Ukuhlolwa Kofuzo Komdlavuza Webele We-Metastatic: Imibuzo Ongayibuza Udokotela Wakho

-Delile

• Kuyini ukuhlolwa kofuzo? Kwenziwa kanjani?
• Ingabe kufanele ngithole ukuhlolwa kofuzo ngomdlavuza webele we-metastatic?
• Ingabe ukuhlolwa kofuzo kudlala kanjani indima ekwelashweni kwami ​​komdlavuza webele we-metastatic?
• Kungani ukuguqulwa kwezakhi zofuzo kuthinta ukwelashwa? Ingabe ezinye izinguquko 'zimbi kakhulu' kunezinye?
• Kuyini ukuguqulwa kwe-PIK3CA? Ilashwa kanjani?
• Ngifunde ngezilingo zomtholampilo zomdlavuza webele we-metastatic. Uma ngifanelekile, ingabe lokhu kuphephile?
• Ingabe zikhona izingozi ekuhlolweni kwezofuzo?
• Kuzothatha isikhathi esingakanani ukuthola imiphumela ekuhlolweni kofuzo?
• Ngizonikwa kanjani imiphumela? Ngubani ozohamba nami ngemiphumela futhi asho ukuthini?

Kuyini ukuhlolwa kofuzo? Kwenziwa kanjani?

Ukuhlolwa kofuzo luhlobo lokuhlolwa kwelabhorethri olunikeza imininingwane ekhethekile mayelana nokuthi ngabe umuntu unokungajwayelekile yini kwizakhi zofuzo, njengokuguquka kwezakhi zofuzo.

Ukuhlolwa kwenziwa ebhodini, imvamisa ngesampula yegazi lesiguli noma amaseli omlomo.

Okunye ukuguqulwa kwezakhi zofuzo kuxhunyaniswe nemidlavuza ethile, njenge I-BRCA1 noma I-BRCA2 izakhi zofuzo zomdlavuza webele.

Ingabe kufanele ngithole ukuhlolwa kofuzo ngomdlavuza webele we-metastatic?

Ukuhlolwa kofuzo kungasiza kunoma ngubani onomdlavuza webele, kodwa akudingeki. Noma ngubani angahlolwa uma efuna. Ithimba lakho le-oncology lingakusiza wenze isinqumo.

Abantu abahlangabezana nenqubo ethile kungenzeka ukuthi babe nokuguqulwa kwezakhi zofuzo. Lokhu kufaka:

• ukuba ngaphansi kweminyaka engama-50 ubudala
• ukuba nomlando oqinile womndeni womdlavuza webele
• ukuba nomdlavuza webele emabeleni womabili
• ukuba nomdlavuza webele ongena kathathu

Kunezinketho ezikhethekile zokwelashwa kweziguli zomdlavuza webele we-metastatic ezihlola ukuthi zinokushintshwa kwezakhi zofuzo, ngakho-ke qiniseka ukuthi ubuza ngokuhlolwa kofuzo.

Ingabe ukuhlolwa kofuzo kudlala kanjani indima ekwelashweni kwami ​​komdlavuza webele we-metastatic?

Ukwelashwa komdlavuza webele kulungiselelwe umuntu ngamunye, kufaka phakathi labo abane-metastatic. Ezigulini ze-metastatic ezinokushintshwa kwezakhi zofuzo, kunezindlela zokwelashwa ezihlukile.

Isibonelo, ukwelashwa okukhethekile njenge-PI3-kinase (PI3K) inhibitors kuyatholakala kubantu abanokushintshwa kwezakhi zofuzo PIK3CA gene uma behlangabezana nenqubo ethile ye-hormone-receptor.

I-PARP inhibitors iyindlela yokukhetha abantu abanomdlavuza webele we-metastatic nge I-BRCA1 noma I-BRCA2 ukuguquka kwezakhi zofuzo. Ukuhlolwa kwemitholampilo kwalokhu kwelashwa kuyaqhubeka. Udokotela wakho angakwazisa uma ngabe uzobhalisela ukhetho.

Kungani ukuguqulwa kwezakhi zofuzo kuthinta ukwelashwa? Ingabe ezinye izinguquko 'zimbi kakhulu' kunezinye?

Izici ezithile ezihambisana nokuguquka kwezakhi zofuzo zingabhekiswa ngemithi eyingqayizivele eyaziwa ngokuthinta umphumela.

