I-Tecfidera (dimethyl fumarate)

-Delile

• Yini iTecfidera?
• Igama elijwayelekile le-Tecfidera
• Imiphumela emibi ye-Tecfidera
• Imiphumela emibi ejwayelekile
• Imiphumela emibi kakhulu
• PML
• Ukuqhuma
• I-Lymphopenia
• Imiphumela yesibindi
• Ukusabela okweqile komzimba
• I-Rash
• Ukulahleka kwezinwele
• Ukuzuza kwesisindo / Ukwehlisa isisindo
• Ukukhathala
• Ubuhlungu besisu
• Uhudo
• Umphumela kwisidoda noma ukuzala kowesilisa
• Ubuhlungu bekhanda
• Ukulunywa
• Ukucindezeleka
• Amaswazi
• Umdlavuza
• Isicanucanu
• Ukuqunjelwa
• Ukuqhakaza
• Ukuqwasha
• Ukulimaza
• Ubuhlungu obuhlangene
• Umlomo owomile
• Imiphumela emehlweni
• Izimpawu ezinjengomkhuhlane
• Imiphumela emibi yesikhathi eside
• I-Tecfidera isebenzisa
• I-Tecfidera ye-MS
• I-Tecfidera ye-psoriasis
• Ezinye izindlela zeTecfidera
• I-Tecfidera vs. ezinye izidakamizwa
• I-Tecfidera vs. Aubagio
• I-Tecfidera vs. Copaxone
• I-Tecfidera vs. Ocrevus
• I-Tecfidera vs. Tysabri
• Tecfidera vs. Gilenya
• I-Tecfidera vs. interferon (Avonex, Rebif)
• I-Tecfidera vs. Protandim
• Umthamo weTecfidera
• Isikali se-multiple sclerosis
• Kuthiwani uma ngiphuthelwa umthamo?
• Ngabe kuzodingeka ngisebenzise lesi sidakamizwa isikhathi eside?
• Ungayithatha kanjani iTecfidera
• Isikhathi
• Ukuthatha iTecfidera ngokudla
• Ngabe iTecfidera ingachotshozwa?
• Ukukhulelwa kanye neTecfidera
• Ukuncelisa ibele neTecfidera
• Isebenza kanjani iTecfidera
• Kuthatha isikhathi esingakanani ukusebenza?
• I-Tecfidera notshwala
• Ukusebenzisana kweTecfidera
• I-Tecfidera ne-ocrelizumab (Ocrevus)
• I-Tecfidera ne-ibuprofen
• I-Tecfidera ne-aspirin
• Imibuzo ejwayelekile ngeTecfidera
• Kungani iTecfidera ibangela ukuqhuma?
• Ungakuvimbela kanjani ukuqhuma kusuka eTecfidera?
• Ingabe iTecfidera ikwenza ukhathele?
• Ingabe iTecfidera i-immunosuppressant?
• Ngabe ngidinga ukukhathazeka ngokuvezwa yilanga ngenkathi ngithatha iTecfidera?
• Iphumelela kangakanani iTecfidera?
• Kungani nginezinkomba zokuqondisa ezahlukene ngemuva kwesonto lokuqala?
• Ngabe ngidinga ukuhlolwa igazi ngenkathi ngikuTecfidera?
• Ukudlula ngokweqile kweTecfidera
• Izimpawu zokudlula ngokweqile
• Okufanele ukwenze uma kwenzeka ukweqisa ngokweqile
• Izexwayiso nge-Tecfidera
• Ukuphelelwa yisikhathi kweTecfidera
• Imininingwane yobungcweti yeTecfidera
• Indlela yokusebenza
• I-Pharmacokinetics ne-metabolism
• Izimo
• Isitoreji
• Ukubeka imininingwane

Yini iTecfidera?

I-Tecfidera (i-dimethyl fumarate) ngumuthi kadokotela ogama lomuthi. Isetshenziselwa ukwelapha amafomu abuyela emuva e-multiple sclerosis (MS).

I-Tecfidera ihlukaniswa njengokwelashwa okuguqula izifo kwe-MS. Iyanciphisa ubungozi bokubuyela emuva kwe-MS ngamaphesenti angama-49 eminyakeni emibili. Kuphinde kunciphise ubungozi bokukhubazeka komzimba cishe ngamaphesenti angama-38.

I-Tecfidera iza njenge-capsule yomlomo ebambezelekile ekhishwe. Itholakala ngamandla amabili: ama-capsules ayi-120-mg nama-capsules angama-240-mg.

Igama elijwayelekile le-Tecfidera

I-Tecfidera yisidakamizwa esinegama lomkhiqizo. Okwamanje ayitholakali njengomuthi ojwayelekile.

I-Tecfidera iqukethe i-dimethyl fumarate yomuthi.

Imiphumela emibi ye-Tecfidera

I-Tecfidera ingadala imiphumela emibi noma emibi. Uhlu olulandelayo luqukethe eminye yemiphumela emibi engase ivele ngenkathi uthatha iTecfidera. Lolu hlu alubandakanyi yonke imiphumela emibi engaba khona.

Ukuthola eminye imininingwane ngemiphumela engemihle ye-Tecfidera, noma amathiphu wokuthi ungabhekana kanjani nemiphumela emibi ekhathazayo, khuluma nodokotela wakho noma usokhemisi.

Imiphumela emibi ejwayelekile

Imiphumela emibi ejwayelekile ye-Tecfidera ifaka:

• ukuqhuma (ukubomvu kobuso nentamo)
• ukucasuka kwesisu
• ubuhlungu besisu
• isifo sohudo
• isicanucanu
• ukuhlanza
• isikhumba esilumayo
• ukuqubuka

Le miphumela emibi ingancipha noma ihambe kungakapheli amasonto ambalwa. Uma zinzima kakhulu noma zingahambi, khuluma nodokotela wakho noma usokhemisi.

Imiphumela emibi kakhulu

Shayela udokotela wakho ngokushesha uma unemiphumela emibi kakhulu. Shayela u-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha. Imiphumela emibi ingafaka okulandelayo:

• ukuqhuma okukhulu
• i-leukoencephalopathy eqhubekayo ehlukahlukene (PML)
• kwehle amazinga emangqamuzana amhlophe egazi (i-lymphopenia)
• ukulimala kwesibindi
• ukusabela okweqile komzimba

Bona ngezansi ukuze uthole ulwazi mayelana nomphumela ngamunye obucayi ngamunye.

PML

I-Progressive multifocal leukoencephalopathy (PML) ukutheleleka okusongela impilo kobuchopho obubangelwa igciwane le-JC. Imvamisa kwenzeka kuphela kubantu amasosha omzimba wabo angasebenzi ngokugcwele. Kuyaqabukela, i-PML yenzeke kubantu abane-MS abathatha iTecfidera. Kulezi zimo, abantu abathuthukise i-PML nabo behlise amazinga emangqamuzana amhlophe egazi.

Ukusiza ukuvimbela i-PML, udokotela wakho uzokwenza ukuhlolwa kwegazi njalo ngesikhathi sokwelashwa kwakho ukuhlola amazinga akho amangqamuzana amhlophe egazi. Uma amazinga akho ehla kakhulu, udokotela wakho angancoma ukuthi uyeke ukuthatha iTecfidera.

