okungavamile) noma i-mania (edidekile, imizwa ejabule ngokungajwayelekile), ukucindezeleka, noma uke wacabanga noma wazama ukuzibulala. Khuluma nodokotela wakho ngesimo sakho, izimpawu zakho, nomlando wakho wezempilo nowomndeni. Wena nodokotela wakho niyonquma ukuthi hlobo luni lwezokwelapha olulungele nina.

I-Duloxetine isetshenziselwa ukwelapha ukudangala kubantu abadala kanye nesifo sokukhathazeka esijwayelekile (i-GAD; ukukhathazeka ngokweqile kanye nokungezwani okuphazamisa impilo yansuku zonke futhi kuhlala izinyanga eziyi-6 noma ngaphezulu) kubantu abadala nezingane ezineminyaka engu-7 nangaphezulu. I-Duloxetine ibuye isetshenziselwe ukwelapha ubuhlungu nokushoshozela okubangelwa yi-diabetes neuropathy (ukulimala kwezinzwa ezingakhula kubantu abanesifo sikashukela) kubantu abadala nase-fibromyalgia (isimo esihlala isikhathi eside esingadala ubuhlungu, ukuqina kwemisipha nobumnene, ukukhathala nobunzima ukulala noma ukulala) kubantu abadala nezingane ezineminyaka engu-13 nangaphezulu. Ibuye isetshenziselwe ukwelapha ubuhlungu obuqhubekayo bamathambo noma bemisipha njengobuhlungu obuphansi emuva noma i-osteoarthritis (ubuhlungu obuhlangene noma ukuqina okungase kube kubi ngokuhamba kwesikhathi) kubantu abadala. I-Duloxetine isekilasini lemithi ebizwa nge-serotonin ekhethiwe ne-norepinephrine reuptake inhibitors (SNRIs). Isebenza ngokwandisa inani le-serotonin ne-norepinephrine, izinto zemvelo ebuchosheni ezisiza ukugcina ukulinganisela kwengqondo nokumisa ukuhamba kwezimpawu zobuhlungu ebuchosheni.

I-Duloxetine iza njengokukhishwa okubambezelekile (kukhipha umuthi emathunjini ukuvikela ukuwohloka kwemithi ngesisu acid) iphilisi elizothathwa ngomlomo. Lapho i-duloxetine isetshenziselwa ukwelapha ukudangala, imvamisa iphuzwa kanye noma kabili ngosuku noma ngaphandle kokudla. Lapho i-duloxetine isetshenziselwa ukwelapha ukukhathazeka okujwayelekile, ubuhlungu besifo sikashukela, i-fibromyalgia, noma ubuhlungu obuqhubekayo bethambo noma imisipha, kuvame ukuthathwa kanye ngosuku noma ngaphandle kokudla. Thatha i-duloxetine cishe ngesikhathi esifanayo (ama) nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-duloxetine njengoba nje uqondisiwe. Ungayithathi kancane noma kancane, yithathe kaningi, noma uyithathe isikhathi eside kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi okukhishwa okulibazisekile; ungawahlukanisi, ungawahlafune noma uwagxoze. Ungavuli amaphilisi okwehlisa ukubambezeleka bese uxuba okuqukethwe neziphuzo noma ufafaze okuqukethwe ekudleni.

Udokotela wakho angakuqala ngomthamo ophansi wemithi futhi akhuphule umthamo wakho ngemuva kwesonto elilodwa.

I-Duloxetine ingasiza ekulawuleni izimpawu zakho kepha ngeke iselaphe isimo sakho. Kungathatha i-1 kuye kumaviki ama-4 noma ngaphezulu ngaphambi kokuthi uzizwe ngokugcwele nge-duloxetine. Qhubeka uthathe i-duloxetine noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-duloxetine ngaphandle kokukhuluma nodokotela wakho. Udokotela wakho mhlawumbe uzokwehlisa umthamo wakho kancane kancane. Uma ngokungazelelwe uyeka ukuthatha i-duloxetine, ungahle ube nezimpawu zokuhoxa ezifana nesicanucanu; ukuhlanza; isifo sohudo; ukukhathazeka; isiyezi; ukukhathala; ikhanda; ubuhlungu, ukuvutha, ukuba ndikindiki, noma ukuhayiza ezandleni noma ezinyaweni; ukucasuka; ubunzima bokulala noma ukulala; ukujuluka; namaphupho amabi. Tshela udokotela wakho uma uhlangabezana nenye yalezi zimpawu lapho umthamo wakho we-duloxetine wehla.

