Umlobi: Gregory Harris
Usuku Lokudalwa: 8 Epreli 2021
Ukuvuselela Usuku: 19 Unovemba 2024
Anonim
Linezolid - Mechanism, side effects and uses
Ividiyo: Linezolid - Mechanism, side effects and uses

-Delile

I-Linezolid isetshenziselwa ukwelapha izifo, kufaka phakathi i-pneumonia, kanye nokutheleleka kwesikhumba. I-Linezolid isekilasini lama-antibacterial okuthiwa i-oxazolidinones. Isebenza ngokumisa ukukhula kwamagciwane.

Ama-antibiotic afana ne-linezolid ngeke asebenzele imikhuhlane, umkhuhlane, nezinye izifo ezibangelwa amagciwane. Ukusebenzisa ama-antibiotic lapho kungadingeki kwandisa ingozi yakho yokuthola ukutheleleka kamuva okuphikisana nokwelashwa kwama-antibiotic.

I-Linezolid iza njengethebhulethi nokumiswa ngomlomo (uketshezi) ukuthatha ngomlomo. Imvamisa kuthathwa ngokudla noma ngaphandle kokudla kabili ngosuku (njalo ngamahora ayi-12) izinsuku eziyi-10 kuye kwangama-28. Izingane ezineminyaka engu-11 nangaphansi zivame ukuthatha i-linezolid ngokudla noma ngaphandle kokudla kabili noma kathathu ngosuku (njalo ngamahora ayisishiyagalombili kuya kwayi-12) izinsuku eziyi-10 kuya kwezingama-28. Ubude bokwelashwa kwakho buncike ohlotsheni lokutheleleka onalo. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-linezolid njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.


Ngaphambi kokusebenzisa ukumiswa ngomlomo, yihlanganise kahle ngokuguqula ibhodlela amahlandla amathathu kuye kwayisihlanu. Unganyakazisi ukumiswa.

Thatha i-linezolid uze uqede incwadi kadokotela, noma ngabe uzizwa ungcono. Ungayeki ukuthatha i-linezolid ngaphandle kokukhuluma nodokotela wakho. Uma uyeka ukuthatha i-linezolid maduzane noma uma weqa imithamo, ukutheleleka kwakho kungenzeka kungalashwa ngokuphelele futhi amabhaktheriya angamelana nemithi elwa namagciwane.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-linezolid,

  • Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-linezolid, noma imuphi omunye umuthi, noma yiziphi izithako zomkhiqizo we-linezolid obekiwe. Buza usokhemisi wakho ukuthola uhlu lwezithako.
  • Tshela udokotela wakho uma uphuza le mishanguzo elandelayo noma uyekile ukuyiphuza emasontweni amabili edlule: isocarboxazid (Marplan) phenelzine (Nardil). i-rasagiline (i-Azilect), i-selegiline (i-Eldepryl, i-Emsam, iZelapar), ne-tranylcypromine (i-Parnate). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-linezolid uma uthatha eyodwa noma ngaphezulu yale mithi, noma uyiphuzile emasontweni amabili edlule.
  • Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-epinephrine (EpiPen); i-meperidine (i-Demerol); imithi ye-migraine efana ne-almotriptan (Axert), i-eletriptan (i-Relpax), i-frovatriptan (i-Frova), i-naratriptan (i-Amerge), i-rizatriptan (i-Maxalt), i-sumatriptan (i-Imitrex, i-Treximet), ne-zolmitriptan (iZomig); i-phenylpropanolamine (ayisatholakali e-US); kanye ne-pseudoephedrine (Sudafed; emithini eminingi ebandayo noma yokuqeda amandla). Tshela nodokotela wakho uma uthatha le mithi elandelayo noma uyekile ukuyiphuza emasontweni amabili edlule: i-bupropion (i-Aplenzin, i-Wellbutrin, i-Zyban, abanye); buspirone; i-serotonin reuptake inhibitors (SSRIs) ekhethiwe efana ne-citalopram (Celexa), i-escitalopram (Lexapro), i-fluvoxamine (i-Luvox), i-paroxetine (i-Brisdelle, i-Paxil, i-Pexeva), i-sertraline (i-Zoloft), ne-vilazodone (i-Vilbyrd); i-serotonin norepinephrine reuptake inhibitors (SNRIs) efana ne-desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), levomilnacipran (Fetzima), ne-venlafaxine (Effexor); kanye ne-tricyclic antidepressants efana ne-amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), ne-trimontramine. Tshela nodokotela wakho uma uthatha i-fluoxetine (i-Prozac, i-Sarafem, i-Selfemra, ku-Symbyax), noma uyekile ukuyiphuza emasontweni ayisi-5 edlule. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-linezolid, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
  • Tshela udokotela wakho uma unesifo esingelapheki (esihlala isikhathi eside), noma uma uke waba ne-carcinoid syndrome (isimo lapho isimila sikhipha khona i-serotonin). isifo sikashukela, umfutho wegazi ophakeme, i-hyperthyroidism (i-thyroid engasebenzi ngokweqile), ukucindezela amasosha omzimba (izinkinga zesistimu yakho yomzimba), i-pheochromocytoma (isimila se-adrenal gland), ukuquleka, noma isifo sezinso.
  • utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-linezolid, shayela udokotela wakho.
  • uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-linezolid.
  • uma une-phenylketonuria (i-PKU, isimo esizuzwe njengefa lapho kufanele kudliwe ukudla okhethekile ukuvimbela ukubola kwengqondo), kufanele wazi ukuthi ukumiswa ngomlomo kuqukethe i-aspartame eyakha i-phenylalanine.

