I-Fedratinib

-Delile

• Ngaphambi kokuthatha i-fedratinib,
• I-Fedratinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Fedratinib ingadala i-encephalopathy (isifo esibi futhi esingahle sibulale uhlelo lwezinzwa), kufaka phakathi i-Wernicke's encephalopathy (uhlobo lwe-encephalopathy olubangelwa ukuntuleka kwe-thiamine [vitamin B1]). Tshela udokotela wakho uma uke waba nokuntuleka kwe-thiamine. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, yeka ukuthatha i-fedratinib bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo: ubunzima bokuhambisa noma ukugcina ibhalansi yakho, ubuthakathaka bemilenze noma izingalo eziqhubeka nokuba zimbi, ukudideka, ukozela, ubunzima bokuqonda noma ukukhuluma, ukulahleka kwememori, izinkinga zombono (kufaka phakathi ukubona kabili nokunyakaza kwamehlo okungajwayelekile), noma izinguquko ebuntwini.

Udokotela wakho angakunikeza imithi yokwehlisa ubungozi bemiphumela emibi ongaba nayo ekuthatheni i-fedratinib. Tshela udokotela wakho ngokushesha uma unesicanucanu, ukuhlanza, isifo sohudo, noma ukwehla kwesisindo okungabi ngcono ngokwelashwa.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ku-fedratinib.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-fedratinib futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo.Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

I-Fedratinib isetshenziselwa ukwelapha abantu abadala abanezinhlobo ezithile ze-myelofibrosis (MF; umdlavuza womnkantsha wamathambo lapho umongo wamathambo uthathelwa indawo izicubu ezibomvu futhi kubangele ukwehla kokukhiqizwa kwamangqamuzana egazi). UFedratinib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukumisa noma ukubambezela ukusabalala kwamangqamuzana omdlavuza.

UFedratinib uza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa kanye ngosuku, noma ngaphandle kokudla. Ukuthatha i-fedratinib ngesidlo esinamafutha amaningi kungasiza ukunciphisa isicanucanu nokuhlanza. Thatha i-fedratinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-fedratinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho uzo-oda ukuhlolwa kwegazi ngaphambi nangesikhathi sokwelashwa kwakho ukuze abone ukuthi uthinteka kanjani lo muthi. Udokotela wakho angakhuphula noma anciphise umthamo wakho we-fedratinib ngesikhathi sokwelashwa kwakho, noma angakutshela ukuthi uyeke ukuthatha i-fedratinib okwesikhashana noma unomphela. Lokhu kuya ngokuthi umuthi usebenza kanjani kuwe, imiphumela yokuhlolwa kwakho kwelebhu, futhi uma uba nemiphumela engemihle. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-fedratinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-fedratinib, noma imuphi omunye umuthi, noma iziphi izithako kuma-capsules e-fedratinib. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-clarithromycin (i-Biaxin, ku-PrevPac), i-diltiazem (i-Cardizem, i-Dilacor, i-Tiazac, abanye), i-erythromycin (i-EES, i-E-mycin, i-Erythrocin), idelalisib (iZydelig), indinavir (Crixivan), itraconazole (Sporanox), ketoconazole (Nizoral), metoprolol (Lopressor, Toprol XL, in Dutoprol, others), midazolam (Versed), nefazodone, nelfinavir (Viracept), omeprazole (Prilosec, eZegerid), ribociclib (Kisqali, Kisqali, Kisqali, Kisqali ), ritonavir (Norvir), ruxolitinib (Jakafi), kanye ne-saquinavir (i-Invirase). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-fedratinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho uma uke waba nesifo sesibindi noma sezinso.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma ukhulelwa ngenkathi uthatha i-fedratinib, shayela udokotela wakho.
• ungancelisi ibele ngesikhathi sokwelashwa kwakho nge-fedratinib futhi okungenani inyanga engu-1 ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-fedratinib.

Khuluma nodokotela wakho ngokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Fedratinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuqunjelwa
• ukukhathala
• ukuphazamiseka kwemisipha
• ubuhlungu bengalo, bomlenze, noma bethambo
• ikhanda
• ukuzuza kwesisindo
• isiyezi

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukopha okungajwayelekile noma ukulinyazwa
• umkhuhlane, ukubanda, ukukhwehlela, ukuchama kabuhlungu noma kaningi, noma ezinye izimpawu zokutheleleka
• isicanucanu, ukukhathala ngokweqile, ukulimaza noma ukopha okungavamile, ukungabi namandla, ukulahlekelwa isifiso sokudla, ubuhlungu engxenyeni engenhla yesokudla yesisu, ukuphuzi kwesikhumba noma kwamehlo, noma izimpawu ezinjengomkhuhlane
• ukuphefumula, ukushaya kwenhliziyo okusheshayo, ikhanda elibuhlungu, isiyezi, isikhumba esiphaphathekile, ukudideka, noma ukukhathala

I-Fedratinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Inrebic^®