Ingabe i-Oxycodone ihlala isikhathi esingakanani kusistimu yakho?

-Delile

• Kuthatha isikhathi esingakanani ukuzwa imiphumela ye-oxycodone?
• Kuthatha isikhathi esingakanani ukuthi imiphumela ye-oxycodone iphele?
• Izici ezinomthelela wokuthi imiphumela ye-oxycodone ihlala isikhathi esingakanani
• Ubudala
• Ubulili
• Umsebenzi wesibindi
• Umsebenzi wezinso
• Uthathe isikhathi esingakanani uthatha i-oxycodone
• Utshwala
• Eminye imithi
• Izimpawu zokuhoxa
• Ukudla okudlela endlini

Ukubuka konke

I-Oxycodone yisidakamizwa se-opioid esisetshenziselwa ukudambisa ubuhlungu obulinganiselayo nobunzima kubantu abadala abangakwazi ukwelashwa ngeminye imithi yezinhlungu. I-Oxycodone ingabekwa ngemuva kokulimala, ukuhlukumezeka, noma ukuhlinzwa okukhulu. Kungabuye kunqunywe ukuphatha ezinye izinhlobo zobuhlungu obukhulu, njengobuhlungu bomdlavuza.

Amagama omkhiqizo we-oxycodone ekhishwa ngokushesha afaka:

• U-Oxaydo
• I-Roxycodone
• Roxybond
• I-Oxy IR

Amagama omkhiqizo wezinguqulo ezilawulwayo noma ezinwetshiwe zokukhishwa kwe-oxycodone zifaka:

• I-OxyContin CR (ukukhishwa okulawulwayo)
• I-Xtampza ER (ukukhululwa okunwetshiwe)

Kukhona nemithi yokuhlanganisa efaka i-oxycodone, efana:

• i-oxycodone ihlangene ne-acetaminophen (Percocet)
• i-oxycodone ihlanganiswe ne-acetaminophen (Xartemis XR)
• i-oxycodone ihlangene ne-aspirin (ejwayelekile iyatholakala)
• i-oxycodone ihlangene ne-ibuprofen (ejwayelekile iyatholakala)

I-Oxycodone itholakala kusitshalo se-poppy. Ibopha kwi-mu opioid receptor futhi ivimbele umuzwa wezinhlungu. Njengoba i-oxycodone isebenza ezikhungweni zobumnandi zobuchopho, inamandla amakhulu okuhlukumeza nokulutha. Ngalesi sizathu, i-oxycodone ihlukaniswa njengezinto ezilawulwa yinhlangano (C-II).

Uma ngabe unikezwe i-oxycodone, ungaba nelukuluku lokuthi imiphumela izohlala isikhathi esingakanani emzimbeni wakho, nokuthi umuthi ungavela isikhathi esingakanani ekuhlolweni kwezidakamizwa. Kubalulekile futhi ukuqonda ukuthi yini okufanele uyenze uma uthatha isinqumo sokuyeka ukuthatha i-oxycodone. Ukumisa ngokungazelelwe umuthi kungaholela ezimpawu zokuhoxa.

Kuthatha isikhathi esingakanani ukuzwa imiphumela ye-oxycodone?

Inani le-oxycodone elidingekayo kwi-analgesia (ukukhululeka kobuhlungu) lihluka kakhulu phakathi kwabantu. Imvamisa, udokotela uzokuqala ngomthamo ophansi bese ukwandisa umthamo kancane kancane kuze kube yilapho ubuhlungu bakho bulawulwa kahle. Abantu abathathe imishanguzo ye-opioid ngaphambili bangadinga ukuthatha umthamo ophakeme ukuze bezwe ukukhululeka kobuhlungu.

I-Oxycodone ithathwa ngomlomo (ngomlomo) futhi kufanele ithathwe ngokudla. Kufanele uqale ukuzwa imiphumela ye-oxycodone ngemizuzu engama-20 kuye kwengu-30 nje. I-Oxycodone ifinyelela ukugxila okuphezulu egazini cishe ngehora elilodwa kuya kwamabili ngemuva kokungeniswa. Ukwenziwa kokukhishwa okwandisiwe nokulawulwa kungathatha amahora amathathu kuya kwamane ukufinyelela ekugxileni okuphezulu egazini.

Ngokuhamba kwesikhathi, ungakha ukubekezelelana kwe-oxycodone. Lokhu kusho ukuthi kungathatha isikhathi eside ukuzwa ukukhululeka kobuhlungu noma ukukhululeka kungazizwa kunamandla. Uma lokhu kwenzeka, udokotela wakho angafuna ukwandisa umthamo wakho noma akushintshele ohlotsheni oluthile lwemithi yezinhlungu. Ungathathi umthamo omkhulu we-oxycodone ngaphandle kokukhuluma nodokotela wakho kuqala.

