Nilotinib

-Delile

• Ngaphambi kokuthatha i-nilotinib,
• I-Nilotinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

I-Nilotinib ingadala ukwandiswa kwe-QT (isigqi senhliziyo esingajwayelekile esingaholela ekuphelelweni amandla, ekulahlekelweni ukwazi, kokuquleka, noma ekufeni okungazelelwe). Tshela udokotela wakho ukuthi ngabe wena noma omunye emndenini wakho une-QT syndrome ende (isimo esizuzwe njengefa lapho umuntu kungenzeka abe ne-QT prolongation) noma uke waba namazinga aphansi we-potassium noma i-magnesium egazini lakho , ukushaya kwenhliziyo okungajwayelekile, noma isifo sesibindi. Tshela udokotela wakho kanye nosokhemisi uma uthatha i-amiodarone (Nexterone, Pacerone); ama-antifungals anjenge ketoconazole, itraconazole (Onmel, Sporanox), noma i-voriconazole (Vfend); i-chloroquine (iPlaquenil); i-clarithromycin (i-Biaxin, ku-Prevpac); i-disopyramide (iNorpace); i-erythromycin (E.E.S., Eryc, PCE); imishanguzo ethile yegciwane lesandulela ngculazi (i-HIV) noma i-immunodeficiency syndrome (i-AIDS) efana ne-atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, e-Kaletra), ne-saquinavir (i-Invirase); i-haloperidol (iHaldol); i-methadone (i-Dolophine, i-Methadose); moxifloxacin (Avelox); nefazodone; ipimozide (i-Orap); procainamide; i-quinidine (ku-Nuedexta); sotalol (Betapace, Betapace AF, abanye); i-telithromycin (Ketek); futhi thioridazine. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, yeka ukuthatha i-nilotinib bese ushayela udokotela wakho ngokushesha: ukushesha, ukushaya ngamandla, noma ukushaya kwenhliziyo okungajwayelekile; ukuquleka; ukulahlekelwa ukwazi; noma ukuquleka.

Ungadli noma yikuphi ukudla okungenani amahora ama-2 ngaphambi kokuthatha i-nilotinib nehora elilodwa ngemuva kokuthatha lo muthi.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzoku-oda izivivinyo ezithile, njengokuhlolwa kwegazi nama-electrocardiograms (EKGs, izivivinyo ezirekhoda ukusebenza kukagesi wenhliziyo) ngaphambi nangesikhathi sokwelashwa kwakho ukuze uqiniseke ukuthi kuphephile yini ukuthi ungathathi i-nilotinib.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-nilotinib futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokuthatha i-nilotinib.

I-Nilotinib isetshenziselwa ukwelapha izinhlobo ezithile ze-myeloid leukemia engapheli (i-CML; uhlobo lomdlavuza wamangqamuzana amhlophe egazi) asanda kuthola ukuthi unalesi simo kubantu abadala nezingane ezineminyaka engu-1 nangaphezulu. Ibuye isetshenziselwe ukwelapha izinhlobo ezithile ze-CML isifo sayo ebesingalapheki ngempumelelo nge-imatinib (Gleevec) noma abantu abadala abangakwazi ukuthatha imatinib. INilotinib ibuye isetshenziselwe ukwelapha izinhlobo ezithile ze-CML ezinganeni ezineminyaka engu-1 ubudala noma ngaphezulu isifo sazo esingalapheki ngempumelelo ngezinye izindlela zokwelapha ze-tyrosine kinase inhibitor. UNilotinib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukumisa noma ukubambezela ukusabalala kwamangqamuzana omdlavuza.

UNilotinib uza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa ngaphandle kokudla kabili ngosuku. I-Nilotinib kufanele ithathwe ngaphandle kwesisu esingenalutho, okungenani amahora amabili ngaphambi noma ihora eli-1 ngemuva kokudla noma yikuphi ukudla. Thatha i-nilotinib ngasikhathi sinye nsuku zonke. Zama ukubeka imithamo yakho cishe amahora angama-12 ngokuhlukana. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-nilotinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi ngengilazi yamanzi; ungawahlukanisi, ungawahlafune noma uwagxoze. Uma ungakwazi ukugwinya wonke ama-capsule, hlanganisa okuqukethwe kwephilisi ngethispuni elilodwa le-appleauce. Gwinya ingxube ngokushesha (kungakapheli imizuzu engu-15.) Ungayigcini leyo ngxube ukuze uyisebenzise esikhathini esizayo.

