IBosentan

-Delile

• Ngaphambi kokuthatha i-bosentan,
• IBosentan ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Lezi zimpawu ezilandelayo azivamile, kepha uma uhlangabezana nenye yazo noma leyo ebhalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Ezigulini zabesilisa nabesifazane:

IBosentan ingadala ukulimala kwesibindi. Tshela udokotela wakho uma uke waba nesifo sesibindi noma wake waba naso. Udokotela wakho uzoku-oda ukuhlolwa kwegazi ukuze aqiniseke ukuthi isibindi sakho sisebenza ngokujwayelekile ngaphambi kokuba uqale ukuthatha i-bosentan kanye nenyanga yonke ngesikhathi sokwelashwa kwakho. Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. IBosentan ingalimaza isibindi ngaphambi kokudala izimpawu. Ukuhlolwa kwegazi njalo kuyindlela kuphela yokuthola ukulimala kwesibindi ngaphambi kokuthi kube unomphela futhi kube nzima. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: isicanucanu, ukuhlanza, umkhuhlane, ubuhlungu besisu, ukuphuzi kwesikhumba noma kwamehlo, noma ukukhathala ngokweqile. Udokotela wakho angakunciphisa umthamo wakho, noma ayeke ukwelashwa kwakho nge-bosentan okwesikhashana noma unomphela uma uba nemiphumela engemihle noma unemiphumela engajwayelekile yelabhu.

Ezigulini zesifazane:

Ungathathi i-bosentan uma ukhulelwe noma uhlela ukukhulelwa. IBosentan ingalimaza umbungu. Uma ukwazi ukukhulelwa, kuzodingeka wenze ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa, njalo ngenyanga ngenkathi welashwa, nangenyanga e-1 ngemuva kokwelashwa kwakho ukukhombisa ukuthi awukhulelwe. Udokotela wakho uzoku-oda izivivinyo zokukhulelwa. Kufanele usebenzise indlela ethembekile yokulawula ukubeletha ngesikhathi sokwelashwa kwakho nenyanga e-1 ngemuva kokwelashwa kwakho. Izindlela zokuvimbela inzalo zeHormonal (amaphilisi okulawula ukubeletha, amabala, izindandatho, isibhamu, okufakelwa kanye namadivayisi we-intrauterine) kungenzeka angasebenzi kahle uma esetshenziswa ne-bosentan futhi akumele isetshenziswe njengendlela yakho kuphela yokulawula ukubeletha. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Ezimweni eziningi kuzodingeka ukuthi usebenzise izindlela ezimbili zokulawula ukubeletha.

Shayela udokotela wakho ngokushesha uma uya ocansini olungaphephile, cabanga ukuthi ukuvimbela inzalo yakho kwehlulekile, wehluleka ukuya esikhathini noma ucabange ukuthi ungakhulelwa ngenkathi uthatha i-bosentan. Musa ukulinda kuze kube ukuqokwa kwakho okulandelayo ukuxoxa ngalokhu nodokotela wakho.

Uma ungumzali noma umnakekeli wesiguli sesifazane esingakafiki ebusheni, hlola ingane yakho njalo ukuze ubone ukuthi ingabe ikhona yini izimpawu zokuthomba (amabele, amabele nezinwele) futhi yazise udokotela wayo nganoma yiziphi izinguquko.

Ngenxa yobungozi bokulimala kwesibindi nokukhubazeka kokuzalwa, i-bosentan itholakala kuphela ngohlelo olukhawulelwe olubizwa nge-Tracleer Risk Evaluation and Mitigation Strategy Program (Tracleer REMS). Ukuze uthole i-bosentan wena nodokotela wakho kufanele nibhaliswe ne-Tracleer REMS, futhi nilandele izidingo zezinhlelo ezifana kanye ngenyanga nokusebenza kwesibindi nokuhlolwa kokukhulelwa. Udokotela wakho uzokubhalisa ohlelweni. IBosentan itholakala kuphela kumakhemisi athile abhaliswe neTracleer REMS. Buza udokotela wakho noma usokhemisi uma unemibuzo mayelana nokuthi ungawugcwalisa kanjani umyalelo wakho.

Uzothola ishidi lemininingwane yeziguli lomkhiqizi (Umhlahlandlela Wokwelashwa) lapho uqala ukwelashwa nge-bosentan futhi isikhathi ngasinye lapho ugcwalisa umuthi. Funda imininingwane ngokucophelela isikhathi ngasinye bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungathola futhi i-Medication Guide kuwebhusayithi ye-FDA: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.

Khuluma nodokotela wakho ngezingozi zokuthatha i-bosentan.

IBosentan isetshenziselwa ukwelapha umfutho wegazi ophakeme wamaphaphu (PAH, umfutho wegazi ophakeme ezitsheni ezihambisa igazi emaphashini) kubantu abadala nezingane ezineminyaka emithathu nangaphezulu. IBosentan ingathuthukisa ikhono lokuzivocavoca futhi yehlise ukwanda kwezimpawu ezigulini ezine-PAH. UBosentan usekilasini lemithi ebizwa nge-endothelin receptor antagonists. Isebenza ngokumisa isenzo se-endothelin, into yemvelo ebangela ukuthi imithambo yegazi inciphise futhi ivimbele ukugeleza kwegazi okujwayelekile kubantu abane-PAH.

