I-insulin Glulisine (umsuka we-rDNA) Injection

-Delile

• Ngaphambi kokusebenzisa i-insulin glulisine,
• I-insulin glulisine ingadala ushintsho kushukela wegazi lakho. Kufanele wazi izimpawu zikashukela wegazi ophansi futhi ophakeme nokuthi yini okufanele uyenze uma unalezi zimpawu.
• I-insulin glulisine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• I-insulini glulisine overdose ingenzeka uma usebenzisa i-insulin ngokweqile noma uma usebenzisa inani elifanele le-insulin glulisine kodwa udle okuncane kunokujwayelekile noma uzivocavoca umzimba kunokujwayelekile. I-insulin glulisine overdose ingadala i-hypoglycemia. Uma unezimpawu ze-hypoglycemia, landela imiyalo kadokotela wakho yokuthi yini okufanele uyenze uma uba ne-hypoglycemia. Ezinye izimpawu zokudlula ngokweqile zingafaka:

I-insulin glulisine isetshenziselwa ukwelapha isifo sikashukela sohlobo 1 (isimo lapho umzimba ungenzi khona i-insulin ngakho-ke awukwazi ukulawula inani likashukela egazini). Ibuye isetshenziselwe ukwelapha abantu abanesifo sikashukela sohlobo lwe-2 (isimo lapho ushukela wegazi uphakeme kakhulu ngoba umzimba awukhiqizi noma usebenzise i-insulin ngokwejwayelekile) abadinga i-insulin ukulawula isifo sikashukela. Ezigulini ezinesifo sikashukela sohlobo 1, i-insulin glulisine ivame ukusetshenziswa nolunye uhlobo lwe-insulin, ngaphandle kwalapho isetshenziswa kwiphampu ye-insulin yangaphandle. Ezigulini ezinesifo sikashukela sohlobo 2, i-insulin glulisine nayo ingasetshenziswa nolunye uhlobo lwe-insulin noma ngemithi yomlomo yesifo sikashukela. I-insulin glulisine yinguqulo efushane, eyenziwe ngumuntu ye-insulin yomuntu. I-insulin glulisine isebenza ngokufaka esikhundleni se-insulin evame ukukhiqizwa ngumzimba nokusiza ukuhambisa ushukela egazini uye kwezinye izicubu zomzimba lapho isetshenziselwa khona amandla. Iphinde ime isibindi ekukhiqizeni ushukela owengeziwe.

Ngokuhamba kwesikhathi, abantu abanesifo sikashukela kanye noshukela ophakeme wegazi bangakhula babe nezinkinga ezinkulu noma ezisongela impilo, kufaka phakathi isifo senhliziyo, isifo sohlangothi, izinkinga zezinso, ukulimala kwemizwa nezinkinga zamehlo. Ukusebenzisa imithi, ukwenza izinguquko endleleni ophila ngayo (isb., Ukudla, ukuzivocavoca, ukuyeka ukubhema), nokuhlola njalo ushukela wegazi lakho kungasiza ukuphatha isifo sikashukela futhi kuthuthukise impilo yakho. Lokhu kwelashwa kunganciphisa namathuba akho okuhlaselwa yisifo senhliziyo, isifo sohlangothi, noma ezinye izinkinga ezihlobene nesifo sikashukela njengokuhluleka kwezinso, ukulimala kwemizwa (okundikindiki, imilenze ebandayo noma izinyawo; ukwehla kwekhono lezocansi kwabesilisa nabesifazane), izinkinga zamehlo, kufaka phakathi izinguquko noma ukulahleka kombono, noma isifo sezinsini. Udokotela wakho nabanye abahlinzeki bezokunakekelwa kwezempilo bazokhuluma nawe ngendlela engcono yokuphatha isifo sikashukela.