Udokotela wakho anganciphisa umthamo wakho we-nilotinib noma ayeke ukwelashwa kwakho ngokuya ngokuthi umuthi usebenza kanjani kuwe futhi uma uhlangabezana neminye imiphumela emibi. Qhubeka uthathe i-nilotinib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-nilotinib ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-nilotinib,

• Tshela udokotela wakho kanye nosokhemisi uma unalellerin nilotinib, noma imiphi eminye imithi, noma iziphi izithako ezikuma-nilotinib capsules. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi uyayisho imishanguzo ebhalwe esigabeni ESIBALULEKILE SEXWAYISO nokunye okulandelayo: ama-angiotensin-receptor blocker anjenge-irbesartan (Avapro, e-Avalide) ne-losartan (Cozaar, e-Hyzaar); ama-anticoagulants (’’ ama-thinner egazi ’’) njenge-warfarin (Coumadin, Jantoven); i-aripiprazole (Abilify); ama-benzodiazepines afana ne-alprazolam (Xanax), i-diazepam (i-Valium), i-midazolam ne-triazolam (i-Halcion); ibuspirone (Buspar); ama-blocker wesiteshi se-calcium anjenge-amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Tiazac, others), felodipine, nicardipine (Cardene), nifedipine (Adalat, Procardia), nisoldipine (Sular), kanye ne-verapamil (Calan, Verelan, abanye) ; imishanguzo ethile yokwehlisa i-cholesterol (ama-statins) afaka i-atorvastatin (Lipitor), i-fluvastatin (i-Lescol XL), i-lovastatin (i-Altoprev), ne-simvastatin (i-Zocor); i-chlorpheniramine (i-Chlor-Trimeton, okunye ukukhwehlela nemikhiqizo ebandayo); i-dexamethasone; i-dihydroergotamine (i-DHH 45, i-Migranal); i-ergotamine (eCafergot, e-Ergomar); i-fentanyl (i-Actiq, i-Duragesic, i-Subsys); i-flecainide (iTambocor); imishanguzo ethile yokudangala efana ne-amitriptyline, desipramine (Norpramin); i-duloxetine (iCymbalta); imipramine (Tofranil); i-paroxetine (Brisdelle, Paxil, Pexeva); kanye ne-venlafaxine (i-Effexor); imithi ethile yomlomo yesifo sikashukela efana ne-glipizide (Glucotrol) ne-tolbutamide; imithi ethile ecindezela amasosha omzimba njenge-cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), kanye ne-tacrolimus (Prograf); imithi ethile yokuquleka efana ne-carbamazepine (i-Equetro, iTegretol, iTeril), i-phenobarbital, ne-phenytoin (iDilantin, Phenytek); i-mexiletine; imishanguzo ethile yokulwa nokuvuvukala (i-NSAID) efana ne-celecoxib (Celebrex), i-diclofenac (i-Voltaren), i-ibuprofen (i-Advil, i-Motrin), i-naproxen (i-Aleve, i-Naprosyn), ne-piroxicam (i-Feldene); i-ondansetron (iZofran); propafenone (Rythmol); ama-proton-pump inhibitors afana ne-esomeprazole (Nexium), i-lansoprazole (i-Prevacid), i-omeprazole (i-Prilosec), i-pantoprazole (i-Protonix), ne-rabeprazole (i-AcipHex); i-quinine (i-Qualaquin); i-rifabutin (i-Mycobutin); i-rifampin (i-Rifadin); i-rifapentine (Priftin); i-risperidone (i-Risperdal); i-sildenafil (i-Viagra, i-Revatio); tamoxifen; testosterone (Androderm, Androgel, Striant, abanye); timolol; i-torsemide; i-tramadol (i-Ultram, ku-Ultracet); i-trazodone; no-vincristine. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingase futhi ihlanganyele ne-nilotinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• uma uthatha ama-antacid aqukethe i-magnesium, aluminium (Maalox, Mylanta, Tums, others), noma i-simethicone, thatha i-antacid 2 hours ngaphambi noma okungenani amahora amabili ngemuva kokuthatha i-nilotinib.
• uma uthatha umuthi we-indigestion, isilungulela, noma izilonda ezifana ne-cimetidine (Tagamet), i-famotidine (i-Pepcid, e-Duexis), i-nizatidine (i-Axid), noma i-ranitidine (i-Zantac), thatha okungenani amahora ayi-10 ngaphambi noma okungenani okungu-2 amahora ngemuva kokuthatha i-nilotinib.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma uke wahlaselwa isifo sohlangothi noma wahlinzwa ukukhipha isisu sonke (i-gastrectomy ephelele). Futhi, tshela udokotela wakho uma ngabe wehlise noma wehla ukugeleza kwegazi emilenzeni yakho, noma yiziphi izinkinga zenhliziyo, izinkinga zokopha, i-pancreatitis (ukuvuvukala kwamanyikwe, indlala engemuva kwalowo okhiqiza izinto ezizosiza ngokugaya), noma yisiphi isimo kwenza kube nzima kuwe ukugaya i-lactose (ubisi ushukela) noma obunye ushukela.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Akufanele ukhulelwe ngenkathi uthatha i-nilotinib. Kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nge-nilotinib nezinsuku eziyi-14 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma ukhulelwa ngenkathi uthatha i-nilotinib, shayela udokotela wakho ngokushesha. UNilotinib angalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthatha i-nilotinib nezinsuku eziyi-14 ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-nilotinib.