Udokotela wakho futhi uzokuqapha ngezimpawu ze-PML ngenkathi uthatha lesi sidakamizwa. Izimpawu zingafaka:

• ubuthakathaka ohlangothini olulodwa lomzimba wakho
• izinkinga zokubona
• ubulukhuni
• izinkinga zememori
• ukudideka

Uma unalezi zimpawu ngenkathi uthatha iTecfidera, shayela udokotela wakho ngokushesha. Udokotela wakho kungenzeka enze izivivinyo ukuze ahlole ukuthi unayo yini i-PML, futhi angamisa ukwelashwa kwakho ngeTecfidera.

Ukuqhuma

Ukuqhuma (ukubomvu kobuso bakho noma intamo) kungumphumela ojwayelekile weTecfidera. Kwenzeka kubantu abangamaphesenti angama-40 abathatha lesi sidakamizwa. Imiphumela ye-Flushing ivame ukwenzeka ngemuva nje kokuba uqale ukuthatha i-Tecfidera, bese uthuthuka noma uhambe ngokuphelele esikhathini esingamasonto ambalwa.

Ezimweni eziningi, ukugeleza ngomnene kuya kokulingene ngobukhali futhi izimpawu zifaka:

• imizwa yokufudumala esikhunjeni
• ukubomvu kwesikhumba
• ukulunywa
• umuzwa wokusha

Kwabanye, izimpawu zokuhlanza zingaba nzima futhi zingabekezeleleki. Cishe amaphesenti ama-3 abantu abathatha iTecfidera bagcina beyeka lesi sidakamizwa ngenxa yokuqhuma kanzima.

Ukuthatha iTecfidera ngokudla kungasiza ekunciphiseni ukuqhuma. Ukuthatha i-aspirin imizuzu engama-30 ngaphambi kokuthatha iTecfidera nakho kungasiza.

I-Lymphopenia

I-Tecfidera ingadala i-lymphopenia, izinga elinciphile lamaseli amhlophe egazi abizwa ngama-lymphocyte. I-Lymphopenia ingandisa ingozi yokutheleleka. Izimpawu ze-lymphopenia zingafaka:

• imfiva
• ama-lymph node akhulisiwe
• amalunga abuhlungu

Udokotela wakho uzohlola igazi ngaphambi nangesikhathi sokwelashwa kwakho neTecfidera. Uma amazinga akho e-lymphocyte eba phansi kakhulu, udokotela wakho angase asikisele ukuthi uyeke ukuthatha i-Tecfidera isikhathi esithile, noma unomphela.

Imiphumela yesibindi

I-Tecfidera ingadala imiphumela emibi yesibindi. Kungakhuphula amazinga ama-enzyme athile wesibindi alinganiswa ngokuhlolwa kwegazi. Lokhu kwanda kuvame ukwenzeka ezinyangeni zokuqala eziyisithupha zokwelashwa.

Kubantu abaningi, lokhu kukhuphuka akubangeli izinkinga. Kepha kubantu abambalwa, bangaba namandla futhi bakhombise ukulimala kwesibindi. Izimpawu zokulimala kwesibindi zingafaka:

• ukukhathala
• ukulahlekelwa isifiso sokudla
• ukuphuzi kwesikhumba sakho noma okumhlophe kwamehlo akho

Ngaphambi nokwelashwa kwakho konke ngeTecfidera, udokotela wakho uzokwenza ukuhlolwa kwegazi ukuze ahlole ukusebenza kwesibindi sakho. Uma ama-enzyme akho esibindi akhula kakhulu, udokotela wakho angakuyekela ukuthatha lo muthi.

Ukusabela okweqile komzimba

Ukusabela okweqile komzimba, kufaka phakathi i-anaphylaxis, kungenzeka kwabanye abantu abathatha iTecfidera. Lokhu kungenzeka nganoma yisiphi isikhathi ngesikhathi sokwelashwa. Izimpawu zokuphendula okweqile zingabandakanya:

• inkinga yokuphefumula
• ukuqubuka kwesikhumba noma isifuba
• ukuvuvukala kwezindebe zakho, ulimi, umphimbo

Uma uthola ukusabela okweqile, shayela udokotela wakho noma isikhungo sendawo sokulawula ubuthi ngokushesha. Uma izimpawu zakho zinzima, shayela ku-911 noma uye egumbini lezimo eziphuthumayo eliseduze.

Uma uke waba nokusabela okweqile okukhulu kulo muthi esikhathini esedlule, ungahle ungakwazi ukuwuthatha futhi. Ukusebenzisa lesi sidakamizwa futhi kungaba yingozi. Uma uke waba nokusabela kulo muthi phambilini, khuluma nodokotela wakho ngaphambi kokuphinda uwuthathe futhi.

I-Rash

Cishe abantu abangamaphesenti ayisishiyagalombili abathatha iTecfidera bathola ukuqubuka kwesikhumba okuncane ngemuva kokuthatha iTecfidera izinsuku ezimbalwa. Ukuqhuma kungahamba nokusetshenziswa okuqhubekayo. Uma ingahambi noma iba inkathazo, khuluma nodokotela wakho.

Uma ukuqubuka kuvela ngokuzumayo ngemuva kokuthatha umuthi, kungaba ukusabela okweqile. Uma unenkinga yokuphefumula noma ukuvuvukala kwezindebe zakho noma ulimi lwakho, lokhu kungaba ukusabela okunzima kwe-anaphylactic. Uma ucabanga ukuthi unenkinga yokungezwani komzimba nalesi sidakamizwa, shayela ku-911.

Ukulahleka kwezinwele

Ukulahleka kwezinwele akuyona imphumela eseceleni eyenzekile ezifundweni zeTecfidera. Kodwa-ke, abanye abantu abathatha iTecfidera balahlekelwe izinwele.

Komunye umbiko, owesifazane oqale ukuthatha iTecfidera waqala ukulahlekelwa yizinwele ngemuva kokuphuza umuthi izinyanga ezimbili kuya kwezintathu. Izinwele zakhe zehla ngemuva kokuqhubeka nokusebenzisa lo muthi izinyanga ezimbili ngaphezulu, nezinwele zakhe zaqala ukukhula.

Ukuzuza kwesisindo / Ukwehlisa isisindo

Ukuzuza kwesisindo noma ukwehlisa isisindo akuyona imiphumela eseceleni eye yenzeka ezifundweni zeTecfidera. Kodwa-ke, abanye abantu abathatha lesi sidakamizwa baye bathola isisindo. Abanye baye balahlekelwa isisindo ngenkathi bethatha iTecfidera. Akucaci ukuthi iTecfidera iyimbangela yokuthola isisindo noma yokwehlisa isisindo.

Ukukhathala

Abantu abathatha iTecfidera bangathola ukukhathala. Kokunye ukuhlola, ukukhathala kwenzeka emaphesentini ayi-17 abantu abakuthathayo. Lo mphumela ohlangothini ungancipha noma uhambe ngokusetshenziswa okuqhubekayo komuthi.

Ubuhlungu besisu

Cishe amaphesenti ayi-18 abantu abathatha iTecfidera banezinhlungu esiswini. Lo mphumela oseceleni uvame kakhulu ngenyanga yokuqala yokwelashwa futhi uvame ukuncipha noma uhambe ngokusetshenziswa okuqhubekayo komuthi.