I-insulin glulisine iza njengesisombululo (uketshezi) ukujova ngomgogodla (ngaphansi kwesikhumba). Imvamisa ijovwa kuze kube yimizuzu eyi-15 ngaphambi kokudla noma kungakapheli imizuzu engama-20 ngemuva kokuqala ukudla. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Sebenzisa i-insulin glulisine njengoba nje uqondisiwe. Ungayisebenzisi ngaphezulu noma ngaphansi kwayo noma uyisebenzise kaningi kunokuyalelwa ngudokotela wakho.

Ungalokothi usebenzise i-insulin glulisine uma unezimpawu ze-hypoglycemia (ushukela ophansi wegazi) noma uma uhlolisise ushukela wegazi lakho wakuthola kuphansi. Ungafaki i-insulin endaweni yesikhumba ebomvu, evuvukile, enukayo noma ejiyile.

I-insulin glulisine ilawula isifo sikashukela kodwa ayiselaphi. Qhubeka nokusebenzisa i-insulin glulisine noma ngabe uzizwa uphilile. Ungayeki ukusebenzisa i-insulin glulisine ngaphandle kokukhuluma nodokotela wakho. Ungashintsheli kolunye uhlobo noma uhlobo lwe-insulin noma ushintshe umthamo wanoma yiluphi uhlobo lwe-insulin oyisebenzisayo ngaphandle kokukhuluma nodokotela wakho. Njalo hlola ilebula le-insulin ukuze uqiniseke ukuthi uthola uhlobo olulungile lwe-insulin ekhemisi.

I-insulini glulisine iza ngezimbiza kanye nasezibayeni zokufaka okuqukethe ama-cartridges emithi. Qiniseka ukuthi uyazi ukuthi uluhlobo luni lwesitsha i-insulin glulisine yakho engenayo nokuthi iziphi ezinye izinto, njengezinaliti, imijovo, noma amapeni, ozodinga ukujova umuthi wakho.

Uma i-insulin glulisine yakho ifika ngezimbiza, kuzodingeka usebenzise imijovo yokujova umthamo wakho. Cela udokotela wakho noma usokhemisi ukuthi akubonise ukuthi ungayijova kanjani i-insulin glulisine usebenzisa isipontsho. Buza udokotela noma usokhemisi wakho uma unemibuzo ngohlobo lomjovo okufanele uwusebenzise.

Uma i-insulin glargine yakho iza ezibayeni, qiniseka ukuthi ufunda futhi uqonde iziyalezo zomkhiqizi. Cela udokotela wakho noma usokhemisi ukuthi akubonise ukuthi uyisebenzisa kanjani ipeni. Landela izinkomba ngokucophelela, futhi njalo wenze ukuhlolwa kokuphepha ngaphambi kokusetshenziswa.

Ungalokothi usebenzise izinaliti noma imijovo futhi ungalokothi wabelane ngezinaliti, imijovo noma izibaya. Uma usebenzisa ipeni le-insulin, hlala njalo ngenaliti ngemuva nje kokujova umthamo wakho. Lahla izinaliti nemijovo esitsheni esingamelana nokubhoboza. Buza udokotela wakho noma usokhemisi ukuthi ungasilahla kanjani isitsha esingamelana nokubhoboza.

Udokotela wakho angakutshela ukuthi uhlanganise i-insulin glulisine yakho nolunye uhlobo lwe-insulin (NPH insulin [Novolin N, Humulin N]) esirinji efanayo. Ungahlanganisi noma uhlaze i-insulin glulisine nganoma yiluphi olunye uhlobo lwe-insulin. Uma uxuba i-insulin glulisine ne-NPH insulin, dweba i-insulin glulisine esirinji kuqala, bese udweba i-NPH insulin esirinji bese ujova ikhambi ngemuva nje kokuxuba.

Ungafaka i-insulin glulisine yakho emathangeni akho, esiswini, noma ezingalweni ezingaphezulu. Ungalokothi ujove i-insulin glulisine emthanjeni noma emisipheni. Shintsha (jikelezisa) indawo yokujova ngaphakathi kwendawo ekhethiwe ngomthamo ngamunye; zama ukugwema ukujova isiza esifanayo kaningi ngaphezu kwesisodwa njalo emavikini ayi-1 kuye kwayi-2.

