Ukuhlolwa kwamaprotheni amaningi we-Bence-Jones

Lokhu kuhlolwa kukala izinga lamaprotheni angajwayelekile abizwa ngamaprotheni eBence-Jones emchameni.

Isampula yomchamo wokubamba ehlanzekile iyadingeka. Indlela yokubamba ehlanzekile isetshenziselwa ukuvimbela amagciwane avela endondeni noma esithweni sangasese ekungeneni kusampula yomchamo. Ukuqoqa umchamo wakho, umhlinzeki wezokunakekelwa kwempilo angakunika ikhithi ekhethekile yokubamba ehlanzekile equkethe isisombululo sokuhlanza kanye nokusula okuyinyumba. Landela imiyalo ngqo ukuze imiphumela inembile.

Isampula lithunyelwa kulebhu. Lapho, enye yezindlela eziningi isetshenziselwa ukuthola amaprotheni eBence-Jones. Enye indlela, ebizwa nge-immunoelectrophoresis, iyona enembe kakhulu.

Isivivinyo sihilela ukuchama okujwayelekile kuphela, futhi akukho ukungaphatheki kahle.

Amaprotheni eBence-Jones ayingxenye yamasosha omzimba avamile abizwa ngamaketanga alula. Lawa maprotheni awavamile emchameni. Kwesinye isikhathi, lapho umzimba wakho wenza amasosha omzimba amaningi kakhulu, izinga lamaketanga alula nalo liyakhuphuka. Amaprotheni eBence-Jones mancane ngokwanele ukuthi angahlungwa izinso. Amaprotheni abe esechithela emchameni.

Umhlinzeki wakho anga-oda lokhu kuhlolwa:

• Ukuhlonza izimo eziholela kumaprotheni emchameni
• Uma unamaprotheni amaningi emchameni wakho
• Uma unezimpawu zomdlavuza wegazi obizwa nge-multiple myeloma

Umphumela ojwayelekile usho ukuthi awekho amaprotheni e-Bence-Jones atholakala emchameni wakho.

Amaprotheni eBence-Jones awatholakali emchameni. Uma kunjalo, kuvame ukuhlotshaniswa ne-myeloma eminingi.

Umphumela ongajwayelekile futhi ungaba ngenxa yalokhu:

• Ukwakhiwa okungajwayelekile kwamaprotheni kwizicubu nezitho (i-amyloidosis)
• Umdlavuza wegazi obizwa ngokuthi yi-chronic lymphocytic leukemia
• Umdlavuza wesistimu ye-lymph (lymphoma)
• I-buildup egazini leprotheyini elibizwa nge-M-protein (i-monoclonal gammopathy yokubaluleka okungaziwa; i-MGUS)
• Ukwehluleka kwezinso okungamahlalakhona

Azikho izingozi ngalokhu kuhlolwa.

Amaketanga wokukhanya we-Immunoglobulin - umchamo; Amaprotheni we-Urine Bence-Jones

• Uhlelo lwesilisa lomchamo

IChernecky CC, iBerger BJ. Amaprotheni electrophoresis - umchamo. Ku: IChernecky CC, iBerger BJ, ama-eds. Ukuhlolwa Kwelabhoratri Nezinqubo Zokuxilonga. Umhlaka 6. ISt Louis, MO: Elsevier Saunders; 2013: 920-922.

URiley RS, uMcPherson RA. Ukuhlolwa okuyisisekelo komchamo. Ku: McPherson RA, Pincus MR, abahleli. UHenry’s Clinical Diagnosis and Management by Laboratory Methods. Umhla ka-23. ISt Louis, MO: Elsevier; 2017: isahluko 28.

URajkumar SV, iDispenzieri A. I-myeloma eminingi kanye nokuphazamiseka okuhlobene. Ku: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, abahleli. I-Abeloff’s Clinical Oncology. Umhlaka 6. IPhiladelphia, PA: Elsevier; 2020: isahluko 101.