Inaliti ye-Brentuximab Vedotin

-Delile

• Umjovo we-Brentuximab vedotin uyasetshenziswa
• Ngaphambi kokuthola umjovo we-brentuximab vedotin,
• Umjovo we-Brentuximab vedotin ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Ukuthola umjovo we-brentuximab vedotin kungakhuphula ubungozi bokuthi uzoba ne-leukoencephalopathy eqhubekayo (i-PML); ukutheleleka okungajwayelekile kobuchopho okungenakulashwa, ukuvinjelwa, noma ukwelashwa okuvame ukubangela ukufa noma ukukhubazeka okukhulu). Tshela udokotela wakho uma ngabe uke waba nesimo esithinta amasosha akho omzimba. Tshela udokotela kanye nosokhemisi wakho uma ngabe uthatha noma yimiphi imithi ecindezela amasosha omzimba. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, yeka ukuthola umjovo we-brentuximab vedotin bese ufonela udokotela wakho ngokushesha: ukuncipha kwamandla noma ubuthakathaka kolunye uhlangothi lomzimba; ukuhamba kanzima; ukulahleka kokuxhumanisa; ikhanda; ukudideka; ubunzima bokucabanga kahle; ukulahleka kwememori; ukushintsha kwemizwa noma kokuziphatha okuvamile; ukukhuluma kanzima; noma izinguquko zombono.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho anga-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho kumjovo we-brentuximab vedotin.

Khuluma nodokotela wakho ngezingozi zokuthola umjovo we-brentuximab vedotin.

Umjovo we-Brentuximab vedotin uyasetshenziswa

• ngokuhlangana neminye imithi yokwelapha ngamakhemikhali ukwelapha i-Hodgkin's lymphoma (isifo sikaHodgkin) kulabo abangakaze bathole ukwelashwa ngaphambilini
• ukwelapha i-Hodgkin's lymphoma kulabo abasengozini yokuthi izifo zabo zibe zimbi kakhulu noma zibuyele emuva kokufakelwa kwe-stem cell (inqubo efaka umongo wethambo onesifo ngomnkantsha onempilo),
• ukwelapha i-Hodgkin's lymphoma kulabo abangaphendulanga ekufakweni kwe-stem cell (inqubo efaka umongo wethambo onesifo ngomnkantsha onempilo) noma okungenani izikhathi ezimbili zokwelashwa ngamakhemikhali,
• ngokuhlanganiswa neminye imishanguzo yokwelapha ngamakhemikhali ukwelapha i-anaplastic large cell lymphoma (sALCL; uhlobo lwe-non-Hodgkin lymphoma) nezinye izinhlobo ze-peripheral T-cell lymphomas (PTCL; uhlobo lwe-non-Hodgkin lymphoma) kulabo abangakaze uthole ukwelashwa,
• ukwelapha i-systemic sALCL kulabo abangaphendulanga kwesinye isikhathi sokwelashwa ngamakhemikhali,
• ukwelapha uhlobo oluthile lwe-primary cutaneous anaplastic large cell lymphoma (pcALCL; uhlobo lwe-non-Hodgkin's lymphoma) kubantu asebethole olunye ukwelashwa ngaphambilini.

Umjovo we-Brentuximab vedotin usesigabeni semithi ebizwa ngama-anti-drug conjugates. Isebenza ngokubulala amangqamuzana omdlavuza.

Umjovo we-Brentuximab vedotin uza njengempuphu ezohlanganiswa noketshezi bese ujovwa ngaphezu kwemizuzu engama-30 ngemithambo (emthanjeni) ngudokotela noma umhlengikazi ehhovisi lezokwelapha noma esibhedlela. Lapho i-brentuximab vedotin inikezwa ukwelapha iHodgkin's lymphoma, i-sALCL, noma i-PTCL, ivamise ukujova kanye njalo emavikini amathathu uma nje udokotela wakho encoma ukuthi uthole ukwelashwa. Lapho i-brentuximab vedotin isetshenziswa kanye ne-chemotherapy ukwelapha i-Hodgkin lymphoma njengokwelashwa kokuqala, kuvamise ukujova kanye njalo emavikini amabili uma nje udokotela wakho encoma ukuthi uthole ukwelashwa.

