I-Eculizumab - yenzelwe ini

-Delile

• Yenzelwe ini
• Intengo
• Isetshenziswa kanjani
• Imiphumela emibi enkulu
• Lapho kungafanele isetshenziswe

I-Eculizumab iyi-anti-monoclonal antibody, ethengiswa ngokuthengisa ngaphansi kwegama likaSoliris. Ithuthukisa impendulo yokuvuvukala futhi inciphise amandla omzimba okuhlasela amangqamuzana ayo egazi, kukhonjiswa ikakhulukazi ukulwa nesifo esingajwayelekile esibizwa nge-night paroxysmal hemoglobinuria.

Yenzelwe ini

Umuthi uSoliris ukhonjisiwe ekwelashweni kwesifo segazi esibizwa nge-paroxysmal nocturnal hemoglobinuria; isifo segazi nezinso esibizwa nge-atypical hemolytic uremic syndrome, lapho kungahle kube khona i-thrombocytopenia ne-anemia, ngaphezu kwamahlule egazi, ukukhathala nokungasebenzi kahle kwezitho ezahlukahlukene, okukhonjiswayo nokwelashwa kwe-Myasthenia gravis ejwayelekile.

Intengo

EBrazil, lo muthi uvunywa yi-Anvisa, futhi wenziwa utholakale yi-SUS ngecala, lingathengiswa ezikhemisi.

Isetshenziswa kanjani

Lo muthi kumele usetshenziswe njengomjovo esibhedlela. Ngokuvamile, ukwelashwa kwenziwa nge-drip emthanjeni, cishe imizuzu engama-45, kanye ngesonto, amasonto ama-5, kuze kube kwenziwa ukulungiswa kumthamo ozosetshenziswa njalo ezinsukwini eziyi-15.

Imiphumela emibi enkulu

I-Eculizumab ivame ukubekezelelwa kahle, okuvame kakhulu ukuqala kwekhanda. Kodwa-ke, imiphumela emibi efana ne-thrombocytopenia, ukwehla kwamaseli abomvu egazi, ubuhlungu esiswini, ukuqunjelwa, uhudo, ukugaya okungalungile, isicanucanu, ubuhlungu besifuba, ukugodola, umkhuhlane, ukuvuvukala, ukukhathala, ubuthakathaka, i-herpes, i-gastroenteritis, ukuvuvukala nakho kungenzeka. , i-arthritis, i-pneumonia, i-meningococcal meningitis, ubuhlungu bemisipha, ubuhlungu beqolo, ubuhlungu bentamo, isiyezi, ukwehla kokunambitheka, ukudlikizela emzimbeni, ukwakheka okuzenzakalelayo, ukukhwehlela, ukucasuka komphimbo, impumu ekhihlizayo, umzimba olumayo, owela ezinweleni, isikhumba esomile.

Lapho kungafanele isetshenziswe

I-Soliris akumele isetshenziswe kubantu abane-aleji kunoma yiziphi izingxenye zefomula, futhi uma kwenzeka kutheleleka nge-Neisseria meningitidis engaxazululiwe, abantu abangazange bathole umuthi wokugomela i-meningitis.

Lo muthi kufanele usetshenziswe kuphela ekukhulelweni, ngaphansi kweseluleko sezokwelapha futhi uma kudingeka ngokusobala, ngoba udlula ku-placenta futhi ungaphazamisa ukujikeleza kwegazi kwengane. Ukusetshenziswa kwayo futhi akuboniswa ngesikhathi sokuncelisa, ngakho-ke uma owesifazane encelisa, kufanele ayeke izinyanga ezinhlanu ngemuva kokusebenzisa lo muthi.