I-Mifepristone (Korlym)

-Delile

• Ngaphambi kokuthatha i-mifepristone,
• I-Mifepristone ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Ezigulini zesifazane:

Ungathathi i-mifepristone uma ukhulelwe noma uhlela ukukhulelwa. I-Mifepristone ingadala ukulahleka kokukhulelwa. Kufanele ube nokuhlolwa kokukhulelwa okungekuhle ngaphambi kokuqala ukwelashwa nge-mifepristone nangaphambi kokuqala ukwelashwa futhi uma uyeka ukuyithatha izinsuku ezingaphezu kwezingu-14. Uma ungakhulelwa, kuzodingeka ugweme ukukhulelwa ngesikhathi sokwelashwa kwakho nge-mifepristone. Kufanele usebenzise izindlela ezamukelekayo zokulawulwa kokubeletha ngesikhathi sokwelashwa kwakho futhi okungenani inyanga eyodwa ngemuva kokuphothulwa kokwelashwa kwakho. Udokotela wakho uzokutshela ukuthi yiziphi izindlela zokulawula ukubeletha ezamukelekayo. Uma ucabanga ukuthi ukhulelwe, uphuthelwa ukuya esikhathini, noma uya ocansini ngaphandle kokulawula inzalo ngenkathi uthatha i-mifepristone noma kungakapheli inyanga eyodwa ukwelashwa kwakho, shayela udokotela wakho ngokushesha.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho anga-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ku-mifepristone.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-mifepristone futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngengozi (s) yokuthatha i-mifepristone.

I-Mifepristone (Korlym) isetshenziselwa ukwelapha i-hyperglycemia (ushukela ophakeme wegazi) kubantu abanohlobo oluthile lwe-Cushing's syndrome lapho umzimba wenza i-cortisol eningi kakhulu (i-hormone) futhi abahlulekile ukuhlinzwa noma abangakwazi ukuhlinzwa ukwelapha lesi simo. UMifepristone usesigabeni semithi ebizwa nge-cortisol receptor blockers. Isebenza ngokuvimba umsebenzi we-cortisol.

IMifepristone iyatholakala futhi njengomunye umkhiqizo (Mifeprex) osetshenziswa wedwa noma uhlanganiswe nomunye umuthi wokuqeda ukukhulelwa ngaphambi kwesikhathi. Le monograph inikezela kuphela ngemininingwane mayelana ne-mifepristone (Korlym) esetshenziselwa ukulawula i-hyperglycemia kubantu abanohlobo oluthile lwe-Cushing's syndrome. Uma usebenzisa i-mifepristone ukukhipha isisu, funda i-monograph enesihloko esithi mifepristone (Mifeprex), ebhalwe ngalo mkhiqizo.

I-Mifepristone iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa kanye ngosuku ngokudla. Thatha i-mifepristone ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-mifepristone ngqo njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze. Tshela udokotela noma usokhemisi wakho uma ungakwazi ukugwinya amaphilisi aphelele.

Udokotela wakho uzokuqala ngomthamo ophansi we-mifepristone futhi akhuphule kancane umthamo wakho, hhayi kaningi ngaphezu kwesisodwa njalo emavikini amabili kuya kwamane. Uma uyeka ukuthatha i-mifepristone, shayela udokotela wakho. Udokotela wakho kungadingeka akuqale futhi kumthamo ophansi kakhulu we-mifepristone futhi akhuphule kancane umthamo wakho.

IMifepristone ingalawula isimo sakho kepha ayiyelaphi. Kungathatha amasonto ayisithupha noma ngaphezulu ngaphambi kokuthi uzwe ngokugcwele nge-mifepristone. Qhubeka uthathe i-mifepristone noma ngabe uzizwa uphilile.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-mifepristone,