Umjovo we-Brentuximab vedotin ungadala ukusabela okweqile komzimba, okuvame ukwenzeka ngesikhathi sokufakwa komuthi noma kungakapheli amahora angama-24 ethola umthamo. Ungathola imishanguzo ethile ngaphambi kokufakwa kwakho ukuvimbela ukusabela okweqile uma ngabe uphendule ngokwelashwa kwangaphambilini. Udokotela wakho uzokubuka ngokucophelela ngenkathi uthola i-brentuximab vedotin. Uma uhlangabezana nalezi zimpawu ezilandelayo, tshela udokotela wakho ngokushesha: umkhuhlane, ukubanda, ukuqubuka, isifuba, ukulunywa, noma ukuphefumula kanzima.

Udokotela wakho angadinga ukubambezela ukwelashwa kwakho, ukulungisa umthamo wakho, noma ukumisa ukwelashwa kwakho uma uhlangabezana nemiphumela ethile emibi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho ngomjovo we-brentuximab vedotin.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-brentuximab vedotin,

• Tshela udokotela wakho kanye nosokhemisi uma une-allergy ku-brentuximab vedotin, noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-brentuximab vedotin. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthola i-bleomycin. Udokotela wakho mhlawumbe uzokutshela ukuthi ungasebenzisi umjovo we-brentuximab vedotin uma uthola lo muthi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-clarithromycin (i-Biaxin, ku-PrevPac), i-indinavir (i-Crixivan), i-itraconazole (i-Sporanox), i-ketoconazole, i-nefazodone, i-nelfinavir (i-Viracept), i-rifampin (i-Rifadin, i-Rimactane, i-Rifater, ne-Rifater) i-ritonavir (iNorvir, eKaletra). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma uke waba nesifo sesibindi noma sezinso.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma ungowesifazane okwaziyo ukukhulelwa, kufanele uthathe ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nezinyanga eziyisithupha ngemuva komthamo wakho wokugcina. Uma ungowesilisa nomlingani wesifazane okhulelwe noma ongakhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nezinyanga eziyisithupha ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthola umjovo we-brentuximab vedotin, shayela udokotela wakho ngokushesha. Umjovo we-Brentuximab vedotin ungalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngenkathi uthola umjovo we-brentuximab vedotin.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala emadodeni. Khuluma nodokotela wakho ngezingozi zokuthola umjovo we-brentuximab vedotin.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo we-Brentuximab vedotin ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuqunjelwa
• izilonda zomlomo
• ukuncipha kokudla
• ukuncipha komzimba
• ukukhathala
• isiyezi
• ubuthakathaka
• ubunzima bokulala noma ukulala
• ukukhathazeka
• isikhumba esomile
• ukulahleka kwezinwele
• ukujuluka ebusuku
• ukujoyina, ithambo, imisipha, iqolo, ingalo, noma ubuhlungu bomlenze
• ukuphazamiseka kwemisipha

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukopha okungajwayelekile noma ukulinyazwa
• ukuba ndikindiki, ukushiswa, noma ukuncinza ezandleni, ezingalweni, ezinyaweni noma emilenzeni
• ubuthakathaka bemisipha
• isikhumba esihlabayo noma esishayayo
• isifuba
• ukuqubuka
• ukulunywa
• isicanucanu
• ukuhlanza
• isifo sohudo
• ukukhwehlela noma ukuphelelwa umoya
• ukuncipha kokuchama
• ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi
• ukuchama okunzima, okubuhlungu, noma okuvamile
• umkhuhlane, ukubanda, ukukhwehlela, noma ezinye izimpawu zokutheleleka
• ubuhlungu obuqhubekayo obuqala endaweni yesisu kepha bungasabalala baye emuva
• isikhumba esiphaphathekile
• ukuphuzi kwesikhumba noma kwamehlo
• ubuhlungu noma ukungaphatheki kahle endaweni engaphezulu yesisu
• umchamo omnyama
• ukunyakaza kwamathumbu anombala wobumba
• ubuhlungu besisu
• ukopha okungajwayelekile noma ukulinyazwa
• indle emnyama neyokulinda
• igazi elibomvu endle

Umjovo we-Brentuximab vedotin ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• umkhuhlane, ukubanda, ukukhwehlela, noma ezinye izimpawu zokutheleleka

Buza usokhemisi wakho noma imiphi imibuzo onayo ngomjovo we-brentuximab vedotin.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Adcetris^®