I-Duloxetine nayo kwesinye isikhathi isetshenziselwa ukwelapha ukungasebenzi kahle komchamo (ukuvuza komchamo ngesikhathi somzimba njengokukhwehlela, ukuthimula, ukuhleka nokuzivocavoca) kwabesifazane. Khuluma nodokotela wakho ngokusebenzisa le mithi ukwelapha isimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-duloxetine,

• Tshela udokotela kanye nosokhemisi wakho uma unegciwane ku-duloxetine, noma imiphi eminye imithi, noma iziphi izithako ezikuma-duloxetine capsule-release release. Buza udokotela wakho noma usokhemisi uhlu lwezithako.
• Tshela udokotela wakho uma uthatha i-thioridazine noma i-monoamine oxidase (MAO) inhibitor, efana ne-isocarboxazid (Marplan), linezolid (Zyvox); i-methylene eluhlaza okwesibhakabhaka; i-phenelzine (i-Nardil), i-selegiline (i-Eldepryl, i-Emsam, i-Zelapar), ne-tranylcypromine (i-Parnate), noma uma uyekile ukuthatha i-MAO inhibitor ezinsukwini eziyi-14 ezedlule. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-duloxetine. Uma uyeka ukuthatha i-duloxetine, kufanele ulinde okungenani izinsuku ezingama-5 ngaphambi kokuqala ukuthatha i-MAO inhibitor.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela noma ongayinikiwe kanye namavithamini owathathayo noma ohlela ukuwathatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven); imishanguzo efana ne-amitriptyline (Elavil), i-amoxapine (i-Asendin), i-clomipramine (i-Anafranil), i-desipramine (i-Norpramin), i-doxepin (i-Adapin, i-Sinequan), i-imipramine (i-Tofranil), i-nortriptyline (i-Aventyl, i-Pamelor), i-protripiline Surmontil); ama-antihistamine; i-aspirin nezinye izidakamizwa ezingezona ukuvuvukala (ama-NSAID) njenge-ibuprofen (Advil, Motrin) ne-naproxen (Aleve, Naprosyn); buspirone; i-cimetidine (Tagamet); isisu (‘amaphilisi amanzi’); fentanyl (Abstral, Actiq, Fentora, Onsolis, abanye); imishanguzo yokushaya kwenhliziyo okungajwayelekile njenge-amiodarone (Cordarone), i-flecainide (Tambocor), i-moricizine (i-Ethmozine), i-propafenone (i-Rythmol), ne-quinidine (i-Quinidex); imishanguzo yokukhathazeka, umfutho wegazi ophakeme, ukugula ngengqondo, ubuhlungu, nesicanucanu; i-propranolol (Inderal); imithi yezinhlungu ze-migraine ezifana ne-almotriptan (Axert), i-eletriptan (i-Relpax), i-frovatriptan (i-Frova), i-naratriptan (i-Amerge), i-rizatriptan (i-Maxalt), i-sumatriptan (i-Imitrex), ne-zolmitriptan (iZomig); lithium (Eskalith, Lithobid); ama-proton pump inhibitors afana ne-lansoprazole (Prevacid), omeprazole (Prilosec), i-pantoprazole (Protonix), ne-rabeprazole (Aciphex); ama-antibiotic e-quinolone njenge-ciprofloxacin (Cipro) ne-enoxacin (i-Penetrex); isidambisi; ama-serotonin reuptake inhibitors (SSRIs) athile afana ne-fluoxetine (Prozac, Sarafem), i-fluvoxamine (i-Luvox) ne-paroxetine (i-Paxil); sibutramine (Meridia); amaphilisi okulala; i-theophylline (Theochron, Theolair); i-tramadol (i-Ultram); kanye nezithambisi. Eminye imithi eminingi ingaxhumana ne-duloxetine, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi iziphi izithako zokudla okunempilo kanye nemikhiqizo yamakhambi oyithathayo, ikakhulukazi imikhiqizo equkethe iSt John's wort noma i-tryptophan.
• utshele udokotela wakho uma uphuza noma wake waphuza utshwala obuningi noma uma usebenzisa noma wake wasebenzisa izidakamizwa zasemgwaqeni noma wake wasebenzisa ngokweqile imithi kadokotela. Tshela nodokotela wakho uma uke wahlaselwa yinhliziyo noma wake wahlaselwa; umfutho wegazi ophakeme; ukuquleka; isifo semithambo yegazi (ukuvimba noma ukunciphisa imithambo yegazi eholela enhliziyweni); noma isifo senhliziyo, isibindi noma sezinso. Uma unesifo sikashukela, qiniseka ukuthi ukhuluma nodokotela wakho mayelana nokuthi sibi kangakanani isimo sakho ukuze udokotela wakho anqume ukuthi ngabe i-duloxetine ikulungele yini.
• Tshela udokotela wakho uma ukhulelwe, ikakhulukazi uma usezinyangeni ezimbalwa ezedlule zokukhulelwa kwakho, noma uma uhlela ukukhulelwa noma ukuncelisa. Uma ukhulelwa ngenkathi uthatha i-duloxetine, shayela udokotela wakho. I-Duloxetine ingadala izinkinga ezinganeni ezisanda kuzalwa ngemuva kokubeletha uma zithathwa ezinyangeni zokugcina zokukhulelwa.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-duloxetine.
• kufanele wazi ukuthi i-duloxetine ingakwenza ukozele, ube nesiyezi, noma ithinte ukwahlulela kwakho, ukucabanga noma ukusebenzisana. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.
• buza udokotela wakho mayelana nokusetshenziswa okuphephile kweziphuzo ezidakayo ngenkathi uthatha i-duloxetine. Utshwala bungakhuphula ubungozi bemiphumela emibi evela ku-duloxetine.
• kufanele wazi ukuthi i-duloxetine ingadala isiyezi, ikhanda elikhanyayo, nokuquleka lapho uvuka ngokushesha okukhulu kusuka endaweni yokulala. Lokhu kuvame kakhulu lapho uqala ukuthatha i-duloxetine noma ngokwanda komthamo. Ukugwema le nkinga, phuma embhedeni kancane, uphumule izinyawo zakho phansi imizuzu embalwa ngaphambi kokuma.
• kufanele wazi ukuthi i-duloxetine ingadala umfutho wegazi ophezulu. Kufanele uhlolwe umfutho wegazi ngaphambi kokuqala ukwelashwa futhi njalo ngenkathi uthatha lo muthi.
• kufanele wazi ukuthi i-duloxetine ingadala i-angle-closure glaucoma (isimo lapho uketshezi luvinjwe khona ngokuzumayo futhi lungakwazi ukuphuma esweni kubangele ukwanda okusheshayo, okunzima kwengcindezi yamehlo okungaholela ekulahlekelweni kombono). Khuluma nodokotela wakho ngokuhlolwa iso ngaphambi kokuba uqale ukusebenzisa le mithi. Uma unesicanucanu, ubuhlungu beso, izinguquko embonweni, njengokubona izindandatho ezinemibala ezungeze izibani, nokuvuvukala noma ukubomvu ngaphakathi noma ezungeze iso, shayela udokotela wakho noma uthole ukwelashwa okuphuthumayo ngokushesha.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Duloxetine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• ukuqunjelwa
• isifo sohudo
• isilungulela
• ubuhlungu besisu
• ukuncipha kokudla
• umlomo owomile
• ukwanda kokuchama
• ubunzima bokuchama
• ukujuluka noma ukujuluka ebusuku
• isiyezi
• ikhanda
• ukukhathala
• ubuthakathaka
• ukozela
• ubuhlungu bemisipha noma amajaqamba
• izinguquko kwisifiso sobulili noma ikhono
• ukuzamazama okungalawuleki kwengxenye yomzimba

