Ukusiza

I-virilization yisimo lapho owesifazane eba khona nezimpawu ezihambisana namahomoni wesilisa (androgens), noma lapho umntwana osanda kuzalwa enezici zokuvezwa kwamahomoni wesilisa lapho ezalwa.

Ukwenza i-virilization kungabangelwa:

• Ukukhiqizwa okweqile kwe-testosterone
• Ukusetshenziswa kwe-anabolic steroids (ukuqinisa ukusebenza noma okuhlobene nokunikezwa kabusha kobulili)

Kubafana noma amantombazane asanda kuzalwa, lesi simo singabangelwa:

• Imithi ethile ethathwe ngumama ngesikhathi ekhulelwe
• I-hyperplasia engokwemvelo ye-adrenal enganeni noma kumama
• Ezinye izimo zezokwelapha kumama (njengezicubu zama-ovari noma izindlala ze-adrenal ezikhipha ama-hormone wesilisa)

Emantombazaneni adlula ebusheni, lesi simo singabangelwa:

• Isifo se-Polycystic ovary
• Imithi ethile, noma ama-anabolic steroids
• I-hyperplasia yokuzalwa ye-adrenal
• Izimila zama-ovari, noma izindlala ze-adrenal ezikhipha ama-hormone wesilisa (androgens)

Kwabesifazane abadala, lesi simo singabangelwa:

• Imithi ethile, noma ama-anabolic steroids
• Izimila zama-ovari noma izindlala ze-adrenal ezikhipha ama-hormone wesilisa

Izimpawu zokuqina kowesifazane kuvame ukuncika ezingeni le-testosterone emzimbeni.

Izinga eliphansi (elijwayelekile):

• Izinwele zobuso ezijiyile, ezimnyama endaweni yentshebe noma yamadevu
• Khulisa ezinweleni zomzimba
• Isikhumba esinamafutha noma induna
• Izikhathi zokuya esikhathini ezingajwayelekile

Ileveli emaphakathi (engajwayelekile):

• Impandla yomuntu wesilisa
• Ukulahleka kokuhanjiswa kwamafutha abesifazane
• Ukwehla kobukhulu besifuba

Izinga eliphakeme (elingavamile):

• Ukukhuliswa kwe-clitoris
• Ukujula kwezwi
• Iphethini yemisipha yabesilisa

Ukuhlolwa kungafaka:

• Ukuhlolwa kwegazi ukuthola i-testosterone eyeqile kwabesifazane
• I-CT scan, i-MRI, noma i-ultrasound ukukhipha izicubu zama-ovari nezindlala ze-adrenal

Uma i-virilization ibangelwa ukuvezwa kwama-androgens (ama-hormone wesilisa) kubantu abadala besifazane, izimpawu eziningi ziyaphela lapho amahomoni emiswa. Kodwa-ke, ukujula kwezwi kungumphumela onomphela wokuchayeka kuma-androgens.

• Ukukhiqizwa kwehypothalamus hormone

UGooren LJ. I-endocrinology yokuziphatha ngokocansi nobunikazi bobulili. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, abahleli. I-Endocrinology: Eyabantu Abadala Neyengane. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 124.

I-Styne DM, i-Grumbach MM. I-Physiology nokuphazamiseka kokuthomba. Ku: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, abahleli. Incwadi kaWilliams ye-Endocrinology. Umhlaka 13. IPhiladelphia, PA: Elsevier; 2016: isahluko 25.