I-Dimethyl Fumarate

-Delile

• Ngaphambi kokuthatha i-dimethyl fumarate,
• I-Dimethyl fumarate ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-dimethyl fumarate bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Dimethyl fumarate isetshenziselwa ukwelapha abantu abadala abanezinhlobo ezahlukahlukene ze-multiple sclerosis (MS; isifo lapho izinzwa zingasebenzi kahle futhi abantu bangathola ubuthakathaka, ukuba ndikindiki, ukulahleka kokuhlangana kwemisipha, nezinkinga ngombono, ukukhuluma, nokulawula isinye) kufaka phakathi:

• i-syndrome ehlukanisiwe nomtholampilo (i-CIS; iziqephu zezimpawu zemizwa ezihlala okungenani amahora angama-24),
• amafomu wokubuyisela emuva (inkambo yesifo lapho izimpawu zivela khona ngezikhathi ezithile), noma
• amafomu wesibili aqhubekayo (inkambo yesifo lapho ukubuyela emuva kwenzeka kaningi).

I-Dimethyl fumarate isekilasini lemithi ebizwa ngokuthi i-Nrf2 activators. Isebenza ngokunciphisa ukuvuvukala nokuvimbela ukulimala kwezinzwa okungadala izimpawu ze-multiple sclerosis.

I-Dimethyl fumarate iza njengokukhishwa okulibazisekile (kukhipha umuthi emathunjini ukuvimbela ukuwohloka kwemithi ngesisu acid) i-capsule ezothathwa ngomlomo. Kuvame ukuthathwa kabili ngosuku. Thatha i-dimethyl fumarate ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-dimethyl fumarate njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

I-Dimethyl fumarate ingathathwa ngokudla noma ngaphandle kokudla. Kodwa-ke, uma uthatha i-dimethyl fumarate ngokudla noma nge-aspirin eboshwe engeyona i-enteric (325 mg noma ngaphansi) imizuzu engama-30 ngaphambi kokuthatha i-dimethyl fumarate, mancane amathuba okuthi uzithole ushawa ngesikhathi sokwelashwa kwakho.

Gwinya wonke amaphilisi; musa ukuhlafuna, noma ukuchoboza. Ungavuli amaphilisi noma ufafaze okuqukethwe ekudleni.

Udokotela wakho kungenzeka akuqale ngomthamo ophansi we-dimethyl fumarate futhi akhuphule umthamo wakho ngemuva kwezinsuku eziyi-7.

I-Dimethyl fumarate ingasiza ekulawuleni i-multiple sclerosis, kepha ngeke iyelaphe. Qhubeka uthathe i-dimethyl fumarate noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-dimethyl fumarate ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

I-Dimethyl fumarate kwesinye isikhathi isetshenziselwa ukwelapha i-psoriasis (isifo sesikhumba lapho kwakhiwa khona amabala abomvu, anezikhala ezindaweni ezithile zomzimba). Khuluma nodokotela wakho ngezingozi zokusebenzisa lo muthi ngesimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-dimethyl fumarate,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-dimethyl fumarate, noma imiphi eminye imithi, noma iziphi izithako ezikuma-dimethyl fumarate capsules. Buza usokhemisi wakho noma hlola imininingwane yesiguli somkhiqizi ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma unanoma yiluphi uhlobo lokutheleleka, kufaka phakathi izifo eziza futhi zihambe nezifo ezingapheli ezingapheli, noma uma uke waba ne-chickenpox noma i-herpes zoster (shingles; ukuqubuka okungenzeka kubantu ngibe nenkukhu esikhathini esidlule); noma ukubalwa kwamaseli egazi amhlophe aphansi.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-dimethyl fumarate, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Dimethyl fumarate ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• imfudumalo, ubomvu, ukulunywa, noma ukushiswa kwesikhumba
• isifo sohudo
• isicanucanu
• ukuhlanza
• isilungulela

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-dimethyl fumarate bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ubunzima bokugwinya noma ukuphefumula
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
• isifuba
• ukuqubuka
• ukulunywa
• ukushaqeka
• izinkinga zokubona
• ubuthakathaka ohlangothini olulodwa lomzimba noma ubulukhuni bezingalo noma imilenze obuya buba bimbi ngokuhamba kwesikhathi
• izinguquko embonweni
• izinguquko ekucabangeni kwakho, ememori, noma ekuqwashiseni okuholela ekudidekeni nasekushintsheni kobuntu
• ukukhathala ngokweqile, ukulahlekelwa isifiso sokudla, ubuhlungu ohlangothini olungakwesokudla esiswini sakho, umchamo omnyama, noma ukuphuzi kwesikhumba noma kwamehlo
• ubuthakathaka ohlangothini olulodwa lomzimba olubi ngokuhamba kwesikhathi; ubulukhuni bezingalo noma bemilenze; izinguquko ekucabangeni kwakho, kwimemori, ekuhambeni, ekulinganiseni, ekukhulumeni, ekubukeni kwamehlo, noma emandleni okuhlala izinsuku ezimbalwa; ikhanda; ukuquleka; ukudideka; noma izinguquko zobuntu
• ukushisa, ukugoba, ukuluma, noma ukuzwela kwesikhumba ngakolunye uhlangothi lomzimba noma ubuso ngokuqubuka okubuhlungu noma amabhamuza avela ezinsukwini ezimbalwa kamuva

I-Dimethyl fumarate ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Ukugcine ekamelweni lokushisa kude nokukhanya, ukushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho anga-oda ukuhlolwa kwegazi ngaphambi kokuba uqale ukwelashwa kwakho futhi anga-oda izivivinyo ezithile zebhu ngesikhathi sokwelashwa kwakho ukuze uhlole impendulo yomzimba wakho ku-dimethyl fumarate.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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