Inaliti ye-Pralatrexate

-Delile

• Ngaphambi kokuthola umjovo we-pralatrexate,
• Umjovo we-Pralatrexate ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

Umjovo we-Pralatrexate usetshenziselwa ukwelapha i-peripheral T-cell lymphoma (PTCL; uhlobo lomdlavuza oluqala ngohlobo oluthile lwamaseli kumasosha omzimba) olungakathuthuki noma olubuyile ngemuva kokwelashwa ngeminye imithi. Umjovo we-Pralatrexate awukhonjisiwe ukusiza abantu abane-lymphoma baphila isikhathi eside. Umjovo wePralatrexate usesigabeni semithi ebizwa nge-folate analogue metabolic inhibitors. Isebenza ngokubulala amangqamuzana omdlavuza.

Umjovo we-Pralatrexate uza njengesisombululo (uketshezi) esizofakwa ngaphakathi (emthanjeni) ngudokotela noma umhlengikazi esibhedlela noma emtholampilo. Imvamisa inikezwa isikhathi semizuzu emi-3 kuye kwemihlanu kanye ngeviki amasonto ayisithupha njengengxenye yomjikelezo wamaviki ayi-7. Ukwelashwa kwakho kuzoqhubeka kuze kube yilapho isimo sakho siba sibi noma uba nemiphumela emibi kakhulu.

Udokotela wakho angadinga ukulungisa umthamo wakho, weqe umthamo, noma umise ukwelashwa kwakho uma uhlangabezana nemiphumela ethile emibi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho ngomjovo we-pralatrexate.

Uzodinga ukuthatha i-folic acid novithamini B₁₂ ngesikhathi sokwelashwa kwakho ngomjovo we-pralatrexate ukusiza ukuvimbela imiphumela ethile emibi. Udokotela wakho mhlawumbe uzokutshela ukuthi uthathe i-folic acid ngomlomo nsuku zonke uqala izinsuku eziyi-10 ngaphambi kokuqala ukwelashwa kwakho nezinsuku ezingama-30 ngemuva komthamo wakho wokugcina womjovo we-pralatrexate. Udokotela wakho futhi uzokutshela ukuthi uzodinga ukuthola uvithamini B₁₂ umjovo kungadluli amasonto ayi-10 ngaphambi komthamo wakho wokuqala womjovo we-pralatrexate nawo wonke amasonto ayi-8 kuye kwayi-10 inqobo nje uma ukwelashwa kwakho kuqhubeka.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-pralatrexate,

• Tshela udokotela wakho kanye nosokhemisi uma une-aleji kumjovo we-pralatrexate, noma yimuphi omunye umuthi, noma iziphi izithako zomjovo we-pralatrexate. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-aspirin neminye imishanguzo yokulwa nokuvuvukala (i-NSAIDS) efana ne-ibuprofen (Advil, Motrin) ne-naproxen (Aleve, Naprosyn); i-probenecid (i-Probalan), ne-trimethoprim / sulfamethoxazole (Bactrim). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• tshela udokotela wakho uma uke waba nesifo sezinso noma sesibindi.
• utshele udokotela wakho uma ukhulelwe, ungakhulelwa, noma uhlele ukukhulelwa. Akufanele ukhulelwe ngenkathi uthola umjovo we-pralatrexate. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma ukhulelwa ngenkathi uthola umjovo we-pralatrexate, shayela udokotela wakho ngokushesha. Umjovo we-Pralatrexate ungalimaza umbungu.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthola umjovo we-pralatrexate.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo we-Pralatrexate ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuqunjelwa
• ukuncipha kokudla
• ukukhathala
• ubuthakathaka
• ukuqubuka
• ukulunywa
• ukujuluka ebusuku
• isisu, iqolo, ingalo, noma ubuhlungu bomlenze
• ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• amabala amhlophe noma izilonda ezindebeni noma emlonyeni nasemphinjeni
• umkhuhlane, umphimbo obuhlungu, ukukhwehlela, ukubanda, noma ezinye izimpawu zokutheleleka
• ukopha okungajwayelekile noma ukulinyazwa
• izinsini ezophayo
• ukuphuma kwamakhala
• amachashazi amancane abomvu noma ansomi esikhunjeni
• igazi emchameni noma esitulweni
• ukuphelelwa umoya
• ubuhlungu besifuba
• ukushaya kwenhliziyo okusheshayo noma okungajwayelekile
• isikhumba esiphaphathekile
• izandla nezinyawo ezibandayo
• ukoma ngokweqile
• umlomo owomile, onamathelayo
• amehlo acwile
• ukuncipha kokuchama
• isiyezi noma ikhanda elikhanyayo

Umjovo we-Pralatrexate ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-pralatrexate.

Buza udokotela wakho noma yimiphi imibuzo onayo ngemithi yakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Folotyn^®