Yini Eyenza Ingubo Yesikhumba Lymphoma Ihluke Kwamanye AmaLymphomas?

-Delile

• I-MCL iyi-B-cell non-Hodgkin's lymphoma
• I-MCL ivame ukuthinta amadoda amadala
• I-MCL ayijwayelekile kakhulu
• Isakazeka kusuka endaweni yengubo
• Kuhlotshaniswa nezinguquko ezithile zofuzo
• Kunolaka futhi kunzima ukwelapha
• Ingelashwa ngezindlela zokwelashwa eziqondisiwe
• Ukuthatha

I-Lymphoma ngumdlavuza wegazi okhula kuma-lymphocyte, uhlobo lweseli elimhlophe. Ama-lymphocyte adlala indima ebalulekile kumasosha akho omzimba. Lapho eba nomdlavuza, anda ngokungalawuleki futhi akhule abe izicubu.

Kunezinhlobo eziningi ze-lymphoma. Izinketho zokwelashwa nokubukwa kuyahlukahluka kuye ngohlobo oluthile kuye kolunye. Thatha isikhashana ufunde ukuthi i-mantle cell lymphoma (MCL) iqhathanisa kanjani nezinye izinhlobo zalesi sifo.

I-MCL iyi-B-cell non-Hodgkin's lymphoma

Kunezinhlobo ezimbili eziyinhloko ze-lymphoma: iHodgkin's lymphoma ne-non-Hodgkin's lymphoma. Kukhona ama-subtypes angaphezu kwama-60 we-non-Hodgkin's lymphoma. I-MCL ingenye yazo.

Kunezinhlobo ezimbili eziyinhloko zama-lymphocyte: Ama-T lymphocyte (T cell) nama-B lymphocyte (B cells). I-MCL ithinta amaseli we-B.

I-MCL ivame ukuthinta amadoda amadala

Ngokwe-American Cancer Society, iHodgkin’s lymphoma ivame ukuthinta abantu abadala abasebasha, ikakhulukazi abantu abaseminyakeni yama-20. Ngokuqhathanisa, i-MCL nezinye izinhlobo ze-non-Hodgkin's lymphoma zivame kakhulu kubantu abadala asebekhulile. ILymphoma Research Foundation ibika ukuthi abantu abaningi abane-MCL bangamadoda angaphezu kweminyaka engama-60.

Ngokuvamile, i-lymphoma ingenye yezinhlobo ezivame kakhulu zomdlavuza ezithinta izingane nentsha. Kepha ngokungafani nezinye izinhlobo ze-lymphoma, i-MCL ayivamile kakhulu kubantu abasha.

I-MCL ayijwayelekile kakhulu

I-MCL ayijwayelekile kakhulu kunezinye izinhlobo ze-lymphoma. Iqukethe cishe amaphesenti ama-5 wawo wonke amacala e-lymphoma, ngokwe-American Cancer Society. Lokhu kusho ukuthi i-MCL imele cishe u-1 kuma-lymphomas angama-20.

Ngokuqhathaniswa, uhlobo oluvame kakhulu lwe-non-Hodgkin's lymphoma lusabalalisa i-B-cell lymphoma enkulu, ebala cishe i-1 kuma-3 e-lymphomas.

Ngoba akuvamile, odokotela abaningi bangahle bangajwayele izindlela zakamuva zocwaningo nokwelashwa kwe-MCL. Uma kwenzeka, kungcono ukuvakashela i-oncologist egxile ku-lymphoma noma i-MCL.

Isakazeka kusuka endaweni yengubo

I-MCL ithola igama layo ngenxa yokuthi yakha endaweni yengubo ye-lymph node. Indawo yengubo iyindandatho yama-lymphocyte azungeze isikhungo se-lymph node.

Ngesikhathi itholakala, i-MCL ivame ukusabalala kwamanye ama-lymph node, kanye nezinye izicubu nezitho. Isibonelo, singasakazeka kumnkantsha wakho wethambo, ubende, namathumbu. Ezimweni ezingavamile, kungathinta ubuchopho bakho nomgogodla.

Kuhlotshaniswa nezinguquko ezithile zofuzo

I-lymph node evuvukile iyisifo esivame kakhulu se-MCL nezinye izinhlobo ze-lymphoma. Uma udokotela wakho esola ukuthi une-lymphoma, bazothatha isampula lezicubu ku-lymph node evuvukele noma kwezinye izingxenye zomzimba wakho ukuyozihlola.

