Ruxolitinib

-Delile

• Ngaphambi kokuthatha i-ruxolitinib,
• I-Ruxolitinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Ruxolitinib isetshenziselwa ukwelapha i-myelofibrosis (umdlavuza womnkantsha wamathambo lapho umnkantsha uthathelwa indawo izicubu ezibomvu futhi kubangele ukwehla kokukhiqizwa kwamangqamuzana egazi). Ibuye isetshenziselwe ukwelapha i-polycythemia vera (i-PV; umdlavuza okhula kancane wegazi lapho umnkantsha wenza amangqamuzana egazi abomvu amaningi kakhulu) kubantu abangakwazanga ukwelashwa ngempumelelo nge-hydroxyurea. I-Ruxolitinib ibuye isetshenziselwe ukwelapha isifo se-graft versus host (GVHD; inkinga ye-hematopoietic stem-cell transplant [HSCT; inqubo efaka umongo wethambo onesifo ngomnkantsha onempilo]) kubantu abadala nezingane ezineminyaka engu-12 ubudala nangaphezulu abelashwa. akuphumelelanga ngemithi ye-steroid. URuxolitinib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ukwelapha i-myelofibrosis ne-PV ngokuvimba amasiginali abangela ukuthi amangqamuzana omdlavuza ande. Lokhu kusiza ukunqanda ukusabalala kwamangqamuzana omdlavuza. Kuyasebenza ukwelapha i-GVHD ngokuvimba amasiginali amaseli adala i-GVHD.

I-Ruxolitinib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa ngokudla noma ngaphandle kokudla kabili ngosuku. Thatha i-ruxolitinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-ruxolitinib njengoba nje kuqondisiwe. Ungayithathi kancane, noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma welashelwa i-myelofibrosis noma i-PV udokotela wakho angakuqala ngomthamo ophansi we-ruxolitinib emasontweni amane okuqala okwelashwa, futhi kancane kancane wandise umthamo wakho emva kwalesi sikhathi, hhayi ngaphezu kwesisodwa njalo emavikini amabili. Uma welashelwa i-GVHD udokotela wakho angakuqala ngomthamo ophansi we-ruxolitinib futhi angakhuphula umthamo wakho ngemuva kwezinsuku okungenani ezintathu zezokwelapha.

Gwinya wonke amaphilisi; ungawahlafune noma uwachoboze.

Uma ungeke ukwazi ukudla ngomlomo futhi une-nasogastric (NG) tube, udokotela wakho angakutshela ukuthi uthathe i-ruxolitinib nge-tube ye-nasogastric (NG). Udokotela wakho noma usokhemisi uzokuchazela ukuthi ungayilungiselela kanjani i-ruxolitinib ukunikela ngepayipi le-NG.

Udokotela wakho uzo-oda ukuhlolwa kwegazi ngaphambi nangesikhathi sokwelashwa kwakho ukuze abone ukuthi uthinteka kanjani lo muthi. Udokotela wakho angakhuphula noma anciphise umthamo wakho we-ruxolitinib ngesikhathi sokwelashwa kwakho, noma angakutshela ukuthi uyeke ukuthatha i-ruxolitinib isikhashana. Lokhu kuya ngokuthi umuthi usebenza kanjani kuwe, imiphumela yokuhlolwa kwakho kwelebhu, futhi uma uba nemiphumela engemihle. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Qhubeka uthathe i-ruxolitinib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-ruxolitinib ngaphandle kokukhuluma nodokotela wakho. Uma udokotela wakho enquma ukumisa ukwelashwa kwakho nge-ruxolitinib, udokotela wakho anganciphisa umthamo wakho kancane kancane.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-ruxolitinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-ruxolitinib, noma imiphi eminye imithi, noma iziphi izithako ezise-ruxolitinib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: imishanguzo yokubulala izinhlungu kubandakanya i-itraconazole (Sporanox), ketoconazole, ne-voriconazole (Vfend); carbamazepine (Carbatrol, Equetro, Tegretol, abanye); i-clarithromycin; efavirenz (Sustiva, e-Atripla, Symfi); i-fluconazole (iDiflucan); Ama-HIV protease inhibitors afaka i-indinavir (Crixivan), i-nelfinavir (i-Viracept), i-ritonavir (i-Norvir, e-Kaletra, i-Viekira Pak), ne-saquinavir (i-Invirase); i-mibefradil (Posicor); nefazodone; i-nevirapine (i-Viramune); i-phenytoin (iDilantin, Phenytek); iPioglitazone (Actos, e-Oseni, eDuetact); i-rifabutin (i-Mycobutin); i-rifampin (i-Rifadin, i-Rimactane, e-Rifamate, i-Rifater); iTelaprevir (Incivik); kanye ne-telithromycin (Ketek). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.Eminye imishanguzo eminingi ingaxhumana ne-ruxolitinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma une-anemia, une-infection, uma unesifo se-dialysis, noma uma ubusanda kusondelana nomuntu onesifo sofuba (i-TB, isifo esinamandla samaphaphu) noma ovakashelwe noma ohlala lapho i-TB ijwayelekile. Phinda utshele udokotela wakho uma ngabe uke waba ne-TB noma wake waba nayo, i-cholesterol ephezulu, umdlavuza wesikhumba, i-hepatitis B noma esinye isifo sesibindi, noma isifo sezinso.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-ruxolitinib, shayela udokotela wakho. Akufanele uncelise ibele ngenkathi uthatha i-ruxolitinib kanye namasonto ama-2 ngemuva komthamo wakho wokugcina.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Ruxolitinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isiyezi
• ikhanda
• ukukhathala
• ubuthakathaka
• ukuphelelwa umoya
• ukuzuza kwesisindo
• igesi
• ubuhlungu besisu
• isifo sohudo
• ukuqunjelwa
• isicanucanu
• ukulunywa
• ukuqubuka
• ubuhlungu bemisipha noma bamalunga
• ukuvuvukala kwezingalo, imilenze noma ezinye izitho zomzimba

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ukopha okungavamile noma okusindayo noma ukulinyazwa
• umkhuhlane, umphimbo obuhlungu, ukugodola, ukukhwehlela, ubuhlungu besifuba, ukujuluka ebusuku, ukuvama njalo, okubuhlungu, ukuchama okuphuthumayo, nezinye izimpawu zokutheleleka
• ukushisa, ukuncinza, ukulunywa, noma ukuzwela kwesikhumba ngakolunye uhlangothi lomzimba noma ubuso ngokuqubuka okubuhlungu noma amabhamuza avela ezinsukwini ezimbalwa kamuva.
• izilonda ezintsha, uhlevane, noma ukushintsha kombala noma ezinye izinguquko esikhunjeni
• isikhumba esikhanyayo, ukukhathala, noma ukuphefumula okuncane (ikakhulukazi ngenkathi uzivocavoca)
• ubunzima bokuhambisa noma ukugcina ibhalansi yakho, ubuthakathaka bemilenze noma izingalo eziqhubeka ziba zimbi, ubunzima bokuqonda noma ukukhuluma, ukulahleka kwememori, izinkinga zombono, noma izinguquko ebuntwini

I-Ruxolitinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukopha okungajwayelekile noma ukulinyazwa
• isiyezi
• ikhanda
• ukukhathala
• umkhuhlane, umphimbo obuhlungu, amakhaza, ukukhwehlela, nezinye izimpawu zokutheleleka

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UJakafi