Uhudo

Cishe amaphesenti ayi-14 abantu abathatha iTecfidera banesifo sohudo. Lo mphumela ohlangothini uvame kakhulu ngenyanga yokuqala yokwelashwa futhi uvame ukuncipha noma uhambe ngokusetshenziswa okuqhubekayo.

Umphumela kwisidoda noma ukuzala kowesilisa

Izifundo zabantu azange zihlolisise umphumela weTecfidera kusidoda noma ekuzaleni owesilisa. Ezifundweni zezilwane, iTecfidera ayizange ithinte ukuzala, kepha izifundo ezilwaneni azihlali zibikezela ukuthi kuzokwenzekani kubantu.

Ubuhlungu bekhanda

Abanye abantu abathatha iTecfidera banekhanda. Kodwa-ke, akucaci ukuthi ngabe iTecfidera iyimbangela yini. Kokunye ukuhlola, amaphesenti ayi-16 abantu abathathe iTecfidera babephathwa yikhanda, kepha ikhanda lalivame ukwenzeka kubantu abathatha iphilisi le-placebo.

Ukulunywa

Cishe amaphesenti ayisishiyagalombili abantu abathatha iTecfidera banesikhumba esilumayo. Lo mphumela ungaphela ngokusetshenziswa okuqhubekayo komuthi. Uma ingahambi noma uma iba inkathazo, khuluma nodokotela wakho.

Ukucindezeleka

Abanye abantu abathatha iTecfidera banesimo sokucindezeleka. Kodwa-ke, akucaci ukuthi ngabe iTecfidera iyimbangela yini. Kokunye ukuhlola, amaphesenti ayisishiyagalombili abantu abathathe iTecfidera babenemizwa yokudana, kepha lokhu kwenzeka kaningi kubantu abaphuza iphilisi le-placebo.

Uma unezimpawu zokucindezeleka eziba nzima, khuluma nodokotela wakho ngezindlela zokuthuthukisa imizwa yakho.

Amaswazi

Ezifundweni zomtholampilo, iTecfidera ayinyusanga ubungozi bokushaywa. Kodwa-ke, kunombiko wamashingles kowesifazane one-multiple sclerosis othathe iTecfidera.

Umdlavuza

Ezifundweni zomtholampilo, iTecfidera ayinyusanga ingozi yomdlavuza. Eqinisweni, abanye abacwaningi baphenya ukuthi ngabe iTecfidera ingasiza yini ukuvimbela noma ukwelapha eminye imidlavuza.

Isicanucanu

Cishe amaphesenti ayi-12 abantu abathatha iTecfidera banesicanucanu. Lo mphumela ungaphela ngokusetshenziswa okuqhubekayo komuthi. Uma ingahambi noma uma iba inkathazo, khuluma nodokotela wakho.

Ukuqunjelwa

Ukuqunjelwa akukabikwa ezifundweni zokwelashwa zeTecfidera. Kodwa-ke, abantu abathatha iTecfidera kwesinye isikhathi banokuqunjelwa. Akucaci ukuthi lokhu kungumphumela wecala weTecfidera.

Ukuqhakaza

Ukuqunjelwa akukabikwa ezifundweni zokwelashwa zeTecfidera. Kodwa-ke, abantu abathatha iTecfidera kwesinye isikhathi banokuqunjelwa. Akucaci ukuthi lokhu kungumphumela wecala weTecfidera.

Ukuqwasha

Ukuqwasha (inkinga yokulala noma ukulala) akukabikwa ezifundweni zokwelashwa zeTecfidera. Kodwa-ke, abantu abathatha iTecfidera kwesinye isikhathi baba nokuqwasha. Akucaci ukuthi lokhu kungumphumela ohlangothini lomuthi.

Ukulimaza

Ezifundweni zomtholampilo, iTecfidera ayinyusanga ubungozi bokulimala. Kodwa-ke, abantu abaningi abane-MS bathi bavame ukulimala. Isizathu salokhu asicaci. Imibono embalwa ibalwe ngezansi.

• Njengoba i-MS iqhubeka, ukugcina ibhalansi nokuxhumana kungaba nzima kakhulu. Lokhu kungaholela ekushayeni ezintweni noma ekuweni, zombili ezingadala ukulimala.
• Umuntu one-MS othatha iTecfidera naye angathatha i-aspirin ukusiza ukuvimbela ukuqhuma. I-aspirin ingakhuphula ukulimaza.
• Abantu abathathe ama-steroids bangaba nesikhumba esincane, esingabenza balimale kalula. Ngakho-ke abantu abane-MS abanomlando wokusetshenziswa kwe-steroid bangahlangabezana nokulimala okuningi.

Uma ukhathazekile ngokulimala ngenkathi uthatha iTecfidera, khuluma nodokotela wakho. Udokotela wakho angenza ukuhlolwa kwegazi ukuze ahlole ezinye izimbangela.

Ubuhlungu obuhlangene

Ubuhlungu obuhlangene bungenzeka kubantu abathatha iTecfidera. Kokunye ukuhlola, amaphesenti ayi-12 abantu abathathe iTecfidera babenezinhlungu ezihlangene. Omunye umbiko uchaze abantu abathathu ababenezinhlungu ezihlangene noma ezinzima zomzimba ngemuva kokuqala i-Tecfidera.

Lo mphumela ohlangothini ungancipha noma uhambe ngokusetshenziswa okuqhubekayo komuthi. Ubuhlungu obuhlangene bungathuthuka futhi lapho iTecfidera imisiwe.

Umlomo owomile

Umlomo owomile awukabikwa ezifundweni zokwelashwa zeTecfidera. Kodwa-ke, abantu abathatha iTecfidera kwesinye isikhathi banomlomo owomile. Akucaci ukuthi lokhu kungumphumela wecala weTecfidera.

Imiphumela emehlweni

Imiphumela emibi ehlobene neso ayikabikwa ezifundweni zokwelashwa zeTecfidera. Kodwa-ke, abanye abantu abathatha lesi sidakamizwa bathe banezimpawu ezinjengalezi:

• amehlo omile
• ukudikiza iso
• ukungaboni kahle

Akucaci ukuthi ngabe le miphumela yamehlo idalwa umuthi noma enye into. Uma unale miphumela futhi ingapheli noma iba inkathazo, khuluma nodokotela wakho.

Izimpawu ezinjengomkhuhlane

Umkhuhlane noma izimpawu ezifana nemikhuhlane zenzekile ezifundweni zabantu abathatha iTecfidera. Kokunye ukufunda okunjalo, amaphesenti ayi-6 abantu abathathe lesi sidakamizwa banayo le miphumela, kepha imiphumela yenzeka kaningi kubantu abathathe iphilisi le-placebo.

Imiphumela emibi yesikhathi eside

Ucwaningo lokuhlola imiphumela yeTecfidera seluthathe iminyaka emibili kuya kweyisithupha. Esifundweni esisodwa esihlala iminyaka eyisithupha, imiphumela emibi kakhulu yilena:

• Ukubuyela emuva kwe-MS
• umphimbo obuhlungu noma ikhala eligobayo
• ukuqhuma
• ukutheleleka kokuphefumula
• ukutheleleka komgudu womchamo
• ikhanda
• isifo sohudo
• ukukhathala
• ubuhlungu besisu
• ubuhlungu emhlane, ezingalweni, noma emilenzeni

Uma uthatha iTecfidera futhi unemiphumela engemihle engapheli noma ibe nzima noma ikhathaze, khuluma nodokotela wakho. Bangaphakamisa izindlela zokunciphisa noma ukuqeda imiphumela emibi, noma bangaphakamisa ukuthi uyeke ukuthatha umuthi.