• Tshela udokotela wakho uma unegciwane le-mifepristone, noma imiphi eminye imishanguzo, noma ezinye izithako ezibhebheni ze-mifepristone. Buza usokhemisi wakho noma hlola imininingwane yesiguli somkhiqizi ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma ngabe uthatha noma imuphi wale mithi elandelayo noma uwaphuzile emasontweni amabili edlule: ama-corticosteroids anjenge-betamethasone (Celestone), i-budesonide (i-Entocort), i-cortisone (i-Cortone), i-dexamethasone (i-Decadron, i-Dexpak, i-Dexasone, abanye) , fludrocortisone (Floriner), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol, Meprolone, others), prednisolone (Prelone, abanye), prednisone (Deltasone, Meticorten, Sterapred, abanye), ne-triamcinolone (Aristocort, Azmacort) imithi evimbela amasosha omzimba njenge-cyclosporine (Neoral, Sandimmune), sirolimus (Rapamune), ne-tacrolimus (Prograf); i-dihydroergotamine (i-DHH 45, i-Migranal); i-ergotamine (i-Ergomar, eCafergot, eMigergot); i-fentanyl (i-Duragesic); i-lovastatin (Mevacor); ipimozide (i-Orap); i-quinidine (i-Quinidex); kanye ne-simvastatin (iZocor). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-mifepristone uma uthatha eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma oyithathile emasontweni amabili edlule. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin); ama-antifungals anjenge-itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), noma i-voriconazole (Vfend); i-aspirin nezinye izidakamizwa ezingezona ukuvuvukala (ama-NSAID) njenge-ibuprofen (Advil, Motrin) ne-naproxen (Aleve, Naprosyn); i-bupropion (Wellbutrin); i-ciprofloxacin (Cipro); i-clarithromycin (i-Biaxin); i-conivaptan (iVaprisol); i-diltiazem (iCardizem); i-erythromycin (E.E.S., E-Mycin, Erythrocin); i-fluvastatin (Lescol); izindlela zokuvimbela inzalo zamahomoni ezifana namaphilisi okulawula inzalo, okufakelwa emzimbeni, amapeshi, amasongo noma imijovo; imithi ye-hepatitis C efana ne-boceprevir (i-Victrelis) ne-telaprevir (Incivek); imishanguzo ye-HIV noma i-AIDS efana ne-amprenavir (Agenerase), atazanavir (Reyataz), efavirenz (Sustiva), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir kanye ne-ritonavir inhlanganisela (Kaletra), nelfinavir (Viracept), ritonavir (Norvir) kanye ne-saquinavir (i-Fortovase, i-Invirase); imishanguzo yokuquleka efana ne-carbamazepine (Tegretol), phenobarbital (Luminal, Solfoton), phenytoin (Dilantin); imithi yesifo sofuba efana ne-rifabutin (Mycobutin), i-rifampin (i-Rifadin, i-Rimactane, i-Rifamate, i-Rifater) ne-rifapentine (i-Priftin); nefazodone (Serzone); i-repaglinide (Prandin); i-telithromycin (Ketek); kanye ne-verapamil (Calan, Isoptin, abanye). Eminye imishanguzo eminingi ingaxhumana ne-mifepristone, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSt John's Wort.
• utshele udokotela wakho ukuthi wake wafakelwa isitho somzimba noma unaso noma wake waba nesifo segilo. Uma ungowesifazane futhi ungazange uhlinzwe ukukhipha isibeletho sakho, tshela udokotela wakho uma ngabe uke waba negazi elichazayo lesitho sangasese, noma i-endometrial hyperplasia (ukwanda kolwelwesi lwesibeletho), noma umdlavuza we-endometrial (umdlavuza wolwelwesi isibeletho sakho). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-mifepristone.
• Tshela udokotela wakho uma uke waba nokuhluleka kwenhliziyo, isikhathi eside se-QT (inkinga yenhliziyo engavamile engabangela ukushaya kwenhliziyo, ukuphelelwa amandla, noma ukufa okungazelelwe), i-potassium ephansi egazini lakho, ukungabi namandla kwe-adrenal (isimo lapho izindlala ze-adrenal azivezi ngokwanele amahomoni athile adingekayo emisebenzini ebalulekile yomzimba), isifo sokopha, noma isibindi, izinso, noma isifo senhliziyo.
• tshela udokotela wakho uma uncelisa.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Mifepristone ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ukuhlanza
• umlomo owomile
• isifo sohudo
• ukuqunjelwa
• ubuhlungu obuhlangene noma besisipha
• ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi
• ukuqubuka
• ukulunywa

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isicanucanu
• ukulahlekelwa isifiso sokudla
• isiyezi noma ikhanda elikhanyayo
• ukukhathala okungajwayelekile noma ubuthakathaka
• uvalo noma ukucasuka
• ukuqhaqhazela
• ukujuluka
• ubuthakathaka bemisipha, ubuhlungu, noma amajaqamba
• ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla
• ukopha okungalindelekile kwesitho sangasese sowesifazane noma ukubona
• ukuphelelwa umoya

I-Mifepristone ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho kanye nabasebenzi be-laboratory ukuthi uthatha i-mifepristone.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Korlym^®