I-Ombitasvir, iParitaprevir, neRitonavir

-Delile

• Ngaphambi kokuthatha i-ombitasvir, i-paritaprevir, ne-ritonavir,
• I-Ombitasvir, i-paritaprevir, ne-ritonavir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Kungenzeka ukuthi usungenwe yi-hepatitis B (igciwane elithelela isibindi futhi lingadala ukulimala kwesibindi) kepha ungabi nazimpawu zesifo. Kulokhu, ukuthatha inhlanganisela ye-ombitasvir, i-paritaprevir, ne-ritonavir kungandisa ubungozi bokuthi ukutheleleka kwakho kuzoba kubi kakhulu noma kusongele impilo futhi uzoba nezimpawu. Tshela udokotela wakho uma ngabe uke waba nokutheleleka ngegciwane le-hepatitis B. Udokotela wakho uzokuyalela ukuhlolwa kwegazi ukuze abone ukuthi uke waba nokutheleleka kwesifo sikashukela B. Udokotela wakho uzokuhlola futhi nangezimpawu zokutheleleka kwesifo sokusha kwesibindi kohlobo B ngesikhathi nangezinyanga ezimbalwa ngemuva kokwelashwa kwakho. Uma kunesidingo, udokotela wakho angakunika imithi yokwelapha lesi sifo ngaphambi nangesikhathi sokwelashwa kwakho ngenhlanganisela ye-ombitasvir, paritaprevir, ne-ritonavir. Uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva kokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhathala ngokweqile, ukuphuzi kwesikhumba noma kwamehlo, ukulahlekelwa isifiso sokudla, isicanucanu noma ukuhlanza, indle ephaphathekile, ubuhlungu besisu, noma umchamo omnyama.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho anga-oda izivivinyo ezithile ngaphambi, ngesikhathi, nangemva kokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ekuhlanganisweni kwe-ombitasvir, paritaprevir, ne-ritonavir.

Khuluma nodokotela wakho ngengcuphe (s) yokuthatha inhlanganisela ye-ombitasvir, paritaprevir, ne-ritonavir.

Inhlanganisela ye-ombitasvir, i-paritaprevir, ne-ritonavir ivame ukusetshenziselwa ukuhlanganiswa ne-ribavirin (i-Copegus, i-Rebetol), kepha kwesinye isikhathi isetshenziswa yodwa ukwelapha uhlobo oluthile lokutheleleka kwesifo sokusha kwesibindi kohlobo C (okungapheli (isikhathi eside) (ukuvuvukala kwesibindi okubangelwa igciwane). I-Ombitasvir igciwane le-hepatitis C (HCV) NS5A inhibitor. Isebenza ngokuvimba igciwane elibangela ukusha kwesibindi kohlobo C ekusakazekeni ngaphakathi komzimba. I-Paritaprevir iyi-protease inhibitor. Isebenza ngokunciphisa inani le-HCV emzimbeni. I-Ritonavir iyi-protease inhibitor. Kuyasiza ukukhulisa inani le-paritaprevir emzimbeni ukuze umuthi ube nomthelela omkhulu. Akwaziwa ukuthi i-ombitasvir, paritaprevir, noma i-ritonavir ivimbela ukusakazeka kwesifo sokusha kwesibindi kohlobo C kwabanye abantu.

