I-dysbetalipoproteinemia ejwayelekile

I-dysbetalipoproteinemia ejwayelekile yinkinga edluliswa emindenini. Kubangela inani eliphakeme le-cholesterol ne-triglycerides egazini.

Ukukhubazeka kofuzo kubanga lesi simo. Isici siphumela ekwakhiweni kwezinhlayiya ezinkulu ze-lipoprotein eziqukethe zombili i-cholesterol nohlobo lwamafutha abizwa nge-triglycerides. Lesi sifo sixhumene namaphutha kuhlobo lwe-apolipoprotein E.

I-Hypothyroidism, ukukhuluphala ngokweqile, noma isifo sikashukela kungenza isimo sibe sibi kakhulu. Izici zobungozi be-dysbetalipoproteinemia yomndeni zifaka umlando womndeni wesifo noma isifo semithambo yegazi.

Izimpawu kungenzeka zingabonakali kuze kube yiminyaka engama-20 noma ngaphezulu.

Ukufakwa okuphuzi kwezinto ezinamafutha esikhunjeni esibizwa ngokuthi ama-xanthomas kungavela emajwazini amahlombe, ezintendeni zezandla, ematheni ezinyawo, noma emathanjeni amadolo nezindololwane.

Ezinye izimpawu zingafaka:

• Ubuhlungu besifuba (i-angina) noma ezinye izimpawu zesifo se-coronary artery zingaba khona zisencane
• Ukucinana kwenkonyane elilodwa noma womabili lapho uhamba
• Izilonda ezinzwaneni ezingapholi
• Izimpawu ezinjengokushaywa unhlangothi ngokungazelelwe njengokukhathazeka ukukhuluma, ukwehla ohlangothini lobuso, ubuthakathaka bengalo noma umlenze, nokulahlekelwa ibhalansi

Ukuhlolwa okungenziwa ukuthola lesi simo kufaka:

• Ukuhlolwa kofuzo kwe-apolipoprotein E (apoE)
• Ukuhlolwa kwegazi lepaneli ye-Lipid
• Izinga le-Triglyceride
• Ukuhlolwa okuphansi kakhulu kwe-lipoprotein (VLDL) test

Inhloso yokwelashwa ukulawula izimo ezifana nokukhuluphala, i-hypothyroidism, nesifo sikashukela.

Ukwenza ushintsho ekudleni ukunciphisa ama-calories, amafutha agcwele, ne-cholesterol kungasiza ukwehlisa i-cholesterol egazini.

Uma amazinga e-cholesterol ne-triglyceride asephakeme ngemuva kokwenza ushintsho ekudleni, umhlinzeki wakho wokunakekelwa kwezempilo kungenzeka ukuthi nawe uthathe imishanguzo. Imithi yokwehlisa amazinga e-triglyceride egazi namazinga e-cholesterol afaka:

• Izinhlaka ze-acid-sequestering.
• Ama-Fibrate (gemfibrozil, fenofibrate).
• I-Nicotinic acid.
• Izitatimende.
• Ama-PCSK9 inhibitors, afana ne-alirocumab (Okubalulekile) ne-evolocumab (Repatha). Lokhu kumelela isigaba esisha semithi yokwelapha i-cholesterol.

Abantu abanalesi simo banengozi eyanda kakhulu yesifo se-coronary artery kanye nesifo semithambo yegazi.

Ngokwelashwa, abantu abaningi bayakwazi ukunciphisa kakhulu amazinga abo e-cholesterol kanye ne-triglycerides.

Izinkinga zingafaka:

• Isifo senhliziyo
• Unhlangothi
• Isifo semithambo yegazi
• Ukuhlukaniswa okuphakathi
• I-Gangrene yemikhawulo engezansi

Shayela umhlinzeki wakho uma utholwe unalesi sifo futhi:

• Izimpawu ezintsha ziyakhula.
• Izimpawu azithuthuki ngokwelashwa.
• Izimpawu ziba zimbi kakhulu.

Ukuhlola amalungu omndeni wabantu abanalesi simo kungaholela ekutholeni nasekwelashweni kusenesikhathi.

Ukwelashwa kusenesikhathi nokunciphisa ezinye izinto ezinobungozi ezifana nokubhema kungasiza ekuvimbeleni ukuhlaselwa yinhliziyo kusenesikhathi, ukushaywa unhlangothi, nokuvimba imithambo yegazi.

Thayipha i-hyperlipoproteinemia yohlobo III; I-apolipoprotein engasebenzi kahle noma enesici

• Isifo semithambo yegazi

UGenest J, ukuphazamiseka kweLibby P. Lipoprotein nesifo senhliziyo. Ku: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, ama-eds. Isifo Senhliziyo SikaBraunwald: Incwadi Yemithi Yezinhliziyo Nemithambo. Umhla ka-11. IPhiladelphia, PA: Elsevier; 2019: isahluko 48.

URobinson JG. Ukuphazamiseka kwe-lipid metabolism. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 195.