Ngaphansi kwesibonakhulu, amaseli e-MCL abukeka efana nezinye izinhlobo ze-lymphoma. Kodwa ezimweni eziningi, amaseli anezimpawu zofuzo ezingasiza udokotela wakho ukuthi afunde ukuthi hlobo luni lwe-lymphoma. Ukuze wenze ukuxilongwa, udokotela wakho uzo-oda ukuhlolwa ukuze ahlole izimpawu ezithile zofuzo kanye namaprotheni.

Udokotela wakho angaphinde ahlele ezinye izivivinyo, njenge-CT scan, ukuze ufunde ukuthi umdlavuza usakaze yini. Bangabuye ba-oda i-biopsy yomnkantsha wakho wethambo, wamathumbu, noma ezinye izicubu.

Kunolaka futhi kunzima ukwelapha

Ezinye izinhlobo ze-non-Hodgkin's lymphoma ziphansi noma aziyeki. Lokho kusho ukuthi bathambekele ekukhuleni kancane, kepha ezimweni eziningi abelapheki. Ukwelashwa kungasiza ukunciphisa umdlavuza, kepha i-lymphoma esezingeni eliphansi ivame ukubuyela emuva, noma ibuye.

Ezinye izinhlobo ze-non-Hodgkin's lymphoma zisezingeni eliphezulu noma ezinolaka. Zivame ukukhula ngokushesha, kodwa zivame ukwelashwa. Lapho ukwelashwa kokuqala kuphumelela, i-high-grade lymphoma ayivame ukubuyela emuva.

I-MCL ayijwayelekile ngoba ikhombisa izici zombili ezinga eliphezulu kanye nezinga eliphansi le-lymphomas. Njengamanye ama-lymphomas ebanga eliphakeme, ivame ukukhula ngokushesha. Kodwa njengama-lymphomas asezingeni eliphansi, ngokuvamile ayelapheki. Iningi labantu abane-MCL bangena ekuxolelweni ngemuva kokwelapha kwabo kokuqala, kepha umdlavuza uvame ukubuyela emuva eminyakeni embalwa.

Ingelashwa ngezindlela zokwelashwa eziqondisiwe

Njengezinye izinhlobo ze-lymphoma, i-MCL ingalashwa ngenye yezindlela ezilandelayo:

• ukulinda okulindile
• izidakamizwa zamakhemikhali
• amasosha omzimba monoclonal
• inhlanganisela yamakhemikhali nokwelashwa kwamagciwane okuthiwa i-chemoimmunotherapy
• ukwelashwa ngemisebe
• ukufakelwa kwe-stem cell

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuphinde kwavuma nemithi emine ekhombe ngqo i-MCL:

• i-bortezomib (Velcade)
• lenalidomide (Revlimid)
• ibrutinib (Imbruvica)
• i-acalabrutinib (i-Calquence)

Yonke le mithi ivunyelwe ukusetshenziswa ngesikhathi sokubuyela emuva, ngemuva kokuthi ezinye izindlela zokwelapha sezivivinyiwe. IBortezomib nayo ivunyelwe njengokwelashwa komugqa wokuqala, okungasetshenziswa ngaphambi kwezinye izindlela. Izivivinyo eziningi zemitholampilo ziyaqhubeka ukutadisha ukusetshenziswa kwe-lenalidomide, ibrutinib, ne-acalabrutinib njengezindlela zokwelapha zomugqa wokuqala, nazo.

Ukuze ufunde kabanzi mayelana nezinketho zakho zokwelashwa, khuluma nodokotela wakho. Uhlelo lwabo lokwelashwa olunconyiwe luzoncika ebudaleni bakho nasempilweni yonke, nokuthi umdlavuza ukhula kuphi futhi kanjani emzimbeni wakho.

Ukuthatha

I-MCL ayivamile futhi iyinselele ukuyelapha. Kepha eminyakeni yamuva nje, izindlela zokwelapha ezintsha sezakhiwe futhi zamukelwa ukukhomba lolu hlobo lomdlavuza. Lezi zindlela zokwelapha ezintsha zikhulise kakhulu izimpilo zabantu abane-MCL.

Uma kunokwenzeka, kungcono ukuvakashela uchwepheshe womdlavuza onolwazi lokwelapha i-lymphoma, kufaka phakathi i-MCL. Lo chwepheshe angakusiza uqonde futhi ulinganise izinketho zakho zokwelashwa.