Qedela

Umphelelisi ukuhlolwa kwegazi okulinganisa ukusebenza kwamaprotheni athile engxenyeni engamanzi yegazi lakho.

Uhlelo lokuncoma luyiqembu lamaprotheni acishe abe ngama-60 akwi-plasma yegazi noma ebusweni bamanye amangqamuzana. Amaprotheni asebenza namasosha akho omzimba futhi abambe iqhaza ekuvikeleni umzimba ezifweni, nokususa amangqamuzana afile nezinto zangaphandle. Imvamisa, abantu bangazuza njengefa ukuswela kwamanye amaprotheni ahambisanayo. Laba bantu bathambekele ezifweni ezithile noma ekuphazamisekeni komzimba.

Kunamaprotheni ayisishiyagalolunye amakhulu ahambisanayo. Zibhalwe ukuthi yi-C1 nge-C9. Lo mbhalo uchaza isivivinyo esilinganisa ingqikithi yomsebenzi wokuncoma.

Kudingeka isampula yegazi. Lokhu kuvame ukuthathwa ngomthambo. Inqubo ibizwa ngokuthi i-venipuncture.

Akukho ukulungiselela okukhethekile.

Lapho kufakwa inaliti ukuze kutholakale igazi, abanye abantu bezwa ubuhlungu obuncane. Abanye bangazizwa beshaywa noma betinyelwa kuphela. Ngemuva kwalokho, kungahle kube nokushaywa okuthile.

Umsebenzi ophelele wokugcwalisa (CH50, CH100) ubheka umsebenzi ophelele wohlelo lokuncoma. Ezimweni eziningi, ezinye izivivinyo eziqonde kakhulu lesi sifo okusolwa ukuthi zenziwa kuqala. I-C3 ne-C4 yizakhi ezihambisanayo ezilinganiswa kaningi.

Isivivinyo sokugcwalisa singasetshenziswa ukuqapha abantu abanesifo sokuzimela. Isetshenziselwa nokubheka ukuthi ngabe ukwelashwa kwesimo sabo kuyasebenza yini. Isibonelo, abantu abane-lupus erythematosus esebenzayo bangaba namazinga aphansi kunokujwayelekile amaprotheni wokugcwalisa i-C3 no-C4.

Umsebenzi wokugcwalisa uyahlukahluka emzimbeni wonke. Isibonelo, kubantu abane-arthritis ye-rheumatoid, ukugcwalisa umsebenzi egazini kungaba okujwayelekile noma okuphezulu kunokujwayelekile, kepha kunciphe kakhulu kunokujwayelekile kuketshezi oluhlangene.

Abantu abanokutheleleka okuthile kwegazi nokushaqeka kwegazi ngokuvamile bane-C3 ephansi kakhulu nezakhi zalokho okwaziwa ngokuthi enye indlela. I-C3 imvamisa iphansi futhi ekuthelelekeni kwefungal kanye nokutheleleka okuthile okuyimifino njengamalaleveva.

Imiphumela ejwayelekile yalolu vivinyo yilena:

• Ingqikithi yezinga lokugcwalisa igazi: amayunithi angama-41 kuya kwangu-90 we-hemolytic
• Izinga le-C1: 14.9 kuye ku-22.1 mg / dL
• Amazinga e-C3: 88 kuya ku-201 mg / dL
• Amazinga e-C4: 15 kuya ku-45 mg / dL

Qaphela: mg / dL = milligrams nge-desilitha ngalinye.

Qaphela: Amabanga wamanani ajwayelekile angahluka kancane kumalabhorethri ahlukile. Khuluma nomhlinzeki wakho wezokunakekelwa kwempilo mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Izibonelo ezingenhla zibonisa izilinganiso ezivamile zemiphumela yalezi zivivinyo. Amanye ama-laboratories asebenzisa izilinganiso ezahlukahlukene noma angahlola izinhlobo ezahlukene.

Umsebenzi owengeziwe wokuncoma ungabonakala ku:

• Umdlavuza
• Izifo ezithile
• I-ulcerative colitis

Ukwehla komsebenzi wokuncoma kungabonakala ku:

• Isifo sokuqina kwesibindi
• I-Glomerulonephritis
• I-angioedema yefa
• Isibindi
• Ukwenqatshwa kokufakelwa izinso
• I-Lupus nephritis
• Ukungondleki
• Uhlelo lupus erythematosus
• Okuvamile kuzuze njengefa ukugcwalisa ukusilela

Izingozi ezihambisana nokudonswa igazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• I-hematoma (ukuqoqwa kwegazi ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

"Umphelelisi we-cascade" uchungechunge lwezinto ezenzeka egazini. I-cascade isebenzisa amaprotheni ahambisanayo. Umphumela uba yunithi yokuhlasela edala izimbobo kulwelwesi lwamagciwane, ibabulale.

Gcwalisa isivivinyo; Qedelela amaprotheni

• Ukuhlolwa kwegazi

IChernecky CC, iBerger BJ. C. Ku: IChernecky CC, uBerger BJ, ama-eds. Ukuhlolwa Kwelabhoratri Nezinqubo Zokuxilonga. Umhlaka 6. ISt Louis, MO: Elsevier Saunders; 2013: 266-432.

Ama-Holers VM. Gcwalisa kanye nokwamukela kwayo: ukuqonda okusha kusifo somuntu. U-Annu Rev Immunol. 2014; 3: 433-459. I-PMID: 24499275 www.ncbi.nlm.nih.gov/pubmed/24499275.

IMerle NS, iSonto SE, iFremeaux-Bacchi V, iRoumenina LT. Gcwalisa ingxenye yohlelo I - izindlela zamangqamuzana zokwenza kusebenze kanye nomthethonqubo. Ngaphambili i-Immunol. 2015; 6: 262. I-PMID: 26082779 www.ncbi.nlm.nih.gov/pubmed/26082779.

IMerle NS, uNoe R, iHalbwachs-Mecarelli L, iFremeaux-Bacchi V, iRoumenina LT. Gcwalisa uhlelo ingxenye II: indima ekuvikeleni umzimba. Ngaphambili i-Immunol. 2015; 6: 257. I-PMID: 26074922 www.ncbi.nlm.nih.gov/pubmed/26074922.

UMorgan BP, uHarris CL. Ukugcwalisa, okubhekiswe ekwelashweni kwezifo ezivuthayo nezikhukhulayo. Nat Rev Izidakamizwa. 2015; 14 (2): 857-877. PMID: 26493766 www.ncbi.nlm.nih.gov/pubmed/26493766.