I-Tecfidera isebenzisa

I-Tecfidera ivunyelwe yi-Food and Drug Administration (FDA) yokwelapha i-multiple sclerosis (MS).

I-Tecfidera ye-MS

I-Tecfidera ivunyelwe ukwelapha amafomu wokubuyela emuva we-MS, amafomu ajwayelekile kakhulu e-MS. Kulezi zinhlobo, ukuhlaselwa kokuwohloka noma izimpawu ezintsha kuyenzeka (kubuyela emuva), kulandelwe izikhathi zokululama okuncane noma okuphelele (ukuthethelelwa).

I-Tecfidera inciphisa ubungozi bokubuyela emuva kwe-MS ngamaphesenti angama-49 eminyakeni emibili. Kuphinde kunciphise ubungozi bokukhubazeka komzimba cishe ngamaphesenti angama-38.

I-Tecfidera ye-psoriasis

I-Tecfidera isetshenziswa ngaphandle kwelebula ukwelapha i-plaque psoriasis. Ukusetshenziswa kwelebula engekho kulapho umuthi uvunyelwe ukwelapha isimo esisodwa kepha usetshenziselwa ukwelapha isimo esihlukile.

Esifundweni somtholampilo, cishe amaphesenti angama-33 abantu abathatha iTecfidera babe namacwecwe abo ecacile noma acishe acace ngokuphelele ngemuva kwamasonto ayishumi nesithupha okwelashwa. Cishe amaphesenti angama-38 wabantu abasebenzisa lesi sidakamizwa abe nokuthuthuka okungamaphesenti angama-75 enkombeni yobunzima be-plaque nendawo ethintekile.

Ezinye izindlela zeTecfidera

Imithi eminingi iyatholakala ukwelapha amafomu abuyayo e-multiple sclerosis (MS). Izibonelo zale mithi zifaka:

• i-interferon beta-1a (Avonex, Rebif)
• i-interferon beta-1b (iBetaseron)
• i-glatiramer acetate (iCopaxone, iGlatopa)
• IV immunoglobulin (Bivigam, Gammagard, abanye)
• amasosha omzimba monoclonal ezifana:
• i-alemtuzumab (Lemtrada)
• i-natalizumab (Tysabri)
• i-rituximab (Rituxan)
• ocrelizumab (Ocrevus)
• i-fingolimod (Gilenya)
• teriflunomide (Aubagio)

Qaphela: Ezinye zezidakamizwa ezibalwe lapha zisetshenziselwa i-off-label ukuphatha amafomu abuyela emuva we-MS.

I-Tecfidera vs. ezinye izidakamizwa

Ungase uzibuze ukuthi iTecfidera iqhathanisa kanjani neminye imithi enqunyelwe ukusetshenziswa okufanayo. Ngezansi ukuqhathanisa phakathi kweTecfidera nemithi eminingana.

I-Tecfidera vs. Aubagio

I-Tecfidera ne-Aubagio (teriflunomide) zombili zihlukaniswa njengezindlela zokwelapha eziguqula izifo. Kokubili kunciphisa imisebenzi ethile yokuvikela umzimba, kepha isebenza ngezindlela ezihlukile.

Isebenzisa

I-Tecfidera ne-Aubagio bobabili bavunyelwe yi-FDA ekwelapheni amafomu abuyela emuva e-multiple sclerosis (MS).

Amafomu ezidakamizwa

I-Tecfidera iza njenge-capsule yomlomo ebambezelekile ethathwa kabili nsuku zonke. I-Aubagio iza njengethebhulethi yomlomo ethathwa kanye nsuku zonke.

Imiphumela emibi kanye nezingozi

I-Tecfidera ne-Aubagio zinemiphumela emibi efanayo futhi ezinye ziyehluka. Ngezansi kunezibonelo zale miphumela emibi.

I-Aubagio inezixwayiso zesibhakela ezivela ku-FDA. Lezi izexwayiso eziqine kakhulu ezidingwa yi-FDA. Isexwayiso sebhokisi sazisa odokotela neziguli ngemiphumela yezidakamizwa engaba yingozi.

Ukusebenza ngempumelelo

Kokubili iTecfidera ne-Aubagio kuyasebenza ekwelapheni i-MS. Ukusebenza kwale mithi akukaze kuqhathaniswe ngqo ezifundweni zokwelashwa. Kodwa-ke, kokunye ukuhlaziywa, zaqhathaniswa ngokungaqondile futhi zatholakala zinezinzuzo ezifanayo.

Izindleko

I-Tecfidera ne-Aubagio zitholakala kuphela njengezidakamizwa ezinegama lomkhiqizo. Izinhlobo ezijwayelekile zale mithi azitholakali. Amafomu ejwayelekile ngokuvamile abiza kakhulu kunezidakamizwa ezinamagama.

I-Tecfidera ngokuvamile ibiza kancane kakhulu kune-Aubagio. Kodwa-ke, inani ngqo olikhokhayo lizoya ngohlelo lwakho lomshuwalense.

I-Tecfidera vs. Copaxone

I-Tecfidera neCopaxone (i-glatiramer acetate) zombili zihlukaniswa njengezindlela zokwelapha eziguqula izifo. Kokubili kunciphisa imisebenzi ethile yokuvikela umzimba, kepha isebenza ngezindlela ezihlukile.

Isebenzisa

I-Tecfidera neCopaxone zombili zivunyelwe i-FDA ekwelapheni amafomu abuyela emuva e-multiple sclerosis (MS).

Amafomu ezidakamizwa

Enye inzuzo yeTecfidera ukuthi ithathwa ngomlomo. Kuza njenge-capsule yomlomo ebambezelekile ethathwa kabili nsuku zonke.

I-Copaxone kufanele ijojowe. Kuza njengomjovo ongazilimaza ongaphansi komjovo. Inganikezwa ekhaya noma kanye nsuku zonke noma kathathu ngesonto.

Imiphumela emibi kanye nezingozi

I-Tecfidera neCopaxone kunemiphumela emibi efanayo futhi eminye yehlukile. Ngezansi kunezibonelo zale miphumela emibi.

Ukusebenza ngempumelelo

Kokubili iTecfidera neCopaxone kuyasebenza ekwelapheni i-MS. Ukusebenza kwale mithi akukaze kuqhathaniswe ngqo ezifundweni zokwelashwa. Kodwa-ke, ngokuya ngokunye ukuhlaziywa, iTecfidera ingasebenza kakhulu kuneCopaxone yokuvikela ukubuyela emuva futhi yehlise ukwanda kokukhubazeka.

Izindleko

I-Tecfidera itholakala kuphela njengesidakamizwa esinegama lomkhiqizo. ICopaxone iyatholakala njengesidakamizwa esinegama lomkhiqizo. Iphinde itholakale ngendlela ejwayelekile ebizwa nge-glatiramer acetate.

Uhlobo olujwayelekile lweCopaxone lubiza kancane kakhulu kuneTecfidera. Igama lomkhiqizo iCopaxone neTecfidera ngokuvamile kubiza ngokufana. Inani langempela olikhokhayo lizoya ngohlelo lwakho lomshuwalense.