IBosentan iza njengethebhulethi futhi njengethebhulethi esakazekayo (ithebhulethi engaqedwa ngoketshezi) ukuthatha ngomlomo. Imvamisa kuthathwa ngokudla noma ngaphandle kokudla kabili ngosuku ekuseni nakusihlwa. Ukukusiza ukuthi ukhumbule ukuthatha i-bosentan, yithathe ngezikhathi ezifanayo nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-bosentan njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma uthatha ithebhulethi ehlakazekayo, beka ithebhulethi enamanzi amancane ngaphambi kokuyithatha. Uma udokotela wakho ekutshele ukuthi uthathe ithebhulethi uhhafu, phula ithebhulethi ehlakazekayo ngokucophelela kulayini. Thatha ithebhulethi uhhafu njengoba uqondisiwe, bese ubeka enye ingxenye emuva kwibhamuza elivuleke ephakeji. Sebenzisa enye ithebhulethi uhhafu zingakapheli izinsuku eziyi-7 Ungaphuli ithebhulethi ehlakazekayo ibe ngamakamelo.

Udokotela wakho kungenzeka akuqale ngomthamo ophansi we-bosentan futhi akhuphule umthamo wakho ngemuva kwamasonto amane.

IBosentan ilawula izimpawu ze-PAH kepha ayiyelaphi. Kungathatha izinyanga ezi-1 kuye kwezi-2 noma ngaphezulu ngaphambi kokuthi uzwe ngokugcwele nge-bosentan. Qhubeka uthathe i-bosentan noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-bosentan ngaphandle kokukhuluma nodokotela wakho. Uma ngokungazelelwe uyeka ukuthatha i-bosentan, izimpawu zakho zingase zibe zimbi kakhulu. Udokotela wakho anganciphisa umthamo wakho kancane kancane.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-bosentan,

• Tshela udokotela kanye nosokhemisi wakho uma uxabana ne-bosentan, noma imuphi omunye umuthi, noma iziphi izithako ezisemaphilisi e-bosentan noma amaphilisi asakazekayo.
• ungathathi i-cyclosporine (Gengraf, Neoral, Sandimmune) noma i-glyburide (i-DiaBeta, i-Glynase) ngenkathi uthatha i-bosentan.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo. Qiniseka ukuthi usho noma ikuphi kokulandelayo: amiodarone (Nexterone, Pacerone); imithi yokwehlisa i-cholesterol (ama-statins) njenge-atorvastatin (Lipitor, eCaduet), i-lovastatin (i-Altoprev), ne-simvastatin (i-Flolopid, i-Zocor, e-Vytorin); diltiazem (Cardizem, Cartia, Diltzac, abanye); i-erythromycin (E.E.S., Eryc, PCE); i-fluconazole (iDiflucan); gemfibrozil (Lopid); itraconazole (Onmel, Sporanox); ketoconazole; i-rifampin (Rifadin, Rimactane, eRifater, eRifamate); i-ritonavir (i-Norvir, eKaletra, e-Viekira Pak, e-Technivie); i-voriconazole (Vfend); kanye ne-warfarin (Coumadin, Jantoven). Eminye imishanguzo eminingi ingaxhumana ne-bosentan, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma ngabe uke wahlushwa yinhliziyo noma wake wahluleka (isimo lapho inhliziyo ingakwazi ukupompa igazi elanele kwezinye izingxenye zomzimba).
• tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa. Udokotela wakho mhlawumbe uzokutshela ukuthi ungancelisi ngenkathi uthatha i-bosentan.
• uma une-phenylketonuria (i-PKU, isimo esizuzwe njengefa lapho kufanele kudliwe ukudla okhethekile ukuvimbela ukubola kwengqondo), kufanele wazi ukuthi amaphilisi ahlakazekayo enziwe nge-aspartame, umthombo we-phenylalanine.

Khuluma nodokotela wakho ngokuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

IBosentan ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ukuqhuma
• ikhala eligobayo, umphimbo obuhlungu, nezinye izimpawu ezibandayo
• ubuhlungu obuhlangene

Eminye imiphumela emibi ingaba mibi. Lezi zimpawu ezilandelayo azivamile, kepha uma uhlangabezana nenye yazo noma leyo ebhalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isifuba; ukuqubuka; ukulunywa; ubunzima bokuphefumula noma ukugwinya; ukuvuvukala kobuso, umphimbo, ulimi, izindebe, namehlo; ukushaqeka; imfiva; ama-lymph node avuvukile; ukukhathala
• ukuvuvukala kwezinyawo, amaqakala, noma imilenze engezansi, ukukhuluphala okungazelelwe, inkinga eningi ngokuphefumula kunokujwayelekile
• ukuphefumula okusha noma okuya kuba kubi; ukukhwehlela okusha noma okuba kubi ngegazi noma ngaphandle kwalo; ubuhlungu besifuba; ukushesha, ukushaya ngamandla, noma ukushaya kwenhliziyo okungajwayelekile
• ukuquleka
• isiyezi; isikhumba esiphaphathekile; ukuphelelwa umoya; ubuthakathaka; ukushesha, ukushaya ngamandla, noma ukushaya kwenhliziyo okungajwayelekile

Izilwane zesilisa zaselabhorethri ezazinikezwa imishanguzo efana ne-bosentan zaba nezinkinga ngamasende azo futhi zakhiqiza isidoda esincane (amaseli okuzala abesilisa) kunokujwayelekile. Akwaziwa ukuthi i-bosentan izolimaza amasende noma yehlise inani lesidoda esikhiqizwa emadodeni. Khuluma nodokotela wakho ngezingozi zokuthatha i-bosentan uma ungathanda ukuba nezingane ngokuzayo.

IBosentan ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ikhanda
• isicanucanu
• ukuhlanza
• ukushaya kwenhliziyo okusheshayo
• ukuquleka
• ukujuluka
• isiyezi
• ukungaboni kahle

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza udokotela wakho noma yimiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Tracleer^®