Ukusebenzisana kwe-CBD Nezidakamizwa: Okudingeka Ukwazi

-Delile

• I-CBD ingashintsha indlela umzimba wakho osebenza ngayo ngemithi ethile
• Imetabolism yezidakamizwa nama-enzyme e-CYP450
• Kungani i-CYP450 ibalulekile uma kukhulunywa nge-CBD nemithi?
• Ukuzama i-CBD ngokuphepha ngenkathi uthatha imishanguzo
• Ukusebenzisana kwezidakamizwa okungenzeka
• Bheka isexwayiso sesithelo samagilebhisi
• Izinhlobo zemithi ejwayele ukuba nesixwayiso samagilebhisi
• Ucwaningo lwamanje ngokusebenzisana phakathi kwe-CBD nemithi
• Ukuphepha nemiphumela engemihle
• Imiphumela emibi okufanele uyibuke
• Khuluma nodokotela wakho

Idizayinwe nguJamie Herrmann

I-CBD ingashintsha indlela umzimba wakho osebenza ngayo ngemithi ethile

I-Cannabidiol (i-CBD), ithole ukunakwa okubanzi ngamandla ayo okunciphisa izimpawu zokuqwasha, ukukhathazeka, ubuhlungu obungapheli, nezinye izimo zezempilo eziningi.

Futhi ngenkathi izifundo ziqhubeka mayelana nokuthi isebenza kanjani i-CBD, abantu abaningi bayazama.

Ucwaningo kuze kube manje lubonisa ukuthi i-CBD ngokuvamile iphephile futhi inemiphumela emibi embalwa, uma ikhona, emincane. Kodwa kukhona i-caveat eyodwa enkulu: i-CBD inamandla okusebenzisana neminye imithi. Ukukhathazeka kuhlobene nokuthi umzimba uhlanganisa kanjani izinto ezithile.

Ngaphambi kokuzama i-CBD, kubalulekile ukuthi ukhulume nodokotela wakho ngawo wonke amavithamini, izithasiselo, nemithi kadokotela oyisebenzisayo. Nakhu ukubuka okujulile kokuthi kungani ukuba nengxoxo kubalulekile.

Imetabolism yezidakamizwa nama-enzyme e-CYP450

Uma uthatha umuthi noma enye into, umzimba wakho kufanele uyisebenzise, ​​noma uyiphule. Imethabolism yezidakamizwa yenzeka emzimbeni wonke, njengasesiswini, kepha isibindi senza ingxenye enkulu yomsebenzi, futhi.

Umndeni wama-enzyme obizwa ngokuthi wenza umsebenzi obalulekile wokuguqula izinto zangaphandle ukuze zisuswe kalula emzimbeni.

Kepha eminye imishanguzo noma izinto zithinta i-CYP450, kungaba ngokunciphisa noma ukusheshisa imetabolism yezidakamizwa. Lokho kuguqulwa kwesilinganiso semetabolism kungashintsha ukuthi umzimba wakho uyicubungula kanjani imishanguzo noma izithako ozithathayo - yingakho ukuxhumana nezidakamizwa.

Kungani i-CYP450 ibalulekile uma kukhulunywa nge-CBD nemithi?

Umndeni we-CYP450 wama-enzyme unesibopho sokwenza ama-cannabinoids amaningi, kufaka phakathi i-CBD, imibukiso yocwaningo. Ngokuqondile, i-CYP3A4, i-enzyme ebalulekile emndenini we-CYP450, iyawenza lo msebenzi. Kepha phakathi nale nqubo, i-CBD nayo iphazamisa i-CYP3A4.

I-enzyme ye-CYP3A4 yiyo ephethe ukugcoba cishe amaphesenti angama-60 wemithi enikezwe emtholampilo. Kepha uma i-CBD ivimbela i-CYP3A4, ayikwazi ukusebenza ngempumelelo ukudiliza imithi kusistimu yakho.

I-reverse kungenzeka, futhi. Imithi eminingi ivimbela i-CYP3A4. Uma ngabe uthatha i-CBD ngenkathi usebenzisa le mithi, umzimba wakho awukwazi ukusebenza ukucubungula i-CBD ngempumelelo.

Uma umzimba wakho uhlanganisa umuthi kancane kakhulu, ungaba nemithi eminingi kusistimu yakho ngesikhathi esisodwa kunalokho obekuhlosiwe - noma ngabe unamathele kumthamo wakho ojwayelekile. Izinga elikhuphukile lomuthi kusistimu yakho lingangeqisa imiphumela yalo, kufaka phakathi imiphumela emibi engafuneki noma eyingozi.