I-Tecfidera vs. Ocrevus

I-Tecfidera ne-Ocrevus (ocrelizumab) zombili zihlukaniswa njengezindlela zokwelapha eziguqula izifo. Kokubili kunciphisa imisebenzi ethile yokuvikela umzimba, kepha isebenza ngezindlela ezihlukile.

Isebenzisa

I-Tecfidera ne-Ocrevus bobabili bavunyelwe yi-FDA ekwelapheni amafomu abuyela emuva e-multiple sclerosis (MS). I-Ocrevus nayo ivunyelwe ukwelapha izinhlobo eziqhubekayo ze-MS.

Amafomu ezidakamizwa

Inzuzo yeTecfidera ukuthi ingathathwa ngomlomo. Kuza njenge-capsule yomlomo ebambezelekile ethathwa kabili nsuku zonke.

I-Ocrevus kufanele ijojowe kusetshenziswa ukumnika okufaka emthanjeni (IV). Kumele inikezwe emtholampilo noma esibhedlela. Ngemuva kwemithamo emibili yokuqala, u-Ocrevus unikezwa njalo ezinyangeni eziyisithupha.

Imiphumela emibi kanye nezingozi

I-Tecfidera ne-Ocrevus zinemiphumela emibi efanayo futhi ezinye ziyehluka. Ngezansi kunezibonelo zale miphumela emibi.

Ukusebenza ngempumelelo

Kokubili iTecfidera ne-Ocrevus kuyasebenza ekwelapheni i-MS, kodwa akucaci ukuthi ngabe enye isebenza kangcono yini kunenye. Ukusebenza kwale mithi akukaze kuqhathaniswe ngqo ezifundweni zokwelashwa.

Izindleko

I-Tecfidera ne-Ocrevus ziyatholakala njengemithi egama lomkhiqizo. Azitholakali ngamafomu ejwayelekile, okungabiza kakhulu kunezidakamizwa ezinamagama.

I-Ocrevus ingabiza ngaphansi kukaTecfidera. Inani langempela olikhokhayo lizoya ngohlelo lwakho lomshuwalense.

I-Tecfidera vs. Tysabri

I-Tecfidera ne-Tysabri (natalizumab) zombili zihlukaniswa njengezindlela zokwelapha eziguqula izifo. Zombili lezi zidakamizwa zinciphisa imisebenzi ethile yokuvikela umzimba, kepha zisebenza ngezindlela ezihlukile.

Isebenzisa

I-Tecfidera ne-Tysabri bobabili bavunyelwe yi-FDA ekwelapheni amafomu abuyela emuva e-multiple sclerosis (MS). I-Tysabri nayo ivunyelwe ukwelashwa kwesifo sikaCrohn.

Amafomu ezidakamizwa

Enye inzuzo yeTecfidera ukuthi ithathwa ngomlomo. I-Tecfidera iza njenge-capsule yomlomo ebambezelekile ethathwa kabili nsuku zonke.

I-Tysabri kumele ifakwe njenge-infravenous (IV) ukumnika okunikezwa emtholampilo noma esibhedlela. Inikezwa kanye ngenyanga.

Imiphumela emibi kanye nezingozi

I-Tecfidera ne-Tysabri zinemiphumela efanayo efanayo kanti eminye yehlukile. Ngezansi kunezibonelo zale miphumela emibi.

* Yomibili le mithi ixhunywe ne-leukoencephalopathy eqhubekayo (i-PML), kepha yiTysabri kuphela enesixwayiso esihlobene nesibhokisi esivela ku-FDA. Lesi yisixwayiso esiqine kakhulu esidingwa yi-FDA. Isexwayiso sebhokisi sazisa odokotela neziguli ngemiphumela yezidakamizwa engaba yingozi.

Ukusebenza ngempumelelo

Kokubili iTecfidera neTysabri kuyasebenza ekwelapheni i-MS. Ukusebenza kwale mithi akukaze kuqhathaniswe ngqo ezifundweni zokwelashwa. Kodwa-ke, ngokusho kokunye ukuhlaziywa, iTysabri ingasebenza kakhulu kuneTecfidera yokuvimbela ukubuyela emuva.

Kubalulekile ukuqaphela ukuthi ngenxa yobungozi bayo be-PML, iTysabri imvamisa akuyona umuthi wokuzikhethela wokuqala we-MS.

Izindleko

I-Tecfidera ne-Tysabri zitholakala kuphela njengezidakamizwa ezinegama lomkhiqizo. Izinhlobo ezijwayelekile zale mithi azitholakali. Imvelo ejwayelekile ibiza kancane kunemithi egama lomkhiqizo.

I-Tecfidera ngokuvamile ibiza ngaphezu kweTysabri. Inani langempela olikhokhayo lizoya ngohlelo lwakho lomshuwalense.

Tecfidera vs. Gilenya

I-Tecfidera ne-Gilenya (fingolimod) zombili zihlukaniswa njengezindlela zokwelapha eziguqula izifo. Kokubili kunciphisa imisebenzi ethile yokuvikela umzimba, kepha isebenza ngezindlela ezihlukile.

Isebenzisa

I-Tecfidera ne-Gilenya zombili zivunyelwe i-FDA ekwelapheni amafomu abuyela emuva e-multiple sclerosis (MS).

Amafomu ezidakamizwa

I-Tecfidera iza njenge-capsule yomlomo ebambezelekile ethathwa kabili nsuku zonke. IGilenya iza njengephilisi lomlomo elithathwa kanye nsuku zonke.

Imiphumela emibi kanye nezingozi

I-Tecfidera ne-Gilenya zinemiphumela emibi efanayo futhi ezinye ziyehluka. Ngezansi kunezibonelo zale miphumela emibi.

Ukusebenza ngempumelelo

Kokubili iTecfidera neGilenya kuyasebenza ekwelapheni i-MS. Ukusebenza kwale mithi akukaze kuqhathaniswe ngqo ezifundweni zokwelashwa. Kodwa-ke, ngokuya ngokuhlaziya okukodwa, iTecfidera neGilenya zisebenza ngokulingana kahle ngokuvimbela ukubuyela emuva.

Izindleko

I-Tecfidera ne-Gilenya zitholakala kuphela njengezidakamizwa ezinegama lomkhiqizo. Izinhlobo ezijwayelekile zale mithi azitholakali. Imvelo ejwayelekile ibiza kancane kunemithi egama lomkhiqizo.

I-Tecfidera ne-Gilenya ngokuvamile zibiza ngokufana. Inani langempela olikhokhayo lizoya ngohlelo lwakho lomshuwalense.

I-Tecfidera vs. interferon (Avonex, Rebif)

I-Tecfidera ne-interferon (Avonex, Rebif) zombili zihlukaniswa njengezindlela zokwelapha eziguqula izifo. Kokubili kunciphisa imisebenzi ethile yokuvikela umzimba, kepha isebenza ngezindlela ezihlukile.

Isebenzisa

I-Tecfidera ne-interferon (i-Avonex, i-Rebif) kuvunyelwe yi-FDA ngayinye ukwelapha amafomu abuyayo e-multiple sclerosis (MS).