Njalo bheka i-insulin glulisine yakho ngaphambi kokuyijova. Kufanele icace futhi ingenambala. Ungayisebenzisi i-insulin glulisine yakho uma inombala, inamafu, noma iqukethe izinhlayiya eziqinile, noma usuku lokuphelelwa yisikhathi ebhodleleni seludlulile.

I-insulin glulisine nayo ingasetshenziswa ngepompo yangaphandle ye-insulin. Ngaphambi kokusebenzisa i-insulin glulisine ohlelweni lokumpompa, funda ilebula lepompo ukuze uqiniseke ukuthi iphampu lingasetshenziselwa ukulethwa okuqhubekayo kwe-insulin esebenza ngokushesha. Funda ibhukwana lempompo lamachibi anconywayo kanye namasethi weshubhu, bese ucela udokotela noma usokhemisi wakho ukuthi akubonise ukuthi uyisebenzisa kanjani ipompo ye-insulin. Ungayinciphisi i-insulin glulisine noma uyixube nanoma yiluphi olunye uhlobo lwe-insulin uma uyisebenzisa kupampu ye-insulin yangaphandle. I-insulini glulisine esetshenziswe kwimpompo yangaphandle ye-insulin kufanele ifakwe esiswini sakho. Uma usebenzisa i-insulin glulisine kwiphampu yangaphandle ye-insulin, buyisela i-insulin echibini bese ushintsha indawo yokufaka amabhubhu, inaliti nendawo yokumnika (indawo lapho iphampu linamathele khona emzimbeni) okungenani njalo emahoreni angama-48. Uma isiza sokumnika sibomvu, siluma, noma sijiyile, tshela udokotela wakho bese usebenzisa indawo ehlukile yokumnika.

