Ukushoda kwe-Factor V

Ukushoda kwe-Factor V yisifo esopha esedluliselwa emindenini. Kuthinta ikhono legazi lokujiya.

Ukujiya kwegazi inqubo eyinkimbinkimbi efaka amaprotheni amaningi afinyelela kwangu-20 e-plasma yegazi. Lawa maprotheni abizwa ngama-coagulation factor.

Ukushoda kweFactor V kudalwa ukungabi bikho kwesici V. Lapho izinto ezithile zokuvala igazi ziphansi noma zilahlekile, igazi lakho aligodli kahle.

Ukushoda kweFactor V akuvamile. Kungabangelwa:

• Isici esinesici se-V esidlulela emindenini (esizuzwe njengefa)
• I-antibody ephazamisa ukusebenza kwe-factor factor V

Ungakha i-antibody ephazamisa i-factor V:

• Ngemuva kokubeletha
• Ngemuva kokuphathwa ngohlobo oluthile lwe-fibrin glue
• Ngemuva kokuhlinzwa
• Ngezifo ezizimele kanye nomdlavuza othile

Kwesinye isikhathi imbangela ayaziwa.

Lesi sifo sifana ne-hemophilia, ngaphandle kokuthi ukopha emalungeni akuvamile. Ngendlela ezuzwe njengefa yokuntuleka kwe-factor V, umlando womndeni wesifo sokopha uyingozi.

Ukopha ngokweqile ngezikhathi zokuya esikhathini nangemva kokubeletha kuvame ukwenzeka. Ezinye izimpawu zingabandakanya:

• Ukopha esikhunjeni
• Ukopha kwezinsini
• Ukulinyazwa ngokweqile
• Ukopha ngamakhala
• Ukwehla kwegazi isikhathi eside noma ngokweqile ngokuhlinzwa noma ukuhlukumezeka
• Isigaxa sombila sisopha

Ukuhlolwa kokuthola ukushoda kwe-factor V kufaka:

• Isivivinyo se-Factor V
• Ukuhlolwa kokuvala igazi, kufaka phakathi isikhathi se-thromboplastin (PTT) kanye nesikhathi se-prothrombin
• Isikhathi sokopha

Uzonikezwa i-plasma yegazi noma ama-infusions amasha afriziwe afriziwe ngesikhathi sesiqephu sokopha noma ngemuva kokuhlinzwa. Lezi zindlela zokwelashwa zizolungisa ukuntuleka okwesikhashana.

Umbono muhle ngokuxilongwa nokwelashwa okufanele.

Ukopha kakhulu (ukopha) kungenzeka.

Iya egumbini labezimo eziphuthumayo noma ushayele ku-911 noma inombolo ephuthumayo yasendaweni uma ulahlekelwe igazi ngokungaqondakali noma isikhathi eside.

I-Parahemophilia; Isifo se-Owren; Ukuphazamiseka kwegazi - ukuntuleka kwesici V

• Ukwakheka kwegazi
• Amahlule egazi

UGailani D, Wheeler AP, Neff AT. Ukukhubazeka okujwayelekile kwe-coagulation factor. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ama-eds. I-Hematology: Izimiso Eziyisisekelo Nokuzijwayeza. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2018: isahluko 137.

I-Ragni MV. Ukuphazamiseka kokopha: ukuswela kwe-coagulation factor. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 165.

UScott JP, uZamcolo VH. Ukushoda kwegazi lokunqanda isici (ukuphazamiseka kwegazi). Ku: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Incwadi kaNelson Yezingane. Umhlaka 21. IPhiladelphia, PA: Elsevier; 2020: isahluko 503.