Umlobi: Laura McKinney
Usuku Lokudalwa: 4 Epreli 2021
Ukuvuselela Usuku: 19 Unovemba 2024
Anonim
Humalog (insulin lispro)
Ividiyo: Humalog (insulin lispro)

-Delile

Yini iHumalog?

I-Humalog umuthi kadokotela wegama lomuthi. Kuvunyelwe i-FDA ukusiza ukulawula amazinga kashukela egazini kubantu abanesifo sikashukela sohlobo 1 noma uhlobo lwesibili sikashukela.

Kunezinhlobo ezimbili ezahlukene zeHumalog: Humalog neHumalog Mix.

Umxube weHumalog neHumalog uvunyelwe ukusetshenziswa kubantu abadala abanesifo sikashukela sohlobo 1 noma sohlobo 2. I-Humalog nayo ivunyelwe ukusetshenziswa ezinganeni ezineminyaka engama-3 nangaphezulu ezinesifo sikashukela sohlobo 1.

Izithako

I-Humalog iqukethe i-insulin lispro, eyi-analog esebenza ngokushesha. (I-analog inguqulo eyenziwe ngumuntu ye-insulin yemvelo eyenziwa ngumzimba wakho.)

I-Humalog Mix iqukethe inhlanganisela ebekiwe ngaphambili ye-insulin lispro kanye ne-insulin esebenza isikhathi eside ebizwa nge-insulin lispro protamine.

Amafomu we-Humalog nokuthi anikezwa kanjani

I-Humalog yisixazululo soketshezi esinikezwa njengomjovo ongaphansi. Lo ngumjovo onikezwa ngqo ngaphansi kwesikhumba.

I-Humalog nayo inganikezwa njengomjovo we-intravenous ngumhlinzeki wezokunakekelwa kwempilo. Lo mjovo ungene emthanjeni.


I-Humalog iza ngezindlela eziningana:

  • I-Vial yokusetshenziswa ngamasirinji we-insulin noma amaphampu e-insulin. Amabhodlela angena osayizi be-3-mL no-10-mL. Zombili zinamandla afanayo: amayunithi ayi-100 e-insulin nge-mL (U-100) ngayinye. Iphampu ye-insulini iyidivayisi eletha umthamo oqhubekayo we-insulin, futhi inganikeza nemithamo eyengeziwe ngezikhathi zokudla.
  • Ipeni lomjovo elilahlwayo, eligcwalisiwe elibizwa ngeHumalog KwikPen. Le peni engu-3-mL itholakala ngamandla amabili: U-100 kanye no-200 amayunithi we-insulin nge-mL (U-200) ngayinye.
  • Ipeni lomjovo elilahlwayo, eligcwalisiwe elibizwa ngeHumalog Junior KwikPen. Le peni engu-3-mL itholakala ngamandla owodwa: U-100.
  • Igobolondo lokusetshenziswa ezibayeni ze-insulin ezingasebenziseka kabusha. Le cartridge engu-3-mL itholakala ngamandla amabili: U-100.

Amafomu we-Humalog Mix nokuthi anikezwa kanjani

I-Humalog Mix inikezwa njengomjovo ongaphansi.

IHumalog Mix iza njengengxube engu-50/50, equkethe i-50% insulin lispro protamine ne-50% insulin lispro. Ibuye futhi njengengxube engu-75/25, equkethe i-75% ye-insulin lispro protamine ne-25% ye-insulin lispro. Kokubili ukumiswa (uhlobo lwengxube kuketshezi) oluza ngalezi zinhlobo:


  • I-Vial yokusetshenziswa ngamasirinji we-insulin. Le vial eyi-10-mL itholakala ngamandla owodwa: U-100.
  • Ipeni lomjovo elilahlwayo, eligcwalisiwe elibizwa ngeHumalog Mix KwikPen. Le peni engu-3-mL itholakala ngamandla owodwa: U-100.

Ukusebenza ngempumelelo

Ngemininingwane yokusebenza kwe-Humalog, bheka isigaba esithi "Humalog uses" ngezansi.

I-genalog ejwayelekile

I-Humalog iyatholakala njengesidakamizwa esijwayelekile esibizwa nge-insulin lispro.

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuphinde kwamukela uhlobo olujwayelekile lweHumalog Mix 75/25, oluzotholakala emakethe ngokuzayo. Isidakamizwa esijwayelekile saziwa njenge-insulin lispro protamine / insulin lispro.

Umuthi ojwayelekile ikhophi eliqondile lomuthi osebenzayo emithini enegama lomkhiqizo. Okujwayelekile kuthathwa njengokuphephile nokusebenza ngempumelelo njengomuthi wokuqala. Imvelo ejwayelekile ijwayele ukubiza ngaphansi kwezidakamizwa ezinamagama.

Izinhlobo ezijwayelekile zeHumalog neHumalog Mix 75/25 zikhiqizwa ngu-Eli Lilly, inkampani efanayo eyenza iHumalog. Le nkampani isebenzisa izinqubo ezifanayo ukudala i-Humalog kanye ne-Humalog Mix 75/25. Kungakho i-insulin lispro protamine / insulin lispro (ifomu ejwayelekile yeHumalog Mix 75/25) ibizwa ngokuthi yinto ejwayelekile.


Kwezinye izimo, umuthi wegama lomkhiqizo nohlobo olujwayelekile lungavela ngezindlela nangamandla ahlukahlukene.

Uhlobo olulandelwayo

Kukhona nenguqulo ye-Humalog elandelayo, ebizwa nge-Admelog. Le inguqulo yenkampani ehlukile ye-Humalog.

Isidakamizwa esilandelwayo kwesinye isikhathi sibizwa ngokuthi yi-biosimilar, futhi sifana nohlobo olujwayelekile lomuthi we-biologic. (Isidakamizwa se-biologic umuthi owenziwe kusuka ezingxenyeni zezinto eziphilayo.) Isidakamizwa esilandelwayo sifana kakhulu nesidakamizwa somzali se-biologic. Kodwa-ke, ngoba umuthi we-biologic wenziwa kusetshenziswa amaseli aphilayo, umuthi olandelwayo awufani ngokuphelele.

Izidakamizwa ezilandelwayo zisetshenziselwa ukwelapha izimo ezifanayo nezomzali. Futhi zibhekwa njengeziphephe futhi zisebenza kahle njengesidakamizwa sabazali. I-Humalog iyisidakamizwa somzali se-Admelog.

I-Humalog iyi-biologic, ngakho-ke imane ibe nenguqulo elandelayo nje. Ngakho-ke, kuyingqayizivele ukuthi enye yamafomu kaHumalog (Humalog Mix 75/25) nayo iza njengejenerikhi (insulin lispro protamine / insulin lispro).

Ukuthola eminye imininingwane nge-insulin njengokujwayelekile noma ukulandela, bheka incazelo ye-American Diabetes Association.

I-insulin ye-Humalog

I-Humalog insulin iyi-analog ye-insulin (inguqulo eyenziwe ngumuntu ye-insulin yemvelo eyenziwa ngumzimba wakho). Kunezinhlobo ezimbili ze-Humalog insulin: I-Humalog ne-Humalog Mix.

Ukwelashwa kwe-insulin kusetshenziswa kubantu abanesifo sikashukela ukufaka esikhundleni noma ukuthuthukisa ukukhiqizwa kwe-insulin yabo yemvelo. Izinhlobo ezahlukahlukene ze-insulin ziyatholakala. Bahlukaniswa ngokuthi baqala ukusebenza ngokushesha kangakanani nokuthi imiphumela yabo ihlala isikhathi esingakanani. Amaqembu amathathu ayinhloko e-insulin yilawa:

  • I-insulin esebenza ngokushesha. Lokhu kufaka:
    • I-insulin esebenza ngokushesha. Lokhu kuqala ukusebenza kungakapheli imizuzu engu-5 kuye kwengu-15, futhi kuhlala cishe amahora angama-4 kuye kwayi-6.
    • I-insulin yomuntu ejwayelekile (ebizwa nangokuthi i-insulin esebenza okwesikhashana). Lokhu kuqala ukusebenza kungakapheli imizuzu engama-30 kuya ehoreni eli-1, futhi kuhlala amahora angu-6 kuye kwayi-8.
  • I-insulin esebenza phakathi. Lokhu kuqala ukusebenza kungakapheli ihora elilodwa kuya kwamabili, futhi kuhlala cishe amahora ayi-12 kuye kwayi-18.
  • I-insulin esebenza isikhathi eside. I-insulin esebenza isikhathi eside ibizwa nangokuthi i-basal insulin. Iqala ukusebenza kungakapheli amahora angu-1.5 kuya kwangu-2, futhi ihlala amahora angama-18 kuye kwangama-24 noma ngaphezulu.

I-Humalog iyi-insulin esebenza ngokushesha equkethe i-insulin lispro. Iqala ukusebenza kungakapheli imizuzu engu-15 futhi ihlala cishe amahora amane kuya kwayisithupha.

I-Humalog Mix iyi-insulin engaphambi kwesikhathi. Iqukethe i-insulin lispro ne-insulin lispro protamine. I-insulin lispro iyi-insulin esebenza ngokushesha, kuyilapho i-insulin lispro protamine iyi-insulin esebenza phakathi. Ngakho-ke iHumalog Mix inezakhiwo zazo zombili izinhlobo. Iqala ukusebenza kungakapheli imizuzu eyi-15, futhi ihlala cishe amahora angama-22.

I-Humalog vs. NovoLog

Ungase uzibuze ukuthi iHumalog iqhathanisa kanjani neminye imithi enqunyelwe ukusetshenziswa okufanayo. Lapha sibheka ukuthi iHumalog neNovoLog zifana kanjani futhi zehlukile.

Izithako

I-Humalog iqukethe i-insulin lispro, kanti iNovoLog iqukethe i-insulin aspart. Lezi zombili zingama-insulins asebenza ngokushesha.

IHumalog neNovoLog ziyatholakala njengama-insulins angaphambi kwesikhathi, abizwa ngeHumalog Mix neNovoLog Mix. Lezi ziqukethe i-insulin esebenza ngokushesha ene-insulin esebenza phakathi. I-Humalog Mix iqukethe i-insulin lispro ene-insulin lispro protamine, kuyilapho iNovoLog Mix iqukethe i-insulin aspart ene-insulin aspart protamine.

Isebenzisa

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvume iHumalog neNovoLog ukusiza ukuphatha amazinga kashukela egazini kubantu abanesifo sikashukela sohlobo 1 noma uhlobo lwesibili.

I-Humalog, i-Humalog Mix, i-NovoLog, ne-NovoLog Mix konke kuvunyelwe ukusetshenziswa kubantu abadala abanohlobo lwesifo sikashukela sohlobo 1 noma uhlobo lwesibili.

IHumalog neNovoLog nazo zivunyelwe ukusetshenziswa ezinganeni ezinesifo sikashukela sohlobo 1. I-Humalog ingasetshenziswa yizingane ezineminyaka engu-3 nangaphezulu, kanti i-NovoLog eyabantwana abaneminyaka engu-2 nangaphezulu.

Amafomu wezidakamizwa nokuphathwa

I-Humalog, i-Humalog Mix, i-NovoLog, ne-NovoLog Mix konke kunikezwa njengemijovo engaphansi. Le yimijovo enikezwa ngaphansi kwesikhumba.

I-Humalog neNovoLog nayo inganikezwa njengemijovo efakwa ngomjovo ngumhlinzeki wezokunakekelwa kwempilo. Lokhu kungukujova emthanjeni.

Izinhlobo ze-insulin

I-Humalog neNovoLog ngama-analogs asebenza ngokushesha we-insulin. (I-analog inguqulo eyenziwe ngumuntu ye-insulin yemvelo eyenziwa ngumzimba wakho.) Ngokuvamile zithathwa ngezikhathi zokudla ukulawula izipikisi kushukela wegazi ezenzeka ngemuva kokudla. Uthatha i-Humalog imizuzu engu-15 ngaphambi kokudla. Uthatha iNovoLog imizuzu emihlanu kuya kwengu-10 ngaphambi kokudla.

I-Humalog Mix ne-NovoLog Mix zingama-insulins angaphambi kwesikhathi asebenza ngokushesha kepha futhi ahlala isikhathi eside. Basiza ukulawula ukwenyuka kwesikhathi sokudla kushukela wegazi, bese besiza ukuphatha ushukela wegazi phakathi kokudla noma ebusuku. Umthamo ngamunye wenzelwe ukumboza izidlo ezimbili, noma isidlo esisodwa kanye nesidlwana.

Amafomu we-Humalog

I-Humalog yisixazululo samanzi esivela ngezindlela eziningi:

  • I-Vial yokusetshenziswa ngamasirinji we-insulin noma amaphampu e-insulin. Izitsha ziqukethe i-3 mL noma i-10 mL ye-Humalog. Iphampu ye-insulini iyidivayisi eletha umthamo oqhubekayo we-insulin, futhi inganikeza nemithamo eyengeziwe ngezikhathi zokudla.
  • Ipeni lomjovo elilahlwayo, eligcwalisiwe elibizwa ngeHumalog KwikPen. Ipeni ngalinye liqukethe i-3 mL yomuthi.
  • Ipeni lomjovo elilahlwayo, eligcwalisiwe elibizwa ngeHumalog Junior KwikPen. Ipeni ngalinye liqukethe i-3 mL yomuthi.
  • Igobolondo lokusetshenziswa ezibayeni ze-insulin ezingasebenziseka kabusha. Igobolondo ngalinye liqukethe u-3 ml womuthi.

Amafomu eNovoLog

INovoLog yisixazululo soketshezi esiza ngezindlela eziningi:

  • I-Vial yokusetshenziswa ngamasirinji we-insulin noma amaphampu e-insulin. I-vial ngayinye iqukethe i-10 mL yeNovoLog.
  • Ipeni lomjovo elilahlwayo, eligcwalisiwe elibizwa nge-NovoLog FlexPen. Ipeni ngalinye liqukethe i-3 mL yomuthi.
  • Ipeni lomjovo elilahlwayo, eligcwalisiwe elibizwa nge-NovoLog FlexTouch. Ipeni ngalinye liqukethe i-3 mL yomuthi.
  • IPenFill cartridge ezosetshenziswa ezibayeni ezingasetshenziswa kabusha ze-insulin. Igobolondo ngalinye liqukethe i-3 mL yomuthi.

