Ukujova kweBamlanivimab ne-Etesevimab

-Delile

• Ngaphambi kokuthola umjovo we-bamlanivimab kanye ne-etesevimab,
• Umjovo we-Bamlanivimab ne-etesevimab kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezisohlwini lwe-HOW section, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Inhlanganisela yomjovo we-bamlanivimab ne-etesevimab okwamanje ifundelwa ukwelashwa kwesifo se-coronavirus 2019 (COVID-19) esibangelwa igciwane le-SARS-CoV-2.

Imininingwane yesivivinyo somtholampilo enomkhawulo kuphela etholakalayo ngalesi sikhathi ukuxhasa ukusetshenziswa kwe-bamlanivimab ne-etesevimab ekwelapheni i-COVID-19. Imininingwane eminingi iyadingeka ukwazi ukuthi i-bamlanivimab ne-etesevimab basebenza kahle kanjani ekwelapheni i-COVID-19 kanye nemicimbi engemihle evela kuyo.

Ukuhlanganiswa kwe-bamlanivimab ne-etesevimab akukaze kutholakale ukubuyekezwa okujwayelekile ukuze kuvunyelwe i-FDA ukuthi isetshenziswe. Kodwa-ke, i-FDA ivume Ukugunyazwa Kokusetshenziswa Okuphuthumayo (i-EUA) ukuvumela abantu abadala nabangekho ezibhedlela abaneminyaka engu-12 ubudala nangaphezulu abanezimpawu ze-COVID-19 eziphakathi nendawo zokuthola umjovo we-bamlanivimab ne-etesevimab.

Inhlanganisela yomjovo we-bamlanivimab ne-etesevimab isetshenziselwa ukwelapha ukutheleleka kwe-COVID-19 kubantu abadala abathile abangalalisiwe esibhedlela nezingane ezineminyaka engu-12 ubudala nangaphezulu ezinesisindo okungenani esingamakhilogremu angama-88 (40 kg) futhi ezinezimpawu ze-COVID-19 eziphakathi nendawo kuya kokulingene. Zisetshenziswa kubantu abanezimo ezithile zezokwelapha ezifana nesifo sikashukela, izimo zokuzivikela emzimbeni, noma isifo sezinso, senhliziyo, noma samaphaphu esibabeka engcupheni enkulu yokuthola izimpawu ezinzima ze-COVID-19 kanye / noma abadinga ukulaliswa esibhedlela kusuka ku-COVID-19. UBamlanivimab no-etesevimab basesigabeni esibizwa ngama-antibody monoclonal. Le mithi isebenza ngokuvimba ukusebenza kwento ethile yemvelo emzimbeni ukunqanda ukusabalala kwegciwane.

IBamlanivimab ne-etesevimab ziza njengezisombululo (uketshezi) ukuze zixutshwe noketshezi olungeziwe bese zifakwa kancane emthanjeni ngudokotela noma unesi. Banikezwa ndawonye njengomthamo wesikhathi esisodwa ngokushesha okukhulu ngemuva kokuhlolwa okuhle kwe-COVID-19 futhi kungakapheli izinsuku eziyi-10 ngemuva kokuqala kwezimpawu zokutheleleka ze-COVID-19 ezinjengomkhuhlane, ukukhwehlela, noma ukuphefumula okuncane.

Ukuhlanganiswa komjovo we-bamlanivimab kanye ne-etesevimab kungadala ukusabela okungathi sína noma okusongela ukuphila ngesikhathi nangemva kokufakwa. Udokotela noma umhlengikazi uzokuqapha ngokucophelela ngenkathi uthola le mithi futhi okungenani ihora elilodwa ngemuva kokuyithola. Tshela udokotela wakho noma umhlengikazi ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva kokumnika: umkhuhlane, ukuphefumula kanzima, ukugodola, ukukhathala, ubuhlungu besifuba, ukungakhululeki kwesifuba, ubuthakathaka, ukudideka, isicanucanu, ikhanda, ukuphefumula, ukuqhuma, umphimbo ukucasuka, ukuqubuka, isifuba, ukulunywa, ukugeleza, ubuhlungu bemisipha noma isiyezi, ikakhulukazi lapho umile, ujuluka, noma ukuvuvukala kobuso, umphimbo, ulimi, izindebe, noma iso. Udokotela wakho angadinga ukwehlisa ukumnika kwakho noma ayeke ukwelashwa kwakho uma uhlangabezana neminye yale miphumela emibi.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-bamlanivimab kanye ne-etesevimab,