Ezinye izinto ziphinde zisheshise umsebenzi womndeni we-CYP450 enzyme. Uma umzimba wakho uhlanganisa umuthi ngokushesha okukhulu ngoba enye into ikhuthaza ama-enzyme, ungahle ungabi nayo imithi eyanele ohlelweni lwakho ngasikhathi sinye ukuphatha inkinga yezempilo.

Ukuzama i-CBD ngokuphepha ngenkathi uthatha imishanguzo

Uma ufuna ukuzama i-CBD njengokwelashwa okungeziwe ukunciphisa izimpawu zesimo esithile, khuluma nodokotela wakho ngakho kuqala.

Bangakwazi ukusiza ukunquma umkhiqizo we-CBD, isilinganiso, kanye neshejuli ephephile ngemithi yakho. Kwezinye izimo, udokotela wakho angafuna ukuqapha amazinga e-plasma yemithi ethile oyiphuzayo.

Ungayeki noma imiphi imithi yakho ukuzama i-CBD, ngaphandle kokuthi udokotela wakho athi kuphephile ukwenza njalo.

Hlala wazi ukuthi i-CBD yama-topical, njengama-lotion, okhilimu, nosawoti, nayo ingaba inketho. Ngokungafani nowoyela, okudliwayo, nezixazululo ze-vaping, ama-topicals awavamisile ukungena egazini - inqobo nje uma kungesona isixazululo se-transdermal esenzelwe ukwenza kanjalo.

Ukusebenzisana kwezidakamizwa okungenzeka

Bheka isexwayiso sesithelo samagilebhisi

Yize izifundo zisaqhubeka ukuthola ukuxhumana okungahle kube khona phakathi kwe-CBD nemithi ethile, kunomthetho owodwa wesithupha ongasiza abathengi okwamanje: Gwema i-CBD uma imishanguzo yakho inesixwayiso se-grapefruit kwilebula.

Lesi sexwayiso sikhombisa ukuthi abantu abathatha imishanguzo kufanele bagweme ukudla i-grapefruit noma ijusi lamagilebhisi.

Ngokusho kwe-grapefruit, ngenkathi usebenzisa eyodwa yale mithi kungaholela ekugxilisweni okuphezulu kwemithi egazini nasemiphumeleni emibi noma ekudluliseni ngokweqile.

Izidakamizwa ezingaphezu kwezingama-85 zisebenzisana no-grapefruit namanye amajusi e-citrus ahlobene kakhulu - njengamawolintshi aseSeville, ama-pomelos, nama-tangelos. Lokho kungenxa yokuthi amakhemikhali asesithelweni samagilebhisi aziwa ngokuthi ama-furanocoumarins avimbela i-CYP3A4, ngendlela efanayo ne-CBD. Umphumela uba ukubambezeleka okuhamba kancane kwemithi.

Izexwayiso zamagilebhisi zivamile ezinhlotsheni eziningana zemithi, kepha akuyona yonke imishanguzo esigabeni ezodinga ukugwenyelwa ubhamubhamu. Hlola imininingwane yokufaka imithi yakho noma ubuze udokotela wakho.

Izinhlobo zemithi ejwayele ukuba nesixwayiso samagilebhisi

• ama-antibiotics kanye nama-antimicrobial
• imishanguzo yokulwa nomdlavuza
• ama-antihistamine
• izidakamizwa ze-antiepileptic (AEDs)
• imishanguzo yegazi
• abahlinza igazi
• imithi ye-cholesterol
• ama-corticosteroids
• imithi yokungasebenzi kwe-erectile
• Imithi ye-GI, efana nokwelapha i-GERD noma isicanucanu
• imithi yesigqi senhliziyo
• ama-immunosuppressants
• imishanguzo yemizwa, njengokulapha ukukhathazeka, ukudangala, noma ukuphazamiseka kwemizwelo
• imithi yezinhlungu
• imishanguzo yesinye

Ucwaningo lwamanje ngokusebenzisana phakathi kwe-CBD nemithi

Abaphenyi basebenzela ukuthola ukuxhumana okuthile phakathi kwe-CBD nemithi ehlukahlukene. Izifundo zenziwe ezilwaneni ngemithi ethile, kepha ezimweni eziningi, ososayensi basanquma ukuthi leyo miphumela ihumusha kanjani kubantu.

Ezinye izivivinyo ezincane zokwelashwa zenziwe. Isibonelo, ocwaningweni olulodwa lwezingane ezingama-25 ezinesifo sokuwa okunzima ukwelashwa, izingane eziyi-13 zanikezwa zombili i-clobazam ne-CBD. Abaphenyi bathole amazinga aphakeme e-clobazam kulezi zingane. Babika ukuthi ukuthatha i-CBD kanye ne-clobazam ndawonye kuphephile, kepha bancoma ukuqapha amazinga emithi ngesikhathi sokwelashwa.