Amafomu we-Humalog Mix

IHumalog Mix iza njengokuxuba okungu-50/50, equkethe i-50% insulin lispro protamine ne-50% insulin lispro. Kuza futhi njengokuhlanganiswa okungama-75/25, okuqukethe ama-75% e-insulin lispro protamine kanye nama-25% e-insulin lispro. Kokubili ukumiswa (uhlobo lwengxube kuketshezi) oluza ngalezi zinhlobo:

  • I-Vial yokusetshenziswa ngamasirinji we-insulin. I-vial ngayinye iqukethe i-10 mL ye-Humalog Mix.
  • Ipeni lomjovo elilahlwayo, eligcwalisiwe elibizwa ngeHumalog Mix KwikPen. Ipeni ngalinye liqukethe i-3 mL yomuthi.

Amafomu we-NovoLog Mix

INovoLog Mix iza njengenhlanganisela engu-70/30 equkethe i-70% ye-insulin aspart protamine ne-30% ye-insulin aspart. Ukumiswa okuza ngalezi zinhlobo:

  • I-Vial yokusetshenziswa ngamasirinji we-insulin. I-vial ngayinye iqukethe i-10 mL yeNovoLog Mix.
  • Ipeni lomjovo elilahlwayo, eligcwalisiwe elibizwa nge-NovoLog Mix FlexPen. Ipeni ngalinye liqukethe i-3 mL yomuthi.

Imiphumela emibi kanye nezingozi

I-Humalog neNovoLog zombili izinhlobo ze-insulin. Ngakho-ke, le mithi ingadala imiphumela emibi efanayo. Ngezansi kunezibonelo zale miphumela emibi.

Imiphumela emibi emincane

Izibonelo zemiphumela emibi ejwayelekile engenzeka ngeHumalog neNovoLog (uma ithathwa ngawodwana) zifaka:

  • ukuphendula kwesiza somjovo, njengobuhlungu, ububomvu, ukulunywa, noma ukuvuvukala okuzungeze indawo yomjovo wakho
  • i-lipodystrophy (ukuqina kwesikhumba noma ukugaya indawo ezungeze indawo yokujova)
  • ukuqubuka
  • ukulunywa
  • ukuvuvukala kwezinyawo zakho noma amaqakala
  • ukuzuza kwesisindo

Imiphumela emibi kakhulu

Izibonelo zemiphumela emibi engaba khona ngeHumalog neNovoLog (uma ithathwa ngawodwana) zifaka:

  • i-hypoglycemia (ushukela ophansi wegazi)
  • ukusabela okweqile komzimba
  • i-hypokalemia (izinga eliphansi le-potassium egazini lakho)

Ukusebenza ngempumelelo

Okuwukuphela kwezimo zombili i-Humalog neNovoLog ezisetshenziselwa ukwelapha uhlobo 1 kanye nohlobo 2 lwesifo sikashukela.

I-Humalog neNovoLog azizange ziqhathaniswe ngqo ezifundweni ezinkulu zemitholampilo. Kodwa-ke, ucwaningo lwango-2017 luhlolisise imiphumela yokwelashwa ngeHumalog noma iNovalog ngokubheka izimangalo zomshuwalense zabantu abanesifo sikashukela sohlobo 1 noma uhlobo lwesibili. Ucwaningo lubheke izinkinga zesifo sikashukela esibe sibi kakhulu nezashintsha emazingeni e-hemoglobin A1c (HbA1c). I-HbA1c isilinganiso samazinga kashukela egazini ezinyangeni ezimbili kuya kwezi-3 ezedlule.

Imiphumela ayibonisanga mehluko ophawulekayo kubantu abathathe noma imuphi umuthi. Kungaphethwa ngokuthi le mithi isebenza ngokufanayo ekusizeni abantu abanesifo sikashukela sohlobo 1 noma uhlobo lwesibili ukuphatha ushukela wegazi labo.

Ucwaningo olulodwa oluncane luqhathanisa ukusetshenziswa kweHumalog Mix 50/50 neNovoLog Mix 70/30 kubantu abanesifo sikashukela sohlobo 2. Lawa ma-insulins abekiwe ngaphambi kwesikhathi atholakale esebenza ngokufanayo ekwehliseni amazinga we-HbA1c nokwenza ngcono ukulawula ushukela wegazi.

Izindleko

I-Humalog neNovoLog zombili izidakamizwa ezinamagama. Izinhlobo ezijwayelekile zemithi yomibili (kubandakanya amafomu abekiwe ngaphambili) ayatholakala. Imithi enegama lomkhiqizo ivame ukubiza ngaphezu kwama-generic.

Ngokuya ngokulinganiselwa ku-GoodRx.com, izindleko zeHumalog neNovoLog zizohluka ngokuya ngohlelo lwakho lokwelashwa. Inani langempela ozolikhokhela noma imuphi umuthi lincike ohlelweni lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

I-Humalog vs. Humulin

NjengoNovoLog (ngenhla), isidakamizwa uHumulin sisebenzisa esifana nalesi seHumalog. Nakhu ukuqhathanisa ukuthi iHumalog neHumulin ziyefana futhi zehlukile kanjani.

Izithako

Kunezinhlobo ezimbili ezihlukile zeHumalog:

  • I-Humalog iqukethe i-insulin lispro.
  • I-Humalog Mix iqukethe inhlanganisela ye-insulin lispro ne-insulin lispro protamine.

Futhi kunezinhlobo ezintathu ezehlukene ze-Humulin:

  • I-Humulin R iqukethe i-insulin yomuntu.
  • I-Humulin N iqukethe i-isophane insulin yomuntu.
  • I-Humulin 70/30 iqukethe inhlanganisela ye-insulin yomuntu kanye ne-isophane insulin yomuntu.

Isebenzisa

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvume iHumalog neHumulin ukusiza ukuphatha amazinga kashukela egazini kubantu abanesifo sikashukela sohlobo 1 noma uhlobo lwesibili.

Umxube weHumalog neHumalog uvunyelwe ukusetshenziswa kubantu abadala abanesifo sikashukela sohlobo 1 noma sohlobo 2. I-Humalog nayo ivunyelwe ukusetshenziswa ezinganeni ezineminyaka engama-3 nangaphezulu ezinesifo sikashukela sohlobo 1.

I-Humulin R ne-Humulin N zivunyelwe ukusetshenziswa kubantu abadala nasezinganeni ezinohlobo lwesifo sikashukela sohlobo 1 noma uhlobo lwesibili. I-Humulin 70/30 ivunyelwe ukusetshenziswa kuphela kubantu abadala abanesifo sikashukela sohlobo 1 noma sohlobo 2.

Amafomu wezidakamizwa nokuphathwa

I-Humalog, i-Humalog Mix, i-Humulin R, i-Humulin N, ne-Humulin 70/30 konke kunikezwa njengemijovo engaphansi. Le yimijovo enikezwa ngaphansi kwesikhumba. I-Humalog ne-Humulin R nayo inganikezwa njengemijovo efakwa ngomjovo ngumhlinzeki wezokunakekelwa kwempilo. Lokhu kungukujova emthanjeni.

Izinhlobo ze-insulin

I-Humalog ne-Humulin R womabili la ma-insulins asebenza ngokushesha asetshenziselwa ukuphatha ukwenyuka kwesikhathi sokudla kushukela wegazi:

  • I-Humalog iyi-analog esebenza ngokushesha ye-insulin ovame ukuthatha imizuzu eyi-15 ngaphambi kokudla. (I-analog inguqulo eyenziwe ngumuntu ye-insulin yemvelo eyenziwa ngumzimba wakho.)
  • I-Humulin R iyi-insulin esebenza okwesikhashana oyithatha imizuzu engama-30 ngaphambi kokudla.

I-Humulin N iyi-insulin esebenza phakathi. Uyithatha ukuphatha ushukela wegazi phakathi kokudla nasebusuku.

I-Humalog Mix ne-Humulin 70/30 zingama-insulins angaphambi kwesikhathi asebenza ngokushesha kepha futhi ahlala isikhathi eside. Basiza ukulawula ukwenyuka kwesikhathi sokudla kushukela wegazi, bese besiza ukuphatha ushukela wegazi phakathi kokudla noma ebusuku. Imvamisa uthatha i-Humalog Mix imizuzu eyi-15 ngaphambi kokudla. Nge-Humulin 70/30, imvamisa uyithatha imizuzu engama-30 kuye kwengama-45 ngaphambi kokudla.

Amafomu we-Humalog

I-Humalog yisixazululo soketshezi esitholakala ngezindlela eziningi:

  • I-Vial yokusetshenziswa ngamasirinji we-insulin noma amaphampu e-insulin. Izitsha ziqukethe i-3 mL noma i-10 mL ye-Humalog. Iphampu ye-insulini iyidivayisi eletha umthamo oqhubekayo we-insulin, futhi inganikeza nemithamo eyengeziwe ngezikhathi zokudla.
  • Ipeni lomjovo elilahlwayo, eligcwalisiwe elibizwa ngeHumalog KwikPen. Ipeni ngalinye liqukethe i-3 mL yomuthi.
  • Ipeni lomjovo elilahlwayo, eligcwalisiwe elibizwa ngeHumalog Junior KwikPen. Ipeni ngalinye liqukethe i-3 mL yomuthi.
  • Igobolondo lokusetshenziswa ezibayeni ze-insulin ezingasebenziseka kabusha. Igobolondo ngalinye liqukethe i-3 mL yomuthi.

Amafomu kaHumulin R

I-Humulin R yisixazululo soketshezi esiza ngalezi zinhlobo:

  • I-Vial yokusetshenziswa ngamasirinji we-insulin noma amaphampu e-insulin. Amabhodlela aqukethe i-3 mL noma i-10 mL ye-Humulin R.
  • I-Vial yokusetshenziswa ngamasirinji we-insulin. Isitsha ngasinye siqukethe ama-20 mL omuthi.
  • Ipeni lomjovo elilahlwayo, eligcwalisiwe elibizwa ngeHumulin R KwikPen. Ipeni ngalinye liqukethe i-3 mL yomuthi.

Amafomu kaHumulin N

I-Humulin N ukumiswa (uhlobo lwengxube kuketshezi) oluza ngalezi zinhlobo:

  • Vial ukusetshenziswa ne-insulin imijovo. Amabhodlela aqukethe i-3 mL noma i-10 mL ye-Humulin N.
  • Ipeni lomjovo elilahlwayo, eligcwalisiwe elibizwa ngeHumulin N KwikPen. Ipeni ngalinye liqukethe i-3 mL yomuthi.

Amafomu we-Humalog Mix

IHumalog Mix iza njengengxube engu-50/50, equkethe i-50% insulin lispro protamine ne-50% insulin lispro. Kuza futhi njengokuhlanganiswa okungama-75/25, okuqukethe ama-75% e-insulin lispro protamine kanye nama-25% e-insulin lispro. Kokubili ukumiswa okuza ngalezi zinhlobo:

  • I-Vial yokusetshenziswa ngamasirinji we-insulin. I-vial ngayinye iqukethe i-10 mL ye-Humalog Mix.
  • Ipeni lomjovo elilahlwayo, eligcwalisiwe elibizwa ngeHumalog Mix KwikPen. Ipeni ngalinye liqukethe i-3 mL yomuthi.

Amafomu we-Humulin 70/30

I-Humulin 70/30 ukumiswa okuza ngalezi zinhlobo:

  • I-Vial yokusetshenziswa ngamasirinji we-insulin. Amabhodlela aqukethe i-3 mL noma i-10 mL ye-Humulin 70/30.
  • Ipeni lomjovo elilahlwayo, eligcwalisiwe elibizwa ngeHumulin 70/30 KwikPen. Ipeni ngalinye liqukethe i-3 mL yomuthi.

Imiphumela emibi kanye nezingozi

I-Humalog ne-Humulin zombili izinhlobo ze-insulin. Ngakho-ke, le mithi ingadala imiphumela emibi efanayo. Ngezansi kunezibonelo zale miphumela emibi.

Imiphumela emibi emincane

Izibonelo zemiphumela emibi ejwayelekile engenzeka ngeHumalog neHumulin (uma ithathwa ngawodwana) zifaka:

  • ukuphendula kwesiza somjovo, njengobuhlungu, ububomvu, ukulunywa, noma ukuvuvukala okuzungeze indawo yomjovo wakho
  • i-lipodystrophy (ukuqina kwesikhumba noma ukugaya indawo ezungeze indawo yokujova)
  • ukuqubuka
  • ukulunywa
  • ukuvuvukala kwezinyawo zakho noma amaqakala
  • ukuzuza kwesisindo

Imiphumela emibi kakhulu

Izibonelo zemiphumela emibi engaba khona ngeHumalog neHumulin (uma ithathwa ngawodwana) zifaka:

  • i-hypoglycemia (ushukela ophansi wegazi)
  • ukusabela okweqile komzimba
  • i-hypokalemia (izinga eliphansi le-potassium egazini lakho)

Ukusebenza ngempumelelo

I-Humalog ne-Humulin zombili zivunyelwe i-FDA ukwelapha uhlobo lwesifo sikashukela sohlobo 1 nohlobo 2.

Imiphumela evela ezifundweni ezimbili zokwelashwa

Le mithi iqhathaniswe ngqo nokwelapha isifo sikashukela ezifundweni ezimbili zokwelashwa. Ucwaningo olulodwa lwabheka uhlobo lwesifo sikashukela sohlobo 1, kanti olunye lwabheka uhlobo lwesifo sikashukela sohlobo 2. Abaphenyi balinganisa umphumela weHumalog neHumulin R emazingeni e-hemoglobin A1c (HbA1c). I-HbA1c isilinganiso samazinga kashukela egazini ezinyangeni ezimbili kuya kwezi-3 ezedlule.

Kubantu abanesifo sikashukela sohlobo 1:

  • amazinga aphakathi no-HbA1c ehle ngo-0.1% kulabo abathathe iHumalog
  • isilinganiso samazinga we-HbA1c enyuke ngo-0.1% kulabo abathathe i-Humulin R

Kubantu abanesifo sikashukela sohlobo 2, amazinga we-HbA1c aphakathi nokwehla ngo-0.7% kubantu abathathe noma yisiphi isidakamizwa.

Lezi zifundo zathola ukuthi iHumalog neHumulin R iyasebenza ngokufanayo ekusizeni abantu abanohlobo 1 noma uhlobo lwesibili sikashukela ukuphatha ushukela wegazi labo.

Imiphumela evela ekubuyekezweni okukhulu kwezifundo

Ukusebenza kweHumalog neHumulin ekwelapheni isifo sikashukela kuqhathaniswe muva nje ekubuyekezweni okukhulu kwezifundo. Abaphenyi bahlole imiphumela yama-insulins asebenza ngokushesha, njengeHumalog, kanye ne-insulin ejwayelekile yomuntu, njengoHumulin R. Abantu abasezifundweni babenohlobo lwesifo sikashukela sohlobo 1 noma uhlobo lwesibili.

