Ukuhlolwa kwe-Cholinesterase: kuyini, kwenzelwa ini nokuthi kusho ukuthini umphumela

-Delile

• Yenzelwe ini
• Amanani ayizethenjwa
• Ukuthi imiphumela isho ukuthini

Ukuhlolwa kwe-cholinesterase ukuhlolwa kwelabhorethri okuceliwe ukuqinisekisa izinga lokuchayeka komuntu emikhiqizweni enobuthi, njengezibulala-zinambuzane, ama-insecticide, ama-herbicides noma umanyolo, ngokwesibonelo, ukuthi kufaneleka kakhulu kubalimi, ngoba bahlala bexhumana njalo imikhiqizo yezolimo.

I-Cholinesterase iyi-enzyme ekhona emzimbeni obhekele ukonakala kwento ebizwa nge-acetylcholine, i-neurotransmitter ebhekele ukulawula imisipha yezinzwa emisipheni. Kunezigaba ezimbili ze-cholinesterase:

• I-Erythrocyte cholinesterase, ethwalwa ngamaseli abomvu egazi;
• I-Plasma cholinesterase noma i-serum, eyi-cholinesterase ekhiqizwa isibindi, amanyikwe namathumbu amancane futhi ajikeleza egazini le-plasma.

Ukuqapha amazinga we-cholinesterase kubalulekile ukuze noma yiziphi izinguquko zingakhonjwa futhi ziphathwe ngokushesha, kugwenywe izinkinga zomuntu.

Yenzelwe ini

Ukuhlolwa kwe-cholinesterase kunconywa udokotela ikakhulukazi ukuqapha izinga lokuchayeka kwabalimi, ngokwesibonelo, izibulala-zinambuzane kanye ne-pesticides.

Ngaphezu kwalokho, umthamo wale enzyme ungacelwa ukuthi ubheke iziguli ezinesifo sesibindi, ikakhulukazi lezo ezifakelwe ukufakelwa isibindi, njengoba zivame ukwehla amazinga e-cholinesterase.

Umthamo we-cholinesterase ungakhonjiswa nakubantu abanezinguquko ezithikameza ukusebenza okulungile noma ukukhiqizwa kwale-enzyme.

Amanani ayizethenjwa

Amanani esithenjwa sokuhlolwa kwe-Cholinesterase ayahluka ngokuya kwelabhorethri kanye nekhithi esetshenziselwa ukwenza isivivinyo. Ngakho-ke, amanani wesethenjwa ajwayelekile angaba phakathi:

• Abesilisa: 4620 - 11500 U / L.
• Abesifazane: 3930 - 10800 U / L

Lokhu kuhlolwa kwenziwa njenganoma yikuphi okunye ukuhlolwa kwegazi, okungukuthi, kuqoqwa isampula legazi elincane bese lithunyelwa elabhorethri ukuze lihlaziywe ngumkhakha we-biochemistry. Ngokuya kwelabhorethri kunganconywa ukuthi uzile ukudla okungenani amahora ama-4.

Ukuthi imiphumela isho ukuthini

Wena amazinga aphansi I-cholinesterase ikakhulu ikhombisa ukuvezwa isikhathi eside kumuthi wokubulala izinambuzane we-organophosphate, okuyizinto ezikhona ezibulala izinambuzane, izibulala-zinambuzane nemithi yokubulala ukhula ekwazi ukuvimbela ukusebenza kwale enzyme, okuholela ekuqongeleleni kwe-acetylcholine futhi okungaholela ekubonakaleni kwezimpawu nezimpawu ezithile, njenge :

• Amajaqamba;
• Uhudo;
• Ukuhlanza;
• Ukweqisa amathe ngokweqile;
• Ubunzima bokubukwa;
• Ukwehla komfutho wegazi;
• Ubuthakathaka bemisipha;
• Ukukhubazeka.

Yize ukwehla kwamazinga e-cholinesterase ikakhulu kuhlobene nokudakwa, kungahle kube nokuncipha kwale enzyme uma kwenzeka i-hepatitis, i-cirrhosis, i-congestive heart failure, ukutheleleka okunamandla kanye ne-infarction.

Ngakho-ke, kubalulekile ukuthi imiphumela yokuhlolwa kwe-cholinesterase ihunyushwe kanye nemiphumela yezinye izivivinyo ukuze kutholakale imbangela yokwehla kwale enzyme futhi kuboniswe ukwelashwa okufanele kakhulu.

Ngokolunye uhlangothi, amazinga aphezulu ye-cholinesterase, evame ukwenzeka ngenxa yokukhuluphala, isifo sikashukela, i-nephrotic syndrome ne-hyperthyroidism.