Amafomu ezidakamizwa

Enye inzuzo yeTecfidera ukuthi ithathwa ngomlomo. I-Tecfidera iza njenge-capsule yomlomo ebambezelekile ethathwa kabili nsuku zonke.

I-Avonex neRebif ngamagama wemikhiqizo ehlukene ye-interferon beta-1a. Womabili la mafomu kufanele ajovwe. I-Rebif iza njengomjovo ongaphansi onikezwa ngaphansi kwesikhumba kathathu ngesonto. I-Avonex iza njengomjovo we-intramuscular ofakwa emisipheni kanye ngesonto. Zombili ziyazenzela ekhaya.

Imiphumela emibi kanye nezingozi

I-Tecfidera ne-interferon kuneminye imiphumela emibi efanayo futhi eminye yehlukile. Ngezansi kunezibonelo zale miphumela emibi.

Ukusebenza ngempumelelo

Kokubili iTecfidera ne-interferon kuyasebenza ekwelapheni i-MS. Ukusebenza kwale mithi akukaze kuqhathaniswe ngqo ezifundweni zokwelashwa. Kodwa-ke, ngokuya ngokunye ukuhlaziywa, iTecfidera ingasebenza kakhulu kune-interferon yokuvimbela ukubuyela emuva futhi inciphise ukwanda kokukhubazeka.

Izindleko

I-Tecfidera ne-interferon (i-Rebif, i-Avonex) zitholakala kuphela njengezidakamizwa ezinegama lomkhiqizo. Izinhlobo ezijwayelekile zale mithi azitholakali. Imvelo ejwayelekile ibiza kancane kunemithi egama lomkhiqizo.

I-Tecfidera ne-interferon ngokuvamile kubiza ngokufana. Imali oyiholayo izoncika kumshwalense wakho.

I-Tecfidera vs. Protandim

I-Tecfidera yisidakamizwa esivunyelwe yi-FDA sokwelapha izinhlobo ezibuyayo ze-multiple sclerosis (MS). Ucwaningo oluningi lwemitholampilo lukhombisile ukuthi kungavimbela ukubuyela kwe-MS futhi kwehle kancane kancane ekukhubazekeni komzimba.

I-Protandim iyisengezo sokudla esiqukethe izithako eziningana, kufaka phakathi:

• ubisi lwameva
• ashwagandha
• itiye eliluhlaza
• i-turmeric
• bacopa

Abanye bathi iProtandim isebenza njengoTecfidera iyasebenza. I-Protandim kwesinye isikhathi ibizwa nge- "Tecfidera yemvelo."

Kodwa-ke, iProtandim ayikaze ifundwe kubantu abane-MS. Ngakho-ke, alukho ucwaningo lomtholampilo oluthembekile olusebenzayo.

Qaphela: Uma udokotela wakho ekuyalisele i-Tecfidera, ungayithathi esikhundleni seProtandim. Uma ungathanda ukuhlola ezinye izindlela zokwelashwa, khuluma nodokotela wakho.

Umthamo weTecfidera

Imininingwane elandelayo ichaza imithamo esetshenziswa kakhulu noma enconywayo. Kodwa-ke, qiniseka ukuthatha isilinganiso udokotela wakho akubekela sona. Udokotela wakho uzonquma isilinganiso esihle kakhulu ukuhlangabezana nezidingo zakho.

Isikali se-multiple sclerosis

Lapho i-Tecfidera iqalwa, isilinganiso singu-120 mg kabili ngosuku ezinsukwini eziyisikhombisa zokuqala. Ngemuva kwaleli sonto lokuqala, umthamo ukhuphukelwa ku-240 mg kabili ngosuku. Lona ngumthamo wesondlo wesikhathi eside.

Kubantu abanemiphumela emibi ekhathazayo evela ku-Tecfidera, umthamo wesondlo ungancipha okwesikhashana uye ku-120 mg kabili ngosuku. Umthamo ophakeme wesondlo ka-240 mg kabili ngosuku kufanele uqaliswe futhi kungakapheli amasonto amane.

Kuthiwani uma ngiphuthelwa umthamo?

Uma uphuthelwa umthamo, wuthathe ngokushesha lapho ukhumbula. Uma cishe sekuyisikhathi sedosi yakho elandelayo, vele uthathe lelo thamo elilodwa. Ungazami ukubamba ngokuthatha imithamo emibili ngasikhathi sinye.

Ngabe kuzodingeka ngisebenzise lesi sidakamizwa isikhathi eside?

Yebo, lo muthi wenzelwe ukuthi uphuzwe isikhathi eside.

Ungayithatha kanjani iTecfidera

Thatha iTecfidera ncamashi ngokwemiyalo kadokotela wakho.

Isikhathi

I-Tecfidera ithathwa kabili nsuku zonke. Ngokuvamile kuthathwa ngesidlo sasekuseni kanye nesidlo sakusihlwa.

Ukuthatha iTecfidera ngokudla

I-Tecfidera kufanele ithathwe ngokudla. Lokhu kungasiza ekunciphiseni umphumela ohlangothini ogelezayo. Ukuhlanza kungabuye kwehliswe ngokuthatha u-325 mg we-aspirin imizuzu engama-30 ngaphambi kokuthatha iTecfidera.

Ngabe iTecfidera ingachotshozwa?

I-Tecfidera akufanele ichotshozwe, noma ivulwe futhi ifafazwe ekudleni. Amaphilisi weTecfidera kufanele aginywe ephelele.

Ukukhulelwa kanye neTecfidera

Ucwaningo lwezilwane lukhombisa ukuthi iTecfidera ingaba yingozi embungwini futhi kungenzeka ingaphephile ukuyithatha ngesikhathi sokukhulelwa. Kodwa-ke, izifundo zezilwane azihlali zibikezela ukuthi kuzokwenzekani kubantu.

Izifundo azizange zihlolisise imiphumela yeTecfidera maqondana nokukhulelwa noma ukukhubazeka kokuzalwa kwabantu.

Uma ukhulelwe noma uhlela ukukhulelwa, khuluma nodokotela wakho mayelana nokuthi kufanele uthathe i-Tecfidera.

Uma ukhulelwa ngenkathi uthatha iTecfidera, ungabamba iqhaza kwiRegfidera Pregnancy Registry. Irejista yokukhulelwa isiza ukuqoqa imininingwane yokuthi imishanguzo ethile ingakuthinta kanjani ukukhulelwa. Uma ungathanda ukujoyina irejista, buza udokotela wakho, shayela ku-866-810-1462, noma uvakashele iwebhusayithi yokubhalisa.

Ukuncelisa ibele neTecfidera

Akuzange kube nezifundo ezanele ukukhombisa ukuthi ngabe iTecfidera iyavela yini ebisini lwebele.

Abanye ochwepheshe batusa ukugwema ukuncelisa ibele ngenkathi uthatha lo muthi. Noma kunjalo, abanye abakwenzi. Uma uthatha iTecfidera futhi ungathanda ukuncelisa ingane yakho ibele, khuluma nodokotela wakho ngezingozi nezinzuzo ezingaba khona.

Isebenza kanjani iTecfidera

I-Multiple sclerosis (MS) isifo esizimele. Ngalolu hlobo lwesimo, amasosha omzimba, alwa nezifo, enza amaphutha amangqamuzana anempilo kubahlaseli bezitha futhi abahlasele. Lokhu kungadala ukuvuvukala okungapheli.