Uma usebenzisa i-insulin glulisine kwimpompo yangaphandle ye-insulin, ushukela ophakeme wegazi kungenzeka ngokushesha uma ipompo iyeka ukusebenza kahle noma uma i-insulin esemgodini wepompo ivezwa ilanga eliqondile noma amazinga okushisa angaphezu kuka-98.6 ° F (37 ° C). Ushukela wegazi ophakeme kungenzeka futhi uma i-tubing ivuza noma ivinjwe, inqanyuliwe, noma i-kinks. Ungadinga ukushintsha isethaphu yokumnika kanye ne-insulin endaweni yokumpompa noma yokumnika uma uneshukela ephezulu yegazi, i-alamu yempompo iyakhala, noma ukugeleza kwe-insulin kuvinjiwe. Uma inkinga ingatholakali ngokushesha futhi ilungiswe, shayela udokotela wakho ngokushesha. Ungadinga ukusebenzisa i-insulin okwesikhashana ngomjovo ongaphansi (usebenzisa imijovo noma ipeni le-insulin). Qiniseka ukuthi une-back-up insulin nanoma yiziphi izinto ezidingekayo esandleni, bese ucela udokotela noma usokhemisi wakho ukuthi akubonise ukuthi uzisebenzisa kanjani.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa i-insulin glulisine,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-insulin (Humulin, Novolin, abanye), noma iziphi izithako ze-insulin glulisine, noma omunye umuthi. Buza usokhemisi wakho noma hlola imininingwane yesiguli somkhiqizi ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-angiotensin-converting enzyme (ACE) inhibitors efana ne-benazepril (Lotensin), i-captopril (Capoten), i-enalapril (i-Vasotec), i-fosinopril (i-Monopril), i-lisinopril (i-Prinivil, i-Zestril), i-moexipcil ( , i-perindopril (i-Aceon), i-quinapril (i-Accupril), i-ramipril (i-Altace), ne-trandolapril (i-Mavik); ama-beta blockers anjenge-atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), nepropranolol (Inderal); imishanguzo ethile yokwehlisa i-cholesterol efana ne-fenofibrate (Antara, Lofibra, TriCor, Triglide), gemfibrozil (Lopid), ne-niacin (Niacor, Niaspan, ku-Advicor); i-clonidine (Catapres, Catapres-TTS, eClorpres); i-danazol; i-disopyramide (iNorpace); isisu (‘amaphilisi amanzi’); i-fluoxetine (i-Prozac, i-Sarafem, ku-Symbyax); i-glucagon (i-Glucagen); ukwelashwa kwe-hormone esikhundleni; i-isoniazid (INH, Nydrazid); lithium (Eskalith, Lithobid); imithi yesifuba somoya nemikhuhlane; imishanguzo ethile yegciwane lengculazi (i-HIV) okubandakanya i-amprenavir (Agenerase), atazanavir (Reyataz), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (eKaletra), nelfinavir (Viracept), ritonavir (eKaletra, Norvir), saquina (Invirase), kanye netipranavir (Aptivus); imithi yokugula ngengqondo kanye nesicanucanu; i-monoamine oxidase (MAO) inhibitors efana ne-isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), ne-tranylcypromine (i-Parnate); izindlela zokuvimbela inzalo zamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, imijovo, noma okufakelwa); i-octreotide (iSandostatin); imithi yomlomo yesifo sikashukela; i-steroids yomlomo efana ne-dexamethasone (i-Decadron, i-Dexone), i-methylprednisolone (i-Medrol), ne-prednisone (i-Deltasone); ipentamidine (NebuPent, Pentam); i-pentoxifylline (i-Pentoxil, iTrental); i-pramlintide (Symlin); qamba kabusha; ubuhlungu be-salicylate buqeda njenge-aspirin, i-choline magnesium trisalicylate (iTricosal, i-Trilisate), i-choline salicylate (i-Arthropan), i-diflunisal (i-Dolobid), i-magnesium salicylate (i-Doan's, abanye), ne-salsalate (i-Argesic, i-Disalcid, i-Salgesic); somatropin (Nutropin, Serostem, abanye); i-sulfa antibiotic; nemithi yegilo. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma ngabe uke waba nomonakalo wezinzwa obangelwa yisifo sikashukela noma ezinye izimo zezokwelapha, kufaka phakathi isifo sezinso noma sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi usebenzisa i-insulin glulisine, shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi usebenzisa i-insulin glulisine.
• utshwala bungadala ushintsho kushukela wegazi. Buza udokotela wakho mayelana nokusetshenziswa okuphephile kweziphuzo ezidakayo ngenkathi usebenzisa i-insulin glulisine.
• buza udokotela wakho ukuthi wenzeni uma ugula, uba nengcindezi engajwayelekile, noma ushintshe izinga lokuzivocavoca nomsebenzi. Lezi zinguquko zingathinta ushukela wegazi lakho kanye nenani le-insulin ongayidinga.
• buza udokotela wakho ukuthi kufanele uhlole kaningi kangakanani ushukela wegazi lakho. Yazi ukuthi i-hypoglycemia ingathinta ikhono lakho lokwenza imisebenzi efana nokushayela bese ubuza udokotela wakho ukuthi udinga ukuhlola ushukela wegazi ngaphambi kokushayela noma ukusebenzisa imishini.

Qiniseka ukuthi ulandela zonke izincomo zokuzivocavoca nezokudla ezenziwa ngudokotela wakho noma udokotela odlayo. Kubalulekile ukudla ukudla okunempilo nokudla cishe inani elifanayo lokudla cishe ngezikhathi ezifanayo usuku ngalunye. Ukweqa noma ukubambezela ukudla noma ukushintsha inani noma uhlobo lokudla okudlayo kungadala izinkinga ngokulawulwa kukashukela egazini lakho.

I-insulin glulisine kufanele ijojowe imizuzu eyi-15 ngaphambi noma kungakapheli imizuzu engama-20 ngemuva kokuqala ukudla. Uma sekudlule isikhathi esithile ngemuva kokudla kwakho, landela imiyalo enikezwe udokotela wakho noma ushayele udokotela wakho ukuthola ukuthi kufanele yini ujove umthamo ongabanjwanga. Musa ukujova umthamo ophindwe kabili ukwenzela okulahlekile.