Abaphenyi baqhathanisa imiphumela yazo zombili izinhlobo ze-insulin ezinyathelweni ezahlukahlukene zikashukela wegazi. Lezi zinyathelo zifaka amazinga kashukela egazini ngemuva kokudla namazinga e-HbA1c.

Thayipha isifo sikashukela sokuqala

Ngokwesifo sikashukela sohlobo 1, ukubuyekezwa kwathola ukuthi ama-insulins asebenza ngokushesha ayengcono kune-insulin ejwayelekile yomuntu ekulawuleni amazinga kashukela egazini ngemuva kokudla. Ama-insulins asebenza ngokushesha atholakala ukuthi asebenza kangcono ekwehliseni amazinga we-HbA1c.

Abaphenyi baphetha ngokuthi ama-insulins asebenza ngokushesha, njengeHumalog, angcono ekusizeni abantu abanesifo sikashukela sohlobo 1 ukuphatha ushukela wabo wegazi kune-insulin ejwayelekile yomuntu, njengeHumulin R.

Thayipha isifo sikashukela sesi-2

Kodwa-ke, iziphetho ezifanayo bezingenziwa ngohlobo lwesifo sikashukela sohlobo 2. Ukubuyekeza kutholakele ukuthi kudingeka eminye imininingwane ukuthola ukuthi ngabe ama-insulins asebenza ngokushesha noma i-insulin ejwayelekile yomuntu iyasebenza yini kubantu abanesifo sikashukela sohlobo 2.

Izindleko

I-Humalog ne-Humulin zombili izidakamizwa ezinamagama. Izinhlobo ezijwayelekile zeHumalog ziyatholakala, kepha okwamanje azikho izinhlobo ezijwayelekile zeHumulin. Imithi enegama lomkhiqizo ivame ukubiza ngaphezu kwama-generic.

Ngokuya ngokulinganiselwa ku-GoodRx.com, izindleko zeHumalog neHumulin zizohluka ngokuya ngohlelo lwakho lokwelashwa. Inani langempela ozolikhokhela noma imuphi umuthi lincike ohlelweni lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

Isikali sokuslayida se-Humalog

Isikali esishelelayo sesifo sikashukela yishadi elibonisa isikali somthamo sokwelashwa kwe-insulin. Kwesinye isikhathi kusetshenziselwa abantu abanesifo sikashukela sohlobo 1 noma uhlobo 2 abanenkinga yokubala isilinganiso sabo se-insulin. Ishadi linikeza umthamo we-insulin okufanele uyithathe ngesidlo ngasinye, kuya ngokuthi liyizinga likashukela egazini lakho kangakanani.

Umhlinzeki wezokunakekelwa kwempilo usebenza nawe ukudala isikali sokuhambisa ngokwezifiso. Kodwa-ke, izikali ziqinile kakhulu. Bathembele kuwe ukuthi udle inani elithile lama-carbohydrate ngesidlo ngasinye futhi ube nokudla kwakho ngesikhathi esimisiwe usuku ngalunye. Izikali ezishelelayo zincike kuwe ekutheni ube nomsebenzi ongaguquguquki womzimba usuku nosuku.

Uma wenza izinguquko kunoma yiziphi zalezi zinto, ungaba sengozini yokuthola ushukela ophakeme wegazi noshukela ophansi wegazi. Ngokuvamile, izikali ezishelelayo aziyona indlela enhle yokuphatha kahle isifo sikashukela, futhi odokotela abaningi beluleka ngokungazisebenzisi.

I-Humalog ingadonswa kusetshenziswa isikali sokuhambisa. Kepha kungenzeka ukuthi uzobala umthamo wakho we-Humalog njalo uma uwuthatha. Uzobeka umthamo ezintweni eziningana, kufaka phakathi:

  • izinga lakho lokuqala likashukela egazini
  • inani lama-carbohydrate ekudleni kwakho
  • uhleleke kangakanani ngokomzimba uhlela ukuba ngaphezu kwamahora ambalwa alandelayo

Umhlinzeki wakho wezokunakekelwa kwempilo angakufundisa ukuthi ungawubala kanjani umthamo wakho we-Humalog.

Isilinganiso se-Humalog

Isilinganiso se-Humalog udokotela wakho asinqumayo sizoxhomeka ezicini eziningana. Lokhu kufaka phakathi:

  • uhlobo nobukhali besifo sakho sikashukela
  • uhlobo lweHumalogo oyithathayo
  • isisindo sakho
  • imikhuba yakho yokudla nokuzilolonga
  • imigomo yezinga likashukela egazini lakho
  • ezinye izimo zezokwelapha ongahle ube nazo
  • eminye imithi ongayiphuza

Imvamisa, udokotela wakho uzokuqala ngomthamo ophansi. Ngemuva kwalokho bazoyilungisa ngokuhamba kwesikhathi ukufinyelela inani elifanele wena. Awukho umthamo omkhulu we-Humalog. Udokotela wakho ekugcineni uzonikeza isilinganiso esincane kunazo zonke esihlinzeka ngomphumela oyifunayo.

Umthamo wakho we-Humalog kwesinye isikhathi ungadinga ukulungiswa. Ungakanani umuthi owudingayo ongashintsha uma uguqula indlela odla ngayo noma isilinganiso sakho esivamile somsebenzi. Ungadinga futhi umthamo ohlukile we-Humalog ngezikhathi zokucindezeleka ngokomzwelo noma uma ugula, ikakhulukazi ngokutheleleka noma ngemfiva. Khuluma nodokotela wakho mayelana nokuthi uzodinga yini ukwenza ushintsho kumthamo wakho we-Humalog.

Qiniseka ukuthi uthatha isilinganiso udokotela wakho akubekela sona. Udokotela wakho uzonquma isilinganiso esihle kakhulu ukulingana nezidingo zakho. Izilinganiso ze-Humalog zinqunywe ngamayunithi.

Amafomu wezidakamizwa namandla

Kunezinhlobo ezimbili ezahlukene zeHumalog: Humalog neHumalog Mix.

I-Humalog itholakala ngamandla amabili: U-100 (amayunithi ayi-100 e-insulin nge-mL) ne-U-200 (amayunithi angama-200 e-insulin nge-mL). Iqukethe i-insulin lispro.

I-Humalog Mix itholakala ngamandla owodwa kuphela: U-100. Iqukethe ingxube ye-insulin lispro ne-insulin lispro protamine.

I-Humalog U-100

Amandla we-U-100 weHumalog eza ngezindlela ezine ezihlukene:

  • Amabhodlela. Izimbali ze-Humalog ziza ngamasayizi ama-3-mL no-10-mL. Ungasebenzisa izitsha ezinezitsha ezimbili ezahlukene. Esinye isipetu se-insulin. Kufanele usebenzise isirinji ye-insulin engu-U-100 ukukala umthamo wakho we-Humalog kusuka ku-vial. Enye into ibizwa ngokuthi yiphampu ye-insulin. Iletha umthamo oqhubekayo we-insulin, futhi inganikeza nokukhishwa okwengeziwe ngezikhathi zokudla.
  • KwikPen. Le ipeni yomjovo elahlwayo engu-3-mL. Inganikeza ngamayunithi angama-60 e-insulin ngomjovo owodwa.
  • UJunior KwikPen. Le ipeni yomjovo elahlwayo engu-3-mL. Inganikela ngamayunithi angama-30 e-insulin ngomjovo owodwa.
  • Igobolondo. Le igobolondo le-3-mL elisetshenziswa nezibaya ze-insulin ezingasetshenziswa kabusha, njenge-HumaPen Luxura HD.

I-Humalog U-200

Amandla we-U-200 weHumalog eza ngendlela eyodwa:

  • KwikPen. Le ipeni yomjovo elahlwayo engu-3-mL. Inganikeza ngamayunithi angama-60 e-insulin ngomjovo owodwa.

I-Humalog Mix 50/50

I-Humalog Mix 50/50 iqukethe ingxube ye-50% insulin lispro protamine ne-50% insulin lispro. Iza ngezindlela ezimbili ezihlukene, futhi ngayinye inamandla ka-U-100. Lawa mafomu yilawa:

  • Isitsha. Lesi sitsha se-10-mL sisetshenziswa ngamajova e-insulin. Kufanele usebenzise isirinji ye-insulini engu-U-100 ukukala umthamo wakho we-Humalog Mix 50/50 kusuka ku-vial.
  • KwikPen. Le ipeni yomjovo elahlwayo engu-3-mL. Inganikeza ngamayunithi angama-60 e-insulin ngomjovo owodwa.

I-Humalog Mix 75/25

I-Humalog Mix 75/25 iqukethe ingxube ye-75% ye-insulin lispro protamine ne-25% ye-insulin lispro. Iza ngezindlela ezimbili ezihlukene, futhi ngayinye inamandla ka-U-100. Lawa mafomu yilawa:

  • Isitsha. Lesi sitsha se-10-mL sisetshenziswa ngamajova e-insulin. Kufanele usebenzise isirinji ye-insulin engu-U-100 ukukala umthamo wakho we-Humalog Mix 75/25 kusuka ku-vial.
  • KwikPen. Le ipeni yomjovo elahlwayo engu-3-mL. Inganikeza ngamayunithi angama-60 e-insulin ngomjovo owodwa.

Izimpahla ozozidinga

Uzodinga ukuthenga izinto ezithile ezizosetshenziswa ngezinhlobo ezithile ze-Humalog noma i-Humalog Mix:

  • Amabhodlela we-Humalog noma i-Humalog Mix: imijovo nezinaliti ezifanele ze-insulin. Kufanele usebenzise inaliti entsha kanye nomjovo omusha we-insulin kumthamo ngamunye.
  • I-Humalog noma i-Humalog Mix KwikPens: izinaliti ezifanele ukuzisebenzisa nezibaya. Kufanele usebenzise inaliti entsha kumthamo ngamunye we-insulin onikezwe ngepeni.
  • Amakhadibhodi we-Humalog: ipeni elisebenzisekayo elifanele ukusetshenziswa kanye nezinaliti ongazisebenzisa nosiba. Kufanele usebenzise inaliti entsha kumthamo ngamunye we-insulin onikezwe ngepeni.

Isilinganiso sohlobo 1 sikashukela

Imininingwane yomkhiqizo we-Humalog ne-Humalog Mix ayiniki izincomo zomthamo eziqondile zokwelapha uhlobo lwesifo sikashukela sohlobo 1. Lokho kungenxa yokuthi isilinganiso esinconyiwe sincike ezintweni eziningi ngazinye, kufaka phakathi lezo ezibalwe ngenhla.

Udokotela wakho uzobala isilinganiso sakho sansuku zonke se-insulin, ngokuya ngesisindo sakho. Ngokusho kwe-American Diabetes Association, isilinganiso esivamile se-insulin yansuku zonke sohlobo 1 sikashukela simayelana no-0.4 kuya ku-1.0 iyunithi ye-insulin ngekhilogremu ngalinye lesisindo somzimba wakho. (Ikhilogremu elilodwa lingamakhilogremu angu-2.2.)

Iningi labantu lithatha cishe uhhafu wethamo labo le-insulin yansuku zonke njenge-insulin esebenza ngokushesha, njengeHumalog, ngezikhathi zokudla. Konke bakuthatha njenge-insulin emaphakathi noma ende esebenza kanye noma kabili ngosuku.

Ngokuvamile uzothatha i-Humalog kuze kube yimizuzu engu-15 ngaphambi kokudla ngakunye noma ngemuva nje kokudla ngakunye. Kungakanani i-Humalog okufanele uyithathe ngesidlo ngasinye kungahluka. Umhlinzeki wakho wezokunakekelwa kwempilo uzokufundisa ukuthi ungalungisa kanjani umthamo wakho. Umthamo uvame ukususelwa ezingeni lakho lokuqala likashukela egazini, inani lama-carbohydrate esidlweni sakho, nokuthi ukhuthele kangakanani ngokomzimba.

Ngokuya ngomthamo owudingayo, ungadinga umjovo ongaphezu koyedwa.

Iphampu ye-insulin

Ngaphezu kokunikezwa njengemijovo, iHumalog U-100 nayo ingasetshenziswa kwimpompo ye-insulin. Uma usebenzisa i-Humalog kwimpompo ye-insulin, udokotela wakho uzokuchazela ukuthi uyiphuza kanjani futhi nini le mithi.

Ukujova ngomjovo

Enye indlela ongathola ngayo iHumalog iwukuba umhlinzeki wezokunakekelwa kwezempilo akunikeze njengomjovo we-intravenous (umjovo emthanjeni wakho). Udokotela wakho uzokunquma isilinganiso esifanele.

Umxube we-Humalog

I-Humalog Mix iqukethe inhlanganisela yama-insulins asebenza ngokushesha nangaphakathi.

Imvamisa ungahlukanisa isilinganiso sakho se-insulin sansuku zonke sibe imijovo emibili. Ngokujwayelekile uzoba nomjovo owodwa imizuzu engu-15 ngaphambi kokudla kwasekuseni neminye imizuzu engu-15 ngaphambi kokudla kwakusihlwa. Lokhu kusiza ukuphatha ukwenyuka kwesikhathi sokudla kushukela wegazi, bese izinga likashukela egazini liyashintsha phakathi kokudla noma ebusuku.

Umthamo ngamunye weHumalog Mix wenzelwe ukumboza izidlo ezimbili, noma isidlo esisodwa kanye nesidlwana.

Isilinganiso sohlobo 2 sikashukela

Imininingwane yomkhiqizo ye-Humalog and Humalog Mix ayiniki izincomo zomthamo eziqondile zokwelapha uhlobo lwesifo sikashukela sohlobo 2. Lokho kungenxa yokuthi isilinganiso esinconyiwe sincike ezintweni eziningi ngazinye, kufaka phakathi lezo ezibalwe ngenhla.

Uma uqala ukusebenzisa i-insulin yohlobo lwesifo sikashukela sohlobo 2, uvamise ukusebenzisa i-insulin esebenza isikhathi eside kanye noma kabili ngosuku. Uma lokhu kungaphathi kahle ushukela wegazi ngokwanele, khona-ke uzoqala ukusebenzisa i-insulin esebenza ngokushesha njengeHumalog ngezikhathi zokudla.

I-Humalog

Uma usebenzisa i-Humalog, i-American Diabetes Association incoma isilinganiso sokuqala samayunithi angama-4, noma i-10% yesilinganiso sakho se-insulin esisebenza isikhathi eside, usuku ngalunye.

Okokuqala, ngokujwayelekile uzothatha i-Humalog kufika kumaminithi angu-15 ngaphambi noma ngemuva nje kokudla kwakho okukhulu kosuku. Ngokuya ngokuthi lokhu kuwuphatha kahle kanjani ushukela wegazi lakho, udokotela wakho angafuna futhi ukuthi uthathe i-Humalog nokunye ukudla. Bazolungisa isilinganiso sakho seHumalog ukukusiza ukuthi ufinyelele imigomo yezinga likashukela egazini lakho.