Ungadli isithelo samagilebhisi, uphuze ijusi lamagilebhisi, noma uthathe noma isiphi isengezo esine-grapefruit ekhishwe ngenkathi uthatha lo muthi.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Nilotinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuqubuka
• ukulunywa
• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuqunjelwa
• isilungulela
• igesi
• ukulahlekelwa isifiso sokudla
• ikhanda
• isiyezi
• ukukhathala
• ubunzima bokulala noma ukulala
• ukujuluka ebusuku
• amajaqamba
• iqolo, ithambo, ilunga, isitho noma ubuhlungu bemisipha
• ukulahleka kwezinwele
• isikhumba esomile noma esibomvu
• ukuba ndikindiki, ukushiswa, noma ukuncinza ezandleni noma ezinyaweni

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ukopha okungajwayelekile noma ukulinyazwa
• igazi emchameni
• ezinegazi noma ezimnyama, izitulo zokulinda
• ikhanda elibuhlungu, ukudideka, noma izinguquko embonweni
• ukukhathala okungajwayelekile noma ubuthakathaka
• ubuhlungu besifuba noma ukungaphatheki kahle
• izinkinga zokuhamba noma ukukhuluma
• ukuba ndikindiki
• ushintsho kumbala wesikhumba somlenze
• ubuhlungu noma ukuzwa okubandayo emilenzeni
• ubuhlungu besisu nesicanucanu nokuhlanza
• umkhuhlane, amakhaza, umphimbo obuhlungu, ukukhwehlela okuqhubekayo nokucinana, noma ezinye izimpawu zokutheleleka
• isikhumba esiphaphathekile
• ukuphelelwa umoya
• ukuzuza kwesisindo
• ukuvuvukala kwezandla, amaqakala, izinyawo, noma ubuso
• ubuhlungu noma ukungaphatheki kahle endaweni engaphezulu yesisu
• ukuphuzi kwesikhumba namehlo
• umchamo omnyama
• ukuchama kaningi kunokujwayelekile

INilotinib ingadala ukuthi izingane zikhule kancane. Udokotela wengane yakho uzobuka ukukhula kwengane yakho ngokucophelela ngenkathi ingane yakho ithatha i-nilotinib. Khuluma nodokotela wengane yakho ngezingozi zokunikeza ingane yakho lo muthi.

I-Nilotinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

• umkhuhlane, umphimbo obuhlungu, amakhaza, noma ezinye izimpawu zokutheleleka
• ukuhlanza
• ukozela

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Tasigna^®