Nge-MS, lokhu kuvuvukala okungapheli kucatshangwa ukuthi kungadala ukulimala kwezinzwa, kufaka phakathi ukwehliswa kwesimo esidala izimpawu eziningi ze-MS. Ukucindezelwa kwe-oxidative (OS) kucatshangwa ukuthi nakho kubangele lo monakalo. I-OS ukungalingani kwama-molecule athile emzimbeni wakho.

I-Tecfidera icatshangwa ukuthi isiza ukwelapha i-MS ngokwenza umzimba ukhiqize iphrotheni ebizwa nge-Nrf2. Le phrotheni kucatshangwa ukuthi izosiza ukubuyisa ibhalansi yomzimba yamangqamuzana. Lo mphumela, nawo, usiza ukunciphisa umonakalo odalwe ukuvuvukala ne-OS.

Ngaphezu kwalokho, iTecfidera ishintsha eminye imisebenzi yamaseli omzimba omzimba ukunciphisa izimpendulo ezithile zokuvuvukala. Kungavimbela nomzimba ekusebenzeni kwamaseli athile omzimba. Le miphumela ingasiza futhi ekunciphiseni izimpawu ze-MS.

Kuthatha isikhathi esingakanani ukusebenza?

I-Tecfidera izoqala ukusebenza emzimbeni wakho khona manjalo, kepha kungathatha amasonto ambalwa ukufinyelela ekusebenzeni kwayo ngokuphelele.

Ngenkathi isebenza, ungahle ungaboni intuthuko enkulu ezimpawu zakho. Lokhu kungenxa yokuthi kuhloswe kakhulu ukuvimbela ukubuyela emuva.

I-Tecfidera notshwala

I-Tecfidera ayihlangani notshwala. Kodwa-ke, utshwala bungaba yimbi kakhulu imiphumela emibi ethile ye-Tecfidera, efana nale:

• isifo sohudo
• isicanucanu
• ukuqhuma

Gwema ukuphuza utshwala obuningi ngokweqile ngenkathi uthatha iTecfidera.

Ukusebenzisana kweTecfidera

I-Tecfidera ingaxhumana neminye imithi. Ngezansi kunohlu lwemithi engasebenzisana neTecfidera. Lolu hlu kungenzeka lungabi nayo yonke imishanguzo engasebenzisana ne-Tecfidera.

Ukuhlangana kwezidakamizwa okuhlukile kungadala imiphumela ehlukile. Isibonelo, ezinye zingaphazamisa ukuthi usebenza kanjani umuthi, kanti ezinye zingadala imiphumela emibi eyengeziwe.

Ngaphambi kokuthatha i-Tecfidera, qiniseka ukuthi utshela udokotela kanye nosokhemisi ngayo yonke imishanguzo kadokotela, i-counter-counter, nezinye izidakamizwa ozithathayo. Batshele futhi nganoma yimaphi amavithamini, amakhambi, nezithako ozisebenzisayo. Ukwabelana ngalolu lwazi kungakusiza ugweme ukuhlangana okungenzeka.

Uma unemibuzo mayelana nokuhlangana kwezidakamizwa okungakuthinta, buza udokotela wakho noma usokhemisi.

I-Tecfidera ne-ocrelizumab (Ocrevus)

Ukuthatha i-Tecfidera nge-ocrelizumab kungakhuphula ubungozi bokuqothulwa komzimba futhi kube nezifo ezimbi. I-immuneosuppression yilapho amasosha omzimba entengantenga.

I-Tecfidera ne-ibuprofen

Akukho ukuxhumana okwaziwayo phakathi kwe-ibuprofen ne-Tecfidera.

I-Tecfidera ne-aspirin

Akukho ukuxhumana okwaziwayo phakathi kwe-aspirin ne-Tecfidera. I-Aspirin ijwayele ukusetshenziswa imizuzu engama-30 ngaphambi kokuthatha iTecfidera ukuvimbela ukuqhuma.

Imibuzo ejwayelekile ngeTecfidera

Nazi izimpendulo zemibuzo ebuzwa njalo ngeTecfidera.

Kungani iTecfidera ibangela ukuqhuma?

Akucaci kahle ukuthi kungani iTecfidera ibangela ukuqhuma. Kodwa-ke, kungenzeka ukuthi ihlobene nokukhuliswa (ukunwetshwa) kwemithambo yegazi ebusweni lapho kwenzeka khona ukuqhuma.

Ungakuvimbela kanjani ukuqhuma kusuka eTecfidera?

Ungahle ungakwazi ukuvimbela ngokuphelele ukuqhuma okubangelwa yi-Tecfidera, kepha kunezinto ezimbili ongazenza ukusiza ukunciphisa lokhu:

• Thatha iTecfidera ngokudla.
• Thatha u-325 mg we-aspirin imizuzu engama-30 ngaphambi kokuthatha iTecfidera.

Uma lezi zinyathelo zingakusizi futhi usenokuhlushwa okukhathazayo, khuluma nodokotela wakho.

Ingabe iTecfidera ikwenza ukhathele?

Abanye abantu abathatha iTecfidera bathi bazizwa bekhathele. Kodwa-ke, imizwa yokukhathala noma ukulala akuyona imiphumela emibi etholakale ezifundweni zokwelashwa zeTecfidera.

Ingabe iTecfidera i-immunosuppressant?

I-Tecfidera iyathinta amasosha omzimba. Iyanciphisa imisebenzi ethile yamasosha omzimba ukunciphisa izimpendulo zokuvuvukala. Kunganciphisa nokusebenza kwamaseli athile omzimba.

Kodwa-ke, i-Tecfidera ayivame ukuhlukaniswa njenge-immunosuppressant. Ngezinye izikhathi ibizwa ngokuthi i-immunomodulator, okusho ukuthi ithinta eminye imisebenzi yamasosha omzimba.

Ngabe ngidinga ukukhathazeka ngokuvezwa yilanga ngenkathi ngithatha iTecfidera?

I-Tecfidera ayenzi isikhumba sakho sizwele kakhulu elangeni njengoba kwenza ezinye izidakamizwa. Kodwa-ke, uma uhlangabezana nokushaywa yi-Tecfidera, ukushiswa yilanga kungawenza ube mubi umuzwa wokushaywa.

Iphumelela kangakanani iTecfidera?

I-Tecfidera itholakale ukuthi inciphisa ukubuyela emuva kwe-MS ngamaphesenti angama-49 eminyakeni emibili. Kutholakale futhi ukunciphisa ingozi yokuba nokukhubazeka komzimba okuba kubi ngamaphesenti angaba ngu-38.

Kungani nginezinkomba zokuqondisa ezahlukene ngemuva kwesonto lokuqala?

Kuvamile ukuthi imishanguzo iqalwe kumthamo ophansi bese inyuswa ngokuhamba kwesikhathi. Lokhu kuvumela umzimba wakho ukucubungula umthamo ophansi njengoba uvumelanisa nemithi.

Kwi-Tecfidera, uqala ngomthamo ophansi ka-120 mg kabili ngosuku nsuku zonke phakathi nezinsuku eziyisikhombisa zokuqala. Ngemuva kwalokho, umthamo ukhuphukelwa ku-240 mg kabili ngosuku, futhi lona ngumthamo ongahlala kuwo. Kodwa-ke, uma unemiphumela emibi kakhulu ngomthamo ophakeme, udokotela wakho anganciphisa umthamo wakho okwesikhashana.

