VIPoma

I-VIPoma ngumdlavuza ongavamile kakhulu ovame ukukhula kusuka kumaseli wama-pancreas abizwa ngokuthi ama-islet cells.

I-VIPoma ibangela ukuthi amaseli kuma-pancreas akhiqize izinga eliphezulu le-hormone ebizwa nge-vasoactive intestinal peptide (VIP). Le hormone yandisa uketshezi oluvela emathunjini. Iphinde ibuyisele eminye imisipha ebushelelezi ohlelweni lwesisu.

Imbangela ngqo yama-VIPomas ayaziwa.

I-VIPomas ivame ukutholwa kubantu abadala, imvamisa iba neminyaka yobudala engama-50. Abantu besifazane basemathubeni amaningi okuthinteka kunabesilisa. Lo mdlavuza uyivelakancane. Unyaka nonyaka, cishe umuntu oyedwa kwabangu-10 wezigidi otholakala ene-VIPoma.

Izimpawu ze-VIPoma zingafaka noma yikuphi okulandelayo:

• Ubuhlungu besisu nokuqaqamba
• Uhudo (amanzi, futhi kaningi ngamanani amakhulu)
• Ukuphela kwamanzi emzimbeni
• Ukuqhuma noma ukubomvu kobuso
• Amajaqamba wemisipha ngenxa ye-potassium yegazi ephansi (i-hypokalemia)
• Isicanucanu
• Ukwehla kwesisindo

Umhlinzeki wezokunakekelwa kwempilo uzokwenza ukuhlolwa ngokomzimba abuze ngomlando nezimpawu zakho zezokwelapha.

Ukuhlolwa okungenziwa kufaka phakathi:

• Ukuhlolwa kwamakhemikhali egazi (iphaneli eyisisekelo noma ephelele yemethaboli)
• I-CT scan yesisu
• I-MRI yesisu
• Ukuhlolwa kwesitokisi ngesizathu sohudo namazinga e-electrolyte
• Izinga le-VIP egazini

Inhloso yokuqala yokwelashwa ukulungisa ukuphela kwamanzi. Uketshezi kuvame ukunikezwa ngomthambo (uketshezi olufakwa emithanjeni) ukubuyisela uketshezi olulahlekile ngohudo.

Inhloso elandelayo ukunciphisa isifo sohudo. Imithi ingasiza ekulawuleni isifo sohudo. Omunye wemithi enjalo yi-octreotide. Kuyindlela eyenziwe ngabantu yehomoni yemvelo evimba isenzo se-VIP.

Ithuba elihle kakhulu lokwelashwa ukuhlinzwa kususwe isimila. Uma isimila singazange sisabalalele kwezinye izitho, ukuhlinzwa kungaselapha lesi sifo.

Unganciphisa ukucindezela kokugula ngokujoyina iqembu lokusekela umdlavuza. Ukwabelana nabanye abanokuhlangenwe nakho okuvamile nezinkinga kungakusiza ungazizwa uwedwa.

Ukuhlinzwa kuvame ukwelapha i-VIPomas. Kodwa, engxenyeni eyodwa kwezintathu kuya kwengxenye yabantu, isimila sesisabalele ngesikhathi sokuxilongwa futhi asikwazi ukwelashwa.

Izinkinga zingafaka:

• Ukusabalala komdlavuza (i-metastasis)
• Ukuboshwa kwenhliziyo kusuka ezingeni eliphansi le-potassium yegazi
• Ukuphela kwamanzi emzimbeni

Uma unesifo sohudo esinamanzi isikhathi esingaphezu kwezinsuku ezimbili kuya kwezi-3, shayela umhlinzeki wakho.

Isigaxa esikhiqiza amathumbu i-peptide emathunjini; I-VIPoma syndrome; Isimila se-Pancreatic endocrine

• Amapancreas

Iwebhusayithi yeNational Cancer Institute. Ukwelashwa kwe-Pancreatic neuroendocrine tumors (islet cell tumors) (PDQ) - inguqulo yezempilo. www.cancer.gov/types/pancreatic/hp/pnet-treatment-pdq. Kubuyekezwe uFebhuwari 8, 2018. Kufinyelelwe ngoNovemba 12, 2018.

USchneider DF, Mazeh H, Lubner SJ, Jaume JC, Chen H. Cancer wohlelo lwe-endocrine. Ku: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, abahleli. I-Abeloff’s Clinical Oncology. Umhlaka 5. IPhiladelphia, PA: Elsevier Saunders; 2014: isahluko 71.

UVella A. Amahomoni emathunjini namathumbu we-endocrine gut. Ku: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, abahleli. Incwadi kaWilliams ye-Endocrinology. Umhlaka 13. IPhiladelphia, PA: Elsevier; 2016: isahluko 38.