Kuthatha isikhathi esingakanani ukuthi imiphumela ye-oxycodone iphele?

Enye indlela yokuthola ukuthi umuthi uzohlala isikhathi esingakanani emzimbeni wakho ukukala impilo yawo engangesiqingatha. Ingxenye yempilo yisikhathi esithatha ukuthi ingxenye yesidakamizwa isuswe emzimbeni.

Ukwakhiwa kokukhishwa ngokushesha kwe-oxycodone kune-half-life average yamahora we-3.2. Ngamanye amagama, kuthatha amahora angu-3.2 ukuthi umuntu ojwayelekile aqede uhhafu womthamo we-oxycodone. Amafomula akhishwe ngokulawulwa / anwetshiwe we-oxycodone anengxenye ende yempilo engaba ngamahora angu-4.5 kuya emahoreni angu-5.6, ngokwesilinganiso.

Kuthatha isigamu-izimpilo ukuqeda ngokuphelele umuthi. Njengoba wonke umuntu ehlanganisa imithi ngokungafani, isigamu sempilo sizohluka kuye ngomuntu. Kubantu abaningi, i-oxycodone izolisula ngokuphelele igazi kungakapheli amahora angama-24, kepha isengatholakala ematheni, emchameni noma ezinweleni isikhathi eside kunalokho.

I-Oxycodone itholakala ku:

• amathe usuku olulodwa kuya kwezine ngemuva kokutholwa komthamo wokugcina
• umchamo izinsuku ezintathu kuya kwezine ngemuva kokuphuzwa komthamo wokugcina
• izinwele kuze kube yizinsuku ezingama-90 ngemuva kokutholwa komthamo wokugcina

Cishe uzoyeka "ukuzwa" ukukhululeka kobuhlungu kwe-oxycodone ngaphambi kokuthi kususe umzimba wakho ngokuphelele. Yingakho udokotela wakho kungenzeka ukuthi uthathe ithebhulethi eyodwa ye-oxycodone njalo emahoreni amane kuya kwayisithupha ngenkathi usezinhlungwini.

Amafomula wokukhishwa alawulwayo noma anwetshiwe ahlala isikhathi eside, ngakho-ke ajwayele ukuthathwa njalo emahoreni ayi-12.

Izici ezinomthelela wokuthi imiphumela ye-oxycodone ihlala isikhathi esingakanani

Ziningi izinto ezingaba nomthelela esikhathini esisithathayo ukuze i-oxycodone isule umzimba. Lokhu kufaka phakathi:

Ubudala

Izingxube zegazi ze-oxycodone zikhonjisiwe ukuthi zingamaphesenti ayi-15 ngaphezulu kwabadala (abangaphezu kweminyaka engama-65) uma kuqhathaniswa nabantu abadala abasebasha. Kungathatha isikhathi eside ukuthi abantu asebekhulile basule i-oxycodone ohlelweni lwabo.

Ubulili

Ngokusho kwephakeji ye-OxyContin, ukugxila kwe-oxycodone kwezifundo zabesifazane ezinempilo kwakukhuphuke ngamaphesenti angama-25 kunabesilisa. Kwabonakala okufanayo ezifundweni zeXtampza ER. Isizathu salokhu asicaci.

Umsebenzi wesibindi

I-half-life average ye-oxycodone inyuka ngamahora ama-2.3 kubantu abanesifo sokungasebenzi kahle kwesibindi. Lokhu kusho ukuthi kuzothatha isikhathi eside ukusula i-oxycodone emzimbeni.

Umsebenzi wezinso

Olunye ucwaningo luthole ukuthi isilinganiso esiphakathi nengxenye sempilo ye-oxycodone sikhula ngehora elilodwa kubantu abanezinkinga zezinso.

Uthathe isikhathi esingakanani uthatha i-oxycodone

Uma uthatha i-oxycodone njalo, inganqwabelana kwizicubu ezinamafutha emzimbeni wakho. Lokhu kusho ukuthi uma uthatha isikhathi eside i-oxycodone, kuzothatha isikhathi eside ukukhishwa ngokuphelele emzimbeni.

Utshwala

Imiphumela ye-oxycodone iyanda uma uphuza utshwala. Ngeke nje kuthathe isikhathi eside ukusula i-oxycodone emzimbeni wakho, kepha futhi kungaholela emiphumeleni emibi eyingozi, kufaka phakathi ukweqisa ngokweqile okungaba yingozi.

Eminye imithi

I-Oxycodone isuswa ngumzimba wakho ngendlela eyaziwa nge-cytochrome P450 3A (CYP3A). Izidakamizwa ezivimbela i-CYP3A4 zenza kube nzima kakhulu emzimbeni wakho ukwehla i-oxycodone. Ukuthatha i-oxycodone ngemithi elandelayo kungaholela ezinkingeni ezinkulu, kufaka phakathi ukucindezeleka kokuphefumula:

• ama-antibiotic e-macrolide, njenge-erythromycin
• ama-azole antifungal agents, njenge-ketoconazole
• ama-protease inhibitors

Ngenye indlela, izidakamizwa ezenza i-CYP3A, efana ne-rifampin, ingehlisa imiphumela ye-oxycodone.