Umxube we-Humalog

Uma usebenzisa i-Humalog Mix, ngokwejwayelekile uzohlukanisa isilinganiso sakho se-insulin yansuku zonke sibe imijovo emibili. Ngokujwayelekile uzoba nomjovo owodwa imizuzu engu-15 ngaphambi kokudla kwasekuseni neminye imizuzu engu-15 ngaphambi kokudla kwakusihlwa.

I-Humalog Mix iqukethe inhlanganisela ye-insulin esheshayo naphakathi. Lokhu kusiza ukuphatha ukwenyuka kwesikhathi sokudla kushukela wegazi, bese izinga likashukela egazini liyashintsha phakathi kokudla noma ebusuku.

Umthamo ngamunye weHumalog Mix wenzelwe ukumboza izidlo ezimbili, noma isidlo esisodwa kanye nesidlwana.

Ngokuya ngomthamo owudingayo, kungadingeka ukuthi ube nomjovo ongaphezu koyedwa we-Humalog Mix.

Abantu abane-type 2 yesifo sikashukela badinga imithamo ephezulu ye-insulin. Uma udinga ukuthatha imithamo ephezulu yeHumalog, khuluma nodokotela wakho. Kungaba lula kakhulu futhi kunethezeke kuwe ukusebenzisa amandla we-U-200 agxile ku-Humalog KwikPen.

Umthamo wezingane

I-Humalog ivunyelwe ukusetshenziswa ezinganeni ezineminyaka engama-3 nangaphezulu ezinesifo sikashukela sohlobo 1.

Imininingwane yomkhiqizo weHumalog ayinikezi izincomo zomthamo ezithile zezingane. Udokotela wengane yakho uzolandela imihlahlandlela efanayo yokulinganisa esetshenziselwa abantu abadala abathatha i-Humalog. Bheka isigaba esingenhla esibizwa ngokuthi “Isikali sohlobo 1 sikashukela” ukuthola eminye imininingwane.

I-Humalog Mix ayivunyelwe ukusetshenziswa ezinganeni.

Kuthiwani uma ngiphuthelwa umthamo?

Ngokuvamile uzothatha i-Humalog ne-Humalog Mix kuze kube yimizuzu engu-15 ngaphambi kokudla. Uma ukhohlwa, ungathatha umthamo wakho ngemuva nje kokuqeda ukudla kwakho. Kepha uma sekuphele isikhathi esingaphezu kwehora udle, kufanele ulinde uthathe umthamo wakho olandelayo njengoba kuhlelwe. Uma uthatha i-Humalog noma i-Humalog Mix isikhathi eside kakhulu ngemuva kokudla, ungahlakulela i-hypoglycemia (ushukela ophansi wegazi).

Ukusiza ukuqinisekisa ukuthi awuphuthelwa umthamo, zama ukusetha isikhumbuzi efonini yakho. Isikhathi semithi singasiza, futhi.

Ngabe kuzodingeka ngisebenzise lesi sidakamizwa isikhathi eside?

I-Humalog ihloselwe ukusetshenziswa njengokwelashwa kwesikhathi eside. Uma wena nodokotela wakho nibona ukuthi i-Humalog iphephile futhi isebenza kahle kini, kungenzeka niyithathe isikhathi eside.

Imiphumela emibi ye-Humalog

I-Humalog ingadala imiphumela emibi noma emibi. Uhlu olulandelayo luqukethe eminye yemiphumela emibi engaba khona ngenkathi ithatha i-Humalog. Lezi zinhlu azibandakanyi yonke imiphumela emibi engaba khona.

Ngeminye imininingwane ngemiphumela emibi yeHumalog, khuluma nodokotela wakho noma usokhemisi. Bangakunika amathiphu okuthi ungabhekana kanjani nanoma yimiphi imiphumela emibi engase ikukhathaze.

Qaphela: Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kulandelela imiphumela emibi yezidakamizwa eyivumile. Uma ungathanda ukubika kwi-FDA imiphumela eseceleni obukade unayo nge-Humalog, ungakwenza lokho nge-MedWatch.

Imiphumela emibi emincane

Imiphumela emibi emincane ye-Humalog ne-Humalog Mix ingafaka:

  • ukuphendula kwesiza somjovo, njengobuhlungu, ububomvu, ukulunywa, noma ukuvuvukala okuzungeze indawo yomjovo wakho
  • i-lipodystrophy (ukuqina kwesikhumba noma ukugaya indawo ezungeze indawo yokujova)
  • ukuqubuka
  • ukulunywa
  • ukuvuvukala kwezinyawo zakho noma amaqakala
  • ukuzuza kwesisindo

Iningi lalemiphumela emibi ingahle ihambe ezinsukwini ezimbalwa noma emasontweni ambalwa. Kepha uma ziba nzima kakhulu noma zingahambi, khuluma nodokotela wakho noma usokhemisi.

* Lolu uhlu oluyingxenye yemiphumela emibi evela ku-Humalog. Ukuze ufunde ngeminye imiphumela emibi, khuluma nodokotela wakho noma usokhemisi, noma vakashela i-Humalog Patient Information ngesimo somuthi owuthathayo:

  • Imininingwane Yesineke Ye-Humalog U-100
  • Imininingwane Yesineke Ye-Humalog U-200 KwikPen
  • Imininingwane Yesineke Ye-Humalog Mix 75/25
  • Humalog Mix 50/50 Imininingwane Yesiguli

Imiphumela emibi kakhulu

Imiphumela emibi ebucayi evela ku-Humalog ayijwayelekile, kepha ingenzeka. Shayela udokotela wakho ngokushesha uma unemiphumela emibi kakhulu. Shayela ku-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Imiphumela emibi kanye nezimpawu zabo zingafaka:

  • I-Hypokalemia (izinga eliphansi le-potassium egazini lakho). Izimpawu zingafaka:
    • ubuthakathaka bemisipha
    • ukukhathala (ukungabi namandla)
    • amajaqamba noma ukujija
    • ukuqunjelwa
    • ukuchama kaningi kunokujwayelekile
    • ngizwe womile
    • ukushaya kwenhliziyo okungajwayelekile

Eminye imiphumela emibi emibi, echazwe ngokuningiliziwe ngezansi ku- "Side effect imininingwane," ifaka:

  • ukusabela okweqile
  • i-hypoglycemia (ushukela ophansi wegazi)

Imiphumela emibi ezinganeni

Imiphumela emibi ye-Humalog ezinganeni iyefana naleyo yabantu abadala abathathe umuthi. Izibonelo zale miphumela emibi zibalwe ngenhla.

Imininingwane yomphumela oseceleni

Ungase uzibuze ukuthi kaningi kangakanani imiphumela emibi ethile eba khona ngalo muthi. Nayi imininingwane ngemiphumela emibi eminingi lo muthi ongayibangela.

Ukusabela okweqile

Njengezidakamizwa eziningi, abanye abantu bangaba ne-allergen reaction ngemuva kokuthatha i-Humalog. Kodwa akwaziwa ukuthi lokhu kwenzeka kaningi kangakanani.

Izimpawu zokuphendula okuncane komzimba zingabandakanya:

  • ukuqubuka kwesikhumba
  • ukulunywa
  • ukuqhuma (ukufudumala nokubomvu esikhunjeni sakho)

Ukusabela okweqile okwedlulele akuvamile kodwa kungenzeka. Izimpawu zokuphendula okweqile kakhulu zingabandakanya:

  • ukuvuvukala ngaphansi kwesikhumba sakho, imvamisa ezinkalweni zakho, izindebe, izandla, noma izinyawo
  • ukuvuvukala kolimi lwakho, umlomo, noma umphimbo
  • inkinga yokuphefumula

Shayela udokotela wakho ngokushesha uma une-reaction engathí sina ye-Humalog. Shayela ku-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Ukuzuza kwesisindo

Ukuzuza kwesisindo kungumphumela ohlangothini ovamile wawo wonke ama-insulins, kufaka phakathi i-Humalog.

Thayipha isifundo sikashukela esingu-1

Esifundweni somtholampilo sabantu abadala nentsha enesifo sikashukela sohlobo 1:

  • labo abasebenzisa i-Humalog bathole isilinganiso esilinganiselwa ku-3.1 lb (1.4 kg) ngaphezulu kwezinyanga eziyi-12
  • labo abasebenzisa i-insulin ehlukile esebenza okwesikhashana ebizwa nge-insulin human (Humulin R) bathole isilinganiso esingu-2.2 lb (1 kg) ngesikhathi esifanayo

Abantu bawo womabili amaqembu baphinde basebenzisa i-insulin esebenza isikhathi eside.

Thayipha isifundo sikashukela sesi-2

Esifundweni somtholampilo sabantu abadala abanesifo sikashukela sohlobo 2:

  • labo abasebenzisa i-Humalog bathole isilinganiso esingu-1.8 lb (0.8 kg) ngaphezulu kwezinyanga ezintathu
  • labo abasebenzisa i-insulin esebenza okwesikhashana i-Humulin R bathole isilinganiso esingu-2 lb (0.9 kg) ngaphezulu kwezinyanga ezintathu

Abantu bawo womabili amaqembu baphinde basebenzisa i-insulin esebenza isikhathi eside.

Isizathu sokuzuza isisindo

Ukuzuza kwesisindo kuhlobene nokuthi i-insulin isebenza kanjani emzimbeni wakho. I-insulin isiza amaseli ukukhipha ushukela omningi egazini lakho. Olunye loshukela omningi luyagcinwa ukuze lusetshenziswe esikhathini esizayo njengamafutha omzimba. Ngokuhamba kwesikhathi, lokhu kungaholela ekutholeni isisindo esithile.

I-Humalog ne-thiazolidinediones

Uma ukhathazekile ngokuzuza kwesisindo ngenkathi usebenzisa iHumalog, khuluma nodokotela wakho. Bangaphakamisa amathiphu wokukusiza ugcine isisindo esinempilo.

Kodwa-ke, uma uthatha i-Humalog nohlobo lwesidakamizwa sikashukela esibizwa nge-thiazolidinedione, bheka udokotela wakho ngokushesha uma ngokungazelelwe uthola isisindo esiningi. Lokhu kungaba uphawu lokugcina uketshezi okungaholela noma kube kubi ngokwehluleka kwenhliziyo. Izibonelo zama-thiazolidinediones zifaka phakathi i-pioglitazone (Actos) ne-rosiglitazone (Avandia).

Izimpawu zokungezwani komzimba

Abanye abantu bangaba nokungezwani komzimba neHumalog (bona ngenhla). Kepha abanye abantu abasebenzisa iHumalog bangaba nezinye izimpawu ezifana nokungezwani komzimba. Lezi zimpawu zingafana nalezo ze-hay fever futhi zibandakanya i-rhinitis (impumu egijimayo noma ejiyile).

Esifundweni somtholampilo sabantu abadala abanesifo sikashukela sohlobo 1, i-rhinitis ibikwe ku:

  • U-24.7% wabantu abasebenzisa iHumalog
  • Abantu abangu-29.1% abasebenzisa i-insulin ehlukile esebenza okwesikhashana ebizwa ngeHumulin R

Esifundweni somtholampilo sabantu abadala abanesifo sikashukela sohlobo 2, i-rhinitis ibikwe ku:

  • U-8.1% wabantu abasebenzisa iHumalog
  • 6.6% wabantu abasebenzisa iHumulin R

Uma uba nezimpawu zokungezwani komzimba neHumalog, khuluma nodokotela wakho ngokuthi ungazilawula kanjani kangcono.

I-Hypoglycemia

I-Hypoglycemia, eyishukela ephansi yegazi, ingumphumela ohlangothini ovame kakhulu kuyo yonke imithi ye-insulin, kufaka phakathi iHumalog.

Kunzima ukusho ukuthi i-hypoglycemia ivela kangaki kubantu abasebenzisa i-Humalog. Izici eziningi ezahlukahlukene zingathinta ushukela wegazi lakho. Isibonelo, kungenzeka ukuthi ube noshukela ophansi wegazi uma weqa ukudla noma uma usebenza kakhulu kunokujwayelekile.

Khuluma nodokotela wakho mayelana nokuthi kufanele uvivinye kangaki ushukela wegazi nokuthi izinga lakho kufanele libe yini. Futhi, qiniseka ukuthi uxoxa ngokuthi ungakugwema kanjani ushukela ophansi wegazi.

Izimpawu ze-hypoglycemia

Izimpawu zikashukela wegazi ophansi zingahluka kuye ngomuntu. Ungase futhi uthole ukuthi izimpawu zakho ziyashintsha ngokuhamba kwesikhathi. Kodwa-ke, izimpawu zokuqala zoshukela ophansi wegazi zingafaka:

  • isiyezi
  • ukuqhaqhazela
  • ukungaboni kahle
  • isicanucanu
  • ukuzwa ukucasuka
  • ukukhathazeka
  • indlala
  • ukushaya kwenhliziyo (ukushaya kwenhliziyo okusheshayo noma okungajwayelekile)
  • ukujuluka

Izimpawu ze-hypoglycemia enzima kakhulu zingafaka:

  • ubuthakathaka
  • unenkinga yokugxila
  • ukudideka
  • inkulumo engahambi kahle
  • ukungabi nangqondo noma ukungena ezingxabanweni
  • izinkinga zokuxhumanisa (njengokuhamba kanzima)

Uma ushukela ophansi wegazi ungalungiswa, ungasheshe ube bucayi. Ushukela wegazi ophansi kakhulu ungaholela ekuqulekeni noma ku-coma, futhi ezimweni ezingavamile, ukufa.

Uma uqala ukuba nezimpawu zikashukela wegazi ophansi ngenkathi uthatha i-Humalog, yidla noma uphuze okuthile okuqukethe ushukela umzimba wakho ongamunca ngokushesha. Izibonelo zifaka ithebhulethi kashukela, ucezu lukaswidi, noma ingilazi yejusi. Isoda yokudla noma idayethi noma uswidi ongenashukela ngeke welaphe i-hypoglycemia. Khuluma nodokotela wakho mayelana nokuthi ungaziphatha kanjani iziqephu zoshukela wegazi ophansi.

Imibuzo ejwayelekile ngeHumalog

Nazi izimpendulo zemibuzo ebuzwa njalo ngeHumalog.

Yiziphi izikhathi zokuqala neziphakeme zeHumalog?

Ngokuvamile, isikhathi sokuqala seHumalog neHumalog Mix singaphakathi kwemizuzu engu-15, futhi umphumela wazo omkhulu uvela ngemuva kwamahora angaba ngu-2. I-Humalog ne-Humalog Mix yizinhlobo ezimbili ze-Humalog.

