Pazopanib

-Delile

• Ngaphambi kokuthatha i-pazopanib,
• I-Pazopanib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka:

I-Pazopanib ingadala ukulimala kwesibindi okunzima noma okusongela impilo. Tshela udokotela wakho uma uke waba nesifo sesibindi noma wake waba naso. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukuphuzi kwesikhumba noma kwamehlo; umchamo omnyama; ukukhathala ngokweqile; isicanucanu; ukuhlanza; ukulahlekelwa ukudla; ubuhlungu engxenyeni engenhla yangakwesokudla yesisu; ukopha okungavamile noma ukulinyazwa.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzoku-oda izivivinyo ezithile zelebhu ngaphambi kokuba uqale ukuthatha i-pazopanib futhi okungenani kanye ngenyanga ezinyangeni ezi-4 zokuqala zokwelashwa kwakho bese uhlala njalo lapho kudingeka.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-pazopanib futhi isikhathi ngasinye lapho ugcwalisa khona incwadi kadokotela. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokuthatha i-pazopanib.

I-Pazopanib isetshenziselwa ukwelapha i-renal cell carcinoma (RCC, uhlobo lomdlavuza oluqala kumaseli ezinso) kubantu abadala. I-Pazopanib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokunciphisa noma ukuvimba ukusabalala kwamangqamuzana omdlavuza.

IPazopanib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa ithathwa esiswini esingenalutho kanye ngosuku, okungenani ihora eli-1 ngaphambi noma amahora amabili ngemuva kokudla. Thatha i-pazopanib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-pazopanib njengoba kushiwo. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Udokotela wakho angalungisa umthamo wakho we-pazopanib ngesikhathi sokwelashwa kwakho noma angayeka ukwelashwa kwakho. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe nanoma yimiphi imiphumela emibi ongayithola. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Qhubeka uthathe i-pazopanib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-pazopanib ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-pazopanib,

• Tshela udokotela wakho kanye nosokhemisi uma une-allergies ku-pazopanib, noma imuphi omunye umuthi, noma iziphi izithako ezibhebheni zepazopanib. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-cisapride (Propulsid) (ayitholakali e-U.S.); i-clarithromycin (i-Biaxin, ku-Prevpac); i-dofetilide (Tikosyn); i-erythromycin (E.E.S., E-Mycin, Erythrocin); ketoconazole (Nizoral); imithi ethile yokushaya kwenhliziyo okungajwayelekile njenge-amiodarone (Cordarone), i-digoxin (i-Digitek, i-Lanoxicaps, i-Lanoxin), i-diltiazem (i-Cardizem, i-Dilacor, i-Tiazac, abanye), i-disopyramide (i-Norpace), i-flecainide (i-Tambocor), i-mexiletine (i-Mexitil), i-procainamide ), propafenone (Rythmol), propranolol (Inderal, Innopran XL, e-Inderide), quinidine, sotalol (Betapace, Betapace AF, Sorine), kanye ne-verapamil (Calan, Isoptin, Verelan); moxifloxacin (Avelox); ipimozide (i-Orap); i-rifampin (iRifadin, eRifamate, eRifater, eRimactane); i-ritonavir (iNorvir, eKaletra); i-sparfloxacin (iZagam) (ayitholakali e-U.S.); kanye ne-thioridazine (Mellaril). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-pazopanib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho uma ukhwehlele igazi noma wopha esiswini, emathunjini, noma ebuchosheni ezinyangeni eziyisithupha ezidlule noma wahlinzwa ezinsukwini eziyi-7 ezedlule. Phinda utshele udokotela wakho uma uke wakha isililo esiswini noma emathunjini akho noma wake; ukuxhumana okungavamile phakathi kwezingxenye ezimbili zomgudu wakho wamathumbu; IGilbert’s syndrome (isimo sofuzo esithinta isibindi futhi singadala i-jaundice [ukuphuzi kwesikhumba noma kwamehlo]); umfutho wegazi ophakeme; isifo sohlangothi; ukushaya kwenhliziyo okungajwayelekile; isikhathi se-QT eside (inkinga yenhliziyo engajwayelekile engadala ukushaya kwenhliziyo okungajwayelekile, ukuquleka, noma ukufa ngokuzuma); isifo senhliziyo; ubuhlungu besifuba; noma isifo senhliziyo noma segilo.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Akufanele ukhulelwe ngenkathi uthatha i-pazopanib. Uma ukhulelwa ngenkathi uthatha i-pazopanib, shayela udokotela wakho. I-Pazopanib ingalimaza umbungu.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-pazopanib.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphakathi kwamahora ayi-12 wedosi yakho elandelayo ehleliwe, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Pazopanib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ukuqunjelwa
• isilungulela
• shintsha emandleni okunambitha ukudla
• ubuhlungu obuhlangene noma besisipha
• ukuvuvukala kobuso
• ithenda, izintende zezandla ezibomvu namathe ezinyawo
• ukulahleka kwezinwele
• izinzipho ezincane, ezinyinyithekayo noma izinwele
• ushintsho kumbala wezinwele
• ukukhanyisa indawo yesikhumba
• ukuqubuka
• ubuthakathaka
• ukudana
• ukungakhululeki okungavamile emazingeni okushisa abandayo
• ukuncipha komzimba

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ukushaya kwenhliziyo okusheshayo noma okungajwayelekile
• ubuhlungu besifuba
• ubuhlungu ezingalweni, emhlane, entanyeni noma emihlathini
• ukuphelelwa umoya
• ikhanda
• inkulumo ehamba kancane noma enzima
• isiyezi noma ukuquleka
• ubuthakathaka noma ukuba ndikindiki kwengalo noma komlenze
• amanxeba angapholi
• ubuhlungu besisu noma ukuvuvukala
• indle emnyama neyokulinda
• igazi elibomvu endle
• ukuhlanza okunegazi
• hlanza okubukeka njengezizathu zekhofi
• igazi emchameni
• ukuphuma kwamakhala
• ekhwehlela igazi

I-Pazopanib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

• ukukhathala ngokweqile

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Votrient^®