Gwema ukudla noma ukuphuza inani elikhulu lokudla neziphuzo eziqukethe i-tyramine ngenkathi uthatha i-linezolid. Ukudla neziphuzo ezifakwe emanzini anosawoti, ezibhemayo noma ezivutshiwe ngokuvamile ziqukethe i-tyramine. Lokhu kudla neziphuzo kufaka phakathi iziphuzo ezidakayo, ikakhulukazi ubhiya, iChianti, namanye amawayini abomvu; ubhiya ongenawo utshwala; ushizi (ikakhulukazi izinhlobo ezinamandla, ezindala, noma ezisetshenzisiwe); i-sauerkraut; iyogathi; omisiwe; ubhanana; ukhilimu omuncu; i-herring eqoshiwe; isibindi (ikakhulukazi isibindi senkukhu); inyama eyomile nesoseji (kufaka phakathi i-hard salami ne-pepperoni); amakhiwane asemathinini; ukwatapheya; I-soy sauce; igalikuni; ukukhishwa kwemvubelo; imikhiqizo yepapaya (kufaka phakathi amathenda athile enyama); ubhontshisi wefava; nezindumba zikabhontshisi ezibanzi.


Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Linezolid ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

  • isifo sohudo
  • ikhanda
  • isicanucanu
  • ukuhlanza
  • ubuhlungu besisu
  • shintsha ngendlela izinto ezinambitha ngayo
  • ukuqubuka
  • ukulunywa
  • isiyezi
  • amabala amhlophe emlonyeni
  • ukucasuka, ukushiswa, noma ukulunywa kwesitho sangasese sowesifazane
  • shintsha umbala wolimi noma amazinyo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

  • isifuba, ukuqubuka, ukulunywa, ukuphefumula kanzima noma ukugwinya, ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala, noma imilenze engezansi, ukuhhahazela
  • isikhumba esishayayo noma esikhanyayo
  • isicanucanu ephindaphindwayo nokuhlanza; ukuphefumula okusheshayo; ukudideka; ngizizwe ngikhathele
  • ubuhlungu, ukuba ndikindiki, noma ubuthakathaka ezandleni, ezinyaweni, noma kwezinye izitho zomzimba
  • Uhudo olunzima (indle enamanzi noma enegazi) engahle yenzeke noma ingenayo imfiva kanye neziqubu zesisu (kungenzeka izinyanga ezi-2 noma ngaphezulu ngemuva kokwelashwa kwakho)
  • ukopha okungajwayelekile noma ukulinyazwa
  • izinguquko kumbono wombala, ukungaboni kahle, noma ezinye izinguquko kumbono
  • isithuthwane

I-Linezolid ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.


Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Yigcine ekamelweni lokushisa kude nokukhanya nokushisa okweqile nomswakama (hhayi endlini yangasese). Ukumiswa ngomlomo kwe-Linezolid kufanele kusetshenziswe kungakapheli izinsuku ezingama-21.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help.Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula ukuhlolwa kwegazi okuthile ukuze ahlole impendulo yomzimba wakho ku-linezolid.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Isidakamizwa sakho kungenzeka ukuthi asigcwaliseki. Uma usenezimpawu zokutheleleka ngemuva kokuqeda i-linezolid, shayela udokotela wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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