Impendulo ye-LH ekuhlolweni kwegazi kwe-GnRH

Impendulo ye-LH ku-GnRH ukuhlolwa kwegazi ukusiza ukuthola ukuthi ngabe indlala yakho yebhinqa ingaphendula kahle yini kwi-gonadotropin ikhipha i-hormone (GnRH). I-LH imele i-luteinizing hormone.

Kuthathwa isampula yegazi, bese unikezwa isibhamu seGnRH. Ngemuva kwesikhathi esishiwo, kuthathwa amasampula amaningi egazi ukuze kukalwe i-LH.

Akukho ukulungiselela okukhethekile okudingekayo.

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bazizwa beshaywa noma betinyelwa kuphela. Ngemuva kwalokho, kungahle kube nokushaywa okuthile noma ukulimazeka okuncane. Lokhu maduzane kuyaphela.

I-GnRH iyi-hormone eyenziwe yindlala ye-hypothalamus. I-LH yenziwa ngendlala ye-pituitary. I-GnRH ibangela (ivuselele) i-pituitary gland ukukhipha i-LH.

Lokhu kuhlolwa kusetshenziselwa ukutshela umehluko phakathi kwe-hypogonadism eyinhloko neyesibili. I-Hypogonadism yisimo lapho izindlala zobulili zenza khona ama-hormone amancane noma zingawenzi nhlobo. Emadodeni, izindlala zocansi (ama-gonads) angama-testes. Kwabesifazane, izindlala zocansi zingamaqanda.

Ngokuya ngohlobo lwe-hypogonadism:

• I-hypogonadism eyinhloko iqala esendeni noma esibelethweni
• I-hypogonadism yesibili iqala ku-hypothalamus noma i-pituitary gland

Lokhu kuhlolwa kungenziwa futhi ukubheka:

• Izinga eliphansi le-testosterone emadodeni
• Izinga eliphansi le-estradiol kwabesifazane

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma avivinye amasampula ahlukile. Khuluma nomhlinzeki wakho wezokunakekelwa kwempilo mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Impendulo eyandisiwe ye-LH iphakamisa inkinga kuma-ovari noma kuma-testes.

Impendulo encishisiwe ye-LH iphakamisa inkinga nge-hypothalamus gland noma i-pituitary gland.

Imiphumela engajwayelekile futhi ingabangelwa:

• Izinkinga ze-pituitary gland, njengokukhishwa kwehomoni eningi (hyperprolactinemia)
• Izimila ezinkulu zepituitary
• Ukwehla kwamahomoni enziwa yizindlala ze-endocrine
• Insimbi eningi kakhulu emzimbeni (hemochromatosis)
• Izinkinga zokudla, njenge-anorexia
• Ukulahleka kwesisindo kwakamuva, njengangemva kokuhlinzwa nge-bariatric
• Ukuthomba okulibazisekile noma okungekho (Kallmann syndrome)
• Ukungabi nezikhathi kwabesifazane (amenorrhea)
• Ukukhuluphala ngokweqile

Kunengozi encane ethintekayo ekuthatheni igazi lakho. Imithambo nemithambo yegazi kuyahluka ngosayizi komunye umuntu kuya kolunye uhlangothi lomzimba kuya kolunye. Ukuthatha igazi kwabanye abantu kungaba nzima kakhulu ukwedlula kwabanye.

Ezinye izingozi ezihlobene nokudonswa igazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• Ukubhoboza okuningi ukuthola imithambo
• I-hematoma (ukuqoqwa kwegazi ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

Ukuphendula kwe-hormone kwe-Luteinizing ku-hormone ekhipha i-gonadotropin

UGuber HA, uFarag AF. Ukuhlolwa komsebenzi we-endocrine. Ku: McPherson RA, Pincus MR, abahleli. UHenry’s Clinical Diagnosis and Management by Laboratory Methods. Umhla ka-23. ISt Louis, MO: Elsevier; 2017: isahluko 24.

I-Haisenleder DJ, uMarshall JC. Ama-gonadotropin: ukulawulwa kokuhlanganiswa nokufihlwa. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, abahleli. I-Endocrinology: Eyabantu Abadala Neyengane. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 116.