• Tshela udokotela kanye nosokhemisi wakho uma unegciwane ku-bamlanivimab, etesevimab, noma imuphi omunye umuthi, noma yiziphi izithako zomjovo we-bamlanivimab kanye ne-etesevimab. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: imishanguzo yokuzivikela njenge-cyclosporine (Gengraf, Neoral, Sandimmune), prednisone, ne-tacrolimus (i-Astagraf, i-Envarsus, i-Prograf). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma ngabe uke waba nezimo zezempilo noma wake waba nazo.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthola umjovo we-bamlanivimab kanye ne-etesevimab, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo we-Bamlanivimab ne-etesevimab kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukopha, ukulimaza, ubuhlungu, ubuhlungu, noma ukuvuvukala endaweni yokujova

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezisohlwini lwe-HOW section, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• umkhuhlane, ukuphefumula kanzima, ushintsho ekushayeni kwenhliziyo, ukukhathala, ubuthakathaka, noma ukudideka

Umjovo we-Bamlanivimab ne-etesevimab kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola le mithi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho.

Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana ne-bamlanivimab kanye nomjovo we-etesevimab.

Kufanele uqhubeke nokuzihlukanisa njengoba uqondiswe ngudokotela wakho futhi ulandele imikhuba yezempilo yomphakathi njengokugqoka imaski, ukuqhela emphakathini, nokugeza izandla kaningi.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

I-American Society of Health-System Pharmacists, Inc. imele ukuthi lolu lwazi olumayelana ne-bamlanivimab ne-etesevimab lwenziwa ngezinga elifanele lokunakekelwa, nangokuhambisana namazinga obuchwepheshe emkhakheni. Abafundi bayaxwayiswa ukuthi i-bamlanivimab ne-etesevimab akuyona imishanguzo evunyelwe yesifo se-coronavirus 2019 (i-COVID-19) ebangelwe yi-SARS-CoV-2, kodwa kunalokho, iyaphenywa futhi okwamanje iyatholakala ngaphansi, kwemvume yokusebenzisa i-FDA ephuthumayo (EUA) ekwelapheni i-COVID-19 emnene kuya kokulingene kwezinye iziguli eziphuma ngaphandle. I-American Society of Health-System Pharmacists, Inc. ayenzi izethulo noma amawaranti, ayivezi noma asikiswanga, kufaka phakathi, kodwa kungagcini, kunoma yisiphi isiqinisekiso esisetshenzisiwe sokuthengiselana kanye / noma ukuqina ngenhloso ethile, maqondana nolwazi, futhi ikakhulukazi izilahla zonke lezi ziqinisekiso. Abafundi bolwazi olumayelana ne-bamlanivimab ne-etesevimab bayelulekwa ukuthi i-ASHP ayinabo obhekene nemali eqhubekayo yolwazi, nganoma yimaphi amaphutha noma ukushiywa, kanye / noma eminye imiphumela evela ekusetshenzisweni kwalolu lwazi. Abafundi bayelulekwa ukuthi izinqumo maqondana nokwelashwa kwezidakamizwa ziyizinqumo eziyinkimbinkimbi zezokwelapha ezidinga isinqumo esizimele, esinolwazi sompetha ofanele wezokunakekelwa kwezempilo, futhi imininingwane equkethwe yilolu lwazi inikezwa ngenhloso yokwaziswa kuphela. I-American Society of Health-System Pharmacists, Inc. ayikukhuthazi noma ukuncoma ukusetshenziswa kwanoma imuphi umuthi. Lolu lwazi olumayelana ne-bamlanivimab ne-etesevimab akufanele lubhekwe njengezeluleko zesiguli ngasinye. Ngenxa yokushintsha kwemininingwane yolwazi ngezidakamizwa, uyelulekwa ukuba ubonane nodokotela noma usokhemisi wakho mayelana nokusetshenziswa kwemitholampilo kwanoma imuphi umuthi.