Isikhathi sokuqala sisho ukuthi umuthi uthatha isikhathi esingakanani ukuqala ukusebenza. Isikhathi esiphakeme kulapho umuthi unomphumela wawo omkhulu. Izikhathi zokuqala nezikhathi eziphakeme zeHumalog zingahluka phakathi kwabantu. Lezi zikhathi nazo zingashintsha kumuntu ofanayo.

Izici ezingathinta ukuthi i-Humalog ithatha isikhathi esingakanani ukusebenza zifaka indawo yomzimba wakho lapho ujove khona nokuthi ngabe ubulolonga yini. I-Humalog ivame ukusebenza ngokushesha lapho ifakwa esiswini (esiswini) kunangesikhathi ifakwa kwezinye izindawo.

Uma unemibuzo mayelana nokuthi i-Humalog izokusebenzela nini, khuluma nodokotela wakho.

Ngabe i-Humalog isebenza ngokushesha noma i-insulin esebenza isikhathi eside?

Kunezinhlobo ezimbili zeHumalog, futhi zombili zingama-insulins asebenza ngokushesha. Kodwa uhlobo olulodwa futhi luhlala isikhathi eside.

Izinhlobo ezimbili ze-Humalog yi-Humalog ne-Humalog Mix:

  • I-Humalog iqukethe i-insulin lispro, eyi-insulin esebenza ngokushesha. Ibizwa nangokuthi i-insulin esebenza ngokushesha. Iqala ukusebenza kungakapheli imizuzu engu-15 futhi ihlala cishe amahora amane kuya kwayisithupha.
  • I-Humalog Mix iyi-insulin engaphambi kwesikhathi. Iqukethe i-insulin lispro esebenza ngokushesha kanye ne-insulin lispro protamine, eyi-insulin esebenza phakathi. Ngakho-ke iHumalog Mix inezici zombili izinhlobo ze-insulin. Lokhu kusho ukuthi isebenza ngokushesha (kungakapheli imizuzu eyi-15) futhi ihlala isikhathi eside (cishe amahora angama-22). Yize iHumalog Mix isebenza isikhathi eside, ayithathwa njenge-insulin esebenza isikhathi eside.

Uma unemibuzo mayelana nokuthi i-Humalog izokusebenzela ngokushesha kangakanani noma isikhathi esingakanani, khuluma nodokotela wakho.

Ihlala isikhathi esingakanani i-Humalog?

Ubude obujwayelekile besikhathi i-Humalog ihlala cishe ngamahora ama-4, kanti i-Humalog Mix ihlala cishe amahora angama-22. I-Humalog ne-Humalog Mix yizinhlobo ezimbili ze-Humalog.

Ingxube ye-Humalog ne-Humalog ihlala isikhathi esingakanani ingahluka phakathi kwabantu. Futhi izikhathi nazo zingashintsha kumuntu ofanayo. Lokhu kungancika kumthamo wakho, indawo yomzimba wakho lapho ujove khona, nokuthi ubusebenze kangakanani ngokomzimba.

Uma unemibuzo mayelana nokuthi i-Humalog ingahlala isikhathi esingakanani kuwe, khuluma nodokotela wakho.

Yini okufanele ngiyenze uma i-Humalog insulin yami ingasebenzi?

Uma ucabanga ukuthi iHumalog ayisebenzi kahle ngokwanele ukuphatha ushukela wegazi lakho, khuluma nodokotela wakho. Bangadinga ukulungisa isilinganiso sakho. Noma kungadingeka ukuthi ushintshe indawo lapho ujova khona iHumalog. Isibonelo, uma ngabe ubuzinika imijovo ezindaweni ezilimele zesikhumba, i-Humalog kungenzeka ingasebenzi futhi.

Uma i-Humalog KwikPen yakho ingasebenzi, hlola incwajana eza nepeni ukuthola imiyalelo. Noma buza udokotela noma usokhemisi wakho usizo. Uma i-knob yedosi kunzima ukuyicindezela, inaliti ingavimba. Ngakho-ke ungazama ukusebenzisa inaliti entsha. Noma kungaba nokuthile ngaphakathi kwepeni, njengothuli noma ukudla. Kulokhu, uzodinga ukuthola ipeni elisha.

Ezinye izindlela zeHumalog

Kukhona nezinye izidakamizwa ezingasetshenziswa ukwelapha isifo sikashukela. Abanye bangakulungela kangcono kuwe kunabanye. Uma unentshisekelo yokuthola enye indlela kuneHumalog, khuluma nodokotela wakho. Bangakutshela ngeminye imithi engakusebenzela kahle.

Ama-insulins wokunye wohlobo 1 nohlobo 2 sikashukela

Abantu abanesifo sikashukela sohlobo 1 badinga ukuthatha i-insulin ngoba imizimba yabo ayikwazi ukuzenzela eyayo i-insulin. Abantu abanesifo sikashukela sohlobo lwesibili baphathwa kakhulu ngezinye izidakamizwa ngaphandle kwe-insulin (bona ngezansi). Kepha uma le mithi ingasebenzi kahle ngokwanele kubo, kungadingeka nokuthi bathathe i-insulin.

Izibonelo ze-insulins, ngaphandle kweHumalog, engasetshenziswa ukusiza ukuphatha amazinga kashukela egazini kubantu abane-type 1 noma uhlobo lwesifo sikashukela esingu-2 afaka:

  • ama-insulins asebenza okwesikhashana, njenge:
    • i-insulin yomuntu, engabizwa nangokuthi i-insulin ejwayelekile (i-Novolin R, i-Humulin R)
  • ama-insulins asebenza ngokushesha, njenge:
    • i-insulin aspart (i-NovoLog, i-Fiasp)
    • I-insulin glulisine (Apidra)
    • i-insulin lispro (i-Admelog)
  • ama-insulins asebenza phakathi, njenge:
    • i-isophane insulin yomuntu (uNovolin N, uHumulin N)
  • ama-insulins asebenza isikhathi eside, njenge:
    • i-insulin degludec (iTresiba)
    • insulini detemir (Levemir)
    • insulini glargine (Lantus, Basaglar, Toujeo)
  • ama-insulins angaphambi kwesikhathi, njenge:
    • I-insulin yomuntu ne-isophane insulin human (Novolin 70/30, Humulin 70/30)

Ezinye izindlela ngaphandle kwe-insulin yohlobo 2 sikashukela

Izidakamizwa eziningana ngaphandle kwe-insulin zingasetshenziswa ukuphatha amazinga kashukela egazini kubantu abanesifo sikashukela sohlobo 2. Izibonelo zale mithi zifaka:

  • ama-biguanides, njenge:
    • i-metformin (iGlucophage)
  • i-dipeptidyl peptidase-4 (DPP-4) inhibitors, efana:
    • i-alogliptin (Nesina)
    • linagliptin (i-Tradjenta)
    • i-saxagliptin (i-Onglyza)
    • sitagliptin (Januvia)
  • i-peptide 1 efana ne-glucagon (GLP-1), njenge:
    • dulaglutide (Trulicity)
    • i-exenatide (i-Byetta, i-Bydureon)
    • i-liraglutide (i-Victoza)
    • i-lixisenatide (i-Adlyxin)
    • i-semaglutide (i-Ozempic)
  • i-sodium-glucose co-transporter 2 (SGLT2) inhibitors, efana ne:
    • i-canagliflozin (i-Invokana)
    • dapagliflozin (Farxiga)
    • empagliflozin (Jardiance)
    • i-ertugliflozin (Steglatro)
  • sulfonylureas, njenge:
    • i-glimepiride (Amaryl)
    • i-glipizide (iGlucotrol)
    • i-glyburide (i-DiaBeta, i-Glynase)
  • thiazolidinediones (TZDs), njenge:
    • pioglitazone (Actos)
    • i-rosiglitazone (Avandia)

Ungayithatha kanjani i-Humalog

Hlala uthatha i-Humalogalog ngokwemiyalo kadokotela wakho noma umhlinzeki wezokunakekelwa kwempilo.

Kunezinhlobo ezimbili ze-Humalog: I-Humalog ne-Humalog Mix. Futhi ngokuvamile anikezwa njengemijovo engaphansi kwesikhumba (imijovo engaphansi kwesikhumba).

I-Humalog nayo ingasetshenziswa kwimpompo ye-insulin, kepha i-Humalog Mix ayinakusetshenziswa ngale ndlela. (Iphampu ye-insulini iyidivayisi eletha umthamo oqhubekayo we-insulin, futhi ingakunikeza nemithamo eyengeziwe ngezikhathi zokudla.) Lapho uqala ukwelashwa, umhlinzeki wakho wezokunakekelwa kwempilo uzokuchazela ukuthi ungayiphuza kanjani imithi yakho.

Umhlinzeki wakho wezokunakekelwa kwempilo kwesinye isikhathi anganikeza iHumalog ngomjovo we-intravenous (ukujova emthanjeni).

Imiyalo yesinyathelo nesinyathelo yokuthi uyisebenzisa kanjani i-Humalog and Humalog Mix KwikPen, izitsha, namakhadibhodi izonikezwa kuphamfulethi eza nomuthi wakho. Imiyalo iyatholakala nakuwebhusayithi yomkhiqizi.

Amaphuzu abalulekile ngokuthatha i-Humalog

Ngokungeziwe ekubhekiseni kwephamfulethi newebhusayithi eshiwo ngenhla, nanka amaphuzu abalulekile ngokuthatha iHumalog:

  • Uma usebenzisa i-Humalog KwikPen noma i-Humalog cartridge esibayeni esivuselelekayo, ungabelani ngepeni lakho nomunye umuntu, noma ngabe ushintshe inaliti. Futhi uma usebenzisa izitsha ze-Humalog, ungabelani ngezinaliti noma imijovo ye-insulin nabanye abantu. Ukwabelana ngezinaliti kungakubeka engcupheni yokubamba noma ukusabalalisa izifo ezithwalwa ngegazi.
  • Uma usebenzisa izinhlobo ezingaphezu kweyodwa ze-insulin, hlola njalo ilebula ku-insulin yakho ngaphambi kokujova. Ukuthatha i-insulin engafanele ngengozi kungadala ukuthi ube noshukela ophansi wegazi.
  • Kufanele ujove i-Humalog ngaphansi kwesikhumba sethanga lakho, isisu (isisu), izinqe, noma ingalo engaphezulu. Ungayifaki emthanjeni noma emisipheni.
  • Sebenzisa indawo yokujova ehlukile njalo lapho ufaka i-Humalog. Lokhu kunciphisa ubungozi be-lipodystrophy (izinguquko esikhunjeni sakho, njengokuphosa, ukuqina, noma izigaxa).
  • Ungafaki i-Humalog esikhunjeni esithambile, esilimele, esinenkani, esiqinile, esinesibazi noma esonakele.

Ukuthatha nini

Kufanele uthathe i-Humalog kuze kube yimizuzu engu-15 ngaphambi kokudla. Kepha ungayisebenzisa futhi ngemuva nje kokuqeda ukudla.

Ngokuqinisekile uzothatha i-Humalog Mix kabili ngosuku, kuze kube yimizuzu engu-15 ngaphambi kokudla (imvamisa ngesidlo sasekuseni nangesidlo sakusihlwa).

Ungathathi i-Humalog noma i-Humalog Mix ngesikhathi sokulala noma phakathi kokudla.

Ukusiza ukuqinisekisa ukuthi awuphuthelwa umthamo, zama ukusetha isikhumbuzi efonini yakho. Isikhathi semithi singasiza, futhi.

Ukuthatha i-Humalog ngokudla

Umxube weHumalog neHumalog kufanele njalo uthathwe nokudla.

Isikhathi esihle sokuphatha i-Humalog kufika kwimizuzu engu-15 ngaphambi kokudla. Kepha ungayisebenzisa futhi ngemuva nje kokuqeda ukudla.

I-Humalog Mix kufanele ithathwe imizuzu eyi-15 ngaphambi kokudla.

Ukusetshenziswa kwe-Humalog nezinye izidakamizwa

Ngokuvamile uzosebenzisa i-Humalog ene-insulin esebenza phakathi noma esebenza isikhathi eside esiza ukuphatha ushukela wegazi lakho phakathi kokudla nasebusuku. Izibonelo zalezi insulins zifaka:

  • i-isophane insulin yomuntu (uNovolin N, uHumulin N)
  • insulini glargine (Lantus, Basaglar, Toujeo)
  • i-insulin degludec (iTresiba)
  • insulini detemir (Levemir)

Uma une-type 2 yesifo sikashukela, kungenzeka futhi usebenzise izidakamizwa ngaphandle kwe-insulin ukusiza ukuphatha ushukela wegazi lakho. Kuningi kwalokhu, futhi ezinye izibonelo zifaka:

  • ama-biguanides, njenge-metformin (iGlucophage)
  • i-dipeptidyl peptidase-4 (DPP-4) inhibitors, efana ne-sitagliptin (Januvia)
  • i-glucagon-like peptide 1 (GLP-1) agonists, efana ne-dulaglutide (Trulicity)
  • i-sodium-glucose co-transporter 2 (SGLT2) inhibitors, efana ne-canagliflozin (i-Invokana)
  • i-sulfonylureas, efana ne-glipizide (Glucotrol)
  • thiazolidinediones (TZDs), njenge pioglitazone (Actos)

Isitoreji se-Humalog, ukuphela kwesikhathi, nokulahlwa

Uma uthola i-Humalog ekhemisi, usokhemisi uzokwengeza usuku lokuphelelwa yisikhathi kwilebula ebhokisini. Lolu suku luvame unyaka owodwa kusukela ngosuku abakhipha ngalo umuthi.

Usuku lokuphelelwa isikhathi lusiza ukuqinisekisa ukuthi umuthi uyasebenza ngalesi sikhathi. Isimo samanje se-Food and Drug Administration (i-FDA) ukugwema ukusebenzisa imishanguzo ephelelwe yisikhathi. Uma usebenzise umuthi ongasetshenziswanga osudlulile esikhathini sokuphelelwa yisikhathi, khuluma nosokhemisi wakho mayelana nokuthi usengakwazi yini ukuwusebenzisa.

Isitoreji

Ukuthi umuthi uhlala ulungile isikhathi eside kangakanani kungancika ezintweni eziningi, kufaka phakathi ukuthi uwugcina kanjani futhi kuphi umuthi.

Ungayigcina kanjani i-Humalog ngaphambi kokuvula

Izimbiza ze-Humalog ne-Humalog ezingavuliwe, ama-KwikPens, namakhadibhodi kudingeka afakwe esiqandisini endaweni yokugcina okushisa okungu-36 ° F kuye ku-46 ° F (2 ° C kuye ku-8 ° C). Qiniseka ukuthi awagodoli. Uma igcinwe esiqandisini, imikhiqizo engavulwa kufanele ihlale kuze kufike usuku lokuphelelwa yisikhathi ephrintiwe emaphaketheni ayo.

