I-Autosomal ngokweqile

Ukweqisa ngokweqile kwe-Autosomal kungenye yezindlela ezimbalwa lapho isici, ukuphazamiseka, noma isifo singadluliselwa emindenini.

Ukuphazamiseka ngokweqile kwe-autosomal kusho ukuthi kufanele kube khona amakhophi amabili wesakhi esingajwayelekile ukuze kuvele lesi sifo noma isici.

Ukuthola ifa lesifo esithile, isimo, noma isici esithile kuncike ohlotsheni lwe-chromosome ethintekile. Lezi zinhlobo ezimbili ngama-chromosomes angama-autosomal nama-chromosomes ocansi. Kuya futhi ngokuthi ngabe le mfanelo iyabusa noma ihlehlisile.

Ukuguqulwa kofuzo kwelinye lama-chromosomes angama-22 okuqala kungaholela ekuphazamisekeni kwe-autosomal.

Izakhi zofuzo ziza ngababili. Isakhi sofuzo esisodwa ngakunye sivela kumama, kanti esinye isakhi sivela kubaba. Ifa eliphindayo lisho ukuthi zombili izakhi zofuzo ngazimbili kufanele zingavamile ukudala izifo. Abantu abanegciwane elilodwa kuphela elonakele kulaba ababili babizwa ngokuthi abathwali.Laba bantu kaningi abathinteki ngalesi simo. Kodwa-ke, bangadlulisela isakhi esingajwayelekile ezinganeni zabo.

AMATHUBA OKUFA IFA NGESIFO

Uma uzalwa ngabazali bobabili abaphethe isakhi sofuzo se-autosomal efanayo, unethuba elilodwa koku-4 lokuthola ifuzo elingajwayelekile kubazali bobabili nokuthuthukisa lesi sifo. Unethuba lama-50% (1 koku-2) lokuthola ifa elilodwa elingavamile. Lokhu kungakwenza ube yisithwali.

Ngamanye amagama, enganeni ezalwa ngabashadikazi bobabili abaphethe isakhi sofuzo (kodwa abanazo izimpawu zesifo), umphumela olindelekile ekukhulelweni ngakunye ngukuthi:

• Amathuba angama-25% okuthi ingane izalwe inezakhi zofuzo ezimbili ezijwayelekile (ezijwayelekile)
• Amathuba angama-50% okuthi ingane izalwe inofuzo olulodwa olujwayelekile nolungavamile (othwala, ngaphandle kwesifo)
• Amathuba angama-25% okuthi ingane izalwe inezakhi zofuzo ezimbili ezingajwayelekile (engcupheni yesifo)

Qaphela: Le miphumela ayisho ukuthi izingane zizoba abathwali noma zithinteke kanzima.

I-genetics - i-autosomal recessive; Ifa - okweqile okuzenzakalelayo

• I-Autosomal ngokweqile
• Iziphazamiso zofuzo ezixhunywe ku-X
• Izakhi zofuzo

UFeero WG, uZazove P, uChen F. Imvelo yomtholampilo. Ku: Rakel RE, Rakel DP, ama-eds. Incwadi Yezokwelapha Yomndeni. Umhlaka 9. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 43.

UGregg AR, uKuller JA. Izakhi zofuzo zabantu namaphethini wefa. Ku: Resnik R, Lockwood CJ, Moore TR, Greene MF, Copel JA, Silver RM, abahleli. ICreasy neResnik's Maternal-Fetal Medicine: Izimiso kanye Nokuzijwayeza. Umhlaka 8. IPhiladelphia, PA: Elsevier; 2019: isahluko 1.

I-Korf BR. Izimiso zofuzo. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 35.