Ukukhula kwama-hormone okukhula - izingane

Ukuntuleka kwehomoni yokukhula kusho ukuthi indlala yebhinqa ayenzi i-hormone yokukhula eyanele.

Indlala ye-pituitary itholakala ezansi kobuchopho. Le ndlala ilawula ukulingana komzimba kwamahomoni. Futhi kwenza i-hormone yokukhula. Le hormone ibangela ingane ukuba ikhule.

Ukuntuleka kwehomoni yokukhula kungaba khona lapho kuzalwa. Ukukhula kwe-hormone yokukhula kungaba ngumphumela wesimo sezokwelapha. Ukulimala kanzima kobuchopho nakho kungadala ukushoda kwe-hormone yokukhula.

Izingane ezinokukhubazeka komzimba nobuso, njenge-cleft lip noma i-cleft palate, kungenzeka zehle izinga lokukhula kwama-hormone.

Isikhathi esiningi, imbangela yokushoda kwe-hormone yokukhula ayaziwa.

Ukukhula kancane kungaqala ukuqashelwa ebuntwaneni futhi kuqhubeke kuze kube ebuntwaneni. Udokotela wezingane uvame ukudweba ijika lokukhula kwengane eshadini lokukhula. Izingane ezinokushoda kwe-hormone yokukhula zinezinga lokukhula elincane noma eliphansi. Ukukhula kancane kungahle kungabonakali kuze kube yilapho ingane ineminyaka emibili noma emithathu ubudala.

Ingane izoba mfushane kakhulu kunezingane eziningi ezilingana nobulili obufanayo. Ingane isazoba nobukhulu obujwayelekile bomzimba, kepha ingahle ibe yisixuku. Ubuso bengane buvame ukubukeka bumncane kunezinye izingane ezilingana nazo. Ingane izoba nokuhlakanipha okujwayelekile ezimweni eziningi.

Ezinganeni ezindala, ukuthomba kungafika sekwedlule isikhathi noma kungafiki nhlobo, kuya ngesizathu.

Ukuhlolwa ngokomzimba, kufaka phakathi isisindo, ukuphakama, nokulingana komzimba, kuzokhombisa izimpawu zokukhula kancane. Ingane ngeke ilandele amajika ajwayelekile okukhula.

I-x-ray yesandla inganquma ubudala bethambo. Ngokuvamile, ubukhulu nokuma kwamathambo kuyashintsha lapho umuntu ekhula. Lezi zinguquko zingabonakala kwi-x-ray futhi zivame ukulandela iphethini lapho ingane ikhula.

Ukuhlola kuvame ukwenziwa ngemuva kokuthi udokotela wezingane ebheke ezinye izimbangela zokukhula okungekuhle. Ukuhlolwa okungenziwa kufaka phakathi:

• Isici sokukhula esinjenge-insulin 1 (IGF-1) ne-insulin efana nokukhula okubopha amaprotheni 3 (IGFBP3). Lezi yizinto ama-hormone okukhula abangela umzimba ukuthi uzenze. Ukuhlolwa kungalinganisa lezi zinto zokukhula. Ukuhlolwa kokushoda kwe-hormone okunembile kuhilela ukuhlolwa kokukhuthaza. Lokhu kuhlolwa kuthatha amahora amaningana.
• I-MRI yekhanda ingakhombisa izindlala ze-hypothalamus kanye ne-pituitary.
• Ukuhlolwa kokukala amanye amazinga ama-hormone kungenziwa, ngoba ukuntuleka kwe-hormone yokukhula kungenzeka kungabi yinkinga kuphela.

Ukwelashwa kubandakanya ukukhula kwe-hormone shots (imijovo) enikezwa ekhaya. Izibhamu zivame ukunikezwa kanye ngosuku. Izingane ezindala zivame ukufunda ukuthi zingazinikeza kanjani isibhamu.

Ukwelashwa nge-hormone yokukhula isikhathi eside, kuvame ukuhlala iminyaka eminingana. Ngalesi sikhathi, ingane idinga ukubonwa njalo ngudokotela wezingane ukuqinisekisa ukuthi ukwelashwa kuyasebenza. Uma kudingeka, umhlinzeki wezempilo uzoshintsha isilinganiso somuthi.

Imiphumela emibi yokwelashwa kwe-hormone yokukhula ayivelakancane. Imiphumela emibi ejwayelekile ifaka phakathi:

• Ubuhlungu bekhanda
• Ukugcinwa kwamanzi
• Ubuhlungu bemisipha namalunga
• Ukushelela kwamathambo enqunu

Lapho lesi sifo silashwa ngaphambi kwesikhathi, kuba ngcono amathuba okuthi ingane ikhule ifinyelele ebudaleni obujwayelekile obujwayelekile. Izingane eziningi zithola ama-intshi amane noma ngaphezulu (cishe amasentimitha ayi-10) ngonyaka wokuqala, kanye nama-intshi amathathu noma ngaphezulu (cishe amasentimitha angu-7.6) phakathi neminyaka emi-2 ezayo. Izinga lokukhula lincipha kancane kancane.

Ukwelashwa kwehomoni yokukhula akusebenzi kuzo zonke izingane.

Ukushiywa kungalashwa, ukushoda kwe-hormone yokukhula kungaholela esimweni esifushane nokubambezeleka kokuthomba.

Ukukhula kwe-hormone yokukhula kungenzeka ngokushoda kwamanye amahomoni afana nalawo alawulayo:

• Ukukhiqizwa kwamahomoni wegilo
• Ibhalansi yamanzi emzimbeni
• Ukukhiqizwa kwamahomoni ocansi owesilisa nowesifazane
• Izindlala ze-adrenal kanye nokukhiqizwa kwazo kwe-cortisol, i-DHEA, namanye ama-hormone

Shayela umhlinzeki wakho uma ingane yakho ibonakala imfishane ngokungafani neminyaka yayo.

Amacala amaningi awavikeleki.

Buyekeza ishadi lokukhula kwengane yakho nodokotela wezingane ekuhloleni ngakunye. Uma kunokukhathazeka ngezinga lokukhula kwengane yakho, kunconywa ukuhlolwa nguchwepheshe.

Ubuncane bepituitary; Ukutholakala kokushoda kwe-hormone yokukhula; Ukuntuleka kwe-hormone yokukhula okuhlukanisiwe; Ukukhubazeka kwe-hormone yokukhula kokuzalwa; I-Panhypopituitarism; Isiqu esifushane - ukushoda kwe-hormone yokukhula

• Izindlala ze-Endocrine
• Ukuphakama / ishadi lesisindo

ICooke DW, iDivall SA, uRadovick S. Ukukhula okujwayelekile nokungajwayelekile ezinganeni. Ku: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, abahleli. Incwadi kaWilliams ye-Endocrinology. Umhlaka 14. IPhiladelphia, PA: Elsevier; 2020: isahluko 25.

IGrimberg A, iDiVall SA, iPolychronakos C, et al. Imihlahlandlela yokukhula kwe-hormone ne-insulin efana nokukhula kwesici-I ukwelashwa ezinganeni nasebusheni: ukukhula kwe-hormone ukukhula, ukukhula okufushane kwe-idiopathic, kanye nokukhula okuyisisekelo okufana ne-insulin. IHorm Res Paediatr. 2016; 86 (6): 361-397. I-PMID: 27884013 www.ncbi.nlm.nih.gov/pubmed/27884013.

IPatterson BC, iFelner EI. I-Hypopituitarism. Ku: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Incwadi kaNelson Yezingane. Umhlaka 21. IPhiladelphia, PA: Elsevier; 2020: isahluko 573.