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yimiphi imiphumela emibi elandelayo, noma leyo eshiwo esigabeni ESIBALULEKILE SEXWAYISO noma SOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukulimaza noma ukopha okungavamile
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• ukuvuvukala kwesisu
• ukulunywa
• ukuphuzi kwesikhumba noma kwamehlo
• umchamo onombala omnyama
• ukulahlekelwa isifiso sokudla
• ukukhathala ngokweqile noma ubuthakathaka
• ukudideka
• izimpawu ezinjengomkhuhlane
• umkhuhlane, ukujuluka, ukudideka, ukushaya kwenhliziyo okusheshayo noma okungajwayelekile, nokuqina kwemisipha okunzima
• imfiva
• amabhamuza noma isikhumba esixobukayo
• ukuqubuka
• isifuba
• ukuphefumula kanzima noma ukugwinya
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukushaqeka

I-Duloxetine ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukuyaluza
• ukubona izinto ezingekho (ukubona izinto noma ukuzwa amazwi angekho)
• ukushaya kwenhliziyo okusheshayo
• imfiva
• ukulahleka kokuxhumanisa
• isicanucanu
• ukuhlanza
• isifo sohudo
• ukozela
• isithuthwane
• isiyezi
• ubumhlophe
• ukuquleka
• ukungaphenduli

Gcina wonke ama-aphoyintimenti nodokotela wakho.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• ICymbalta^®