UMosisi

I-Mosaicic yisimo lapho amaseli kumuntu ofanayo enezakhi zofuzo ezihlukile. Lesi simo singathinta noma yiluphi uhlobo lweseli, kufaka phakathi:

• Amaseli egazi
• Amaqanda nesidoda
• Amaseli esikhumba

I-Mosaicism idalwa yiphutha lokwehlukaniswa kwamaseli kusenesikhathi ekukhuleni kwengane engakazalwa. Izibonelo zobuciko bomusa zifaka:

• I-Mosaic Down syndrome
• I-Mosaic Klinefelter syndrome
• I-Mosaic Turner syndrome

Izimpawu ziyahlukahluka futhi kunzima kakhulu ukubikezela. Izimpawu kungenzeka zingabi nzima uma unamaseli womabili ajwayelekile futhi angajwayelekile.

Ukuhlolwa kofuzo kungathola ukuthi i-mosaicism.

Ukuhlolwa kuzodinga ukuthi kuphindwe ukuze kuqinisekiswe imiphumela, nokusiza ekutholeni uhlobo nobukhulu besifo.

Ukwelashwa kuzoya ngohlobo nobukhulu besifo. Ungadinga ukwelashwa okuncane kakhulu uma kuphela amanye amangqamuzana angajwayelekile.

Wenza kahle kangakanani kuncike ekutheni yiziphi izitho nezicubu ezithintekayo (ngokwesibonelo, ubuchopho noma inhliziyo). Kunzima ukubikezela imiphumela yokuthola imigqa emibili ehlukene yamaseli kumuntu oyedwa.

Ngokuvamile, abantu abanesibalo esiphezulu samaseli angajwayelekile banombono ofanayo nowabantu abanesimo esijwayelekile sesifo (labo abanamaseli angajwayelekile). Ifomu elijwayelekile libizwa nangokuthi akuyona i-mosaic.

Abantu abanenombolo ephansi yamaseli angajwayelekile bangathinteka kancane. Bangase bangatholi ukuthi bane-mosaicism kuze kube yilapho bebeletha ingane enesimo esingeyona i-mosaic yalesi sifo. Kwesinye isikhathi ingane ezalwe ifomu elingelona ele-mosaic ngeke isinde, kepha ingane ezalwe ngobuciko be-mosaicism izosinda.

Izinkinga zincike ekutheni mangaki amangqamuzana athinteka wuguquko lofuzo.

Ukuxilongwa kwe-mosaicism kungadala ukudideka nokungaqiniseki. Umeluleki wezofuzo angasiza ukuphendula noma imiphi imibuzo mayelana nokuxilongwa nokuhlolwa.

Okwamanje ayikho indlela eyaziwayo yokuvimbela ukubumbana.

I-Chromosomal mosaicism; I-Gonadal mosaicism

UDriscoll DA, uSimpson JL, uHolzgreve W, u-Otaño L. Ukuhlolwa kofuzo nokuxilongwa kwezakhi zofuzo ngaphambi kokubeletha. Ku: Gabbe SG, Niebyl JR, Simpson JL, et al, eds. Ama-Obstetrics: Ukukhulelwa Okujwayelekile Nenkinga. Umhla wesi-7. IPhiladelphia, PA: Elsevier; I-2017: isahluko 10.

UNussbaum RL, McInnes RR, uWillard HF. Ukuxilongwa nokuhlolwa ngaphambi kokubeletha. Ku: Nussbaum RL, McInnes RR, Willard HF, ama-eds. Thompson noThompson Genetics kwezokwelapha. Umhlaka 8. IPhiladelphia, PA: Elsevier; 2016: isahluko 17.