Ucwaningo Lwakamuva nge-Endometriosis: Okudingeka Ukwazi

-Delile

• Okwakamuva ekwelapheni i-endometriosis
• Imithi emisha yomlomo
• Izinketho zokuhlinzwa nokuhlolwa komtholampilo okuzayo
• Okwakamuva ekuhloleni i-endometriosis
• Ucwaningo olwengeziwe lwe-endometriosis emkhathizwe
• Amaseli enza kabusha
• Ukwelashwa kwe-Gene
• Ukuthatha

Ukubuka konke

I-Endometriosis ithinta abesifazane abalinganiselwa. Uma uphila ne-endometriosis, ungathatha izinyathelo ukuphatha izimpawu zalesi simo. Alikho ikhambi okwamanje, kodwa ososayensi basebenza kanzima befunda i-endometriosis nokuthi ingelashwa kanjani kangcono.

Eminyakeni yakamuva, ucwaningo olukhulayo luye lwahlola izimbangela ze-endometriosis, izindlela ezingezona ezesabekayo ezisetshenziselwa ukuxilonga lesi simo, nezinketho zokwelashwa zesikhathi eside. Funda ukuze ufunde ngentuthuko yakamuva.

Okwakamuva ekwelapheni i-endometriosis

Ukuphathwa kobuhlungu kuyinjongo eyinhloko yokwelashwa okuningi kwe-endometriosis. Kokubili imishanguzo kadokotela kanye neyezinhlungu zasesitolo kanye nezindlela zokwelapha ngamahomoni kuvame ukunconywa. Ukuhlinzwa nakho kuyindlela yokwelashwa.

Imithi emisha yomlomo

Ehlobo lika-2018, i-U.S.Food and Drug Administration (i-FDA) ivume ophikisana nomlomo wokuqala we-gonadotropin-release-hormone (GnRH) ukusiza abesifazane abanobuhlungu obulinganiselayo nobunzima be-endometriosis.

I-Elagolix iyi-. Isebenza ngokumisa ukukhiqizwa kwe-estrogen. Ihomoni estrogen inegalelo ekukhuleni kwesibazi se-endometrium nezimpawu ezingakhululekile.

Kubalulekile ukuthi wazi ukuthi abamelene ne-GnRH empeleni bafaka umzimba esikhathini sokuya esikhathini. Lokho kusho ukuthi imiphumela emibi ingafaka ukulahleka kwesisindo samathambo, ukushisa okushisayo, noma ukoma kwesitho sangasese sowesifazane, phakathi kwabanye.

Izinketho zokuhlinzwa nokuhlolwa komtholampilo okuzayo

I-Endometriosis Foundation of America ibheka ukuhlinzekwa nge-laparoscopic excision operation njengezinga legolide ekwelashweni kwalesi simo. Umgomo wokuhlinzwa ukususa izilonda ze-endometrium ngenkathi kugcinwa izicubu ezinempilo.

Ukuhlinzwa kungaphumelela ekwehliseni ubuhlungu obuhlobene ne-endometriosis, kuphawula ukubuyekeza kumagazini i-Women’s Health. Kungenzeka ngisho, ngokuvuma kusengaphambili, ukuthi udokotela ohlinzayo enze ukuhlinza ukukhipha i-endometriosis njengengxenye yenqubo efanayo yokuxilonga lesi simo. Ucwaningo lwango-2018 olubandakanya ababambiqhaza abangaphezu kuka-4,000 luthole ukuthi ukuhlinzwa nge-laparoscopic excision nakho kuyasebenza ekwelapheni ubuhlungu be-pelvic nezimpawu ezihlobene namathumbu ze-endometriosis.

Isivivinyo esisha somtholampilo eNetherlands sihlose ukwenza ukuhlinzwa kuphumelele ngokwengeziwe. Udaba olulodwa ngezindlela zokuhlinza zamanje ukuthi uma izilonda ze-endometriosis zingasuswa ngokuphelele, izimpawu zingabuya. Uma lokhu kwenzeka, ukuhlinzwa kungadinga ukuphindwa. Isivivinyo esisha somtholampilo sihlola ukusetshenziswa kwe-fluorescence imaging ukusiza ukuvimbela isidingo sokuhlinzwa okuphindaphindiwe.