Izimpawu zokuhoxa

Ungayeki ukuthatha i-oxycodone ngokungazelelwe ngaphandle kokubonisana nodokotela wakho ngoba ungaba nezimpawu ezinkulu zokuhoxa. Izimpawu zokuhoxa zenzeka lapho umzimba usuthembele emuthini.

Uma uhlangabezana nezimpawu zokuhoxa, akusho ukuthi ungumlutha we-oxycodone. Ukuthembela kuhlukile ekuluthweni umlutha. Ekuncikeni kwezidakamizwa, umzimba usujwayele ukutholakala komuthi, ngakho-ke uma uyeka ukuthatha lowo muthi ngokuzumayo, uzohlangabezana nezimpawu ezingalindeleka ezaziwa njengezimpawu zokuhoxa.

Lokhu kungafaka:

• ukungahlaliseki
• amehlo anamanzi
• ikhala eligijimayo
• kuzamula
• ukungakwazi ukulala
• amajaqamba
• ubuhlungu obuhlangene
• ukuhlanza
• ukujuluka
• ukuphefumula okusheshayo
• ukushaya kwenhliziyo okusheshayo

Ukuncika ngokuvamile akwenzeki kuze kube ngemuva kwamasonto ambalwa wokuthatha umuthi ngokungaguquguquki. Udokotela wakho anganciphisa umthamo wakho kancane kancane ngokuhamba kwesikhathi ukuvimbela ukuhoxa. Lokhu kubizwa ngokuthi yi-tapering. Kunconywa ukuthi umthamo wehliswe kancane kancane ngenkathi uqapha ngokucophelela izimpawu nezimpawu zokuhoxa.

Uma uhlangabezana nezimpawu zokuhoxa, zingahlukaniswa njengezipholile, ezilinganiselayo, noma ezinzima. Wonke umuntu uhlangabezana nokuhoxa ngokuhlukile, kepha kwizimpawu ezijwayelekile ziqala ukuthuthuka kungakapheli amahora angama-72 futhi zehle kakhulu kungakapheli isonto. Udokotela wakho angakusiza ukuphatha izimpawu zakho.

Ukudla okudlela endlini

Umphumela wokuphumula kobuhlungu we-oxycodone okhishwa ngokushesha uzophela kungakapheli amahora amane kuya kwayisithupha, kepha umuthi usengatholakala ematheni nasemchameni izinsuku ezingamahora amane kanye nasezinwele izinsuku ezingama-90 ngemuva komthamo wokugcina.

Kunezici eziningi ezingashintsha isikhathi esithathayo ukuze i-oxycodone isule umzimba, kufaka phakathi:

• ubudala
• ubulili
• impilo yesibindi nezinso
• uthathe isikhathi esingakanani uthatha i-oxycodone
• imithi ethile

Akufanele uphuze utshwala noma uthathe ezinye izidakamizwa zasemgwaqeni ngenkathi uthatha i-oxycodone ngoba lokhu kuzokwandisa ubungozi bokuthola imiphumela emibi emibi, okubandakanya nezinkinga ezinkulu zokuphefumula. Tshela udokotela wakho uma uthatha noma imiphi eminye imithi.

Ungalokothi uthathe okungaphezu komthamo obekiwe we-oxycodone, noma ngabe unomuzwa wokuthi umuthi awusebenzi. Kungenzeka ukweqisa i-oxycodone.

Funa ukunakekelwa okuphuthumayo uma uhlangabezana nalezi zimpawu ezilandelayo ngemuva kokuthatha i-oxycodone:

• ukuphefumula kanzima
• yehlisa noma yeka ukuphefumula
• kubanda, isikhumba se-clammy
• ukulahlekelwa ukwazi noma ikhoma
• ukulala ngokweqile
• abafundi abacindezelwe
• izicubu ezixegayo noma ezibuthakathaka
• ukuhlanza

Ama-opioid afana ne-oxycodone ahlotshaniswa nezinkinga ezinkulu zezempilo, kufaka phakathi ukuluthwa ngokweqile nokudlula ngokweqile. Ngo-2015, abantu abangaphezu kuka-20 000 babulawa ukweqisa izidakamizwa okuhlobene nemithi ye-opioid e-United States, ngokusho kwe-American Society of Addiction Medicine.

Kufanele ufunde ngokucophelela imininingwane equkethwe ilebula yomkhiqizo ngaphambi kokuba uqale ukwelashwa nge-oxycodone. Thatha umthamo wakho obekiwe kuphela. Xhumana nodokotela wakho uma unemibuzo noma ukukhathazeka.