Inaliti ye-Denosumab

-Delile

• Kusetshenziswa umjovo we-Denosumab (Prolia)
• Umjovo weDenosumab (Xgeva) usetshenziswa umjovo weDenosumab usekilasini lemithi ebizwa ngeRANK ligand inhibitors. Isebenza ukuvimbela ukulahleka kwethambo ngokuvimba i-receptor ethile emzimbeni ukunciphisa ukwehla kwethambo. Kuyasebenza ukwelapha i-GCTB ngokuvimba i-receptor ethile kumaseli wesimila okubambezela ukukhula kwesimila. Isebenza ukwelapha amazinga aphezulu e-calcium ngokunciphisa ukonakala kwamathambo njengoba ukonakala kwamathambo kukhipha i-calcium.
• Ngaphambi kokuthola umjovo we-denosumab,
• Umjovo we-Denosumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Kusetshenziswa umjovo we-Denosumab (Prolia)

• ukwelapha i-osteoporosis (isimo lapho amathambo eba mancane futhi abuthakathaka futhi aphuke kalula) kwabesifazane abathole ukuya esikhathini ('' ushintsho lwempilo; '' ukuphela kwezikhathi zokuya esikhathini) abanengozi eyengeziwe yokwaphuka (amathambo aphukile) noma ongakwazi ukuthatha noma ongaphendulanga kweminye imithi yokwelashwa kwamathambo.
• ukwelapha abesilisa abanengozi eyengeziwe yokwaphuka (amathambo aphukile) noma abangakwazi ukuthatha noma abangaphendulanga kwezinye izindlela zokwelapha i-osteoporosis.
• welapha i-osteoporosis ebangelwa yimithi ye-corticosteroid emadodeni nakwabesifazane abazothatha imishanguzo ye-corticosteroid okungenani izinyanga eziyisithupha futhi babe nengozi eyengeziwe yokwaphuka noma abangakwazi ukuthatha noma abangaphenduli kwezinye izindlela zokwelapha i-osteoporosis.
• ukwelapha ukulahleka kwamathambo emadodeni alashelwa umdlavuza wendlala yesinye ngemithi ethile edala ukulahleka kwamathambo,
• ukwelapha ukulahleka kwethambo kwabesifazane abanomdlavuza webele abathola imishanguzo ethize ekhulisa ubungozi bokuphuka.

Umjovo weDenosumab (Xgeva) usetshenziswa umjovo weDenosumab usekilasini lemithi ebizwa ngeRANK ligand inhibitors. Isebenza ukuvimbela ukulahleka kwethambo ngokuvimba i-receptor ethile emzimbeni ukunciphisa ukwehla kwethambo. Kuyasebenza ukwelapha i-GCTB ngokuvimba i-receptor ethile kumaseli wesimila okubambezela ukukhula kwesimila. Isebenza ukwelapha amazinga aphezulu e-calcium ngokunciphisa ukonakala kwamathambo njengoba ukonakala kwamathambo kukhipha i-calcium.

• ukunciphisa ubungozi bokuqhekeka kubantu abane-myeloma eminingi (umdlavuza oqala kumaseli e-plasma futhi udale ukulimala kwamathambo), nakubantu abanezinhlobo ezithile zomdlavuza eziqale kwenye ingxenye yomzimba kodwa sezisabalele emathanjeni.
• kubantu abadala nakwabanye abasebasha ukwelapha isimila esikhulu samathambo (i-GCTB; uhlobo lwesimila samathambo) esingelashwa ngokuhlinzwa.
• ukwelapha amazinga aphezulu e-calcium adalwa ngumdlavuza kubantu abangaphendulanga kweminye imithi.

Umjovo weDenosumab uza njengesisombululo (uketshezi) okufanele ujovwe ngomgogodla (ngaphansi kwesikhumba) engalweni yakho ephezulu, ethangeni eliphezulu, noma endaweni yesisu. Imvamisa ijojowe ngudokotela noma umhlengikazi ehhovisi lezokwelapha noma emtholampilo. Umjovo weDenosumab (Prolia) uvame ukunikezwa kanye ezinyangeni eziyisithupha. Lapho umjovo we-denosumab (Xgeva) usetshenziselwa ukunciphisa ubungozi bokuqhekeka okuvela ku-myeloma eminingi, noma umdlavuza osabalalele emathanjeni, uvame ukunikezwa kanye njalo emavikini amane. Lapho umjovo we-denosumab (Xgeva) usetshenziselwa ukwelapha isimila esikhulu samathambo, noma amazinga aphezulu e-calcium abangelwa ngumdlavuza, uvame ukunikezwa njalo ezinsukwini eziyi-7 ngemithamo yokuqala emithathu (ngosuku 1, usuku 8, nosuku 15) bese kanye njalo emavikini amane ukuqala amasonto ama-2 ngemuva kwemithamo yokuqala emithathu.

