Vorinostat

-Delile

• Ngaphambi kokuthatha i-vorinostat,
• IVorinostat ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

IVorinostat isetshenziselwa ukwelapha i-T-cell lymphoma (CTCL, uhlobo lomdlavuza) kubantu abanezifo ezingakathuthuki, ziye zaba zimbi kakhulu, noma zabuya ngemuva kokuthatha eminye imishanguzo. IVorinostat isekilasini lemithi ebizwa nge-histone deacetylase (HDAC) inhibitors. Isebenza ngokubulala noma ngokumisa ukukhula kwamangqamuzana omdlavuza.

IVorinostat iza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa kanye ngosuku ngokudla. Udokotela wakho uzokutshela ukuthi uthathe i-vorinostat nsuku zonke noma ngezinsuku ezithile zeviki. Thatha i-vorinostat ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-vorinostat njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungazivuli, uzihlafune noma uzichoboze. Uma ungakwazi ukugwinya wonke amaphilisi, shayela udokotela wakho. Uma ama-vorinostat capsules evulwe ngengozi noma echotshoziwe, ungawathinti ama-capsule noma i-powder. Uma i-powder ephuma ekhanda elivuliwe noma elichoboziwe ifika esikhunjeni sakho noma emehlweni noma ekhaleni, geza indawo kahle ngamanzi amaningi bese ushayela udokotela wakho ucingo.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-vorinostat,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-vorinostat, noma imiphi eminye imithi, noma iziphi izithako kuma-vorinostat capsules. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi kokulandelayo: ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven), i-belinostat (i-Beleodaq), ne-valproic acid (i-Depakene). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma unesicanucanu, uhlanza, noma uhudo; futhi uma uke waba negazi emaphashini noma emthanjeni (umthambo wegazi); ushukela ophakeme wegazi noma isifo sikashukela; arrhythmias (ukushaya kwenhliziyo okungavamile noma izinkinga zesigqi senhliziyo); amazinga aphansi we-potassium noma i-magnesium, nenhliziyo, izinso, noma isifo sesibindi.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Kuzofanele wenze ukuhlolwa kokukhulelwa okungenani ezinsukwini eziyi-7 ngaphambi kokuqala imishanguzo. Uma ungowesifazane okwaziyo ukukhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nezinyanga eziyisithupha ngemuva komthamo wakho wokugcina. Uma ungowesilisa nomlingani wesifazane ongakhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nezinyanga ezi-3 ngemuva komthamo wakho wokugcina. Uma ukhulelwa ngenkathi uthatha i-vorinostat, shayela udokotela wakho ngokushesha. IVorinostat ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa. Akufanele uncelise ibele ngenkathi uthatha i-vorinostat kanye neviki elilodwa ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi i-vorinostat ingakwenza ukozele. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.
• kufanele wazi ukuthi i-vorinostat ingadala ukwanda kweglucose egazini. Uma unesifo sikashukela noma ushukela ophakeme wegazi, hlola ushukela wegazi kaningi njengokuyalelwa ngudokotela wakho. Uma ushukela wegazi lakho uphakeme kunokujwayelekile, shayela udokotela wakho. Tshela udokotela wakho ngokushesha uma unanoma iyiphi yalezi zimpawu ezilandelayo ngenkathi uthatha i-vorinostat: ukoma ngokweqile, ukuchama kaningi, ukulamba ngokweqile, ukungaboni kahle, noma ubuthakathaka. Kubaluleke kakhulu ukubiza udokotela wakho ngokushesha uma unezinye zalezi zimpawu, ngoba ushukela wegazi ongelashwa ungadala isimo esibi esibizwa nge-ketoacidosis. I-Ketoacidosis ingasongela impilo uma ingelashwa kusenesikhathi. Izimpawu ze-ketoacidosis zibandakanya umlomo owomile, isisu esibuhlungu nokuhlanza, ukuphefumula okuncane, ukuphefumula okunuka izithelo, nokuncipha kokuqonda. Shayela udokotela wakho uma ungakwazi ukudla noma ukuphuza ngokwejwayelekile ngenxa yesicanucanu, ukuhlanza, noma isifo sohudo ngenkathi uthatha i-vorinostat. Udokotela wakho angadinga ukushintsha indlela odla ngayo noma imithi yakho ukusiza ukulawula ushukela wegazi ngenkathi uthatha i-vorinostat.

Qiniseka ukuthi uphuza okungenani izinkomishi zamanzi ezingama-8-ounce (240-milliliter) zamanzi noma ezinye iziphuzo nsuku zonke ngenkathi uthatha i-vorinostat ukuze ungaphelelwa amanzi emzimbeni.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

IVorinostat ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• isicanucanu
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• ukuhlanza
• ukuqunjelwa
• ukukhathala ngokweqile
• Ukugodola
• shintsha ngendlela izinto ezinambitha ngayo
• umlomo owomile
• ukulahleka kwezinwele
• isiyezi
• ukuvuvukala kwemilenze, izinyawo, noma amaqakala
• ukulunywa
• ukukhwehlela
• imfiva
• ikhanda
• ubuhlungu bemisipha

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ukopha okungajwayelekile noma ukulinyazwa
• isikhumba esiphaphathekile
• ukuvuvukala okungazelelwe, ububomvu, imfudumalo, ubuhlungu, kanye / noma isisa emlenzeni
• ukubomvu kwesikhumba noma ukushintsha kombala wesikhumba
• ubuhlungu besifuba obubukhali ngokungazelelwe
• ukuphelelwa umoya
• ekhwehlela igazi
• ukujuluka
• ukushaya kwenhliziyo okusheshayo
• ukuquleka
• ukuzizwa ngikhathazekile

IVorinostat ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-vorinostat.

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho kanye nabasebenzi belebhuthi ukuthi uthatha i-vorinostat.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho; buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa imishanguzo yakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UZolinza^®