Uma kudingeka, ungagcina imikhiqizo ye-Humalog engavuliwe ekamelweni lokushisa elingaphansi kwe-86 ° F (30 ° C). Uma uzigcina ngaphandle kwesiqandisi, nakhu ukuthi zizolungela isikhathi esingakanani:

  • Izimbali ze-Humalog, i-KwikPens, ne-cartridges: Izinsuku ezingama-28
  • Izimbali ze-Humalog Mix: Izinsuku ezingama-28
  • I-Humalog Mix KwikPens: Izinsuku eziyi-10

Ungayigcina kanjani i-Humalog ngemuva kokuvula

Lapho usuvule imikhiqizo ye-Humalog ukuze isetshenziswe, nansi indlela okufanele ugcine ngayo okulandelayo:

  • Amabhodlela we-Humalog ne-Humalog Mix vials: Esiqandisini (36 ° kuya ku-46 ° F / 2 ° kuye ku-8 ° C) noma ekamelweni lokushisa elingaphakeme ngaphezu kuka-86 ° F (30 ° C). Kuzo zombili lezi zimo, isitsha esivuliwe sizolungela izinsuku ezingama-28.
  • Amapeni namakhadibhodi: Ekamelweni lokushisa elingadluli ku-86 ° F (30 ° C). Zizoba zinhle izinsuku ezingama-28.
  • I-Humalog Mix KwikPens: Ekamelweni lokushisa elingadluli ku-86 ° F (30 ° C). Zizoba zinhle izinsuku eziyi-10.

Ukulahlwa

Ngemuva nje kokusebenzisa isipetu noma inaliti, yilahle esitsheni sokulahla esivunyelwe i-FDA esivunyiwe. Lokhu kusiza ukuvimbela abanye, kufaka phakathi izingane nezilwane ezifuywayo, ekuthatheni lesi sidakamizwa ngengozi noma ukuzilimaza ngenaliti. Ungathenga isitsha esibukhali online, noma ubuze udokotela wakho, usokhemisi, noma inkampani yomshuwalense wezempilo ukuthi ungayithola kuphi.

Lo mbhalo unikeza ngamathiphu amaningi awusizo ngokulahlwa kwemithi. Ungabuza futhi usokhemisi wakho imininingwane yokuthi ungayilahla kanjani imithi yakho.

Ukusetshenziswa kwe-Humalog

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvumela imishanguzo kadokotela efana neHumalogal ukwelapha izimo ezithile.

Humalog yohlobo 1 sikashukela

I-Humalog ivunyelwe yi-FDA ukusiza ukulawula amazinga kashukela egazini kubantu abanesifo sikashukela sohlobo 1. Lokhu kufaka phakathi abantu abadala kanye nezingane ezineminyaka engama-3 nangaphezulu.

Thayipha isifo sikashukela sokuqala chaza

Uhlobo lwesifo sikashukela sohlobo 1 yisimo sempilo lapho amanyikwe engenzi i-hormone ebizwa nge-insulin. I-insulin isiza umzimba wakho ukucubungula ushukela (ushukela). Ngaphandle kwe-insulin, amazinga kashukela egazini angakhuphuka kakhulu, futhi lokhu kungalimaza amaseli emzimbeni wakho.

Amazinga kashukela aphakeme egazi angaholela ezinkingeni ezingxenyeni ezahlukahlukene zomzimba wakho, ikakhulukazi amehlo akho, izinso nezinzwa. Izinkinga zingafaka ukulimala kulezo zindawo.

Uma unesifo sikashukela sohlobo 1, udinga ukuthatha i-insulin ukuphatha ushukela wegazi lakho nokukuvikela ukuthi ungakhuphuki kakhulu.

Kuchazwe uHumalog

I-Humalog umuthi we-insulin. Kunezinhlobo ezimbili ezihlukene: I-Humalog ne-Humalog Mix.

I-Humalog iqukethe i-insulin lispro, eyi-analog esebenza ngokushesha. (I-analog inguqulo eyenziwe ngumuntu ye-insulin yemvelo eyenziwa ngumzimba wakho.) Le ndlela ye-insulin isebenza ngokushesha okukhulu. Uyithatha ngezikhathi zokudla ukusiza ukuphatha ukwanda kukashukela wegazi okungenzeka ngemuva kokudla.

I-Humalog Mix iqukethe inhlanganisela ebekiwe ngaphambili ye-insulin lispro kanye ne-insulin esebenza isikhathi eside ebizwa nge-insulin lispro protamine. I-Humalog Mix isebenza ngokushesha okukhulu, kepha ihlala isikhathi eside kune-Humalog. I-Humalog Mix isiza ukulawula ukwenyuka kwesikhathi sokudla kushukela wegazi bese isiza ukuphatha ushukela wegazi phakathi kokudla noma ebusuku. Umthamo ngamunye weHumalog Mix uhloselwe ukumboza izidlo ezimbili noma isidlo esisodwa kanye nesidlwana.

Ukusebenza kohlobo lwesifo sikashukela sohlobo 1

Izifundo zomtholampilo zithole iHumalog ukuthi isebenza ngendlela efanayo kwi-insulin yomuntu (Humulin R) yokuphatha ushukela wegazi kubantu abanesifo sikashukela sohlobo 1.

I-Humulin R iyi-insulin esebenza okwesikhashana oyithatha ngezikhathi zokudla ngokusebenzisa isiponji noma ipeni elincanyelwayo. Lesi sidakamizwa singasetshenziswa nepompo ye-insulin. Iphampu ye-insulini iyidivayisi eletha umthamo oqhubekayo we-insulin, futhi inganikeza nemithamo eyengeziwe ngezikhathi zokudla.

I-Humulin R ikhophi eliqondile le-insulin elenziwa ngumzimba wakho ngokwemvelo. Lo muthi ukwelashwa okwenziwe kahle kwe-insulin okulawula ngempumelelo ushukela wegazi.

Lezi zifundo ziqhathanisa amazinga e-hemoglobin A1c (HbA1c) kubantu abathathe iHumalog noma iHumulin R. HbA1c isilinganiso samazinga kashukela egazini ezinyangeni ezimbili kuya kwezi-3 ezedlule. I-American Diabetes Association incoma umgomo we-HbA1c ongaphansi kuka-7% kubantu abaningi abadala.

Imijovo yesikhathi sokudla

Izifundo ezimbili ziqhathanise imijovo yesikhathi sokudla yeHumalog nemijovo yesikhathi sokudla kaHumulin R. Kulezi zifundo, abantu baphinde bathatha i-insulin esebenza isikhathi eside ukuphatha ushukela wegazi phakathi kokudla nasebusuku.

Kubantu abadala kanye nezingane ezineminyaka eyi-12 nangaphezulu, isilinganiso samazinga we-HbA1c:

  • kwehle ngo-0.1% ngaphezu kwezinyanga eziyi-12 kulabo abathathe iHumalog
  • inyuke ngo-0.1% ngaphezu kwezinyanga eziyi-12 kulabo abathathe i-Humulin R

Lo mehluko awuthathwa njengebalulekile ngokwezibalo.

Kubantu abaneminyaka eyi-9 kuye kwengu-19, isilinganiso samazinga we-HbA1c enyuke ngo-0.1% ngaphezulu kwezinyanga eziyi-8 kulabo abathathe iHumalog. Umphumela ofanayo ubonwe kulabo abathatha uHumulin R.

Ukusetshenziswa kwepompo ye-insulin

Ezinye izifundo zaqhathanisa i-Humalog ne-insulin yomuntu lapho isetshenziswa kwimpompo ye-insulin.

Ocwaningweni lwabantu abadala, amazinga aphakathi ne-HbA1c anciphe ngo:

  • 0.6% ngaphezu kwamasonto ayi-12 kulabo abasebenzisa iHumalog kwimpompo yabo
  • 0.3% ngaphezu kwamasonto ayi-12 kulabo abasebenzisa i-insulin yomuntu empompa yabo

Ocwaningweni lwabantu abadala nentsha eneminyaka eyi-15 nangaphezulu, amazinga we-HbA1c aphakathi nokwehla ngo-0.3% ngaphezu kwamasonto ayi-12 kulabo abasebenzisa iHumalog epompa labo. Ngokuqhathanisa, amazinga we-HbA1c ajwayelekile awashintshanga kulabo abasebenzisa i-insulin yomuntu empompa yabo.

Olunye ucwaningo lwaqhathanisa iHumalog ne-insulin aspart (NovoLog) lapho isetshenziswa kwimpompo ye-insulin ezinganeni ezineminyaka engu-4 kuya kwengu-18. Isilinganiso samazinga we-HbA1c ehle ngo-0.1% ngaphezulu kwamasonto ayi-16 kulabo abasebenzisa iHumalog kwimpompo yabo. Imiphumela efanayo yabonakala kulabo abasebenzisa i-insulin aspart empompini yabo.

Umenzi weHumalog Mix akakhiphanga ngemininingwane yokusebenza komuthi ekwelapheni uhlobo lwesifo sikashukela sohlobo 1.

Humalog yohlobo 2 sikashukela

I-Humalog nayo ivunyelwe yi-FDA ukusiza ukulawula amazinga kashukela egazini kubantu abadala abanesifo sikashukela sohlobo 2. Ngaphezu kwalokho, uhlobo lwesibili lweHumalog olubizwa ngeHumalog Mix livunyelwe ukusetshenziswa okufanayo.

Thayipha isifo sikashukela sesi-2 sichaziwe

Uhlobo lwesifo sikashukela sohlobo lwesibili yisimo lapho amaseli emzimbeni wakho emelana nemiphumela yehomoni ebizwa nge-insulin.

I-insulin isiza umzimba wakho ukucubungula ushukela (ushukela). Uma amaseli akho emelana ne-insulin, awacubunguli ushukela njengoba kufanele. Ukumelana ne-insulin kungadala ukuthi izinga likashukela egazini lakho likhuphuke kakhulu.

Ngokuhamba kwesikhathi, amanyikwe akho nawo angayeka ukwenza i-insulin eyanele. Ngalesi sikhathi, uzodinga ukwelashwa nge-insulin ukusiza ukuphatha amazinga kashukela egazini lakho.

I-Humalog ne-Humalog Mix ichaziwe

I-Humalog iqukethe i-insulin lispro, eyi-analog esebenza ngokushesha. (I-analog inguqulo eyenziwe ngumuntu ye-insulin yemvelo eyenziwa ngumzimba wakho.) Le ndlela ye-insulin isebenza ngokushesha okukhulu. Uyithatha ngezikhathi zokudla ukusiza ukuphatha ukwanda kukashukela wegazi okungenzeka ngemuva kokudla.

I-Humalog Mix iqukethe inhlanganisela ebekiwe ngaphambili ye-insulin lispro kanye ne-insulin esebenza isikhathi eside ebizwa nge-insulin lispro protamine. I-Humalog Mix isebenza ngokushesha okukhulu, kepha ihlala isikhathi eside kune-Humalog.I-Humalog Mix isiza ukulawula ukwenyuka kwesikhathi sokudla kushukela wegazi bese isiza ukuphatha ushukela wegazi phakathi kokudla noma ebusuku.

Umthamo ngamunye weHumalog Mix uhloselwe ukumboza izidlo ezimbili noma isidlo esisodwa kanye nesidlwana.

Ukusebenza kohlobo lwesibili sikashukela

Ucwaningo lomtholampilo luthole iHumalog isebenza ngokufanayo kwi-insulin yomuntu (i-Humulin R) yokuphatha ushukela wegazi kubantu abanesifo sikashukela sohlobo 2.

I-Humulin R iyi-insulin esebenza okwesikhashana oyithatha ngezikhathi zokudla. Yikhophi le-insulin elenziwa ngumzimba wakho ngokwemvelo. I-Humulin R yindlela yokwelashwa kwe-insulin esungulwe kahle elawula ushukela wegazi ngempumelelo.

Kulolu cwaningo, abantu baphinde bathatha i-insulin esebenza isikhathi eside ukuphatha ushukela wegazi phakathi kokudla nasebusuku.

Lolu cwaningo lilinganise umphumela we-Humalog no-Humulin R kumazinga we-HbA1c. I-HbA1c isilinganiso samazinga kashukela egazini ezinyangeni ezimbili kuya kwezi-3 ezedlule. I-American Diabetes Association incoma umgomo we-HbA1c ongaphansi kuka-7% kubantu abaningi abadala.

Kulolu cwaningo, amazinga we-HbA1c aphakathi nokwehla ngo-0.7% kubantu abadala abathathe iHumalog. Umphumela ofanayo ubonwe kubantu abadala abathathe uHumulin R.

Umenzi weHumalog Mix akakahlinzeki ngemininingwane ngokusebenza komuthi ekwelapheni uhlobo lwesifo sikashukela sohlobo 2.

I-Humalog nezingane

I-Humalog ivunyelwe yi-FDA ukusiza ukulawula amazinga kashukela egazini ezinganeni ezineminyaka engama-3 nangaphezulu ezinesifo sikashukela sohlobo 1. Akwaziwa ukuthi umuthi uphephile noma uyasebenza yini ezinganeni ezingaphansi kweminyaka engu-3. Bona isigaba esithi "Humalog sohlobo 1 sikashukela" ukuthola eminye imininingwane ngokusebenzisa i-Humalog ezinganeni ezinesifo sikashukela sohlobo 1.

Uhlobo lwesibili lwe-Humalog olubizwa nge-Humalog Mix aluvunyelwe ukusetshenziswa ezinganeni ezinesifo sikashukela sohlobo 1. Akwaziwa ukuthi kuphephile noma kuyasebenza yini ezinganeni ezingaphansi kweminyaka yobudala eyi-18.

I-Humalog ne-Humalog Mix ayifundwanga ezinganeni ezinesifo sikashukela sohlobo 2.

Isebenza kanjani iHumalog

I-Humalog isetshenziselwa ukusiza ukuphatha amazinga kashukela egazini kubantu abanesifo sikashukela sohlobo 1 noma uhlobo lwesibili.

Kwenzekani ngesifo sikashukela

Ngohlobo lwesifo sikashukela sohlobo 1, amanyikwe akho awenzi i-hormone ebizwa nge-insulin. I-insulin isiza umzimba wakho ukucubungula ushukela (ushukela).

Ngaphandle kwe-insulin, amazinga kashukela egazini angakhuphuka kakhulu, futhi lokhu kungalimaza amaseli emzimbeni wakho. Amazinga kashukela aphakeme egazi angaholela ezinkingeni ezingxenyeni ezahlukahlukene zomzimba wakho, ikakhulukazi amehlo akho, izinso nezinzwa. Izinkinga zingafaka ukulimala kulezo zindawo.