Udokotela wakho uzokutshela ukuthi uthathe izithasiselo ze-calcium nevithamini D ngenkathi welashwa ngomjovo we-denosumab. Thatha lezi zithako njengoba kuqondisiwe.

Lapho umjovo we-denosumab (Prolia) usetshenziselwa ukwelapha i-osteoporosis noma ukulahleka kwethambo, udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo we-denosumab futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-denosumab,

• Tshela udokotela wakho kanye nosokhemisi uma une-allergen ku-denosumab (Prolia, Xgeva), noma imiphi eminye imithi, i-latex, noma izithako zomjovo we-denosumab. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• kufanele wazi ukuthi umjovo we-denosumab uyatholakala ngaphansi kwegama lomkhiqizo elithi Prolia noXgeva. Akufanele uthole umkhiqizo ongaphezu kowodwa oqukethe i-denosumab ngasikhathi sinye. Qiniseka ukuthi utshela udokotela wakho uma uphathwa ngenye yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha.Qiniseka ukuthi usho noma yikuphi okulandelayo: angiogenesis inhibitors njenge-axitinib (Inlyta), bevacizumab (Avastin), everolimus (Afinitor, Zortress), pazopanib (Votrient), sorafenib (Nexavar), noma sunitinib (Sutent); ama-bisphosphonates afana ne-alendronate (Binosto, Fosamax), etidronate, ibandronate (Boniva), pamidronate, risedronate (Actonel, Atelvia), zoledronic acid (Reclast); imithi yomdlavuza yamakhemikhali; imishanguzo ecindezela amasosha omzimba njenge-azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), sirolimus (Rapamune), ne-tacrolimus (Astagraf XL, Envarsus, Prograf) ; i-steroids efana ne-dexamethasone, i-methylprednisolone (i-A-Methapred, i-Depo-Medrol, i-Medrol, i-Solu-Medrol), ne-prednisone (i-Rayos); noma imishanguzo esetshenziselwa ukwehlisa amazinga akho e-calcium, njenge-cinacalcet (i-Sensipar). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• tshela udokotela wakho uma ngabe uke waba nezinga eliphansi le-calcium egazini lakho noma. Udokotela wakho mhlawumbe uzohlola izinga le-calcium egazini lakho ngaphambi kokuba uqale ukwelashwa futhi mhlawumbe uzokutshela ukuthi ungatholi umjovo we-denosumab uma izinga liphansi kakhulu.
• utshele udokotela wakho uma uthola ukwelashwa nge-dialysis noma uma uke waba nayo noma wake waba ne-anemia (isimo lapho amangqamuzana abomvu egazi engalethi umoya-mpilo owenele kuzo zonke izingxenye zomzimba); umdlavuza; noma yiluphi uhlobo lokutheleleka, ikakhulukazi emlonyeni wakho; izinkinga ngomlomo wakho, amazinyo, izinsini, noma amazinyo okufakelwa; ukuhlinzwa kwamazinyo noma komlomo (kukhishwe amazinyo, ukufakelwa amazinyo); noma isiphi isimo esivimba igazi lakho ekunqandeni ngokujwayelekile; noma isiphi isimo esinciphisa ukusebenza kwamasosha akho omzimba; ukuhlinzwa ku-gland yakho yegciwane noma i-parathyroid gland (i-gland encane entanyeni); ukuhlinzwa ukuze ususe ingxenye yamathumbu akho amancane; izinkinga ngesisu noma amathumbu akho ezenza kube nzima emzimbeni wakho ukuncela izakhamzimba; i-polymyalgia rheumatica (ukuphazamiseka okubangela ubuhlungu bemisipha nobuthakathaka); isifo sikashukela, noma isifo separathyroid noma sezinso.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uzodinga ukuhlolwa kokukhulelwa okungekuhle ngaphambi kokuqala ukwelashwa ngomjovo we-denosumab. Akufanele ukhulelwe ngenkathi uthola umjovo we-denosumab. Kufanele usebenzise indlela ethembekile yokulawula ukubeletha ukuvimbela ukukhulelwa ngenkathi uthola umjovo we-denosumab futhi okungenani izinyanga ezinhlanu ngemuva kokwelashwa kwakho kokugcina. Uma ukhulelwa ngenkathi uthola umjovo we-denosumab, noma kungakapheli izinyanga ezinhlanu ukwelashwa kwakho, shayela udokotela wakho ngokushesha. UDenosumab angalimaza umbungu.
• kufanele wazi ukuthi umjovo we-denosumab ungadala i-osteonecrosis yomhlathi (i-ONJ, isimo esibi sethambo lomhlathi), ikakhulukazi uma uhlinzwa noma ukwelashwa ngenkathi uthola lo muthi. Udokotela wamazinyo kufanele ahlole amazinyo akho futhi enze noma yiziphi izindlela zokwelashwa ezidingekayo, kufaka phakathi ukuhlanza noma ukulungisa amazinyo okufakelwa angalungile, ngaphambi kokuba uqale ukuthola umjovo we-denosumab. Qiniseka ukuthi uxubha amazinyo futhi uhlanze umlomo wakho kahle ngenkathi uthola umjovo we-denosumab. Khuluma nodokotela wakho ngaphambi kokuthola noma yikuphi ukwelashwa kwamazinyo ngenkathi uthola lo muthi.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa isikhathi sokuthola umjovo we-denosumab, kufanele ushayele umhlinzeki wakho wezokunakekelwa kwezempilo ngokushesha okukhulu. Umthamo ongabanjwanga kufanele unikezwe ngokushesha lapho ungahlelwa kabusha. Lapho umjovo we-denosumab (Prolia) usetshenziselwa i-osteoporosis noma ukulahleka kwethambo, ngemuva kokuthola umthamo ongabanjwanga, umjovo wakho olandelayo kufanele uhlelelwe izinyanga eziyi-6 kusukela ngosuku lomjovo wakho wokugcina.