Kwesinye isifundo, abantu abadala abangama-39 nezingane ezingama-42 ezithatha ama-AED nazo zanikezwa i-CBD ngendlela ye-Epidiolex. Imithamo ye-CBD inyuswe njalo emavikini amabili.

Abaphenyi baqaphe amazinga e-serum ama-AED ezifundweni ngokuhamba kwesikhathi. Ngenkathi amazinga e-serum ahlala ebangeni lokwelashwa elamukelekayo iningi lawo, imishanguzo emibili - i-clobazam ne-desmethylclobazam - yayinamazinga we-serum ngaphandle kwebanga lokwelapha.

Ucwaningo lokuqala lubonisa ukuthi i-CBD nakanjani ingaxakaniseka ngamazinga emithi kusistimu yakho, noma ngabe uthatha isilinganiso sakho obekiwe. Kepha kudingeka olunye ucwaningo ukuthola ubunzima bokusebenzisana kwe-CBD emithini ehlukahlukene kanye nokuthuthukisa izincomo zokuyithatha kanye ne-CBD.

Ukuphepha nemiphumela engemihle

Ngaphansi kokuqapha ngokucophelela kukadokotela wakho, usengakwazi ukusebenzisa ngokuphepha i-CBD ngemithi, ngisho nalezo ezinesixwayiso samagilebhisi.

Uma kunesidingo, udokotela wakho angaqapha amazinga e-plasma serum omuthi owasebenzisayo. Bangase futhi bakhethe ukuqapha ukusebenza kwesibindi sakho.

Uma uthatha i-CBD ngemithi, kubalulekile ukuthi unake noma yiziphi izinguquko ezingaba khona ekutheni umuthi noma i-CBD ikuthinta kanjani.

Imiphumela emibi okufanele uyibuke

• imiphumela emibi yokwanda noma emisha yemithi, njenge:
  • ukozela
  • ukuthambisa
  • isicanucanu
• ukwehla kokusebenza kwemithi, njenge:
  • ukuqhuma kokuqhuma
• imiphumela emibi ejwayelekile ye-CBD noma ushintsho kuyo, njenge:
  • ukukhathala
  • isifo sohudo
  • izinguquko ekudleni
  • izinguquko esisindweni

Khuluma nodokotela wakho

Okusemqoka ukuthi ngaso sonke isikhathi uthintane nodokotela wakho kuqala uma ungathanda ukuzama i-CBD, ikakhulukazi uma unesimo sempilo futhi udla imishanguzo. Ungayeki ukuthatha imishanguzo yakho kadokotela ukuze uzame i-CBD, ngaphandle kwalapho uqhubeka nodokotela wakho.

Imithi eza nesixwayiso samagilebhisi kungenzeka ihlanganyele ne-CBD. Kodwa-ke, noma ngabe uthatha owodwa wale mithi, udokotela wakho angakwazi ukwakha uhlelo olusebenzela ngokuqapha okuseduze kwamazinga emithi kusistimu yakho. Ngaleyo ndlela, ungasebenzisa kokubili kadokotela wakho kanye ne-CBD njengokwelapha.

Udokotela wakho noma usokhemisi naye angakwazi ukuncoma umkhiqizo wekhwalithi we-CBD ohlangabezana nezidingo zakho. Ungathola nemikhiqizo enedumela elihle ngocwaningo oluncane nokwazi ngokufunda amalebula e-CBD.

Ingabe i-CBD isemthethweni? Imikhiqizo ye-CBD eyenziwe nge-Hemp (engaphansi kwamaphesenti angu-0,3 iTHC) isemthethweni ezingeni likahulumeni, kepha namanje ayikho emthethweni ngaphansi kweminye imithetho yezwe. Imikhiqizo ye-CBD etholakala ngensangu ayikho emthethweni ezingeni likahulumeni, kodwa isemthethweni ngaphansi kweminye imithetho yezwe.Hlola imithetho yesifundazwe sakho naleyo yanoma iyiphi indawo ohamba kuyo. Khumbula ukuthi imikhiqizo ye-CBD engabhalisiwe ayivunyelwe yi-FDA, futhi ingabhalwa ngokunganembile.

UJennifer Chesak uyintatheli yezokwelapha yezincwadi eziningana zikazwelonke, umfundisi wokubhala, kanye nomhleli wencwadi ezizimele. Uthole iMasters yakhe yeSayensi kwezobuntatheli eNorthwestern’s Medill. Ungumhleli ophethe umagazini wezincwadi, iShift. UJennifer uhlala eNashville kodwa uvela eNyakatho Dakota, futhi lapho engabhali noma enamathela ekhaleni encwadini, uvame ukugijima emizileni noma azungeze ingadi yakhe. Mlandele ku-Instagram noma ku-Twitter.