I-progesterone engu-17-OH

I-17-OH progesterone ukuhlolwa kwegazi okulinganisa inani le-progesterone engu-17-OH. Le yihomoni ekhiqizwa yizindlala ze-adrenal nezindlala zocansi.

Kudingeka isampula yegazi. Isikhathi esiningi, igazi likhishwa emthanjeni ongaphakathi endololwaneni noma ngemuva kwesandla.

Ezinsaneni noma ezinganeni ezincane, ithuluzi elibukhali elibizwa ngokuthi i-lancet lingasetshenziselwa ukubhoboza isikhumba.

• Igazi liqoqa kuthubhu encane yengilazi ebizwa nge-pipette, noma kwi-slide noma kumugqa wokuhlola.
• Kubekwa ibhandishi phezu kwale ndawo ukunqanda ukuphuma kwegazi.

Imithi eminingi ingaphazamisa imiphumela yokuhlolwa kwegazi.

• Umhlinzeki wakho wezokunakekelwa kwempilo uzokutshela uma kudingeka uyeke ukuthatha noma yimiphi imithi ngaphambi kokwenza lokhu kuhlolwa.
• Ungayeki noma ushintshe imithi yakho ngaphandle kokukhuluma nomhlinzeki wakho kuqala.

Ungase uzwe ubuhlungu obuncane noma isitinyela lapho kufakwa inaliti. Ungase futhi uzizwe ushaywa yisiza ngemuva kokukhishwa kwegazi.

Ukusetshenziswa okuyinhloko kwalesi sivivinyo ukuhlola izinsana ngesifo esizuzwe njengefa esithinta indlala ye-adrenal, ebizwa nge-congenital adrenal hyperplasia (CAH). Kuvame ukwenziwa ezinganeni ezizalwa nezitho zangasese zangaphandle ezingabonakali kahle njengezomfana noma ezentombazane.

Lokhu kuhlolwa kusetshenziselwa ukukhomba abantu ababa nezimpawu ze-CAH kamuva empilweni, isimo esibizwa nge-nonclassical adrenal hyperplasia.

Umhlinzeki angancoma lokhu kuhlolwa kwabesifazane noma amantombazane anezici zesilisa ezifana:

• Ukukhula kwezinwele okweqile ezindaweni lapho amadoda amadala ekhulisa khona izinwele
• Izwi elijulile noma ukwanda kwesisindo semisipha
• Ukungabikho kwama-mens
• Ukungabi nenzalo

Izindinganiso ezijwayelekile nezingajwayelekile ziyehluka ezinganeni ezizalwe zinesisindo esiphansi sokuzalwa. Ngokuvamile, imiphumela ejwayelekile imi kanje:

• Izingane ezingaphezu kwamahora angama-24 ubudala - ngaphansi kwama-nanograms angama-400 kuye kwangama-600 nge-decilita ngayinye (ng / dL) noma ngo-12.12 kuye ku-18.18 ama-nanomoles ngelitha ngalinye (nmol / L)
• Izingane ngaphambi kokuthomba cishe i-100 ng / dL noma i-3.03 nmol / L
• Abantu abadala - ngaphansi kuka-200 ng / dL noma u-6.06 nmol / L

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Khuluma nomhlinzeki wakho mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Izibonelo ezingenhla zibonisa izilinganiso ezivamile zemiphumela yalezi zivivinyo. Amanye ama-laboratories asebenzisa izilinganiso ezahlukahlukene noma angahlola izinhlobo ezahlukene.

Izinga eliphakeme le-progesterone engu-17-OH kungenzeka ngenxa ye:

• Amathumba endlala ye-adrenal
• I-congenital adrenal hyperplasia (CAH)

Ezinganeni ezine-CAH, izinga le-17-OHP lisukela ku-2 000 kuye ku-40,000 ng / dL noma ku-60.6 kuye ku-1212 nmol / L. Kubantu abadala, ileveli enkulu kune-200 ng / dL noma i-6.06 nmol / L ingahle ibangelwe yi-nonclassical adrenal hyperplasia.

Umhlinzeki wakho angaphakamisa ukuhlolwa kwe-ACTH uma ileveli ye-progesterone engu-17-OH iphakathi kuka-200 kuya ku-800 ng / dL noma u-6.06 kuye ku-24.24 nmol / L.

17-hydroxyprogesterone; Iprogesterone - 17-OH

UGuber HA, uFarag AF. Ukuhlolwa komsebenzi we-endocrine. Ku: McPherson RA, Pincus MR, abahleli. UHenry’s Clinical Diagnosis and Management by Laboratory Methods. Umhla ka-23. ISt Louis, MO: Elsevier; 2017: isahluko 24.

Rey RA, Josso N. Ukuxilongwa nokwelashwa kokuphazamiseka kokuthuthuka kwezocansi. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, abahleli. I-Endocrinology: Eyabantu Abadala Neyengane. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 119.

I-PC emhlophe. I-congenital adrenal hyperplasia kanye nokuphazamiseka okuhlobene nayo. Ku: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Incwadi kaNelson Yezingane. Umhlaka 21. IPhiladelphia, PA: Elsevier; 2020: isahluko 594.