Umjovo we-Denosumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isikhumba esibomvu, esomile noma esilumayo
• ama-blisters aqhakazile noma ama-crusty esikhunjeni
• ukukhipha isikhumba
• ukuhlungu obusemhlane
• ubuhlungu ezandleni zakho
• ukuvuvukala kwezingalo noma imilenze
• ubuhlungu bemisipha noma bamalunga
• isicanucanu
• isifo sohudo
• ukuqunjelwa
• ubuhlungu besisu
• ikhanda

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqina kwemisipha, ukudikiza, amajaqamba, noma ama-spasms
• ukuba ndikindiki noma ukuncinza eminweni yakho, ezinzwaneni noma emlonyeni wakho
• isifuba, ukuqubuka, ukulunywa, ubunzima bokuphefumula noma ukugwinya, ukuvuvukala kobuso, amehlo, umphimbo, ulimi noma izindebe,
• umkhuhlane noma amakhaza
• ububomvu, isisa, ukuvuvukala noma ukufudumala kwendawo yesikhumba
• umkhuhlane, ukukhwehlela, ukuphelelwa umoya
• ukudonsa izindlebe noma ubuhlungu bendlebe obunzima
• isidingo esivamile noma esiphuthumayo sokuchama, umuzwa ovuthayo lapho uchama
• ubuhlungu obukhulu besisu
• izinsini ezibuhlungu noma ezivuvukile, ukukhululeka kwamazinyo, ukuba ndikindiki noma ukuzwa okusindayo emhlathini, ukuphulukiswa kabi komhlathi
• ukopha okungajwayelekile noma ukulinyazwa
• isicanucanu, ukuhlanza, ikhanda, nokuncipha kokuqapha ngemuva kokumisa i-denosumab futhi kuze kube unyaka ongu-1 ngemuva kwalokho

Umjovo weDenosumab ungakhuphula ubungozi bokuthi uzophula amathambo / amathanga akho Ungase uzwe ubuhlungu okhalweni lwakho, emgodini, noma emathangeni amasonto ambalwa noma izinyanga ngaphambi kokuphuka kwamathambo, futhi ungathola ukuthi elilodwa noma womabili amathambo akho amathanga aphukile yize ungazange uwe noma uhlangabezane nokunye ukuhlukumezeka. Akujwayelekile ukuthi ithambo lethanga liphuke kubantu abaphilile, kepha abantu abane-osteoporosis bangaliphula leli thambo noma bengatholi umjovo we-denosumab. Umjovo weDenosumab nawo ungadala ukuthi amathambo aphukile aphole kancane futhi angaphazamisa ukukhula kwamathambo futhi avimbele amazinyo ukuthi angene kahle ezinganeni. Khuluma nodokotela wakho ngezingozi zokuthola umjovo we-denosumab.

Umjovo we-Denosumab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Unganyakazisi umjovo we-denosumab. Yigcine esiqandisini bese uyivikela ekukhanyeni. Ungafrizi. Umjovo weDenosumab ungagcinwa ekamelweni lokushisa kuze kube yizinsuku eziyi-14.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze aqiniseke ukuthi kuphephile yini kuwe ukujova i-denosumab nokuhlola impendulo yomzimba wakho kumjovo we-denosumab.

Ungavumeli omunye umuntu asebenzise imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UProlia^®
• Xgeva^®