Uma unesifo sikashukela sohlobo 1, udinga ukuthatha i-insulin ukuphatha ushukela wegazi lakho nokukuvikela ukuthi ungakhuphuki kakhulu.

Ngohlobo lwesifo sikashukela sohlobo 2, amaseli emzimbeni wakho ayamelana nemiphumela ye-insulin. Lokhu kusho ukuthi amangqamuzana awacubunguli ushukela njengoba kufanele. Ukumelana ne-insulin kungadala ukuthi izinga likashukela egazini lakho likhuphuke kakhulu.

Ngokuhamba kwesikhathi, amanyikwe akho nawo angayeka ukwenza i-insulin eyanele. Ngalesi sikhathi, uzodinga ukwelashwa nge-insulin ukusiza ukuphatha amazinga kashukela egazini lakho.

Okwenziwa yiHumalog

I-Humalog umuthi we-insulin osiza ukulawula ushukela wegazi lakho. Isebenza ngendlela efanayo ne-insulin eyenziwa ngumzimba wakho ngokwemvelo.

I-insulin ilawula amazinga kashukela egazini lakho ngoku:

  • ukusiza amaseli emzimbeni wakho ukumunca ushukela egazini lakho ukuze bakwazi ukusebenzisa ushukela amandla
  • ukusiza imisipha yakho ukusebenzisa ushukela ukuthola amandla
  • ukuvimba isibindi sakho ekwenzeni nasekukhipheni ushukela omningi egazini lakho
  • ukusiza umzimba wakho ukwenza amaprotheni nokugcina ushukela njengamafutha

I-Humalog nayo isebenza ngalezi zindlela ukusiza ukuvimbela izinga likashukela egazini lakho ukuthi likhuphuke kakhulu.

Kuthatha isikhathi esingakanani ukusebenza?

I-Humalog nohlobo lwesibili lwe-Humalog olubizwa nge-Humalog Mix uqobo luqala ukulawula ushukela wegazi kungakapheli imizuzu eyi-15 selifakiwe.

Ukudlula ngokweqile kwe-Humalog

Sebenzisa okungaphezu kwesilinganiso esinconyiwe seHumalog kungaholela emiphumeleni emibi kakhulu.

Ungasebenzisi i-Humalog eningi kunokuba udokotela wakho ancoma.

Izimpawu zokudlula ngokweqile

Izimpawu zokudlula ngokweqile kweHumalog zingafaka:

  • i-hypoglycemia (izinga eliphansi likashukela egazini), elingadala:
    • ukukhathazeka
    • ukuqhaqhazela
    • isiyezi
    • ukudideka
    • inkulumo engahambi kahle
    • isithuthwane
    • ikhoma
  • i-hypokalemia (izinga eliphansi le-potassium egazini lakho), futhi lokhu kungaholela ku:
    • ubuthakathaka
    • ukuqunjelwa
    • ukuqunjelwa kwemisipha
    • ukushaya kwenhliziyo (ukushaya kwenhliziyo okusheshayo noma okungajwayelekile)

Okufanele ukwenze uma kwenzeka ukweqisa ngokweqile

Uma ucabanga ukuthi uthathe kakhulu lo muthi, shayela udokotela wakho. Ungashayela futhi i-American Association of Poison Control Centers ku-800-222-1222 noma usebenzise ithuluzi labo eliku-inthanethi. Kepha uma izimpawu zakho zinzima, shayela ku-911 noma uye egumbini lezimo eziphuthumayo eliseduze ngokushesha.

Ukusebenzisana kwe-Humalog

I-Humalog ingaxhumana neminye imithi eminingana. Ukuxhumana okuhlukile kungadala imiphumela ehlukile. Isibonelo, ukuxhumana okuthile kungaphazamisa ukusebenza kwesidakamizwa. Okunye ukuxhumana kungakhuphula inani lemiphumela emibi noma kubenze babe nzima kakhulu.

I-Humalog neminye imithi

Ngezansi kunohlu lwemithi engasebenzisana neHumalog. Lolu hlu aluqukethe yonke imishanguzo engasebenzisana ne-Humalog.

Ngaphambi kokuthatha i-Humalog, khuluma nodokotela wakho nosokhemisi. Batshele ngayo yonke imishanguzo oyinikezwa ngudokotela, i-counter-counter, nezinye izidakamizwa oziphuzayo. Batshele futhi nganoma yimaphi amavithamini, amakhambi, nezithako ozisebenzisayo. Ukwabelana ngalolu lwazi kungakusiza ugweme ukuhlangana okungenzeka.

Uma unemibuzo mayelana nokuhlangana kwezidakamizwa okungakuthinta, buza udokotela wakho noma usokhemisi.

Izidakamizwa ze-Humalog nesifo sikashukela ezibizwa ngokuthi i-thiazolidinediones

Ukusetshenziswa kweHumalog nohlobo lwesidakamizwa sikashukela esibizwa nge-thiazolidinedione kungadala noma kubhebhethekise ukwehluleka kwenhliziyo.

Izibonelo zemithi ye-thiazolidinedione zifaka phakathi i-rosiglitazone (Avandia) ne-pioglitazone (Actos).

Uma uthatha i-Humalog nge-thiazolidinedione, tshela udokotela wakho ngokushesha uma uba nezimpawu ezintsha noma eziya ziba zimbi zokuhluleka kwenhliziyo. Lokhu kungafaka:

  • ukuphelelwa umoya
  • ukukhathala
  • ukuvuvukala kwemilenze, amaqakala, noma izinyawo
  • ukuzuza kwesisindo ngokungazelelwe

I-Humalog nezinye izidakamizwa zesifo sikashukela

Izidakamizwa zesifo sikashukela zifaka zonke izinhlobo ze-insulin, kanye nezidakamizwa zomlomo nezomjovo zohlobo lwesibili sikashukela. Yonke imithi yesifo sikashukela isebenza ngokwehlisa ushukela wegazi. Ngakho-ke ukuthatha iHumalog nanoma iziphi ezinye izidakamizwa zesifo sikashukela kungakhuphula ubungozi bakho be-hypoglycemia (ushukela ophansi wegazi).

Izibonelo zezinye izidakamizwa zesifo sikashukela zifaka:

  • ama-biguanides, njenge-metformin (iGlucophage)
  • i-dipeptidyl peptidase-4 (DPP-4) inhibitors, efana ne-sitagliptin (Januvia)
  • i-glucagon-like peptide 1 (GLP-1) agonists, efana ne-dulaglutide (Trulicity)
  • i-sodium-glucose co-transporter 2 (SGLT2) inhibitors, efana ne-canagliflozin (i-Invokana)
  • i-sulfonylureas, efana ne-glipizide (Glucotrol)
  • thiazolidinediones (TZDs), njenge pioglitazone (Actos)

Uma uthatha i-Humalog nganoma yisiphi esinye isidakamizwa sikashukela, udokotela wakho angalungisa isilinganiso sakho somuthi owodwa noma yomibili. Lokhu kuzosiza ukunciphisa ubungozi boshukela ophansi wegazi. Udokotela wakho futhi angakucela ukuthi ubheke amazinga kashukela egazini lakho kaningi kunokujwayelekile.

I-Humalog nezinye izidakamizwa eziphakamisa ubungozi boshukela ophansi wegazi

Ukuthatha i-Humalog nezinye izidakamizwa kungakhuphula ingozi ye-hypoglycemia. Uma usebenzisa i-Humalog ngomunye wale mithi, kungadingeka ukuthi uhlole amazinga kashukela egazini lakho kaningi kunokujwayelekile. Udokotela wakho futhi angadinga ukwehlisa umthamo wakho weHumalog.

Izibonelo zemithi engakhuphula ubungozi boshukela ophansi wegazi ngeHumalog ifaka:

  • i-angiotensin eguqula i-enzyme (ACE) inhibitors, efana:
    • i-benazepril (Lotensin)
    • i-enalapril (Vasotec)
    • perindopril
    • i-quinapril (i-Accupril)
    • i-ramipril (Altace)
  • ama-angiotensin II receptor blockers (ama-ARB), anjenge:
    • i-candesartan (Atacand)
    • I-irbesartan (Avapro)
    • i-olmesartan (i-Benicar)
    • i-valsartan (Diovan)
  • izidakamizwa ezithile zokucindezeleka, njenge:
    • i-fluoxetine (Prozac, Sarafem)
    • isocarboxazid (Marplan)
    • i-phenelzine (Nardil)
    • i-tranylcypromine (iParnate)
  • izidakamizwa ezithile zokwehlisa i-cholesterol, njenge:
    • fenofibrate (Antara)
    • gemfibrozil (Lopid)
  • eminye imithi, njenge:
    • i-disopyramide (i-Norpace)
    • pentoxifylline
    • i-sulfamethoxazole / trimethoprim (iBactrim, Septra)
    • i-octreotide (iSandostatin)

I-Humalog nezidakamizwa ezandisa amazinga kashukela egazini lakho

Imithi ethile ingakhuphula amazinga kashukela egazini lakho. Uma uthatha i-Humalog ngomunye wale mithi, kungadingeka ukuthi uhlole amazinga kashukela egazini lakho kaningi kunokujwayelekile. Udokotela wakho futhi angadinga ukukhulisa isilinganiso sakho seHumalog.

Izibonelo zemithi engakhuphula amazinga kashukela egazini afaka:

  • imishanguzo ethile elwa nokulwa nezengqondo, njenge:
    • i-chlorpromazine
    • i-clozapine (Clozaril, Fazaclo)
    • i-olanzapine (Zyprexa)
  • ama-corticosteroids, anjenge:
    • i-budesonide (i-Entocort EC, i-Pulmicort, i-Uceris)
    • i-prednisone (iRayos)
    • i-prednisolone (i-Orapred, Prelone)
    • i-methylprednisolone (Medrol)
    • i-hydrocortisone (iCortef, abanye abaningi)
  • isisu, njenge:
    • lindoku
    • i-hydrochlorothiazide (i-Microzide)
    • metolazone
    • indapamide
  • ama-protease inhibitors e-HIV, njenge:
    • i-atazanavir (Reyataz)
    • i-darunavir (Prezista)
    • i-fosamprenavir (Lexiva)
    • i-ritonavir (Norvir)
    • i-tipranavir (Aptivus)
  • izinto zokuvimbela inzalo ngomlomo (amaphilisi okulawula ukubeletha)
  • eminye imithi, njenge:
    • i-albuterol (i-ProAir, i-Proventil, i-Ventolin HFA)
    • danazol
    • i-isoniazid
    • i-levothyroxine (Levoxyl, Synthroid, Tirosint, Unithroid)
    • i-niacin (i-Niaspan, iSlo-Niacin, abanye)
    • somatropin (Genotropin, Norditropin, Saizen, abanye)

Humalog kanye nemithi ethile yengcindezi yegazi

Ukusetshenziswa kweHumalog enemithi ethile yengcindezi yegazi kungenza izimpawu ze-hypoglycemia (ushukela wegazi ophansi) zingabonakali kakhulu. Lokhu kungakwenza ungazi lapho ushukela wegazi lakho wehle kakhulu, futhi ngenxa yalokho, ungahle ungalapheki.

I-hypoglycemia engalashwa ingaholela ezinkingeni ezinkulu. Ukuze ufunde kabanzi ngalokhu, bona i- "Hypoglycemia" esigabeni "semininingwane eseceleni" ngenhla.

Izibonelo zemithi yomfutho wegazi engenza izimpawu ze-hypoglycemia zingabonakali kangako zifaka:

  • i-metoprolol (iLopressor, iTrolrol XL)
  • i-propranolol (Inderal, Innopran XL)
  • i-clonidine (Catapres, Kapvay)
  • i-atenolol (Tenormin)
  • i-nadolol (Corgard)
  • qalela kabusha

Uma uthatha i-Humalog ngomunye wale mithi yomfutho wegazi, khuluma nodokotela wakho. Bangancoma ukuthi uhlole amazinga kashukela egazini lakho kaningi kunokujwayelekile.

I-Humalog namakhambi nezithako

Awekho amakhambi noma izengezo ezibikwe ngokukhethekile ukuthi zisebenzisana ne-Humalog. Kodwa-ke, kusamele uhlole udokotela wakho noma usokhemisi ngaphambi kokusebenzisa noma iyiphi yale mikhiqizo ngenkathi uthatha iHumalog.

I-Humalog nokudla

Akukho okunye ukudla okubikwe ngokukhethekile ukuthi kusebenzisana ne-Humalog. Uma unemibuzo mayelana nokudla ukudla okuthile ngeHumalog, khuluma nodokotela wakho.

Humalog notshwala

I-Humalog notshwala kungakwehlisa ushukela wegazi lakho. Ngakho-ke kungenzeka ukuthi uthuthukise i-hypoglycemia (ushukela ophansi wegazi) uma uphuza utshwala ngenkathi usebenzisa i-Humalog.

Uma uphuza utshwala, khuluma nodokotela wakho ngokuthi kungakanani okuphephile ukuthi ungakuphuza ngesikhathi sokwelashwa kwakho kwe-Humalog. Ungahle udinge ukuqapha amazinga kashukela egazi eduze kakhulu.

Izindleko ze-Humalog

Njengayo yonke imithi, izindleko zeHumalog zingahluka. Ukuthola izintengo zamanje ze-Humalog vials (noma amanye amafomu), hlola i-GoodRx.com.

Izindleko ozithola ku-GoodRx.com yilokho ongakukhokha ngaphandle komshwalense. Intengo yangempela ozoyikhokha incike ohlelweni lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

Ngaphambi kokuvuma ukufakwa kweHumalog, inkampani yakho yomshuwalense ingakudinga ukuthi uthole ukugunyazwa kwangaphambili. Lokhu kusho ukuthi udokotela wakho nenkampani yomshuwalense bazodinga ukuxhumana ngomuthi wakho ngaphambi kokuba inkampani yomshuwalense izokwemboza umuthi. Inkampani yomshuwalense izobuyekeza isicelo sangaphambilini sokugunyazwa bese inquma ukuthi umuthi uzokhokhelwa yini.

Uma ungenaso isiqiniseko sokuthi uzodinga ukuthola ukugunyazwa kwangaphambili kwe-Humalog, xhumana nenkampani yakho yomshuwalense.

Usizo lwezezimali nolomshuwalense

Uma udinga ukwesekwa kwezezimali ukukhokhela i-Humalog, noma uma udinga usizo lokuqonda ukumbozwa kwakho komshuwalense, usizo luyatholakala.