Ngabe ngidinga ukuhlolwa igazi ngenkathi ngikuTecfidera?

Yebo. Ngaphambi kokuba uqale ukuthatha i-Tecfidera, udokotela wakho uzokwenza ukuhlolwa kwegazi ukuhlola ukubalwa kwamaseli egazi nokusebenza kwesibindi sakho. Lezi zivivinyo kungenzeka ziphindwe ngesikhathi sokwelashwa kwakho nomuthi. Ngonyaka wokuqala wokwelashwa, lezi zivivinyo zivame ukwenziwa okungenani njalo ezinyangeni eziyisithupha.

Ukudlula ngokweqile kweTecfidera

Ukuthatha kakhulu lo muthi kungandisa ubungozi bemiphumela emibi kakhulu.

Izimpawu zokudlula ngokweqile

Izimpawu zokudlula ngokweqile zingabandakanya:

• isifo sohudo
• isicanucanu
• ukuqhuma
• ukuhlanza
• ukuqubuka
• isisu esibuhlungu
• ikhanda

Okufanele ukwenze uma kwenzeka ukweqisa ngokweqile

Uma ucabanga ukuthi uthathe kakhulu lo muthi, shayela udokotela wakho noma funa ukuholwa yi-American Association of Poison Control Centers ku-800-222-1222 noma ngethuluzi labo eliku-inthanethi. Kepha uma izimpawu zakho zinzima, shayela ku-911 noma uye egumbini lezimo eziphuthumayo eliseduze ngokushesha.

Izexwayiso nge-Tecfidera

Ngaphambi kokuthatha iTecfidera, khuluma nodokotela wakho nganoma yiziphi izimo zezokwelapha onazo. I-Tecfidera kungenzeka ingakulungeli uma unezimo ezithile zezokwelapha. Lezi zimo zifaka:

• Ukucindezelwa kwesistimu yomzimba: Uma amasosha akho omzimba ecindezelwe, iTecfidera ingase isibhebhethekise lesi simo. Lo mphumela ungakhuphula ubungozi bokutheleleka okunzima.
• Isifo sesibindi: I-Tecfidera ingadala ukulimala kwesibindi. Uma usuvele unesifo sesibindi, singasenza sibe sibi isimo sakho.

Ukuphelelwa yisikhathi kweTecfidera

Lapho iTecfidera ikhishwa ekhemisi, usokhemisi uzokwengeza usuku lokuphelelwa yisikhathi kwilebula esebhodleleni. Lolu suku luvame unyaka owodwa kusukela ngosuku okwakhishwa ngalo umuthi.

Inhloso yezinsuku zokuphelelwa isikhathi ezinjalo ukuqinisekisa ukusebenza komuthi ngalesi sikhathi. Isimo samanje se-Food and Drug Administration (i-FDA) ukugwema ukusebenzisa imishanguzo ephelelwe yisikhathi. Kodwa-ke, ucwaningo lwe-FDA lukhombise ukuthi imishanguzo eminingi isengaba mihle ngaphambi kosuku lokuphelelwa yisikhathi okubalulwe ebhodleleni.

Ukuthi umuthi uhlala ulungile isikhathi eside kangakanani kungancika ezintweni eziningi, kufaka phakathi ukuthi umuthi ugcinwa kanjani futhi kuphi. I-Tecfidera kufanele igcinwe ekamelweni lokushisa esitsheni sokuqala futhi ivikelwe ekukhanyeni.

Uma usebenzise umuthi ongasetshenziswanga osudlulile esikhathini sokuphelelwa yisikhathi, khuluma nosokhemisi wakho mayelana nokuthi usengakwazi yini ukuwusebenzisa.

Imininingwane yobungcweti yeTecfidera

Imininingwane elandelayo inikezwa odokotela nabanye ochwepheshe bezempilo.

Indlela yokusebenza

Indlela yokusebenza yeTecfidera iyinkimbinkimbi futhi ayiqondakali ngokuphelele. Isebenzela i-multiple sclerosis (MS) ngemiphumela elwa nokuvuvukala kanye nemiphumela ye-antioxidant. Ukuvuvukala kanye nengcindezi ye-oxidative kucatshangwa ukuthi izinqubo ezibalulekile zokugula ezigulini ezine-MS.

I-Tecfidera inciphisa i-1 factor yenukliya (etholakala nge-erythroid 2)-efana ne-2 (Nrf2) antioxidant, evikela ekulimaleni kwe-oxidative ohlelweni lwezinzwa oluphakathi futhi inciphise ukudilizwa kwemizwa.

I-Tecfidera ibuye ivimbele izindlela eziningi zokuzivikela ezifweni ezihlobene nama-toll-like receptors, anciphisa ukukhiqizwa kwe-cytokine evuthayo. I-Tecfidera futhi inciphisa ukusebenza kwama-immune T-cell.

I-Pharmacokinetics ne-metabolism

Ngemuva kokuphathwa ngomlomo kweTecfidera, ihlanganiswa ngokushesha ngama-esterase kuya kumetabolite yayo esebenzayo, i-monomethyl fumarate (MMF). Ngakho-ke, i-dimethyl fumarate ayinakulinganiswa kwi-plasma.

Isikhathi sokuhlushwa okuphezulu kwe-MMF (Tmax) ngamahora angu-2-2.5.

Ukuphefumula isikhutha kuyisibopho sokuqeda amaphesenti angama-60 omuthi. Ukuqedwa kwe-renal ne-fecal yimizila emincane.

Impilo yengxenye yeMMF icishe ibe yihora elilodwa.

Izimo

I-Tecfidera iphikisana neziguli ezine-hypersensitivity eyaziwayo kwi-dimethyl fumarate noma yiziphi izinto ezithandwayo.

Isitoreji

I-Tecfidera kufanele igcinwe ekamelweni lokushisa, 59 ° F kuye ku-86 ° F (15 ° C kuye ku-30 ​​° C). Kufanele igcinwe esitsheni sokuqala futhi ivikelwe ekukhanyeni.

Ukubeka imininingwane

Imininingwane ephelele yokubeka imininingwane yeTecfidera ingatholakala lapha.

UkuzikhululaI-MedicalNewsToday yenze yonke imizamo yokuqinisekisa ukuthi lonke ulwazi luyiqiniso, luphelele futhi lusesikhathini. Kodwa-ke, le ndatshana akufanele isetshenziswe njengokungena esikhundleni solwazi nobungoti bochwepheshe bezokunakekelwa kwezempilo onelayisense. Kufanele uhlale uthintana nodokotela wakho noma omunye uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuthatha noma imuphi umuthi. Imininingwane yezidakamizwa equkethwe lapha ingashintsha futhi ayihloselwe ukumboza konke ukusetshenziswa okungaba khona, izinkomba, izixwayiso, izexwayiso, ukuxhumana kwezidakamizwa, ukungezwani komzimba, noma imiphumela emibi. Ukungabikho kwezixwayiso noma olunye ulwazi lomuthi othile awukhombisi ukuthi inhlanganisela yezidakamizwa noma yezidakamizwa iphephile, iyasebenza, noma ilungele zonke iziguli noma konke ukusetshenziswa okuthile.