I-insulin glulisine ingadala ushintsho kushukela wegazi lakho. Kufanele wazi izimpawu zikashukela wegazi ophansi futhi ophakeme nokuthi yini okufanele uyenze uma unalezi zimpawu.

I-insulin glulisine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ububomvu, ukuvuvukala, noma ukulunywa esizeni somjovo
• izinguquko ekuzizweleni kwesikhumba sakho, ukuqina kwesikhumba (ukwakhiwa kwamafutha), noma ukuqaqanjelwa okuncane esikhunjeni (ukonakala kwamafutha)
• ukuvuvukala kwezandla nezinyawo
• ukuzuza kwesisindo
• ukuqunjelwa

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka kanye / noma ukulunywa emzimbeni wonke
• ukuphelelwa umoya
• isifuba
• isiyezi
• ukungaboni kahle
• ukushaya kwenhliziyo okusheshayo
• ukujuluka
• ukukhanya / ukuquleka
• ukuphefumula kanzima noma ukugwinya
• ubuthakathaka
• amajaqamba
• ukushaya kwenhliziyo okungavamile

I-insulin glulisine ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Gcina izitsha ze-insulin ezingavuliwe nezibaya esiqandisini kude nokukhanya. Ungalokothi uvumele i- insulin glulisine iqhwa; ungasebenzisi i-insulin glulisine efriziwe yancibilika. Izitsha ze-insulin glulisine ezivulekile zingafakwa esiqandisini noma zingagcinwa ekamelweni lokushisa, kude nelanga eliqondile nokushisa, izinsuku ezingama-28. Izibaya ezigcwalisiwe ezingasetshenziswanga zingafakwa esiqandisini noma zingagcinwa ekamelweni lokushisa, kude nokushisa okuqondile nelanga, kuze kube yizinsuku ezingama-28. Izibaya ezigcwaliswe ngaphambili ezisetshenzisiwe akufanele zifakwe esiqandisini; kufanele zigcinwe ekamelweni lokushisa kuze kube yizinsuku ezingama-28 ngemuva kokusetshenziswa kokuqala. Lahla izitsha ze-insulin ezivulekile nezibaya ngemuva kwezinsuku ezingama-28. Lahla i-insulin engafakwanga evuliwe, efrijini ngemuva kosuku lokuphelelwa yisikhathi oluprintwe kulebula. Lahla noma iyiphi i-insulin glulisine eye yaba yiqhwa noma yashiswa ukushisa okukhulu.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

I-insulini glulisine overdose ingenzeka uma usebenzisa i-insulin ngokweqile noma uma usebenzisa inani elifanele le-insulin glulisine kodwa udle okuncane kunokujwayelekile noma uzivocavoca umzimba kunokujwayelekile. I-insulin glulisine overdose ingadala i-hypoglycemia. Uma unezimpawu ze-hypoglycemia, landela imiyalo kadokotela wakho yokuthi yini okufanele uyenze uma uba ne-hypoglycemia. Ezinye izimpawu zokudlula ngokweqile zingafaka:

• ukulahlekelwa ukwazi
• isithuthwane

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Ushukela wegazi kanye ne-hemoglobin eglycosylated (HbA1c) kufanele ihlolwe njalo ukuthola impendulo yakho ku-insulin glulisine. Udokotela wakho uzokutshela nokuthi ungayihlola kanjani impendulo yakho ku-insulin ngokulinganisa amazinga kashukela egazini lakho ekhaya. Landela le miyalo ngokucophelela.

Kufanele njalo ufake isongo lokuhlonza isifo sikashukela ukuze uqiniseke ukuthi uthola ukwelashwa okufanele esimeni esiphuthumayo.

Ungavumeli omunye umuntu asebenzise imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Apidra^®