Okwakamuva ekuhloleni i-endometriosis

Kusukela ekuhlolweni kwe-pelvic kuya kuma-ultrasound ukuya ekuhlinzekweni kwe-laparoscopic, izindlela eziphumelela kakhulu zokuthola i-endometriosis ziyahlasela kakhulu. Odokotela abaningi bangathola i-endometriosis ngokuya ngomlando wezokwelapha kanye nokuhlolwa komzimba. Kodwa-ke, ukuhlinzekwa nge-laparoscopic - okubandakanya ukufaka ikhamera encane ukuhlola ukusikeka kwe-endometrial - kuseyindlela ekhethwayo yokuxilonga.

I-Endometriosis ingathatha cishe iminyaka eyi-7 nengu-10 ukuxilonga. Ukushoda kwezivivinyo zokuxilonga ezingezona ezihlasela ngesinye sezizathu zaleso sikhathi eside.

Lokho kungashintsha ngelinye ilanga. Muva nje, ososayensi abane-Feinstein Institute of Medical Research bashicilele ucwaningo oluphakamisa ukuthi ukuhlolwa kwamasampuli egazi lokuya esikhathini kunganikeza indlela esebenzayo, engeyona eyokuhlasela yokuthola i-endometriosis.

Abaphenyi bathole ukuthi amaseli egazini lokuya esikhathini labesifazane abane-endometriosis anezici ezithile. Ngokuqondile, igazi lokuya esikhathini liqukethe amaseli ambalwa wesibeletho semvelo wesibeletho. Futhi bekuvame ukuba namaseli ama-stem "okwehlisa amandla okususa," inqubo elungiselela isibeletho sokukhulelwa.

Ucwaningo olwengeziwe luyadingeka. Kodwa kungenzeka ukuthi lezi zimaki ngelinye ilanga zinganikeza ngendlela esheshayo futhi engeyona eyokuhlasela yokuthola i-endometriosis.

Ucwaningo olwengeziwe lwe-endometriosis emkhathizwe

Ucwaningo lokutholakala kwe-endometriosis nokwelashwa luyaqhubeka. Izifundo ezimbili ezinkulu - futhi ezinye ze-sci-fi - zavela ekupheleni kuka-2018:

Amaseli enza kabusha

Ocwaningweni olwenziwe eNyakatho Ntshonalanga Yezokwelapha, abacwaningi bathole ukuthi amaseli we-stem womuntu (i-iPS) angenziwa "angahlelwa kabusha" aguqulwe abe ngamaseli wesibeletho anempilo, angena esikhundleni. Lokhu kusho ukuthi amaseli wesibeletho abangela ubuhlungu noma ukuvuvukala angashintshwa ngamaseli aphilile.

Lawa maseli adalwe ngokuhlinzekwa kowesifazane amaseli e-iPS. Lokho kusho ukuthi abukho ubungozi bokwaliwa komzimba, njengoba kukhona nezinye izinhlobo zokufakelwa.

Ucwaningo olwengeziwe luyadingeka. Kodwa kukhona okungenzeka ukuthi ukwelashwa okwenziwe ngamaseli kube yisixazululo sesikhathi eside se-endometriosis.

Ukwelashwa kwe-Gene

Isizathu se-endometriosis asikaziwa. Olunye ucwaningo lubonisa ukuthi ukucindezelwa kohlobo oluthile kungadlala indima.

Ososayensi baseYale University bashicilele ucwaningo oluthola ukuthi i-microRNA Let-7b - eyandulela izakhi zofuzo elawula izinkulumo zofuzo - icindezelwe kwabesifazane abane-endometriosis. Liyini ikhambi? Ukuphatha i-Let-7b kwabesifazane kungasiza ekwelapheni lesi simo.

Kuze kube manje, ukwelashwa kuboniswe ukuthi kusebenza kumagundane kuphela. Abaphenyi babone ukwehliswa okukhulu kwezilonda ze-endometrial ngemuva kokujova amagundane nge-Let-7b. Ucwaningo oluningi luyadingeka ngaphambi kokuhlolwa kubantu.

Uma ukwelashwa kwezakhi zofuzo kusebenza ngempumelelo kubantu, kungaba yindlela engeyona yokuhlinza, engeyona eyokuhlasela, futhi engeyona eye-hormonal yokwelapha i-endometriosis.

Ukuthatha

Yize lungekho ikhambi le-endometriosis, liyelapheka. Ucwaningo ngesimo, izinketho zokwelashwa, kanye nokuphathwa kuyaqhubeka. Uma unentshisekelo yokufunda kabanzi, khuluma nodokotela wakho. Bangakwazi ukuphendula imibuzo yakho futhi basikisele izinsiza zokuthola okwengeziwe.