I-angioedema yefa: kuyini, izimpawu nokwelashwa

-Delile

• Ziyini izimpawu
• Izimbangela ezingaba khona
• Yiziphi izinkinga ezingavela
• Yini ukuxilongwa
• Yelashwa kanjani
• Okufanele ukwenze ngesikhathi sokukhulelwa

I-hereditary angioedema yisifo sofuzo esidala izimpawu ezifana nokuvuvukala emzimbeni wonke, nobuhlungu besisu obuphindaphindayo obungahambisana nesicanucanu nokuhlanza. Kwezinye izimo, ukuvuvukala kungathinta nezitho ezifana namanyikwe, isisu nobuchopho.

Ngokuvamile, lezi zimpawu zivela ngaphambi kweminyaka yobudala engu-6 futhi ukuhlaselwa kokuvuvukala kuhlala cishe izinsuku ezi-1 kuye kwezi-2, kanti ubuhlungu besisu bungahlala izinsuku ezifika kwezinhlanu. Lesi sifo singahlala isikhathi eside ngaphandle kokubanga izinkinga noma ukungaphatheki kahle esigulini, kuze kuvele izinkinga ezintsha.

I-hereditary angiedema isifo esingajwayelekile, esingavela noma singekho emndenini wale nkinga, sihlukaniswa ngezinhlobo ezintathu ze-angiedema: uhlobo 1, uhlobo 2 nohlobo 3, ngokusho kweprotheni ethintekayo emzimbeni.

Ziyini izimpawu

Ezinye zezimpawu ezivame kakhulu ze-angioedema ukuvuvukala kuwo wonke umzimba, ikakhulukazi ebusweni, ezandleni, ezinyaweni nasezitho zangasese, ubuhlungu besisu, isicanucanu, ukuhlanza futhi, ezimweni ezinzima kakhulu, ukuvuvukala kwezitho ezifana namanyikwe, isisu nobuchopho.

Izimbangela ezingaba khona

I-Angioedema idalwa ukuguquka kwezakhi zofuzo esakhiweni esikhiqiza iprotheni ehlobene namasosha omzimba, okuholela ekubonakaleni kokuvuvukala noma nini lapho kusebenze amasosha omzimba.

Izinkinga nazo zingakhuliswa uma kwenzeka ukuhlukumezeka, ukucindezeleka, noma ngesikhathi sokuzivocavoca umzimba. Ngaphezu kwalokho, abesifazane basengozini yokuquleka ngesikhathi sokuya esikhathini nokukhulelwa.

Yiziphi izinkinga ezingavela

Inkinga enkulu ye-angiedema yefa ukuvuvukala emphinjeni, okungadala ukufa ngenxa yokuphelelwa umoya. Ngaphezu kwalokho, lapho ukuvuvukala kwezitho ezithile kwenzeka, lesi sifo singaphazamisa nokusebenza kwaso.

Ezinye izinkinga zingenzeka futhi ngenxa yemiphumela emibi yezidakamizwa ezisetshenziselwa ukulawula lesi sifo, nezinkinga ezinjengezi:

• Isisindo;
• Ikhanda;
• Izinguquko zemizwa;
• Ukwanda induna;
• Umfutho wegazi ophezulu;
• I-cholesterol ephezulu;
• Izinguquko zokuya esikhathini;
• Igazi emchameni;
• Izinkinga zesibindi.

Ngesikhathi sokwelashwa, iziguli kufanele zihlolwe igazi njalo ezinyangeni eziyisithupha ukuze zihlole ukusebenza kwesibindi, futhi izingane kufanele zihlolwe njalo ezinyangeni ezimbili kuya kwezi-3, kufaka phakathi ukuskena kwesisu esiswini njalo ezinyangeni eziyisithupha.

Yini ukuxilongwa

Ukutholakala kwalesi sifo kwenziwa ngezimpawu nokuhlolwa kwegazi okulinganisa amaprotheni e-C4 emzimbeni, asemazingeni aphansi ezimweni ze-angiedema yefa.

Ngaphezu kwalokho, udokotela futhi anga-oda umthamo wokulinganisa nobungako be-C1-INH, futhi kungadingeka ukuphinda izivivinyo ngesikhathi senhlekelele yalesi sifo.

Yelashwa kanjani

Ukwelashwa kwe-angiedema yefa kwenziwa ngokuqina nobuningi bezimpawu, nezidakamizwa ezenzelwe ama-hormone, njenge-danazol, i-stanozolol ne-oxandrolone, noma amakhambi we-antifibrinolytic, njenge-epsilon-aminocaproic acid kanye ne-tranexamic acid, angasetshenziswa ukuvimbela okusha izingqinamba.

Ngesikhathi sezinkinga, udokotela angakhuphula umthamo wemithi futhi ancoma nokusetshenziswa kwezidakamizwa ukulwa nobuhlungu besisu kanye nesicanucanu.

Kodwa-ke, uma inkinga ibangela ukuvuvukala emphinjeni, isiguli kufanele siyiswe ngokushesha egumbini lezimo eziphuthumayo, ngoba ukuvuvukala kungavimba indlela yomoya futhi kuvimbele ukuphefumula, okungaholela ekufeni.

Okufanele ukwenze ngesikhathi sokukhulelwa

Ngesikhathi sokukhulelwa, iziguli ezine-angiedema yefa kufanele ziyeke ukusetshenziswa kwemithi, okungcono ngaphambi kokukhulelwa, ngoba zingadala ukukhubazeka embungwini. Uma kuvela izinkinga, ukwelashwa kufanele kwenziwe ngokuyalelwa ngudokotela.

Ngesikhathi sokubeletha okujwayelekile, ukuqala kokuhlaselwa akuvamile, kepha uma kuvela, kuvame ukuba nzima. Endabeni yokulethwa ngokuhlinzwa, kunconywa ukusetshenziswa kwe-anesthesia yendawo kuphela, ukugwema i-anesthesia ejwayelekile.