Izinguquko ezahlukahlukene zofuzo zihambisana nezingozi ezahlukahlukene. Enye akuyona "embi kakhulu" kakhulu kunenye, kepha ukuguqulwa kwakho okuqondile kuthinta ngqo ukwelashwa ozokuthola.

Kuyini ukuguqulwa kwe-PIK3CA? Ilashwa kanjani?

PIK3CA yisakhi esibalulekile ekusebenzeni kweseli. Ukungajwayelekile (okungukuthi, ukuguquka) kofuzo akukuvumeli ukuthi kusebenze kahle. Ucwaningo luye lwabonisa ukuthi lokhu kuguquka kuvamile kubantu abanomdlavuza webele. Kunconywa ukuthi abanye abantu, kufaka phakathi labo abanomdlavuza webele we-metastatic, bahlolelwe izakhi zofuzo ukuze bahlaziyele lolu shintsho.

Uma unayo, ungaba yilowo ofuna ukuthola ukwelashwa okuqondisiwe njenge-PI3K inhibitor, ebheka ngqo imbangela yokuguquka.

Ngifunde ngezilingo zomtholampilo zomdlavuza webele we-metastatic. Uma ngifanelekile, ingabe lokhu kuphephile?

Ukuhlolwa kwemitholampilo kuyindlela enhle kubantu abaningi abanomdlavuza webele we-metastatic. Isivivinyo senzelwe ukuphendula imibuzo ebalulekile mayelana nokwelashwa okuhle kakhulu. Bangakunikeza ukufinyelela okukhethekile kumaphrothokholi ongahle ungakwazi ukuthola ngenye indlela.

Kungaba nezingozi ngokuhlolwa komtholampilo. Izingozi ezaziwayo kumele zabelwane nawe ngaphambi kokuqala. Ngemuva kokuthi waziswe ngokuphelele ngocwaningo nobungozi balo, kufanele unikeze imvume ngaphambi kokuthi uqale. Ithimba lecala lihlola njalo ubungozi futhi lihlanganyele nganoma yiluphi ulwazi olusha.

Ingabe zikhona izingozi ekuhlolweni kwezofuzo?

Kunobungozi ekuhlolweni kofuzo ngokwabantu abanikezwa imininingwane ebalulekile ngesimo sezakhi zofuzo zabo. Lokhu kungadala ukucindezeleka ngokomzwelo.

Kungaba futhi nezingqinamba zezezimali ngokuya ngomshuwalense wakho. Kuzodingeka futhi ukuthi ubheke ukuthi uzoludalula kanjani ulwazi kumalungu omndeni wakho. Ithimba lakho lokunakekela lingasiza ngalesi sinqumo.

Imiphumela emihle yokuhlolwa ingakhombisa nokuthi udinga uhlelo lokwelashwa olubanzi kakhulu.

Kuzothatha isikhathi esingakanani ukuthola imiphumela ekuhlolweni kofuzo?

Kungumqondo omuhle ukuxoxa ngokuhlolwa kofuzo nodokotela wakho ngokushesha okukhulu ngemuva kokutholakala ngoba imiphumela ithatha isikhathi ukuyicubungula.

Ukuhlolwa kofuzo okuningi kuthatha amaviki amabili kuya kwamane ukuthola imiphumela.

Ngizonikwa kanjani imiphumela? Ngubani ozohamba nami ngemiphumela futhi asho ukuthini?

Imvamisa, udokotela oyalele ukuhlolwa noma isazi sezakhi zofuzo uzohamba nawe ngemiphumela. Lokhu kungenziwa mathupha noma ngocingo.

Kuyabuye kunconywe kakhulu ukubona umeluleki wezofuzo ukuze abuyekeze imiphumela yakho ngokuqhubekayo.

UDkt Michelle Azu ungudokotela ohlinzayo oqinisekiswe yibhodi ogxile ekuhlinzweni kwamabele nezifo zesifuba. UDkt.Azu waphothula iziqu zakhe e-University of Missouri-Columbia ngo-2003 nodokotela wakhe wobudokotela. Njengamanje usebenza njengomqondisi wezinsizakalo zokuhlinza amabele esibhedlela saseNew York-Presbyterian / Lawrence. Ubuye asebenze njengoprofesa osizayo kuzo zombili i-Columbia University Medical Center kanye neRutgers School of Public Health. Ngesikhathi sakhe sokuphumula, uDkt Azu ukujabulela ukuhamba nokuthwebula izithombe.