Inhlanganisela ye-ombitasvir, i-paritaprevir, ne-ritonavir iza njengethebhulethi ezothathwa ngomlomo. Thatha i-ombitasvir, paritaprevir, ne-ritonavir njalo ekuseni ngokudla. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-ombitasvir, paritaprevir, ne-ritonavir ngezikhathi ezifanayo nsuku zonke. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Inhlanganisela ye-ombitasvir, i-paritaprevir, ne-ritonavir ilawula i-HCV kepha ayiyelaphi. Kuvame ukuthathwa amasonto ayi-12. Qhubeka uthathe i-ombitasvir, paritaprevir, ne-ritonavir noma ngabe uzizwa uphilile. Ubude bokwelashwa kwakho buncike ekutheni uphendula kanjani emithini nokuthi unemiphumela emibi kakhulu yini. Ungayeki ukuthatha i-ombitasvir, paritaprevir, ne-ritonavir ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-ombitasvir, i-paritaprevir, ne-ritonavir,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-ombitasvir, paritaprevir, ne-ritonavir, noma imuphi omunye umuthi, noma iziphi izithako ezise-ombitasvir, paritaprevir, kanye ne-ritonavir tablet. Uma uke waba nokusabela okungathi sína noma okusongela ukuphila ku-ritonavir (ukuqubuka, ukushaywa ngamabhalane noma ukuxebuka kwesikhumba), udokotela wakho uzotshela ukuthi angathathi i-ombitasvir, paritaprevir, ne-ritonavir. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• tshela udokotela wakho uma uthatha i-alfuzosin (Uroxatral); i-apalutamide (i-Erleada); i-atorvastatin (Lipitor, eCaduet); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol); i-cisapride (Propulsid; ayisatholakali e-U.S.); i-dronedarone (iMultaq); i-efavirenz (iSustiva, e-Atripla); i-ergot equkethe imishanguzo efana ne-dihydroergotamine mesylate (D.H 45, Migranal), ergonovine, ergotamine (Ergomar, eCafergot, eMigergot), ne-methylergonovine (Methergine); izindlela zokuvimbela inzalo ze-ethinyl estradiol ezinjengalezi ezithile (‘amaphilisi okulawula ukuzalwa’), amabala, izindandatho zesitho sangasese sowesifazane kanye neminye imikhiqizo ye-ethinyl estradiol; everolimus (Afinitor, Zortress); lomitapide (Juxtapid); i-lovastatin (Altoprev); i-lurasidone (Latuda); i-midazolam (ngomlomo); i-phenobarbital; i-phenytoin (iDilantin, Phenytek); ipimozide (i-Orap); i-ranolazine (Ranexa); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); i-sildenafil (i-Revatio) yokwelashwa komfutho wegazi ophezulu we-pulmonary; simvastatin (Flolipid, Zocor, eVytorin); i-sirolimus (i-Rapamune); ISt John's wort; i-tacrolimus (i-Astagraf XL, i-Envarsus XR, i-Prograf); noma i-triazolam (Halcion). Futhi, tshela udokotela wakho uma uthatha i-colchicine (Colcrys, Mitigare) futhi unesifo sesibindi noma sezinso. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-ombitasvir, paritaprevir, ne-ritonavir uma uthatha eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-acetaminophen ne-hydrocodone (i-Anexsia, i-Zyfrel); i-alprazolam (Xanax); i-angiotensin receptor blocker (ARB) efana ne-candesartan (Atacand, e-Atacand HCT), losartan (Cozaar, e-Hyzaar), ne-valsartan (Diovan, eDiovan HCT, Exforge); ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven); i-buprenorphine ne-naloxone (i-Suboxone, iZubsolv); ama-calcium channel blocker afana ne-amlodipine (Norvasc, eCaduet), diltiazem (Cardizem, Cartia), nifedipine (Adalat, Afeditab), ne-verapamil (Calan, Verelan); i-carisoprodol (iSoma); i-cyclobenzaprine (Amrix); i-cyclosporine (Gengraf, Neoral, Sandimmune); diazepam (Valium); elagolix (Orilissa); encorafenib (Braftovi); i-fluticasone (i-Flonase, i-Flovent, e-Advair); i-fostamatinib (iTavalisse); i-furosemide (i-Lasix); izindlela ezithile zokwelapha ezibuyisela ama-hormone (HRT); ibrutinib (Imbruvica); ivosidenib (Tibsovo); ketoconazole; i-metformin (iGlucophage, iRiomet); imishanguzo yokushaya kwenhliziyo okungajwayelekile njenge-amiodarone (Nexterone, Pacerone), bepridil (ayisatholakali e-US), digoxin (Lanoxin), disopyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), ne-quinidine ( ku-Nuedexta); omeprazole (Prilosec); i-pravastatin (Pravachol); i-quetiapine (iSeroquel); i-rilpivirine (i-Edurant; eComplera); i-ritonavir (i-Norvir, e-Kaletra) isetshenziswa ngokuhlangana namanye ama-HIV protease inhibitors afana ne-atazanavir (Reyataz, e-Evotaz), i-darunavir (i-Prezista, e-Prezcobix), ne-lopinavir (e-Kaletra); i-salmeterol (iSerevent, e-Advair); kanye ne-voriconazole (Vfend). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma unanoma yiluphi uhlobo lwesifo sesibindi ngaphandle kwe-hepatitis C. Udokotela wakho angakutshela ukuthi ungathathi i-ombitasvir, paritaprevir, ne-ritonavir.
• utshele udokotela wakho ukuthi wake wafakelwa isibindi noma unesifo sikashukela noma i-human immunodeficiency virus (HIV).
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-ombitasvir, paritaprevir, ne-ritonavir, shayela udokotela wakho.
• kufanele wazi ukuthi i-ombitasvir, i-paritaprevir, ne-ritonavir inganciphisa ukusebenza kwezindlela zokuvimbela inzalo ngamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, okufakelwa, imijovo, kanye namadivayisi we-intrauterine). Sebenzisa enye indlela yokulawula ukubeletha ngenkathi uthatha i-ombitasvir, paritaprevir, ne-ritonavir kanye namasonto ama-2 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezinhlobo zokulawulwa kokubeletha ezizokusebenzela ngesikhathi sokwelashwa kwakho nge-ombitasvir, paritaprevir, ne-ritonavir futhi uze uqalise futhi ukuthatha umuthi wakho wokuvimbela inzalo wamahomoni.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma ngabe kungamahora ayi-12 noma ngaphansi ngemuva kokuphuthelwa umthamo we-ombitasvir, i-paritaprevir, ne-ritonavir, thatha isilinganiso ongasitholanga ngokudla ngokushesha nje lapho usikhumbula. Kodwa-ke, uma kungaphezu kwamahora we-12 kusukela ngesikhathi obekufanele uthathe i-dos yakho, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Ombitasvir, i-paritaprevir, ne-ritonavir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubunzima bokulala noma ukulala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka
• ukubomvu kwesikhumba
• isifuba
• ukulunywa
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ubuthakathaka
• ukudideka

I-Ombitasvir, i-paritaprevir, ne-ritonavir ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi ebhokisini efike kuyo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Ungawasusi amaphilisi kwiphakethe ledosi lansuku zonke elihlinzekwe ngumenzi lize lilungele ukuwaphuza.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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