U-Eli Lilly neNkampani, umenzi weHumalog, banikela ngeLilly Diabetes Solution Center ukukusiza ekutholeni izindlela zokwelashwa ongazikhokhela. Ukuthola eminye imininingwane nokuthola ukuthi uyakufanelekela yini ukwesekwa, shayela ku-833-808-1234 noma vakashela iwebhusayithi.

Uhlobo olujwayelekile

I-Humalog itholakala ngendlela ejwayelekile ebizwa nge-insulin lispro. Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuphinde kwamukela uhlobo olujwayelekile lweHumalog Mix 75/25, oluzotholakala emakethe ngokuzayo. Isidakamizwa esijwayelekile saziwa njenge-insulin lispro protamine / insulin lispro.

Umuthi ojwayelekile ikhophi eliqondile lomuthi osebenzayo emithini enegama lomkhiqizo. Okujwayelekile kuthathwa njengokuphephile nokusebenza ngempumelelo njengomuthi wokuqala. Futhi ama-generic athambekele ekubizeni ngaphansi kwezidakamizwa ezinegama lomkhiqizo. Ukuthola ukuthi izindleko zeHumalog ziqhathaniswa kanjani nezindleko ze-insulin lispro, vakashela i-GoodRx.com.

Uma udokotela wakho enikeze uHumalog futhi unentshisekelo yokusebenzisa i-insulin lispro esikhundleni salokho, khuluma nodokotela wakho. Bangaba nokuthanda kwenguqulo eyodwa noma enye. Kuzodingeka futhi uhlole uhlelo lwakho lomshuwalense, ngoba lungahlanganisa eyodwa noma enye kuphela.

Humalog nokukhulelwa

Akwaziwa ngokuqinisekile ukuthi ngabe i-Humalog iphephile ukusetshenziswa ngenkathi ukhulelwe. Imininingwane evela kwezinye izifundo iphakamisa ukuthi i-Humalog ayinabungozi lapho isetshenziswa ngesikhathi sokukhulelwa. Kodwa-ke, iHumalog ayikaze ifundwe ngqo kwabesifazane abakhulelwe.

Izifundo ezilwaneni azitholanga imiphumela eyingozi yeHumalog ekukhulelweni. Kepha izifundo zezilwane azikhombisi njalo ukuthi kuzokwenzekani kubantu.

Kuyaziwa ukuthi uma isifo sikashukela singalawulwa kahle ngesikhathi sokukhulelwa, kungaholela ezinkingeni ezinkulu kumama nakumbungu. Lezi zinkinga zibandakanya i-preeclampsia (umfutho wegazi ophakeme namaprotheni emchameni) kunina, ukuphuphunyelwa yisisu, nezinkinga zokuzalwa.

I-American Diabetes Association incoma i-insulin njengokwelashwa okukhethwayo kokuphatha ushukela wegazi kwabesifazane abakhulelwe abanesifo sikashukela sohlobo 1 noma sohlobo 2.

Uma ukhulelwe noma uhlela ukukhulelwa ngenkathi usebenzisa i-Humalog, khuluma nodokotela wakho ngezingozi nezinzuzo zomuthi. Ukukhulelwa kungashintsha izidingo zakho ze-insulin, ngakho-ke uma uzosebenzisa i-Humalog, umthamo wakho kungenzeka ushintshe phakathi nesikhathi sokukhulelwa kwakho.

I-Humalog nokulawulwa kokuzalwa

Uma uhlanganyela ocansini futhi wena noma umlingani wakho ningakhulelwa, khuluma nodokotela wakho ngezidingo zakho zokulawula ukubeletha ngenkathi usebenzisa i-Humalog.

Ukuthola eminye imininingwane ngokuthatha i-Humalog ngesikhathi sokukhulelwa, bheka isigaba se- "Humalog nokukhulelwa" ngenhla.

I-Humalog nokuncelisa

I-Humalog ngokuvamile ibhekwa njengephephile ukuyisebenzisa ngenkathi uncelisa.

Akwaziwa ukuthi iHumalog idlulela yini ebisini lwebele. Kodwa-ke, umzimba awuyimunci i-insulin (kufaka neHumalog) uma uyithatha ngomlomo. Lokhu kusho ukuthi noma ngabe i-insulin idlula obisini lwakho lwebele, ingane yakho ayikwazi ukuluncela ekunceliseni ibele. I-insulin ivame ukubhekwa njengephephile ukuyisebenzisa ngesikhathi sokuncelisa ibele.

Izidingo zakho ze-insulin kungenzeka zihluke ngenkathi uncelisa. Lokhu kungenxa yokuthi umzimba wakho uhlangabezana nezinguquko eziningi ezingathinta ushukela wegazi lakho. Futhi uzoba namaphethini ahlukene okudla nokulala alethwe ngokuba nomntwana omusha. Khuluma nodokotela wakho mayelana nokuthi umthamo wakho weHumalog ungadinga ukuguquka kanjani.

Izinyathelo zokuqapha ze-Humalog

Ngaphambi kokuthatha i-Humalog, khuluma nodokotela wakho ngomlando wakho wezempilo. I-Humalog kungenzeka ingakulungeli uma unezimo ezithile zezokwelapha noma ezinye izinto ezithinta impilo yakho. Lokhu kufaka phakathi:

  • I-Hypoglycemia. Ungathathi i-Humalog uma unesiqephu se-hypoglycemia (ushukela wegazi ophansi) .Usebenzisa i-Humalog ngenkathi ushukela wegazi usuvele uphansi kungaholela ku-hypoglycemia esongela impilo. (Bona i- "Hypoglycemia" esigabeni esithi "Side effect imininingwane" ngenhla ukuze ufunde kabanzi.)
  • Ukusabela okweqile. Uma ngabe uke waba nokungezwani komzimba ne-Humalog noma ezinye izithako zayo, akufanele uthathe i-Humalog. Buza udokotela wakho ukuthi yimiphi eminye imithi ongakhetha kangcono kuwe.
  • I-Hypokalemia. I-Humalog ingadala futhi ibe yimbi i-hypokalemia (izinga eliphansi le-potassium egazini lakho). Lokhu kungakhuphula ingozi yakho yemiphumela emibi kakhulu. (Bheka uhlu oluthi "Imiphumela emibi kakhulu" ngenhla ukuze ufunde kabanzi.) Uma usuvele une-potassium ephansi, noma usengozini yale nkinga, udokotela wakho angaqapha izinga lakho le-potassium ngenkathi uthatha i-Humalog.
  • Izinkinga zezinso noma zesibindi. Uma unezinkinga zezinso noma zesibindi, kungenzeka ukuthi ube namazinga kashukela aphansi ngeHumalog. Kulezi zinkinga kubalwa ukwehluleka kwezinso nesibindi. Khuluma nodokotela wakho ngezinyathelo ongazithatha ukusiza ukuvimbela ushukela wegazi ophansi.
  • Ukwehluleka kwenhliziyo. Uma uthatha i-Humalog nemithi yesifo sikashukela ebizwa ngokuthi i-thiazolidinediones, efana ne-pioglitazone (Actos) noma i-rosiglitazone (i-Avandia), lokhu kungakhubaza ukwehluleka kwenhliziyo. Uma unesifo senhliziyo futhi izimpawu zakho ziba zimbi kakhulu, khuluma nodokotela wakho. Izimpawu zokuwohloka kwenhliziyo zihlanganisa ukuphefumula okuncane, ukuvuvukala kwamaqakala noma izinyawo zakho, nokuzuza kwesisindo okungazelelwe. Ungadinga ukuyeka ukuthatha i-thiazolidinediones nge-Humalog.
  • Ukukhulelwa. Akwaziwa ngokuqinisekile ukuthi ngabe i-Humalog iphephile ukuthatha ngesikhathi sokukhulelwa. Ukuthola eminye imininingwane, bheka isigaba esithi "Humalog and pregnancy" ngenhla.
  • Ukuncelisa ibele. I-Humalog ngokuvamile ibhekwa njengephephile ukuyisebenzisa ngenkathi uncelisa. Noma kunjalo, ungadinga izinguquko kumthamo wakho. Ukuthola eminye imininingwane, bheka isigaba esithi "Humalog kanye nokuncelisa ibele" ngaphezulu.

Qaphela: Ngeminye imininingwane ngemiphumela emibi engaba khona yeHumalog, bheka isigaba esingenhla esithi "Humalog side effects".

Imininingwane yobungcweti yeHumalog

Imininingwane elandelayo inikezwa odokotela nabanye ochwepheshe bezempilo.

Izinkomba

I-Humalog ne-Humalog Mix ivunyelwe yi-Food and Drug Administration (FDA) ukusiza ukuphatha ushukela wegazi kuhlobo 1 nohlobo 2 sikashukela.

I-Humalog ayifundwanga ezinganeni ezingaphansi kweminyaka yobudala emi-3 ngohlobo lwesifo sikashukela sohlobo 1 noma ezinganeni ezingaphansi kweminyaka yobudala eyi-18 ezinesifo sikashukela sohlobo 2.

IHumalog Mix ayikaze ifundwe ezinganeni ezingaphansi kweminyaka yobudala eyi-18.

Ukuphatha

I-Humalog ilawulwa ngumjovo ongaphansi. I-Humalog U-100 nayo ilungele ukusetshenziswa kumaphampu e-insulin. I-Humalog U-100 nayo ingahlinzekwa ngemithambo yegazi uchwepheshe wezokunakekelwa kwezempilo lapho kutholakala khona ukuqapha okusondele kwamazinga eglucose ne potassium.

I-Humalog Mix ilawulwa ngumjovo ongaphansi kuphela. Ayifanele ukusetshenziswa kumaphampu e-insulin.

Indlela yokusebenza

I-Humalog iqukethe i-insulin lispro, i-analog esebenza ngokushesha ye-insulin. I-Humalog Mix iyi-insulin engaphambi kwesikhathi equkethe i-insulin lispro ene-insulin lispro protamine, i-insulin esebenza phakathi. I-Humalog Mix inezici zombili.

I-Humalog inyusa ukutholwa kwe-glucose ezicutshini zemisipha namafutha futhi inciphisa i-hepatic gluconeogenesis.Iphinde ivimbele ukuwohloka kwamaprotheni namafutha, futhi yenyuse amaprotheni synthesis. Ngaphezu kwalokho, i-Humalog yehlisa ushukela wegazi futhi ithuthukise ukulawulwa kwe-glycemic kusifo sikashukela.

I-Pharmacokinetics ne-metabolism

I-Humalog inokuqala kwesenzo kungakapheli imizuzu eyi-15 yomjovo ongaphansi. Izinga le-serum eliphakeme lifinyelelwa kumizuzu engama-30 kuya kwengu-90. Umphumela omkhulu ubonakala ngemuva kwamahora angaba ngu-2, nobude besenzo cishe amahora angama-4 kuye kwayi-6.

I-Humalog Mix inesenzo sokuqala kungakapheli imizuzu eyi-15 yomjovo ongaphansi. Izinga le-serum eliphakeme lifinyelelwa kumizuzu engama-60. Umphumela omkhulu ubonakala ngemuva kwamahora angaba ngu-2, nobude besenzo cishe amahora angama-22.

I-insulini lispro ihlanganiswa ngendlela efanayo ne-insulin ejwayelekile yomuntu.

Ngemuva komjovo ongaphansi komhlaba, isigamu sempilo seHumalog yihora elilodwa. Ngemuva komjovo we-intravenous we-0.1 unit / kg umthamo, i-Humalog ine-half-life average yemizuzu engama-51. Ngemuva komjovo we-intravenous we-0.2 unit / kg dose, ine-half-life average yemizuzu engama-55.

Akunakwenzeka ukunikela ngengxenye yempilo yangempela yeHumalog Mix, ngenxa yokwehluka kwamazinga wokumunca ingxube ye-insulin.

Izimo

I-Humalog akufanele inikezwe phakathi kweziqephu ze-hypoglycemia.

I-Humalog iyaphikiswa kubantu abane-hypersensitivity to insulin lispro noma ezinye izithako eziqukethwe ngumuthi.

Isitoreji

Okulandelayo kuyimiyalo yokugcina imikhiqizo ye-Humalog engavulwa futhi evuliwe.

Ngaphambi kokuvula

Gcina izigaxa zeHumalog neHumalog Mix ezingavulwa, amaKwikPens, namakhadibhodi esiqandisini (36 ° F kuye ku-46 ° F / 2 ° C kuye ku-8 ° C). Qinisekisa ukuthi awaqandi. Uma kugcinwa esiqandisini, zizohlala kuze kufike usuku lokuphelelwa yisikhathi eziphrintiwe emaphaketheni.

Imikhiqizo engavuliwe ye-Humalog nayo ingagcinwa ngaphandle kwesiqandisini ekamelweni lokushisa elingaphansi kwe-86 ° F (30 ° C) kubude besikhathi obulandelayo:

  • Izimbali ze-Humalog, i-KwikPens, ne-cartridges: Izinsuku ezingama-28
  • Izimbali ze-Humalog Mix: Izinsuku ezingama-28
  • I-Humalog Mix KwikPens: Izinsuku eziyi-10

Ngemuva kokuvula

Lapho nje imikhiqizo ye-Humalog ivuliwe ukuthi isetshenziswe, kufanele igcinwe kanjena:

  • Amabhodlela we-Humalog ne-Humalog Mix vials: Esiqandisini noma ekamelweni lokushisa elingadluli u-86 ° F (30 ° C) izinsuku ezingama-28.
  • Amapeni namakhadibhodi: Ekamelweni lokushisa elingadluli ku-86 ° F (30 ° C) izinsuku ezingama-28.
  • I-Humalog Mix KwikPens: Ekamelweni lokushisa elingadluli ku-86 ° F (30 ° C) izinsuku ezingama-10.

Ukuzikhulula: IMedical News Namuhla yenze yonke imizamo yokuqinisekisa ukuthi yonke imininingwane iyiqiniso, iphelele futhi ihambisana nesikhathi. Kodwa-ke, le ndatshana akufanele isetshenziswe njengokungena esikhundleni solwazi nobungoti bochwepheshe bezokunakekelwa kwezempilo onelayisense. Kufanele uhlale uthintana nodokotela wakho noma omunye uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuthatha noma imuphi umuthi. Imininingwane yezidakamizwa equkethwe lapha ingashintsha futhi ayihloselwe ukumboza konke ukusetshenziswa okungaba khona, izinkomba, izixwayiso, izexwayiso, ukuxhumana kwezidakamizwa, ukungezwani komzimba, noma imiphumela emibi. Ukungabikho kwezixwayiso noma olunye ulwazi lomuthi othile awukhombisi ukuthi inhlanganisela yezidakamizwa noma yezidakamizwa iphephile, iyasebenza, noma ilungele zonke iziguli noma konke ukusetshenziswa okuthile.

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